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• 2012

  Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In: Scientific reports. 2, 700.

  Research output: Contribution to journal › Article › peer-review

  • Pathology
  • Brain
  • Alzheimer Disease
  • Amyloid angiopathy
  • Genetically Modified Animals
  262 Scopus citations

• Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

  Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In: Frontiers in Neurology. JAN, Article 5.

  Research output: Contribution to journal › Article › peer-review

  • Amyloidosis
  • Skin
  • Brain
  • Protein Aggregates
  • Amyloid Plaques
  10 Scopus citations

• Differential activation of the ER stress factor XBP1 by oligomeric assemblies

  Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In: Neurochemical Research. 37, 8, p. 1707-1717 11 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Box Binding Protein 1
  • Factor X
  • Oligomers
  • Amyloid
  • Chemical activation
  25 Scopus citations

• Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In: FASEB Journal. 26, 5, p. 1946-1959 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Agglomeration
  • Alzheimer Disease
  • Brain
  246 Scopus citations

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  18 Scopus citations

• Tau protein: Function and pathology

  Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In: International Journal of Alzheimer's Disease. 707482.

  Research output: Contribution to journal › Editorial › peer-review
  6 Scopus citations

• Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

  Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Vaccination
  • Cognition
  • Hemorrhage
  • Vaccines
  29 Scopus citations

• α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

  Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Oligomers
  • Calcineurin
  • Long-Term Potentiation
  • Memory
  66 Scopus citations
• 2016

  Advances in tau immunotherapy

  Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Toxicity
  • Alzheimer's Disease
  • Protein
  • Vaccination
  • Antibody

• Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart

  Troncone, L., Luciani, M., Coggins, M., Wilker, E. H., Ho, C. Y., Codispoti, K. E., Frosch, M. P., Kayed, R. & del Monte, F., Dec 6 2016, In: Journal of the American College of Cardiology. 68, 22, p. 2395-2407 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Heart Diseases
  • Alzheimer Disease
  • Heart
  • Pathology
  62 Scopus citations

• Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

  Kim, Y. D., Choi, H., Lee, W. J., Park, H., Kam, T. I., Hong, S. H., Nah, J., Jung, S., Shin, B., Lee, H., Choi, T. Y., Choo, H., Kim, K. K., Choi, S. Y., Kayed, R. & Jung, Y. K., Mar 1 2016, In: Neurobiology of Disease. 87, p. 19-28 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Caspases
  • Transgenic Mice
  • Memory
  • Memory Disorders
  • Hippocampus
  33 Scopus citations

• Potential mechanisms and implications for the formation of tau oligomeric strains

  Gerson, J. E., Mudher, A. & Kayed, R., Nov 1 2016, In: Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 482-496 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prions
  • Pathology
  • Neurodegenerative diseases
  • Tauopathies
  • Neurodegenerative Diseases
  27 Scopus citations

• Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity

  Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In: Scientific reports. 6, 35865.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Proteostasis Deficiencies
  • Immunoglobulin Fragments
  • Atomic Force Microscopy
  • Immunotherapy
  8 Scopus citations

• Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

  Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Cognitive Dysfunction
  • Pathology
  • Brain
  • Neurodegenerative Diseases
  39 Scopus citations

• Therapeutic approaches targeting pathological tau aggregates

  Gerson, J. & Kayed, R., Jul 1 2016, In: Current Pharmaceutical Design. 22, 26, p. 4028-4039 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Poisons
  • Neurofibrillary Tangles
  • Therapeutics
  • Immunotherapy
  • Neurodegenerative Diseases
  10 Scopus citations

• The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

  Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In: EBioMedicine. 6, p. 42-49 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oligomers
  • Toxicity
  • Amyloid
  • Immunotherapy
  • Conformations
  269 Scopus citations
• 2018

  AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

  Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In: Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Nerve Crush
  • Retinal Ganglion Cells
  • Endoplasmic Reticulum Stress
  • Optic Nerve
  • Down-Regulation
  6 Scopus citations

• Azure C Targets and Modulates Toxic Tau Oligomers

  Lo Cascio, F. & Kayed, R., Jun 20 2018, In: ACS chemical neuroscience. 9, 6, p. 1317-1326 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Azure C
  • Oligomers
  • Poisons
  • Alzheimer Disease
  • Toxicity
  17 Scopus citations

• Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

  Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In: Chemical Communications. 54, 72, p. 10120-10123 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligosaccharides
  • Heparin
  • Oligomers
  • Poisons
  • Cytotoxicity
  10 Scopus citations

• Elevated phospholipase D isoform 1 in Alzheimer's disease patients’ hippocampus: Relevance to synaptic dysfunction and memory deficits

  Krishnan, B., Kayed, R. & Taglialatela, G., 2018, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 89-102 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer disease type 1
  • Phospholipase D
  • Memory Disorders
  • Protein Isoforms
  • Hippocampus
  12 Scopus citations

• Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).

  Research output: Contribution to conference › Poster › peer-review

• Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1657

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease

  Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In: Acta Neuropathologica Communications. 6, 1, p. 113 1 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  • Brain
  • Proteins
  9 Scopus citations

• Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

  Research output: Contribution to conference › Abstract › peer-review

  • Tauopathies
  • Genetically Modified Animals
  • Passive Immunization
  • Immunotherapy
  • Clone Cells

• Preparation and characterization of tau oligomer strains

  Sengupta, U., Carretero-Murillo, M. & Kayed, R., 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Prion Proteins
  • In Vitro Techniques
  6 Scopus citations

• Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

  Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In: npj Vaccines. 3, 1, 9.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Passive Immunization
  • Immunotherapy
  • Alzheimer Disease
  • Poisons
  25 Scopus citations

• Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

  Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In: Protein Science. 27, 11, p. 1901-1909 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sonication
  • Poisons
  • Oligomers
  • Amyloidogenic Proteins
  • Prions
  26 Scopus citations

• Tau Immunotherapy for Alpha-Synucleinopathy

  Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1442

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Tau Immunotherapy for Alpha-Synucleinopathy

  Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1412

  Research output: Contribution to journal › Article › peer-review

• Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

  Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In: Molecular Neurodegeneration. 13, 1, 13.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Immunotherapy
  • Poisons
  • Monoclonal Antibodies
  • Lewy Bodies
  25 Scopus citations

• α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

  Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Oct 1 2018, In: Biological Psychiatry. 84, 7, p. 499-508 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Poisons
  • Parkinson Disease
  • Brain
  • Disease Progression
  29 Scopus citations
• 2019

  Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

  Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

  Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Transgenic Mice
  • Poisons
  • Light
  • Synaptosomes
  5 Scopus citations

• NLRP3 inflammasome activation drives tau pathology

  Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Drive
  • Amyloid
  • Pathology
  • Neurofibrillary Tangles
  136 Scopus citations

• Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

  Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Conformation
  • Synucleins
  • Conformations
  • Poisons
  • Agglomeration
  10 Scopus citations

• Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

  Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lamins
  • Tauopathies
  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  8 Scopus citations

• Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

  Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Curcumin
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Microtubule-Associated Proteins
  14 Scopus citations