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  • Jia Zhou
2020

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In : Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journalArticle

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

Liu, Z., Chen, H., Wang, P., Li, Y., Wold, E. A., Leonard, P. G., Joseph, S., Brasier, A. R., Tian, B., Tian, B., Zhou, J., Zhou, J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5242-5256 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Epigenetic suppression of HIV in myeloid cells by the BRD4-selective small molecule modulator ZL0580

Alamer, E., Zhong, C., Liu, Z., Niu, Q., Long, F., Guo, L., Gelman, B. B., Soong, L., Zhou, J. & Hu, H., Jun 1 2020, In : Journal of virology. 94, 11, e01880-19.

Research output: Contribution to journalArticle

1 Scopus citations

HJC0152 suppresses human non–small-cell lung cancer by inhibiting STAT3 and modulating metabolism

Lu, L., Li, H., Wu, X., Rao, J., Zhou, J., Fan, S. & Shen, Q., Mar 1 2020, In : Cell Proliferation. 53, 3, e12777.

Research output: Contribution to journalArticle

Open Access

Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist

Shao, H., Mohamed, H., Boulton, S., Huang, J., Wang, P., Chen, H., Zhou, J., Luchowska-Stańska, U., Jentsch, N. G., Armstrong, A. L., Magolan, J., Yarwood, S. & Melacini, G., May 14 2020, In : Journal of medicinal chemistry. 63, 9, p. 4762-4775 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Liu, X., Xu, J., Zhou, J. & Shen, Q., 2020, (Accepted/In press) In : Genes and Diseases.

Research output: Contribution to journalReview article

Open Access

Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection

Xu, J., Berastegui-Cabrera, J., Chen, H., Pachón, J., Zhou, J. & Sánchez-Céspedes, J., Mar 26 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 3142-3160 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5159-5184 26 p.

Research output: Contribution to journalArticle

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling

Brasier, A. R. & Zhou, J., Jan 2020, In : Drug Discovery Today. 25, 1, p. 126-132 7 p.

Research output: Contribution to journalReview article

3 Scopus citations