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Author

  • John Papaconstantinou
2019

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

Neelakantan, H., Brightwell, C. R., Graber, T. G., Maroto, R., Wang, H. Y. L., McHardy, S. F., Papaconstantinou, J., Fry, C. S. & Watowich, S. J., May 2019, In : Biochemical Pharmacology. 163, p. 481-492 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
Open Access
6 Scopus citations
2017

Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning

Cortez, I. D., Bulavin, D. V., Wu, P., McGrath, E. L., Cunningham, K. A., Wakamiya, M., Papaconstantinou, J. & Dineley, K. T., Mar 30 2017, In : Behavioural Brain Research. 322, p. 212-222 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging

German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Apr 14 2016, (Accepted/In press) In : Mechanisms of Ageing and Development.

Research output: Contribution to journalArticle

9 Scopus citations

Amnion-epithelial-cell-derived exosomes demonstrate physiologic state of cell under oxidative stress

Sheller, S., Papaconstantinou, J., Urrabaz-Garza, R., Richardson, L., Saade, G., Salomon, C. & Menon, R., Jun 2016, In : PloS one. 11, 6, e0157614.

Research output: Contribution to journalArticle

50 Scopus citations

Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway

Al Lahham, R., Deford, J. H. & Papaconstantinou, J., Jan 5 2016, In : Molecular and Cellular Endocrinology. 419, p. 1-11 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
24 Scopus citations
2015

Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells

Papaconstantinou, J., Wang, C. Z., Zhang, M., Yang, S., Deford, J., Bulavin, D. V. & Ansari, N. H., 2015, In : Aging. 7, 9, p. 718-733 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity

Papaconstantinou, J. & Hsieh, C. C., 2015, In : Oncotarget. 6, 34, p. 35315-35323 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Klotho protects dopaminergic neuron oxidant-induced degeneration by modulating ASK1 and p38 MAPK signaling pathways

Brobey, R. K., German, D., Sonsalla, P. K., Gurnani, P., Pastor, J., Hsieh, C. C., Papaconstantinou, J., Foster, P. P., Kuro-O, M. & Rosenblatt, K. P., Oct 9 2015, In : PloS one. 10, 10, e0139914.

Research output: Contribution to journalArticle

30 Scopus citations

Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn

Wang, C. Z., Ayadi, A. E., Goswamy, J., Finnerty, C. C., Mifflin, R., Sousse, L., Enkhbaatar, P., Papaconstantinou, J., Herndon, D. N. & Ansari, N. H., 2015, In : Burns. 41, 8, p. 1775-1787 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro

Menon, R., Boldogh, I., Hawkins, H. K., Woodson, M., Polettini, J., Syed, T. A., Fortunato, S. J., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Jun 2014, In : American Journal of Pathology. 184, 6, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

104 Scopus citations

HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes

Bredeson, S., Papaconstantinou, J., Deford, J. H., Kechichian, T., Syed, T. A., Saade, G. & Menon, R., 2014, In : PLoS One. 9, 12, p. e113799

Research output: Contribution to journalArticle

65 Scopus citations
2013

Senescence of primary amniotic cells via oxidative DNA damage

Menon, R., Boldogh, I., Urrabaz-Garza, R., Polettini, J., Syed, T. A., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Dec 27 2013, In : PloS one. 8, 12, e83416.

Research output: Contribution to journalArticle

56 Scopus citations
2012

Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

Lee, J. S., Ward, W. O., Ren, H., Vallanat, B., Darlington, G. J., Han, E. S., Laguna, J. C., DeFord, J. H., Papaconstantinou, J., Selman, C. & Corton, J. C., Jul 1 2012, In : Mechanisms of Ageing and Development. 133, 7, p. 467-478 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

Intestinal mitochondrial apoptotic signaling is activated during oxidative stress

Baregamian, N., Song, J., Papaconstantinou, J., Hawkins, H. K., Evers, B. M. & Chung, D. H., Aug 2011, In : Pediatric Surgery International. 27, 8, p. 871-877 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ishemia-Reperfusion enhances GAPDH nitration in aging skeletal muscle

Bailey, C. E., Hammers, D. W., DeFord, J. H., Dimayuga, V. L., Amaning, J. K., Farrar, R. & Papaconstantinou, J., Oct 2011, In : Aging. 3, 10, p. 1003-1017 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mitochondrial electron transport chain functions in long-lived Ames dwarf mice

Choksi, K. B., Nuss, J. E., DeFord, J. H. & Papaconstantinou, J., Aug 2011, In : Aging. 3, 8, p. 754-767 14 p.

Research output: Contribution to journalArticle

21 Scopus citations