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  • Alan Barrett
2020

Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality

Maciejewski, S., Ruckwardt, T. J., Morabito, K. M., Foreman, B. M., Burgomaster, K. E., Gordon, D. N., Pelc, R. S., DeMaso, C. R., Ko, S. Y., Fisher, B. E., Yang, E. S., Nair, D., Foulds, K. E., Todd, J. P., Kong, W. P., Roy, V., Aleshnick, M., Speer, S. D., Bourne, N., Barrett, A. D. & 10 others, Nason, M. C., Roederer, M., Gaudinski, M. R., Chen, G. L., Dowd, K. A., Ledgerwood, J. E., Alter, G., Mascola, J. R., Graham, B. S. & Pierson, T. C., Jun 10 2020, In : Science Translational Medicine. 12, 547, eaaw9066.

Research output: Contribution to journalArticle

Finding Their Type: Elusive Antigenic Sites on Dengue Virus 3 Mapped with Human Antibodies

Sarathy, V. V. & Barrett, A. D. T., May 13 2020, In : Cell Host and Microbe. 27, 5, p. 681-682 2 p.

Research output: Contribution to journalArticle

Molecular Characterization of Hamster-Adapted Yellow Fever Virus

Mcarthur, M. A., Zhang, S. L., Li, L., Tesh, R. B. & Barrett, A. D. T., Mar 2020, In : Vector-Borne and Zoonotic Diseases. 20, 3, p. 222-227 6 p.

Research output: Contribution to journalArticle

Peli1 signaling blockade attenuates congenital zika syndrome

Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 2020, In : PLoS pathogens. 16, 6, e1008538.

Research output: Contribution to journalArticle

Open Access

Review of data and knowledge gaps regarding yellow fever vaccine-induced immunity and duration of protection

Staples, J. E., Barrett, A. D. T., Wilder-Smith, A. & Hombach, J., Dec 1 2020, In : npj Vaccines. 5, 1, 54.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Structure-Function of the Yellow Fever Virus Envelope Protein: Analysis of Antibody Epitopes

Davis, E. H. & Barrett, A. D. T., Jan 1 2020, In : Viral Immunology. 33, 1, p. 12-21 10 p.

Research output: Contribution to journalArticle

Using next generation sequencing to study the genetic diversity of candidate live attenuated zika vaccines

Collins, N. D., Shan, C., Nunes, B. T. D., Widen, S. G., Shi, P. Y., Barrett, A. D. T. & Sarathy, V. V., Apr 2020, In : Vaccines. 8, 2, 161.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
1 Scopus citations
2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Are booster doses of yellow fever vaccine needed?

Vasconcelos, P. F. C. & Barrett, A. D. T., Dec 2019, In : The Lancet Infectious Diseases. 19, 12, p. 1275-1276 2 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Attenuation of live-attenuated yellow fever 17D vaccine virus is localized to a high-fidelity replication complex

Davis, E. H., Beck, A. S., Strother, A. E., Thompson, J. K., Widen, S. G., Higgs, S., Wood, T. G. & Barrett, A. D. T., 2019, In : mBio. 10, 5, e02294.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Attenuation of zika virus by passage in human HeLa cells

Li, L., Collins, N. D., Widen, S. G., Davis, E. H., Kaiser, J. A., White, M. M., Greenberg, M. B., Barrett, A. D. T., Bourne, N. & Sarathy, V. V., Sep 2019, In : Vaccines. 7, 3, 93.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine

Wilder-Smith, A., Hombach, J., Ferguson, N., Selgelid, M., O'Brien, K., Vannice, K., Barrett, A., Ferdinand, E., Flasche, S., Guzman, M., Novaes, H. M., Ng, L. C., Smith, P. G., Tharmaphornpilas, P., Yoon, I. K., Cravioto, A., Farrar, J. & Nolan, T. M., Jan 2019, In : The Lancet Infectious Diseases. 19, 1, p. e31-e38

Research output: Contribution to journalReview article

50 Scopus citations

Genotypic and phenotypic characterization of West Nile virus NS5 methyltransferase mutants

Kaiser, J. A., Luo, H., Widen, S. G., Wood, T., Huang, C. Y. H., Wang, T. & Barrett, A. D. T., Nov 15 2019, In : Vaccine. 37, 48, p. 7155-7164 10 p.

Research output: Contribution to journalArticle

Japanese encephalitis vaccine-specific envelope protein E138K mutation does not attenuate virulence of West Nile virus

Kaiser, J. A., Luo, H., Widen, S. G., Wood, T. G., Huang, C. Y. H., Wang, T. & Barrett, A. D. T., Dec 1 2019, In : npj Vaccines. 4, 1, 50.

Research output: Contribution to journalArticle

Open Access

Long-term protection after fractional-dose yellow fever vaccination

Wilder-Smith, A., Barrett, A., Vannice, K. & Hombach, J., Jul 16 2019, In : Annals of internal medicine. 171, 2, p. 145-146 2 p.

Research output: Contribution to journalLetter

1 Scopus citations

Meeting Report: WHO consultation on considerations for regulatory expectations of Zika virus vaccines for use during an emergency

Vannice, K. S., Giersing, B. K., Kaslow, D. C., Griffiths, E., Meyer, H., Barrett, A., Durbin, A. P., Wood, D. & Hombach, J., Nov 28 2019, In : Vaccine. 37, 50, p. 7443-7450 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Summit proceedings: Biomedical countermeasure development for emerging vector-borne viral diseases

Blackman, M. A., Marchionni, M. A., Gilly, J., Hepburn, M., Innis, B. L., Barrett, A. D. T., Kester, K. E., Mascola, J. R., Cummings, J. F., Monath, T. P., Cassetti, M. C., Kim, J. H., Saville, M. & Thomas, S. J., Oct 8 2019, In : Vaccine. 37, 43, p. 6248-6254 7 p.

Research output: Contribution to journalArticle

Twenty Years of Progress Toward West Nile Virus Vaccine Development

Kaiser, J. A. & Barrett, A. D. T., Sep 5 2019, In : Viruses. 11, 9

Research output: Contribution to journalReview article

Open Access
4 Scopus citations
2018

Analysis By Deep Sequencing of Discontinued Neurotropic Yellow Fever Vaccine Strains

Beck, A. S., Wood, T. G., Widen, S. G., Thompson, J. K. & Barrett, A. D. T., Dec 1 2018, In : Scientific reports. 8, 1, 13408.

Research output: Contribution to journalArticle

5 Scopus citations

Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development review-article

Hallam, H. J., Hallam, S., Rodriguez, S. E., Barrett, A. D. T., Beasley, D. W. C., Chua, A., Ksiazek, T. G., Milligan, G. N., Sathiyamoorthy, V. & Reece, L. M., Dec 1 2018, In : npj Vaccines. 3, 1, 11.

Research output: Contribution to journalArticle

31 Scopus citations

Characterization of a murine model of non-lethal, symptomatic dengue virus infection

Sarathy, V. V., White, M., Li, L., Kaiser, J. A., Campbell, G. A., Milligan, G. N., Bourne, N. & Barrett, A. D. T., Dec 1 2018, In : Scientific reports. 8, 1, 4900.

Research output: Contribution to journalArticle

9 Scopus citations

Clinical development and regulatory points for consideration for second-generation live attenuated dengue vaccines

Vannice, K. S., Wilder-Smith, A., Barrett, A. D. T., Carrijo, K., Cavaleri, M., de Silva, A., Durbin, A. P., Endy, T., Harris, E., Innis, B. L., Katzelnick, L. C., Smith, P. G., Sun, W., Thomas, S. J. & Hombach, J., Jun 7 2018, In : Vaccine. 36, 24, p. 3411-3417 7 p.

Research output: Contribution to journalComment/debate

24 Scopus citations

Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development

Reece, L. M., Beasley, D., Milligan, G., Sarathy, V. & Barrett, A., Apr 1 2018, In : Current Opinion in Virology. 29, p. 72-78 7 p.

Research output: Contribution to journalReview article

7 Scopus citations
36 Scopus citations

Developing Zika vaccines: The lessons for disease X

Barrett, A. D. T., Jun 26 2018, In : Genome Medicine. 10, 1, 47.

Research output: Contribution to journalComment/debate

3 Scopus citations

Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses

Collins, N. D., Beck, A. S., Widen, S. G., Wood, T. G., Higgs, S. & Barrett, A. D. T., Oct 30 2018, In : mBio. 9, 5, e01871-18.

Research output: Contribution to journalArticle

11 Scopus citations

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In : Molecular Neurodegeneration. 13, 1, 13.

Research output: Contribution to journalArticle

17 Scopus citations

Terrestrial bird migration and west nile virus circulation, United States

Swetnam, D., Widen, S. G., Wood, T. G., Reyna, M., Wilkerson, L., Debboun, M., Symonds, D. A., Mead, D. G., Beaty, B. J., Guzman, H., Tesh, R. B. & Barrett, A. D. T., Dec 2018, In : Emerging infectious diseases. 24, 12, p. 2184-2194 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

The reemergence of yellow fever

Barrett, A., Aug 31 2018, In : Science. 361, 6405, p. 847-848 2 p.

Research output: Contribution to journalArticle

16 Scopus citations

West Nile in Europe: an increasing public health problem

Barrett, A., Jan 1 2018, In : Journal of Travel Medicine. 25, 1

Research output: Contribution to journalArticle

10 Scopus citations

Zika, dengue and yellow fever viruses induce differential anti-viral immune responses in human monocytic and first trimester trophoblast cells

Luo, H., Winkelmann, E. R., Fernandez-Salas, I., Li, L., Mayer, S. V., Danis-Lozano, R., Sanchez-Casas, R. M., Vasilakis, N., Tesh, R., Barrett, A. D., Weaver, S. C. & Wang, T., Mar 2018, In : Antiviral research. 151, p. 55-62 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2017

Active evolution of memory B-cells specific to viral gH/gL/ pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection

Xia, L., Tang, A., Meng, W., Freed, D. C., He, L., Wang, D., Li, F., Li, L., Xiong, W., Gui, X., Schultz, R. D., Chen, H., He, X., Swoyer, R., Ha, S., Liu, Y., Morris, C. D., Zhou, Y., Wang, I. M., Zhao, Q. & 10 others, Luo, W., Xia, N., Espeseth, A. S., Hazuda, D. J., Rupp, R. E., Barrett, A. D., Zhang, N., Zhu, J., Fu, T. M. & An, Z., Jan 1 2017, In : Oncotarget. 8, 43, p. 73654-73669 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

A DENV-2-type-specific monoclonal antibody binds to the denv-complex-reactive antigenic site on envelope protein domain 3

Sarathy, V., Pitcher, T. J., Gromowski, G. D., Roehrig, J. T. & Barrett, A., Jun 1 2017, In : Journal of General Virology. 98, 6, p. 1299-1304 6 p., 000785.

Research output: Contribution to journalArticle

1 Scopus citations

A lethal model of disseminated dengue virus type 1 infection in AG129 mice

Milligan, G. N., Sarathy, V. V., White, M. M., Greenberg, M. B., Campbell, G. A., Pyles, R. B., Barrett, A. D. T. & Bourne, N., Oct 2017, In : Journal of General Virology. 98, 10, p. 2507-2519 13 p., 000923.

Research output: Contribution to journalArticle

7 Scopus citations

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In : Nature Medicine. 23, 6, p. 763-767 5 p.

Research output: Contribution to journalArticle

143 Scopus citations

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In : Nature communications. 8, 1, 676.

Research output: Contribution to journalArticle

70 Scopus citations

Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014

Cajimat, M. N. B., Rodriguez, S. E., Schuster, I. U. E., Swetnam, D. M., Ksiazek, T. G., Habela, M. A., Negredo, A. I., Estrada-Peña, A., Barrett, A. D. T. & Bente, D. A., Oct 2017, In : Vector-Borne and Zoonotic Diseases. 17, 10, p. 714-719 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Live Attenuated Yellow Fever 17D Vaccine: A Legacy Vaccine Still Controlling Outbreaks In Modern Day

Collins, N. D. & Barrett, A. D. T., Mar 1 2017, In : Current Infectious Disease Reports. 19, 3, 14.

Research output: Contribution to journalReview article

30 Scopus citations

MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

Luo, H., Winkelmann, E., Xie, G., Fang, R., Peng, B. H., Li, L., Lazear, H. M., Paessler, S., Diamond, M. S., Gale, M., Barrett, A. D. & Wang, T., 2017, In : Journal of virology. 91, 6, e02097-16.

Research output: Contribution to journalArticle

5 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In : Antiviral research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., Muruato, A. E., Foreman, B. M., Luo, H., Wang, T., Barrett, A. D., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L., Ciaramella, G., Mysorekar, I. U. & 3 others, Pierson, T. C., Shi, P. Y. & Diamond, M. S., Jul 13 2017, In : Cell. 170, 2, p. 273-283.e12

Research output: Contribution to journalArticle

110 Scopus citations

Virulence determinants of West Nile virus: How can these be used for vaccine design?

Kaiser, J. A., Wang, T. & Barrett, A. D. T., May 2017, In : Future Virology. 12, 5, p. 283-295 13 p.

Research output: Contribution to journalReview article

5 Scopus citations
22 Scopus citations
2016

A humanized monoclonal antibody neutralizes yellow fever virus strain 17D-204 inA vitro but does not protect a mouse model from disease

Calvert, A. E., Dixon, K. L., Piper, J., Bennett, S. L., Thibodeaux, B. A., Barrett, A., Roehrig, J. T. & Blair, C. D., Jul 1 2016, In : Antiviral Research. 131, p. 92-99 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In : Cell Host and Microbe. 19, 6, p. 891-900 10 p.

Research output: Contribution to journalArticle

147 Scopus citations

Differential Infectivities among Different Japanese Encephalitis Virus Genotypes in Culex quinquefasciatus Mosquitoes

Huang, Y. J. S., Hettenbach, S. M., Park, S. L., Higgs, S., Barrett, A. D. T., Hsu, W. W., Harbin, J. N., Cohnstaedt, L. W. & Vanlandingham, D. L., Oct 5 2016, In : PLoS neglected tropical diseases. 10, 10, e0005038.

Research output: Contribution to journalArticle

15 Scopus citations

Dysregulation of toll-like receptor 7 compromises innate and adaptive T cell responses and host resistance to an attenuated West Nile virus infection in old mice

Xie, G., Luo, H., Pang, L., Peng, B., Winkelmann, E., McGruder, B., Hesse, J., Whiteman, M., Campbell, G., Milligan, G., Cong, Y., Barrett, A. & Wang, T., 2016, In : Journal of Virology. 90, 3, p. 1333-1344 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Fast-track zika vaccine development-is it possible?

Thomas, S. J., L'Azou, M., Barrett, A. & Jackson, N. A. C., Sep 29 2016, In : New England Journal of Medicine. 375, 13, p. 1212-1216 5 p.

Research output: Contribution to journalReview article

38 Scopus citations