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  • Jian Sha
2020

New host-directed therapeutics for the treatment of Clostridioides difficile infection

Andersson, J. A., Peniche, A. G., Galindo, C. L., Boonma, P., Sha, J., Luna, R. A., Savidge, T. C., Chopra, A. K. & Dann, S. M., Mar 1 2020, In : mBio. 11, 2, e00053-20.

Research output: Contribution to journalArticle

Open Access
2018

A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague

Tao, P., Mahalingam, M., Zhu, J., Moayeri, M., Sha, J., Lawrence, W. S., Leppla, S. H., Chopra, A. K. & Rao, V. B., Sep 1 2018, In : mBio. 9, 5, e01926-18.

Research output: Contribution to journalArticle

12 Scopus citations

Combating multidrug-resistant pathogens with host-directed nonantibiotic therapeutics

Andersson, J. A., Sha, J., Kirtley, M. L., Reyes, E., Fitts, E. C., Dann, S. M. & Chopra, A. K., Jan 2018, In : Antimicrobial agents and chemotherapy. 62, 1, e01943.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Identification of new virulence factors and vaccine candidates for Yersinia pestis

Andersson, J. A., Sha, J., Erova, T. E., Fitts, E. C., Ponnusamy, D., Kozlova, E. V., Kirtley, M. L. & Chopra, A. K., Oct 17 2017, In : Frontiers in Cellular and Infection Microbiology. 7, OCT, 448.

Research output: Contribution to journalArticle

12 Scopus citations
2016

A Replication-Defective human type 5 adenovirus-based trivalent vaccine confers complete protection against plague in mice and nonhuman primates

Sha, J., Kirtley, M. L., Klages, C., Erova, T. E., Telepnev, M., Ponnusamy, D., Fitts, E. C., Baze, W. B., Sivasubramani, S. K., Lawrence, W. S., Patrikeev, I., Peel, J. E., Andersson, J. A., Kozlova, E. V., Tiner, B. L., Peterson, J. W., Mcwilliams, D., Patel, S., Rothe, E., Motin, V. L. & 1 others, Chopra, A. K., Jul 2016, In : Clinical and Vaccine Immunology. 23, 7, p. 586-600 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis

Ponnusamy, D., Kozlova, E. V., Sha, J., Erova, T. E., Azar, S. R., Fitts, E. C., Kirtley, M. L., Tiner, B. L., Andersson, J. A., Grim, C. J., Isom, R. P., Hasan, N. A., Colwell, R. R. & Chopra, A. K., Jan 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 3, p. 722-727 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
5 Scopus citations

New insights into autoinducer-2 signaling as a virulence regulator in a mouse model of pneumonic plague

Fitts, E. C., Andersson, J. A., Kirtley, M. L., Sha, J., Erova, T. E., Chauhan, S., Motin, V. L. & Chopra, A. K., Nov 1 2016, In : mSphere. 1, 6, e00342-16.

Research output: Contribution to journalArticle

6 Scopus citations

New role for FDA-approved drugs in combating antibiotic-resistant bacteria

Andersson, J. A., Fitts, E. C., Kirtley, M. L., Ponnusamy, D., Peniche, A. G., Dann, S. M., Motin, V. L., Chauhan, S., Rosenzweig, J. A., Sha, J. & Chopra, A. K., Jun 2016, In : Antimicrobial agents and chemotherapy. 60, 6, p. 3717-3729 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar typhimurium braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

Erova, T. E., Kirtley, M. L., Fitts, E. C., Ponnusamy, D., Baze, W. B., Andersson, J. A., Cong, Y., Tiner, B. L., Sha, J. & Chopra, A. K., Nov 10 2016, In : Frontiers in Cellular and Infection Microbiology. 6, NOV, 148.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Combinational deletion of three membrane protein-encoding genes highly attenuates Yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague

Tiner, B. L., Sha, J., Kirtley, M. L., Erova, T. E., Popov, V. L., Baze, W. B., van Lier, C. J., Ponnusamy, D., Andersson, J. A., Motin, V. L., Chauhan, S. & Chopra, A. K., Jan 1 2015, In : Infection and immunity. 83, 4, p. 1318-1338 21 p.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations

High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection

Ponnusamy, D., Fitts, E. C., Sha, J., Erova, T. E., Kozlova, E. V., Kirtley, M. L., Tiner, B. L., Andersson, J. A. & Chopra, A. K., 2015, In : Infection and immunity. 83, 5, p. 2065-2081 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intramuscular immunization of mice with a live-Attenuated triple mutant of yersinia pestis co92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague

Tiner, B. L., Sha, J., Ponnusamy, D., Baze, W. B., Fitts, E. C., Popov, V. L., Van Lier, C. J., Erova, T. E. & Chopra, A. K., Dec 2015, In : Clinical and Vaccine Immunology. 22, 12, p. 1255-1268 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Deletion of braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague

Van Lier, C. J., Sha, J., Kirtley, M. L., Cao, A., Tiner, B. L., Erova, T. E., Cong, Y., Kozlova, E. V., Popov, V. L., Baze, W. B. & Chopra, A. K., 2014, In : Infection and immunity. 82, 6, p. 2485-2503 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Functional genomic characterization of virulence factors from necrotizing fasciitis-causing strains of Aeromonas hydrophila

Grim, C. J., Kozlova, E. V., Ponnusamy, D., Fitts, E. C., Sha, J., Kirtley, M. L., van Lier, C. J., Tiner, B. L., Erova, T. E., Joseph, S. J., Read, T. D., Shak, J. R., Joseph, S. W., Singletary, E., Felland, T., Baze, W. B., Horneman, A. J. & Chopra, A. K., 2014, In : Applied and Environmental Microbiology. 80, 14, p. 4162-4183 22 p.

Research output: Contribution to journalArticle

32 Scopus citations
2013

A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague

Sha, J., Rosenzweig, J. A., Kirtley, M. L., van Lier, C. J., Fitts, E. C., Kozlova, E. V., Erova, T. E., Tiner, B. L. & Chopra, A. K., Feb 2013, In : Microbial Pathogenesis. 55, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Characterization of Aeromonas hydrophila wound pathotypes by comparative genomic and functional analyses of virulence genes

Grim, C. J., Kozlov, E. V., Sha, J., Fitts, E. C., van Lier, C. J., Kirtley, M. L., Joseph, S. J., Read, T. D., Burd, E. M., Tall, B. D., Joseph, S. W., Horneman, A. J., Chopra, A. K. & Shak, J. R., Mar 2013, In : mBio. 4, 2, e00064-13.

Research output: Contribution to journalArticle

40 Scopus citations

Deletion of the braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium

Sha, J., Kirtley, M. L., van Lier, C. J., Wang, S., Erova, T. E., Kozlova, E. V., Cao, A., Cong, Y., Fitts, E. C., Rosenzweig, J. A. & Chopra, A. K., Mar 2013, In : Infection and immunity. 81, 3, p. 815-828 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new-generation recombinant plague vaccine

Erova, T. E., Rosenzweig, J. A., Sha, J., Suarez, G., Sierra, J. C., Kirtley, M. L., Van Lier, C. J., Telepnev, M. V., Motin, V. L. & Chopra, A. K., Feb 2013, In : Clinical and Vaccine Immunology. 20, 2, p. 227-238 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in aeromonas hydrophila SSU pathogenesis

Sha, J., Rosenzweig, J. A., Kozlova, E. V., Wang, S., Erova, T. E., Kirtley, M. L., van Lier, C. J. & Chopra, A. K., Jun 1 2013, In : Microbiology (United Kingdom). 159, PART 6, p. 1120-1135 16 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mutated and Bacteriophage T4 Nanoparticle Arrayed F1-V Immunogens from Yersinia pestis as Next Generation Plague Vaccines

Tao, P., Mahalingam, M., Kirtley, M. L., van Lier, C. J., Sha, J., Yeager, L. A., Chopra, A. K. & Rao, V. B., Jul 2013, In : PLoS pathogens. 9, 7, e1003495.

Research output: Contribution to journalArticle

28 Scopus citations

The effects of modeled microgravity on growth kinetics, antibiotic susceptibility, cold growth, and the virulence potential of a yersinia pestis ymoa-deficient mutant and its isogenic parental strain

Lawal, A., Kirtley, M. L., Van Lier, C. J., Erova, T. E., Kozlova, E. V., Sha, J., Chopra, A. K. & Rosenzweig, J. A., Sep 1 2013, In : Astrobiology. 13, 9, p. 821-832 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

Suarez, G., Khajanchi, B. K., Sierra, J. C., Erova, T. E., Sha, J. & Chopra, A. K., Sep 15 2012, In : Gene. 506, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
11 Scopus citations

The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila

Khajanchi, B. K., Kozlova, E. V., Sha, J., Popov, V. L. & Chopra, A. K., Jan 2012, In : Microbiology. 158, 1, p. 259-271 13 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

Cethromycin-mediated protection against the plague pathogen Yersinia pestis in a rat model of infection and comparison with levofloxacin

Rosenzweig, J. A., Brackman, S. M., Kirtley, M. L., Sha, J., Erova, T. E., Yeager, L. A., Peterson, J. W., Xu, Z. Q. & Chopra, A. K., Nov 2011, In : Antimicrobial agents and chemotherapy. 55, 11, p. 5034-5042 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Characterization of an F1 deletion mutant of Yersinia pestis CO92, pathogenic role of F1 antigen in bubonic and pneumonic plague, and evaluation of sensitivity and specificity of F1 antigen capture-based dipsticks

Sha, J., Endsley, J. J., Kirtley, M. L., Foltz, S. M., Huante, M. B., Erova, T. E., Kozlova, E. V., Popov, V. L., Yeager, L. A., Zudina, I. V., Motin, V. L., Peterson, J. W., DeBord, K. L. & Chopra, A. K., May 2011, In : Journal of Clinical Microbiology. 49, 5, p. 1708-1715 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Progress on plague vaccine development

Rosenzweig, J. A., Jejelowo, O., Sha, J., Erova, T. E., Brackman, S. M., Kirtley, M. L., Van Lier, C. J. & Chopra, A. K., Jul 1 2011, In : Applied Microbiology and Biotechnology. 91, 2, p. 265-286 22 p.

Research output: Contribution to journalReview article

28 Scopus citations

Quorum sensing and c-di-GMP-dependent alterations in gene transcripts and virulence-associated phenotypes in a clinical isolate of Aeromonas hydrophila

Kozlova, E. V., Khajanchi, B. K., Sha, J. & Chopra, A. K., May 2011, In : Microbial Pathogenesis. 50, 5, p. 213-223 11 p.

Research output: Contribution to journalArticle

25 Scopus citations