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  • Michael Sheetz
2020

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

Doss, B. L., Pan, M., Gupta, M., Grenci, G., Mège, R. M., Lim, C. T., Sheetz, M. P., Voituriez, R. & Ladoux, B., Jun 9 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 12817-12825 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Extracellular Matrix Rigidity Modulates Human Cervical Smooth Muscle Contractility—New Insights into Premature Cervical Failure and Spontaneous Preterm Birth

Vink, J., Yu, V., Dahal, S., Lohner, J., Stern-Asher, C., Mourad, M., Davis, G., Xue, Z., Wang, S., Myers, K., Kitajewski, J., Chen, X., Wapner, R. J., Ananth, C. V., Sheetz, M. & Gallos, G., 2020, (Accepted/In press) In : Reproductive Sciences.

Research output: Contribution to journalArticle

Micro-stepping extended focus reduces photobleaching and preserves structured illumination super-resolution features

Hu, X., Jalal, S., Sheetz, M., Bakke, O. & Margadant, F., May 2020, In : Journal of Cell Science. 133, 10, 240796.

Research output: Contribution to journalArticle

Open Access

Stopping transformed cancer cell growth by rigidity sensing

Yang, B., Wolfenson, H., Chung, V. Y., Nakazawa, N., Liu, S., Hu, J., Huang, R. Y. J. & Sheetz, M. P., Feb 1 2020, In : Nature Materials. 19, 2, p. 239-250 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

A tale of two states: Normal and transformed, with and without rigidity sensing

Sheetz, M., 2019, In : Annual Review of Cell and Developmental Biology. 35, p. 169-190 22 p.

Research output: Contribution to journalReview article

2 Scopus citations

Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading

Kalappurakkal, J. M., Anilkumar, A. A., Patra, C., van Zanten, T. S., Sheetz, M. P. & Mayor, S., Jun 13 2019, In : Cell. 177, 7, p. 1738-1756.e23

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions

Changede, R., Cai, H., Wind, S. J. & Sheetz, M. P., Dec 1 2019, In : Nature Materials. 18, 12, p. 1366-1375 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Large and reversible myosin-dependent forces in rigidity sensing

Lohner, J., Rupprecht, J. F., Hu, J., Mandriota, N., Saxena, M., de Araujo, D. P., Hone, J., Sahin, O., Prost, J. & Sheetz, M., Jul 1 2019, In : Nature Physics. 15, 7, p. 689-695 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

Alieva, N. O., Efremov, A. K., Hu, S., Oh, D., Chen, Z., Natarajan, M., Ong, H. T., Jégou, A., Romet-Lemonne, G., Groves, J. T., Sheetz, M. P., Yan, J. & Bershadsky, A. D., Dec 1 2019, In : Nature communications. 10, 1, 3593.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Steps in Mechanotransduction Pathways that Control Cell Morphology

Wolfenson, H., Yang, B. & Sheetz, M. P., Feb 10 2019, In : Annual review of physiology. 81, p. 585-605 21 p.

Research output: Contribution to journalReview article

27 Scopus citations
2018

Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Feb 5 2018, In : Developmental cell. 44, 3, p. 326-336.e3

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Correction to: Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus (Oncogene, (2007), 26, 26, (3878-3891), 10.1038/sj.onc.1210162)

Karni-Schmidt, O., Friedler, A., Zupnick, A., McKinney, K., Mattia, M., Beckerman, R., Bouvet, P., Sheetz, M., Fersht, A. & Prives, C., Aug 30 2018, In : Oncogene. 37, 35, p. 4901-4902 2 p.

Research output: Contribution to journalComment/debate

Open Access

EGFR family and Src family kinase interactions: mechanics matters?

Chen, Z., Oh, D., Dubey, A. K., Yao, M., Yang, B., Groves, J. T. & Sheetz, M., Apr 1 2018, In : Current Opinion in Cell Biology. 51, p. 97-102 6 p.

Research output: Contribution to journalReview article

17 Scopus citations

Erratum: Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions (Developmental cell (2018) 44 3 (326-336.e3) PII: S1534-5807(18)30409-X)

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Jun 4 2018, In : Developmental cell. 45, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Cai, H., Muller, J., Depoil, D., Mayya, V., Sheetz, M. P., Dustin, M. L. & Wind, S. J., Jul 1 2018, In : Nature Nanotechnology. 13, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2017

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Wang, Y. H., Hariharan, A., Bastianello, G., Toyama, Y., Shivashankar, G. V., Foiani, M. & Sheetz, M. P., Dec 1 2017, In : Nature communications. 8, 1, 2118.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

EGFR and HER2 activate rigidity sensing only on rigid matrices

Saxena, M., Liu, S., Yang, B., Hajal, C., Changede, R., Hu, J., Wolfenson, H., Hone, J. & Sheetz, M. P., Jul 1 2017, In : Nature Materials. 16, 7, p. 775-781 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

Saxena, M., Changede, R., Hone, J., Wolfenson, H. & Sheetz, M., Dec 13 2017, In : Nano Letters. 17, 12, p. 7242-7251 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics

Changede, R. & Sheetz, M., Jan 1 2017, In : BioEssays. 39, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

MDia1 senses both force and torque during F-actin filament polymerization

Yu, M., Yuan, X., Lu, C., Le, S., Kawamura, R., Efremov, A. K., Zhao, Z., Kozlov, M. M., Sheetz, M., Bershadsky, A. & Yan, J., Dec 1 2017, In : Nature communications. 8, 1, 1650.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Mechanotransmission and Mechanosensing of Human alpha-Actinin 1

Le, S., Hu, X., Yao, M., Chen, H., Yu, M., Xu, X., Nakazawa, N., Margadant, F. M., Sheetz, M. & Yan, J., Dec 5 2017, In : Cell Reports. 21, 10, p. 2714-2723 10 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Molecular stretching modulates mechanosensing pathways

Hu, X., Margadant, F. M., Yao, M. & Sheetz, M. P., Jul 1 2017, In : Protein Science. 26, 7, p. 1337-1351 15 p.

Research output: Contribution to journalReview article

23 Scopus citations

Polymer fiber-based models of connective tissue repair and healing

Lee, N. M., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W. N. & Lu, H. H., Jan 1 2017, In : Biomaterials. 112, p. 303-312 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Spatial control of biological ligands on surfaces applied to T cell activation

Cai, H., Depoil, D., Muller, J., Sheetz, M. P., Dustin, M. L. & Wind, S. J., 2017, Methods in Molecular Biology. Humana Press Inc., p. 307-331 25 p. (Methods in Molecular Biology; vol. 1584).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2015

Cyclic stretching of soft substrates induces spreading and growth

Cui, Y., Hameed, F. M., Yang, B., Lee, K., Pan, C. Q., Park, S. & Sheetz, M., Feb 23 2015, In : Nature communications. 6, 6333.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations

Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

Yu, C. H., Rafiq, N. B. M., Cao, F., Zhou, Y., Krishnasamy, A., Biswas, K. H., Ravasio, A., Chen, Z., Wang, Y. H., Kawauchi, K., Jones, G. E. & Sheetz, M. P., Oct 28 2015, In : Nature communications. 6, 8672.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Mechanobiology

Shivashankar, G. V., Sheetz, M. & Matsudaira, P., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1091-1092 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M. P., Kam, L. C. & Iskratsch, T., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

Changede, R., Xu, X., Margadant, F. & Sheetz, M. P., 2015, In : Developmental cell. 35, 5, p. 614-621 8 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Parallel near-field photolithography with metal-coated elastomeric masks

Wu, J., Yu, C. H., Li, S., Zou, B., Liu, Y., Zhu, X., Guo, Y., Xu, H., Zhang, W., Zhang, L., Liu, B., Tian, D., Huang, W., Sheetz, M. & Huo, F., Jan 27 2015, In : Langmuir. 31, 3, p. 1210-1217 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

Yan, J., Yao, M., Goult, B. T. & Sheetz, M. P., 2015, In : Cellular and Molecular Bioengineering. 8, 1, p. 151-159 9 p.

Research output: Contribution to journalReview article

Open Access
49 Scopus citations
2014

Appreciating force and shape-the rise of mechanotransduction in cell biology

Iskratsch, T., Wolfenson, H. & Sheetz, M. P., Dec 11 2014, In : Nature Reviews Molecular Cell Biology. 15, 12, p. 825-833 9 p.

Research output: Contribution to journalReview article

299 Scopus citations

Can small institutes address some problems facing biomedical researchers?

Sheetz, M., Nov 1 2014, In : Molecular Biology of the Cell. 25, 21, p. 3267-3269 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Early events in cell spreading as a model for quantitative analysis of biomechanical events

Wolfenson, H., Iskratsch, T. & Sheetz, M. P., Dec 2 2014, In : Biophysical journal. 107, 11, p. 2508-2514 7 p.

Research output: Contribution to journalReview article

Open Access
24 Scopus citations

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P. & Yan, J., Apr 9 2014, In : Scientific reports. 4, 4610.

Research output: Contribution to journalArticle

Open Access
155 Scopus citations

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M. P., Apr 2014, In : Journal of Cell Science. 127, 7, p. 1394-1405 12 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility

Zaburdaev, V., Biais, N., Schmiedeberg, M., Eriksson, J., Jonsson, A. B., Sheetz, M. P. & Weitz, D. A., Oct 7 2014, In : Biophysical journal. 107, 7, p. 1523-1531 9 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M. & Sheetz, M., Aug 19 2014, In : FEBS Letters. 588, 16, p. 2663-2670 8 p.

Research output: Contribution to journalReview article

Open Access
205 Scopus citations
2013

Analysis of the local organization and dynamics of cellular actin networks

Luo, W., Yu, C. H., Lieu, Z. Z., Allard, J., Mogilner, A., Sheetz, M. P. & Bershadsky, A. D., 2013, In : Journal of Cell Biology. 202, 7, p. 1057-1073 17 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

Bifunctional nanoarrays for probing the immune response at the single-molecule level

Cai, H., Depoil, D., Palma, M., Sheetz, M. P., Dustin, M. L. & Wind, S. J., Nov 2013, In : Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures. 31, 6, 6F902.

Research output: Contribution to journalArticle

12 Scopus citations

Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions

Lynch, C. D., Lazar, A. M., Iskratsch, T., Zhang, X. & Sheetz, M. P., Jan 1 2013, In : Molecular Biology of the Cell. 24, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

Iskratsch, T., Yu, C. H., Mathur, A., Liu, S., Stévenin, V., Dwyer, J., Hone, J., Ehler, E. & Sheetz, M., Dec 9 2013, In : Developmental cell. 27, 5, p. 545-559 15 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Higuchi, S., Lin, Q., Wang, J., Lim, T. K., Joshi, S. B., Anand, G. S., Chung, M. C. M., Sheetz, M. P. & Fujita, H., Mar 2013, In : Journal of Bioscience and Bioengineering. 115, 3, p. 320-325 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

Roca-Cusachs, P., Del Rio, A., Puklin-Faucher, E., Gauthier, N. C., Biais, N. & Sheetz, M. P., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. E1361-E1370

Research output: Contribution to journalArticle

Open Access
163 Scopus citations

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces

Yu, C. H., Rafiq, N. B. M., Krishnasamy, A., Hartman, K. L., Jones, G. E., Bershadsky, A. D. & Sheetz, M. P., Dec 12 2013, In : Cell Reports. 5, 5, p. 1456-1468 13 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations

Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function

Chen, H., Chandrasekar, S., Sheetz, M. P., Stossel, T. P., Nakamura, F. & Yan, J., Apr 10 2013, In : Scientific reports. 3, 1642.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

Gupta, P., Gauthier, N. C., Cheng-Han, Y., Zuanning, Y., Pontes, B., Ohmstede, M., Martin, R., Knölker, H. J., Döbereiner, H. G., Krendel, M. & Sheetz, M., 2013, In : Biology Open. 2, 12, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Substrate topography and size determine the fate of human embryonic stem cells to neuronal or glial lineage

Ankam, S., Suryana, M., Chan, L. Y., Moe, A. A. K., Teo, B. K. K., Law, J. B. K., Sheetz, M., Low, H. Y. & Yim, E. K. F., Jan 1 2013, In : Acta Biomaterialia. 9, 1, p. 4535-4545 11 p.

Research output: Contribution to journalArticle

100 Scopus citations

Toward a modular analysis of cell mechanosensing and mechanotransduction: A manual for cell mechanics

Dubin-Thaler, B. J. & Sheetz, M., Jan 1 2013, Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues. Cambridge University Press, Vol. 9780521895231. p. 181-195 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M. P., Trepat, X. & Ladoux, B., Jul 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations