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  • Ashok Chopra
2020

New host-directed therapeutics for the treatment of Clostridioides difficile infection

Andersson, J. A., Peniche, A. G., Galindo, C. L., Boonma, P., Sha, J., Luna, R. A., Savidge, T. C., Chopra, A. K. & Dann, S. M., Mar 1 2020, In : mBio. 11, 2, e00053-20.

Research output: Contribution to journalArticle

Open Access
2019

A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells

Zhu, J., Tao, P., Mahalingam, M., Sha, J., Kilgore, P., Chopra, A. K. & Rao, V., Aug 21 2019, In : Science Advances. 5, 8, eaax0064.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity

Alamer, E., Carpio, V. H., Ibitokou, S. A., Kirtley, M. L., Phoenix, I. R., Opata, M. M., Wilson, K. D., Cong, Y., Dann, S. M., Chopra, A. K. & Stephens, R., Jul 1 2019, In : Parasitology research. 118, 7, p. 2277-2285 9 p.

Research output: Contribution to journalArticle

T6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- And polymicrobial infections

Fernández-Bravo, A., Kilgore, P. B., Andersson, J. A., Blears, E., Figueras, M. J., Hasan, N. A., Colwell, R. R., Sha, J. & Chopra, A. K., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24084-24092 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague

Tao, P., Mahalingam, M., Zhu, J., Moayeri, M., Sha, J., Lawrence, W. S., Leppla, S. H., Chopra, A. K. & Rao, V. B., Sep 1 2018, In : mBio. 9, 5, e01926-18.

Research output: Contribution to journalArticle

12 Scopus citations

Combating multidrug-resistant pathogens with host-directed nonantibiotic therapeutics

Andersson, J. A., Sha, J., Kirtley, M. L., Reyes, E., Fitts, E. C., Dann, S. M. & Chopra, A. K., Jan 2018, In : Antimicrobial agents and chemotherapy. 62, 1, e01943.

Research output: Contribution to journalArticle

7 Scopus citations
2017

A bivalent anthrax-plague vaccine that can protect against two Tier-1 bioterror pathogens, Bacillus anthracis and Yersinia pestis

Tao, P., Mahalingam, M., Zhu, J., Moayeri, M., Kirtley, M. L., Fitts, E. C., Andersson, J. A., Lawrence, W. S., Leppla, S. H., Chopra, A. K. & Rao, V. B., Jun 26 2017, In : Frontiers in immunology. 8, JUN, 687.

Research output: Contribution to journalArticle

15 Scopus citations

Identification of new virulence factors and vaccine candidates for Yersinia pestis

Andersson, J. A., Sha, J., Erova, T. E., Fitts, E. C., Ponnusamy, D., Kozlova, E. V., Kirtley, M. L. & Chopra, A. K., Oct 17 2017, In : Frontiers in Cellular and Infection Microbiology. 7, OCT, 448.

Research output: Contribution to journalArticle

12 Scopus citations

Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy

Falik Zaccai, T. C., Savitzki, D., Zivony-Elboum, Y., Vilboux, T., Fitts, E. C., Shoval, Y., Kalfon, L., Samra, N., Keren, Z., Gross, B., Chasnyk, N., Straussberg, R., Mullikin, J. C., Teer, J. K., Geiger, D., Kornitzer, D., Bitterman-Deutsch, O., Samson, A. O., Wakamiya, M., Peterson, J. W. & 7 others, Kirtley, M. L., Pinchuk, I. V., Baze, W. B., Gahl, W. A., Kleta, R., Anikster, Y. & Chopra, A. K., 2017, In : Brain. 140, 2, p. 370-386 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis

Sim, B. K. L., Li, M., Osorio, M., Wu, Y., Wai, T. T., Peterson, J. W., James, E. R., Chakravarty, S., Gao, L., Xu, R., Kc, N., Stafford, R. E., Lawrence, W. S., Yeager, L. A., Peel, J. E., Sivasubramani, S. K., Chopra, A. K., Filippova, S. & Hoffman, S. L., Dec 1 2017, In : npj Vaccines. 2, 1, 17.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Combinational deletion of three membrane protein-encoding genes highly attenuates Yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague

Tiner, B. L., Sha, J., Kirtley, M. L., Erova, T. E., Popov, V. L., Baze, W. B., van Lier, C. J., Ponnusamy, D., Andersson, J. A., Motin, V. L., Chauhan, S. & Chopra, A. K., Jan 1 2015, In : Infection and immunity. 83, 4, p. 1318-1338 21 p.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations

High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection

Ponnusamy, D., Fitts, E. C., Sha, J., Erova, T. E., Kozlova, E. V., Kirtley, M. L., Tiner, B. L., Andersson, J. A. & Chopra, A. K., 2015, In : Infection and immunity. 83, 5, p. 2065-2081 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intramuscular immunization of mice with a live-Attenuated triple mutant of yersinia pestis co92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague

Tiner, B. L., Sha, J., Ponnusamy, D., Baze, W. B., Fitts, E. C., Popov, V. L., Van Lier, C. J., Erova, T. E. & Chopra, A. K., Dec 2015, In : Clinical and Vaccine Immunology. 22, 12, p. 1255-1268 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Deletion of braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague

Van Lier, C. J., Sha, J., Kirtley, M. L., Cao, A., Tiner, B. L., Erova, T. E., Cong, Y., Kozlova, E. V., Popov, V. L., Baze, W. B. & Chopra, A. K., 2014, In : Infection and immunity. 82, 6, p. 2485-2503 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Functional genomic characterization of virulence factors from necrotizing fasciitis-causing strains of Aeromonas hydrophila

Grim, C. J., Kozlova, E. V., Ponnusamy, D., Fitts, E. C., Sha, J., Kirtley, M. L., van Lier, C. J., Tiner, B. L., Erova, T. E., Joseph, S. J., Read, T. D., Shak, J. R., Joseph, S. W., Singletary, E., Felland, T., Baze, W. B., Horneman, A. J. & Chopra, A. K., 2014, In : Applied and Environmental Microbiology. 80, 14, p. 4162-4183 22 p.

Research output: Contribution to journalArticle

32 Scopus citations

Low-shear force associated with modeled microgravity and spaceflight does not similarly impact the virulence of notable bacterial pathogens

Rosenzweig, J. A., Ahmed, S., Eunson, J. & Chopra, A. K., 2014, In : Applied Microbiology and Biotechnology. 98, 21, p. 8797-8807 11 p.

Research output: Contribution to journalReview article

25 Scopus citations
2013

A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague

Sha, J., Rosenzweig, J. A., Kirtley, M. L., van Lier, C. J., Fitts, E. C., Kozlova, E. V., Erova, T. E., Tiner, B. L. & Chopra, A. K., Feb 2013, In : Microbial Pathogenesis. 55, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Characterization of Aeromonas hydrophila wound pathotypes by comparative genomic and functional analyses of virulence genes

Grim, C. J., Kozlov, E. V., Sha, J., Fitts, E. C., van Lier, C. J., Kirtley, M. L., Joseph, S. J., Read, T. D., Burd, E. M., Tall, B. D., Joseph, S. W., Horneman, A. J., Chopra, A. K. & Shak, J. R., Mar 2013, In : mBio. 4, 2, e00064-13.

Research output: Contribution to journalArticle

40 Scopus citations

Deletion of the braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium

Sha, J., Kirtley, M. L., van Lier, C. J., Wang, S., Erova, T. E., Kozlova, E. V., Cao, A., Cong, Y., Fitts, E. C., Rosenzweig, J. A. & Chopra, A. K., Mar 2013, In : Infection and immunity. 81, 3, p. 815-828 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new-generation recombinant plague vaccine

Erova, T. E., Rosenzweig, J. A., Sha, J., Suarez, G., Sierra, J. C., Kirtley, M. L., Van Lier, C. J., Telepnev, M. V., Motin, V. L. & Chopra, A. K., Feb 2013, In : Clinical and Vaccine Immunology. 20, 2, p. 227-238 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in aeromonas hydrophila SSU pathogenesis

Sha, J., Rosenzweig, J. A., Kozlova, E. V., Wang, S., Erova, T. E., Kirtley, M. L., van Lier, C. J. & Chopra, A. K., Jun 1 2013, In : Microbiology (United Kingdom). 159, PART 6, p. 1120-1135 16 p.

Research output: Contribution to journalArticle

27 Scopus citations

In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine

Tao, P., Mahalingam, M., Marasa, B. S., Zhang, Z., Chopra, A. K. & Rao, V. B., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 5846-5851 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
14 Scopus citations

Mutated and Bacteriophage T4 Nanoparticle Arrayed F1-V Immunogens from Yersinia pestis as Next Generation Plague Vaccines

Tao, P., Mahalingam, M., Kirtley, M. L., van Lier, C. J., Sha, J., Yeager, L. A., Chopra, A. K. & Rao, V. B., Jul 2013, In : PLoS pathogens. 9, 7, e1003495.

Research output: Contribution to journalArticle

28 Scopus citations

The effects of modeled microgravity on growth kinetics, antibiotic susceptibility, cold growth, and the virulence potential of a yersinia pestis ymoa-deficient mutant and its isogenic parental strain

Lawal, A., Kirtley, M. L., Van Lier, C. J., Erova, T. E., Kozlova, E. V., Sha, J., Chopra, A. K. & Rosenzweig, J. A., Sep 1 2013, In : Astrobiology. 13, 9, p. 821-832 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
15 Scopus citations
2012

Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

Suarez, G., Khajanchi, B. K., Sierra, J. C., Erova, T. E., Sha, J. & Chopra, A. K., Sep 15 2012, In : Gene. 506, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Shniffer, A., Visschedyk, D. D., Ravulapalli, R., Suarez, G., Turgeon, Z. J., Petrie, A. A., Chopra, A. K. & Merrill, A. R., Oct 26 2012, In : Journal of Biological Chemistry. 287, 44, p. 37030-37041 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
11 Scopus citations

Impact of QseBC system in c-di-GMP-dependent quorum sensing regulatory network in a clinical isolate SSU of Aeromonas hydrophila

Kozlova, E. V., Khajanchi, B. K., Popov, V. L., Wen, J. & Chopra, A. K., Sep 2012, In : Microbial Pathogenesis. 53, 3-4, p. 115-124 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
Open Access
7 Scopus citations

The future of plague vaccines: Hopes raised by a surrogate, live-attenuated recombinant vaccine candidate

Rosenzweig, J. A. & Chopra, A. K., Jun 1 2012, In : Expert review of vaccines. 11, 6, p. 659-661 3 p.

Research output: Contribution to journalReview article

8 Scopus citations

The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila

Khajanchi, B. K., Kozlova, E. V., Sha, J., Popov, V. L. & Chopra, A. K., Jan 2012, In : Microbiology. 158, 1, p. 259-271 13 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

Cethromycin-mediated protection against the plague pathogen Yersinia pestis in a rat model of infection and comparison with levofloxacin

Rosenzweig, J. A., Brackman, S. M., Kirtley, M. L., Sha, J., Erova, T. E., Yeager, L. A., Peterson, J. W., Xu, Z. Q. & Chopra, A. K., Nov 2011, In : Antimicrobial agents and chemotherapy. 55, 11, p. 5034-5042 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Characterization of an F1 deletion mutant of Yersinia pestis CO92, pathogenic role of F1 antigen in bubonic and pneumonic plague, and evaluation of sensitivity and specificity of F1 antigen capture-based dipsticks

Sha, J., Endsley, J. J., Kirtley, M. L., Foltz, S. M., Huante, M. B., Erova, T. E., Kozlova, E. V., Popov, V. L., Yeager, L. A., Zudina, I. V., Motin, V. L., Peterson, J. W., DeBord, K. L. & Chopra, A. K., May 2011, In : Journal of Clinical Microbiology. 49, 5, p. 1708-1715 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Immunomodulatory and protective Roles of quorum-sensing signaling molecules N-Acyl homoserine lactones during infection of mice with Aeromonas hydrophila

Khajanchi, B. K., Kirtley, M. L., Brackman, S. M. & Chopra, A. K., Jul 2011, In : Infection and immunity. 79, 7, p. 2646-2657 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Progress on plague vaccine development

Rosenzweig, J. A., Jejelowo, O., Sha, J., Erova, T. E., Brackman, S. M., Kirtley, M. L., Van Lier, C. J. & Chopra, A. K., Jul 1 2011, In : Applied Microbiology and Biotechnology. 91, 2, p. 265-286 22 p.

Research output: Contribution to journalReview article

28 Scopus citations

Quorum sensing and c-di-GMP-dependent alterations in gene transcripts and virulence-associated phenotypes in a clinical isolate of Aeromonas hydrophila

Kozlova, E. V., Khajanchi, B. K., Sha, J. & Chopra, A. K., May 2011, In : Microbial Pathogenesis. 50, 5, p. 213-223 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Ribonucleases and bacterial virulence

Lawal, A., Jejelowo, O., Chopra, A. K. & Rosenzweig, J. A., Sep 2011, In : Microbial Biotechnology. 4, 5, p. 558-571 14 p.

Research output: Contribution to journalShort survey

14 Scopus citations