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  • Kathryn Cunningham
2020

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In : Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journalArticle

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In : Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex

Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In : Neuroscience. 435, p. 161-173 13 p.

Research output: Contribution to journalArticle

Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants

Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In : Frontiers in Psychiatry. 11, 532.

Research output: Contribution to journalArticle

Open Access

Serotonin neurobiology in cocaine use disorder

Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

Research output: Chapter in Book/Report/Conference proceedingChapter

Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In : Neuropharmacology. 168, 108009.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journalArticle

18 Scopus citations

Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats

Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In : Appetite. 133, p. 231-239 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Chronic poly-drug administration damages adult mouse brain neural stem cells

McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J., Dineley, K., Cunningham, K., Kaphalia, B. & Wu, P., Nov 15 2019, In : Brain Research. 1723, 146425.

Research output: Contribution to journalArticle

Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder

Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In : Psychiatry Research - Neuroimaging. 294, 110977.

Research output: Contribution to journalArticle

2 Scopus citations
1 Scopus citations

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats

Anastasio, N. C., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. D. & Cunningham, K. A., Sep 1 2019, In : Neuropsychopharmacology. 44, 10, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex

Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. C. & Cunningham, K. A., Jul 17 2019, In : ACS chemical neuroscience. 10, 7, p. 3241-3248 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)

Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., 2019, In : Frontiers in Pharmacology. 10, JULY, 907.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges

Sholler, D. J. & Cunningham, K. A., Jul 17 2019, In : ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro

Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In : Scientific reports. 9, 1, 16737.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Targeting the 5-ht2c receptor in biological context and the current state of 5-ht2c receptor ligand development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

8 Scopus citations

The 5-HT2A receptor (5-HT2AR) regulates impulsive action and cocaine cue reactivity in Male Sprague-Dawley rats

Sholler, D. J., Stutz, S. J., Fox, R. G., Boone, E. L., Wang, Q., Rice, K. C., Gerard Moeller, F., Anastasio, N. C. & Cunningham, K. A., Jan 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Translating pharmacology into therapeutics to fight the opioid crisis

Marek, G. J., Cunningham, K. A. & Rasmussen, K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 394-395 2 p.

Research output: Contribution to journalEditorial

Open Access
2018

Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder

Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 30 2018, In : Psychiatry Research - Neuroimaging. 271, p. 59-66 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

A protocol for measuring cue reactivity in a rat model of cocaine use disorder

Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In : Journal of Visualized Experiments. 2018, 136, e55864.

Research output: Contribution to journalArticle

4 Scopus citations

Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction

Felsing, D. E., Anastasio, N. C., Miszkiel, J. M., Gilbertson, S. R., Allen, J. A. & Cunningham, K. A., Aug 2018, In : PloS one. 13, 8, e0203137.

Research output: Contribution to journalArticle

10 Scopus citations
6 Scopus citations

Editors' Favorites of 2017

Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In : ACS Chemical Neuroscience. 9, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

1 Scopus citations

Innovative Therapeutic Intervention for Opioid Use Disorder

Moeller, F. G. & Cunningham, K. A., Jan 1 2018, In : Neuropsychopharmacology. 43, 1, p. 220-221 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations

Novel Bivalent 5-HT 2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo

Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C., Cunningham, K. A., Gilbertson, S. R. & Anastasio, N. C., Mar 21 2018, In : ACS chemical neuroscience. 9, 3, p. 514-521 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

PPARγ agonism attenuates cocaine cue reactivity

Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. A. & Dineley, K. T., Jan 2018, In : Addiction Biology. 23, 1, p. 55-68 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
9 Scopus citations

Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience

Nilsson, C. L. & Cunningham, K., Jan 17 2018, In : ACS Chemical Neuroscience. 9, 1, 1 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907

Gilbertson, S. R., Chen, Y. C., Soto, C. A., Yang, Y., Rice, K. C., Cunningham, K. A. & Anastasio, N. C., May 1 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 8, p. 1381-1385 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning

Cortez, I. D., Bulavin, D. V., Wu, P., McGrath, E. L., Cunningham, K. A., Wakamiya, M., Papaconstantinou, J. & Dineley, K. T., Mar 30 2017, In : Behavioural Brain Research. 322, p. 212-222 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine

Simmler, L. D., Anacker, A. M. J., Levin, M. H., Vaswani, N. M., Gresch, P. J., Nackenoff, A. G., Anastasio, N. C., Stutz, S. J., Cunningham, K. A., Wang, J., Zhang, B., Henry, L. K., Stewart, A., Veenstra-VanderWeele, J. & Blakely, R. D., Jan 1 2017, In : British Journal of Pharmacology. 174, 16, p. 2716-2738 23 p.

Research output: Contribution to journalArticle

8 Scopus citations

Editors’ Favorites of 2016

Lindsley, C. W., Hooker, J. M., Cunningham, K. A. & Andrews, A. M., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Lorcaserin Suppresses Oxycodone Self-Administration and Relapse Vulnerability in Rats

Neelakantan, H., Holliday, E. D., Fox, R. G., Stutz, S. J., Comer, S. D., Haney, M., Anastasio, N. C., Moeller, F. G. & Cunningham, K. A., May 17 2017, In : ACS chemical neuroscience. 8, 5, p. 1065-1073 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial

Schmitz, J. M., Green, C. E., Hasan, K. M., Vincent, J., Suchting, R., Weaver, M. F., Moeller, F. G., Narayana, P. A., Cunningham, K. A., Dineley, K. T. & Lane, S. D., Oct 2017, In : Addiction. 112, 10, p. 1861-1868 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption

McGrath, E. L., Gao, J., Kuo, Y. F., Dunn, T. J., Ray, M. J., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Dec 12 2017, In : Stem Cell Reports. 9, 6, p. 1916-1930 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist

Chen, Y. C., Hartley, R. M., Anastasio, N. C., Cunningham, K. A. & Gilbertson, S. R., May 17 2017, In : ACS chemical neuroscience. 8, 5, p. 1004-1010 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

Gao, Y., Yao, T., Deng, Z., Sohn, J. W., Sun, J., Huang, Y., Kong, X., Yu, K. J., Wang, R. T., Chen, H., Guo, H., Yan, J., Cunningham, K. A., Chang, Y., Liu, T. & Williams, K. W., Jan 17 2017, In : Cell Reports. 18, 3, p. 583-592 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2016

Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U

Kasper, J. M., McCue, D. L., Milton, A. J., Szwed, A., Sampson, C. M., Huang, M., Carlton, S., Meltzer, H. Y., Cunningham, K. A. & Hommel, J. D., Dec 1 2016, In : Biological Psychiatry. 80, 11, p. 878-887 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system

Swinford-Jackson, S. E., Anastasio, N. C., Fox, R. G., Stutz, S. J. & Cunningham, K. A., Jun 2 2016, In : Neuroscience. 324, p. 50-61 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Is There a causal relation between maternal acetaminophen administration and ADHD?

Saad, A., Hegde, S., Kechichian, T., Gamble, P., Rahman, M., Stutz, S. J., Anastasio, N. C., Alshehri, W., Lei, J., Mori, S., Kajs, B., Cunningham, K. A., Saade, G., Burd, I. & Costantine, M., Jun 2016, In : PloS one. 11, 6, e0157380.

Research output: Contribution to journalArticle

3 Scopus citations

Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In : ACS Chemical Neuroscience. 7, 5, p. 546-552 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Frontiers of biomolecular exploration in brain disorders

Nilsson, C. L. & Cunningham, K. A., Jan 2014, In : Neuropsychopharmacology. 39, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

Functional status of the serotonin 5-HT 2C receptor (5-HT 2C R) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence

Anastasio, N. C., Stutz, S. J., Fox, R. G., Sears, R. M., Emeson, R. B., Dileone, R. J., O'Neil, R. T., Fink, L. H., Li, D., Green, T. A., Gerard Moeller, F. & Cunningham, K. A., Jan 2014, In : Neuropsychopharmacology. 39, 2, p. 360-372 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Multi-well plate immunoassays for measuring signaling protein activations/deactivations and membrane vs. intracellular receptor levels

Watson, C. S., Jeng, Y. J., Bulayeva, N. N., Finnerty, C. C., Koong, L. Y., Zivadinovic, D., Alyea, R. A., Midoro-Horiuti, T., Goldblum, R. M., Anastasio, N. C., Cunningham, K. A., Seitz, P. K. & Smith, T. D., 2014, In : Methods in Molecular Biology. 1204, p. 123-133 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction

Cunningham, K. A. & Anastasio, N. C., 2014, In : Neuropharmacology. 76, PART B, p. 460-478 19 p.

Research output: Contribution to journalReview article

79 Scopus citations

Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity

Anastasio, N. C., Liu, S., Maili, L., Swinford, S., Lane, S. D., Fox, R. G., Hamon, S. C., Nielsen, D. A., Cunningham, K. A. & Moeller, F. G., 2014, In : Translational psychiatry. 4, e369.

Research output: Contribution to journalArticle

27 Scopus citations
2013

Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 1 2013, In : Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.

Research output: Contribution to journalArticle

10 Scopus citations