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• 2012

  Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

  Simmons, C. P., Wolbers, M., Nguyen, M. N., Whitehorn, J., Shi, P. Y., Young, P., Petric, R., Nguyen, V. V. C., Farrar, J. & Wills, B., Sep 2012, In: PLoS neglected tropical diseases. 6, 9, e1752.

  Research output: Contribution to journal › Article › peer-review
  25 Scopus citations

• The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation

  Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G. & Lok, S. M., Nov 23 2012, In: Journal of Biological Chemistry. 287, 48, p. 40525-40534 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Viruses
  • Dengue
  • Membrane Proteins
  • Exosomes
  • Dengue Virus
  32 Scopus citations

• The structural basis for serotype-specific neutralization of dengue virus by a human antibody

  Teoh, E. P., Kukkaro, P., Teo, E. W., Lim, A. P. C., Tan, T. T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V. A., Leo, Y. S., Chan, S. H., Smith, K. G. C., Chan, A. H. Y., Zou, G., Ooi, E. E., Kemeny, D. M., Tan, G. K., Ng, J. K. W., Ng, M. L., Alonso, S. & 5 others, Fisher, D., Shi, P. Y., Hanson, B. J., Lok, S. M. & MacAry, P. A., Jun 20 2012, In: Science Translational Medicine. 4, 139, 139ra83.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Serogroup
  • Antibodies
  • Immunity
  • Cryoelectron Microscopy
  165 Scopus citations

• U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication

  Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 2012, In: Antiviral research. 93, 1, p. 191-198 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
  • Anticholesteremic Agents
  • Virus Internalization
  • Dengue Virus
  • Virus Replication
  72 Scopus citations
• 2011

  A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-Dependent RNA polymerase

  Niyomrattanakit, P., Abas, S. N., Lim, C. C., Beer, D., Shi, P. Y. & Chen, Y. L., Feb 2011, In: Journal of Biomolecular Screening. 16, 2, p. 201-210 10 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Dengue Virus
  • Viruses
  • Assays
  • Fluorescence
  39 Scopus citations

• Anti-infectives: Can cellular screening deliver?

  Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 2011, In: Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Emerging Communicable Diseases
  • Drug Discovery
  • Diarylquinolines
  • Screening
  • Viruses
  22 Scopus citations

• A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

  Grant, D., Tan, G. K., Qing, M., Ng, J. K. W., Yip, A., Zou, G., Xie, X., Yuan, Z. Y., Schreiber, J., Schul, W., Shi, P. Y. & Alonso, S., Aug 2011, In: Journal of virology. 85, 15, p. 7775-7787 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • dengue
  • Dengue Virus
  • Dengue
  • Viral RNA
  67 Scopus citations

• A translation inhibitor that suppresses dengue virus in vitro and in vivo

  Wang, Q. Y., Kondreddi, R. R., Xie, X., Rao, R., Nilar, S., Xu, H. Y., Qing, M., Chang, D., Dong, H., Yokokawa, F., Lakshminarayana, S. B., Goh, A., Schul, W., Kramer, L., Keller, T. H. & Shi, P. Y., Sep 2011, In: Antimicrobial agents and chemotherapy. 55, 9, p. 4072-4080 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Benzomorphans
  • Viral RNA
  • In Vitro Techniques
  • Pharmacokinetics
  39 Scopus citations

• Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

  Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 2011, In: Antiviral research. 89, 1, p. 26-34 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucosidases
  • Dengue Virus
  • Ribavirin
  • 4-nitrophenyl-alpha-glucosidase
  • glucosidase I
  69 Scopus citations

• Corrigendum to "Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes" [Virology 404 (2010) 89-95]

  Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Feb 20 2011, In: Virology. 410, 2, p. 437 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Dengue drug discovery

  Shi, P. Y., Yin, Z., Nilar, S. & Keller, T. H., Oct 31 2011, Third World Diseases. Elliot, R. (ed.). p. 243-276 34 p. (Topics in Medicinal Chemistry; vol. 7).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Dengue
  • Drug Discovery
  • Antiviral Agents
  • Dengue Vaccines
  • Serogroup
  4 Scopus citations

• Development and characterization of a stable luciferase dengue virus for high-throughput screening

  Zou, G., Xu, H. Y., Qing, M., Wang, Q. Y. & Shi, P. Y., Jul 1 2011, In: Antiviral research. 91, 1, p. 11-19 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Luciferases
  • Viruses
  • Complementary DNA
  • Renilla Luciferases
  83 Scopus citations

• Functional analysis of two cavities in flavivirus NS5 polymerase

  Zou, G., Chen, Y. L., Dong, H., Lim, C. C., Yap, L. J., Yau, Y. H., Shochat, S. G., Lescar, J. & Shi, P. Y., Apr 22 2011, In: Journal of Biological Chemistry. 286, 16, p. 14362-14372 11 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Functional analysis
  • Flavivirus
  • Dengue Virus
  • Viruses
  84 Scopus citations

• Inhibition of dengue virus by targeting viral NS4B protein

  Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 2011, In: Journal of virology. 85, 21, p. 11183-11195 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • viral proteins
  • Viral Proteins
  • Replicon
  93 Scopus citations

• Inhibition of dengue virus through suppression of host pyrimidine biosynthesis

  Wang, Q. Y., Bushell, S., Qing, M., Xu, H. Y., Bonavia, A., Nunes, S., Zhou, J., Poh, M. K., de Sessions, P. F., Niyomrattanakit, P., Dong, H., Hoffmaster, K., Goh, A., Nilar, S., Schul, W., Jones, S., Kramer, L., Compton, T. & Shi, P. Y., Jul 2011, In: Journal of virology. 85, 13, p. 6548-6556 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • pyrimidine
  • Dengue Virus
  • dihydroorotate dehydrogenase
  • pyrimidines
  105 Scopus citations

• Keratinocytes are cell targets of west nile virus in vivo

  Lim, P. Y., Behr, M. J., Chadwick, C. M., Shi, P. Y. & Bernard, K. A., May 2011, In: Journal of virology. 85, 10, p. 5197-5201 5 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • keratinocytes
  • Keratinocytes
  • Skin
  • cells
  75 Scopus citations

• Nonconsensus west nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo

  Ebel, G. D., Fitzpatrick, K. A., Lim, P. Y., Bennett, C. J., Deardorff, E. R., Kramer, G. V. S. J., Zhou, Y., Shi, P. Y. & Bernard, K. A., Dec 2011, In: Journal of virology. 85, 23, p. 12605-12613 9 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Culicidae
  • pathogenesis
  • RNA helicases
  • RNA Helicases
  19 Scopus citations

• Small molecule inhibitors that selectively block dengue virus methyltransferase

  Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, Keller, T. H. & Shi, P. Y., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Methyltransferases
  • Molecules
  • Flavivirus
  108 Scopus citations

• The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

  Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In: Journal of virology. 85, 4, p. 1900-1905 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA replication
  • Flavivirus
  • Flaviviridae
  • Culicidae
  • Viral RNA
  54 Scopus citations

• The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry

  Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In: Virology. 410, 1, p. 170-180 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Virus Assembly
  • Virus Internalization
  • Dengue Virus
  • Membrane Proteins
  • Mutation
  26 Scopus citations

• The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry

  Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 2011, In: Journal of virology. 85, 10, p. 5159-5171 13 p.

  Research output: Contribution to journal › Article › peer-review

  • virus assembly
  • Viral Envelope Proteins
  • Dengue virus
  • Virus Assembly
  • Virus Internalization
  34 Scopus citations

• West nile virus experimental evolution in vivo and the trade-off hypothesis

  Deardorff, E. R., Fitzpatrick, K. A., Jerzak, G. V. S., Shi, P. Y., Kramer, L. D. & Ebel, G. D., Nov 2011, In: PLoS pathogens. 7, 11, e1002335.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Viruses
  • Culicidae
  • Culex
  • Birds
  70 Scopus citations