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• 2013

  Tau aggregates as immunotherapeutic targets

  Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Toxicity
  • Tauopathies
  • Neurodegenerative diseases
  30 Scopus citations
• 2012

  Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In: Scientific reports. 2, 700.

  Research output: Contribution to journal › Article › peer-review

  • Pathology
  • Brain
  • Alzheimer Disease
  • Amyloid angiopathy
  • Genetically Modified Animals
  259 Scopus citations

• Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

  Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In: Frontiers in Neurology. JAN, Article 5.

  Research output: Contribution to journal › Article › peer-review

  • Amyloidosis
  • Skin
  • Brain
  • Protein Aggregates
  • Amyloid Plaques
  10 Scopus citations

• Differential activation of the ER stress factor XBP1 by oligomeric assemblies

  Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In: Neurochemical Research. 37, 8, p. 1707-1717 11 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Box Binding Protein 1
  • Factor X
  • Oligomers
  • Amyloid
  • Chemical activation
  25 Scopus citations

• Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In: FASEB Journal. 26, 5, p. 1946-1959 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Agglomeration
  • Alzheimer Disease
  • Brain
  241 Scopus citations

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  17 Scopus citations

• Tau protein: Function and pathology

  Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In: International Journal of Alzheimer's Disease. 707482.

  Research output: Contribution to journal › Editorial › peer-review
  6 Scopus citations

• Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

  Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Vaccination
  • Cognition
  • Hemorrhage
  • Vaccines
  29 Scopus citations

• α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

  Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Oligomers
  • Calcineurin
  • Long-Term Potentiation
  • Memory
  64 Scopus citations
• 2011

  Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

  Lasagna-Reeves, C. A., Glabe, C. G. & Kayed, R., Jun 24 2011, In: Journal of Biological Chemistry. 286, 25, p. 22122-22130 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Brain
  • Alzheimer Disease
  • Toxicity
  • In Vitro Techniques
  101 Scopus citations

• ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function

  Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2011, In: International Journal of Alzheimer's Disease. 792070.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4
  • Amyloid
  • Apolipoprotein E3
  • Apolipoproteins E
  • Neprilysin
  21 Scopus citations

• Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

  Lasagna-Reeves, C. A. & Kayed, R., Oct 3 2011, In: FEBS Letters. 585, 19, p. 3052-3057 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Astrocytes
  • Amyloid
  • Brain
  • Alzheimer Disease
  • Conformations
  28 Scopus citations

• Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis

  Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In: British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Cutaneous Amyloidosis
  • Immunoglobulin Light Chains
  • Amyloid
  • Immunoglobulins
  • Keratinocytes
  12 Scopus citations

• Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis

  Clos, A. L., Lasagna-Reeves, C. A., Kelly, B., Wagner, R., Wilkerson, M., Jackson, G. R. & Kayed, R., Nov 1 2011, In: Journal of the American Academy of Dermatology. 65, 5, p. 1023-1031 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Cutaneous Amyloidosis
  • Amyloid
  • Skin
  • antibiotic I-11
  • thioflavin T
  10 Scopus citations

• Tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Jackson, G. R. & Kayed, R., Sep 1 2011, In: Current Alzheimer Research. 8, 6, p. 659-665 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Immunotherapy
  • Alzheimer Disease
  • Neurofibrillary Tangles
  • tau Proteins
  57 Scopus citations

• Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R. & Kayed, R., 2011, In: Molecular Neurodegeneration. 6, 1, 39.

  Research output: Contribution to journal › Article › peer-review

  • Electron Transport Complex I
  • Tauopathies
  • human MAPT protein
  • Alzheimer Disease
  • Septins
  278 Scopus citations