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• 2019

  A tale of two states: Normal and transformed, with and without rigidity sensing

  Sheetz, M., 2019, In: Annual Review of Cell and Developmental Biology. 35, p. 169-190 22 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cytoskeletal Proteins
  • MicroRNAs
  • Growth
  • Neoplasms
  • Wound Healing
  4 Scopus citations

• Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading

  Kalappurakkal, J. M., Anilkumar, A. A., Patra, C., van Zanten, T. S., Sheetz, M. P. & Mayor, S., Jun 13 2019, In: Cell. 177, 7, p. 1738-1756.e23

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanoclusters
  • Cell membranes
  • Glycosylphosphatidylinositols
  • Integrins
  • Myosins
  25 Scopus citations

• Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions

  Changede, R., Cai, H., Wind, S. J. & Sheetz, M. P., Dec 1 2019, In: Nature Materials. 18, 12, p. 1366-1375 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanoclusters
  • nanoclusters
  • Integrins
  • Adhesion
  • Fibers
  23 Scopus citations

• Large and reversible myosin-dependent forces in rigidity sensing

  Lohner, J., Rupprecht, J. F., Hu, J., Mandriota, N., Saxena, M., de Araujo, D. P., Hone, J., Sahin, O., Prost, J. & Sheetz, M., Jul 1 2019, In: Nature Physics. 15, 7, p. 689-695 7 p.

  Research output: Contribution to journal › Article › peer-review

  • myosins
  • rigidity
  • contraction
  • filaments
  • cells
  10 Scopus citations

• Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

  Alieva, N. O., Efremov, A. K., Hu, S., Oh, D., Chen, Z., Natarajan, M., Ong, H. T., Jégou, A., Romet-Lemonne, G., Groves, J. T., Sheetz, M. P., Yan, J. & Bershadsky, A. D., Dec 1 2019, In: Nature communications. 10, 1, 3593.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nonmuscle Myosin Type IIA
  • myosins
  • Pseudopodia
  • Adhesion
  • filaments
  13 Scopus citations

• Steps in Mechanotransduction Pathways that Control Cell Morphology

  Wolfenson, H., Yang, B. & Sheetz, M. P., Feb 10 2019, In: Annual review of physiology. 81, p. 585-605 21 p.

  Research output: Contribution to journal › Review article › peer-review

  • Controlled Environment
  • Receptor Protein-Tyrosine Kinases
  • Extracellular Matrix
  • Fibrosis
  • Homeostasis
  37 Scopus citations
• 2017

  DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

  Wang, Y. H., Hariharan, A., Bastianello, G., Toyama, Y., Shivashankar, G. V., Foiani, M. & Sheetz, M. P., Dec 1 2017, In: Nature communications. 8, 1, 2118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ataxia
  • Ataxia Telangiectasia
  • Phosphatidylinositols
  • lipids
  • deoxyribonucleic acid
  27 Scopus citations

• EGFR and HER2 activate rigidity sensing only on rigid matrices

  Saxena, M., Liu, S., Yang, B., Hajal, C., Changede, R., Hu, J., Wolfenson, H., Hone, J. & Sheetz, M. P., Jul 1 2017, In: Nature Materials. 16, 7, p. 775-781 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Epidermal Growth Factor
  • rigidity
  • Rigidity
  • ErbB Receptors
  • matrices
  34 Scopus citations

• Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

  Saxena, M., Changede, R., Hone, J., Wolfenson, H. & Sheetz, M. P., Dec 13 2017, In: Nano Letters. 17, 12, p. 7242-7251 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Talin
  • Calpain
  • rigidity
  • cleavage
  • Rigidity
  22 Scopus citations

• Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics

  Changede, R. & Sheetz, M., Jan 1 2017, In: BioEssays. 39, 1, p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mechanics
  • Cadherins
  • Integrins
  • Cell Adhesion
  • Cell adhesion
  44 Scopus citations

• MDia1 senses both force and torque during F-actin filament polymerization

  Yu, M., Yuan, X., Lu, C., Le, S., Kawamura, R., Efremov, A. K., Zhao, Z., Kozlov, M. M., Sheetz, M., Bershadsky, A. & Yan, J., Dec 1 2017, In: Nature communications. 8, 1, 1650.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polymerization
  • Torque
  • Actin Cytoskeleton
  • torque
  • polymerization
  36 Scopus citations

• Mechanotransmission and Mechanosensing of Human alpha-Actinin 1

  Le, S., Hu, X., Yao, M., Chen, H., Yu, M., Xu, X., Nakazawa, N., Margadant, F. M., Sheetz, M. P. & Yan, J., Dec 5 2017, In: Cell Reports. 21, 10, p. 2714-2723 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • human ACTN1 protein
  • Actinin
  • Vinculin
  • Mechanical stability
  • Actins
  26 Scopus citations

• Molecular stretching modulates mechanosensing pathways

  Hu, X., Margadant, F. M., Yao, M. & Sheetz, M. P., Jul 1 2017, In: Protein Science. 26, 7, p. 1337-1351 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Stretching
  • Proteins
  • Mechanics
  • Protein Domains
  • Molecules
  23 Scopus citations

• Polymer fiber-based models of connective tissue repair and healing

  Lee, N. M., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W. N. & Lu, H. H., Jan 1 2017, In: Biomaterials. 112, p. 303-312 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanofibers
  • Connective Tissue
  • Polymers
  • Tissue
  • Repair
  35 Scopus citations

• Spatial control of biological ligands on surfaces applied to T cell activation

  Cai, H., Depoil, D., Muller, J., Sheetz, M. P., Dustin, M. L. & Wind, S. J., 2017, Methods in Molecular Biology. Humana Press Inc., p. 307-331 25 p. (Methods in Molecular Biology; vol. 1584).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Ligands
  • T-Lymphocytes
  • Glass
  • Adsorption
  • Sulfhydryl Compounds
  2 Scopus citations
• 2015

  Cyclic stretching of soft substrates induces spreading and growth

  Cui, Y., Hameed, F. M., Yang, B., Lee, K., Pan, C. Q., Park, S. & Sheetz, M., Feb 23 2015, In: Nature communications. 6, 6333.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stretching
  • myocardin
  • Substrates
  • Stress Fibers
  • Growth
  130 Scopus citations

• Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

  Yu, C. H., Rafiq, N. B. M., Cao, F., Zhou, Y., Krishnasamy, A., Biswas, K. H., Ravasio, A., Chen, Z., Wang, Y. H., Kawauchi, K., Jones, G. E. & Sheetz, M. P., Oct 28 2015, In: Nature communications. 6, 8672.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Integrin beta3
  • Clathrin
  • machinery
  • traction
  • Traction
  41 Scopus citations

• Mechanobiology

  Shivashankar, G. V., Sheetz, M. & Matsudaira, P., Oct 1 2015, In: Integrative Biology (United Kingdom). 7, 10, p. 1091-1092 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  6 Scopus citations

• Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

  Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M. P., Kam, L. C. & Iskratsch, T., Oct 1 2015, In: Integrative Biology (United Kingdom). 7, 10, p. 1272-1284 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-cells
  • Lymphocyte Function-Associated Antigen-1
  • Mechanics
  • T-Cell Antigen Receptor
  • Cytoskeleton
  39 Scopus citations

• Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

  Changede, R., Xu, X., Margadant, F. & Sheetz, M. P., 2015, In: Developmental cell. 35, 5, p. 614-621 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Talin
  • Rigidity
  • Integrins
  • Adhesion
  • Chemical activation
  60 Scopus citations

• Parallel near-field photolithography with metal-coated elastomeric masks

  Wu, J., Yu, C. H., Li, S., Zou, B., Liu, Y., Zhu, X., Guo, Y., Xu, H., Zhang, W., Zhang, L., Liu, B., Tian, D., Huang, W., Sheetz, M. & Huo, F., Jan 27 2015, In: Langmuir. 31, 3, p. 1210-1217 8 p.

  Research output: Contribution to journal › Article › peer-review

  • elastomeric
  • Photolithography
  • photolithography
  • Masks
  • Metals
  19 Scopus citations

• Talin Dependent Mechanosensitivity of Cell Focal Adhesions

  Yan, J., Yao, M., Goult, B. T. & Sheetz, M. P., Mar 2015, In: Cellular and Molecular Bioengineering. 8, 1, p. 151-159 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Talin
  • Mechanobiology
  • Adhesion
  • Integrin
  • Focal Adhesions
  49 Scopus citations
• 2014

  Appreciating force and shape-the rise of mechanotransduction in cell biology

  Iskratsch, T., Wolfenson, H. & Sheetz, M. P., Dec 11 2014, In: Nature Reviews Molecular Cell Biology. 15, 12, p. 825-833 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cell Biology
  • Cell Movement
  • Cell-Matrix Junctions
  • Biophysics
  • Growth
  315 Scopus citations

• Can small institutes address some problems facing biomedical researchers?

  Sheetz, M., Nov 1 2014, In: Molecular Biology of the Cell. 25, 21, p. 3267-3269 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Biomedical Research
  • Research Personnel
  • Paranoid Disorders
  • National Institutes of Health (U.S.)
  • Costs and Cost Analysis
  2 Scopus citations

• Early events in cell spreading as a model for quantitative analysis of biomechanical events

  Wolfenson, H., Iskratsch, T. & Sheetz, M. P., Dec 2 2014, In: Biophysical journal. 107, 11, p. 2508-2514 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Fibronectins
  • Integrins
  • Fibroblasts
  • Cell-Matrix Junctions
  • Decision Trees
  25 Scopus citations

• Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

  Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P. & Yan, J., Apr 9 2014, In: Scientific reports. 4, 4610.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Talin
  • Vinculin
  • Focal Adhesions
  • Mutation
  • Growth
  165 Scopus citations

• N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

  Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M. P., Apr 2014, In: Journal of Cell Science. 127, 7, p. 1394-1405 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pseudopodia
  • Polymerization
  • Actins
  • Phosphorylation
  • src-Family Kinases
  22 Scopus citations

• Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility

  Zaburdaev, V., Biais, N., Schmiedeberg, M., Eriksson, J., Jonsson, A. B., Sheetz, M. P. & Weitz, D. A., Oct 7 2014, In: Biophysical journal. 107, 7, p. 1523-1531 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neisseria gonorrhoeae
  • Bacteria
  • Cell Body
  • Sexually Transmitted Diseases
  • Direction compound
  29 Scopus citations

• YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

  Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M. & Sheetz, M., Aug 19 2014, In: FEBS Letters. 588, 16, p. 2663-2670 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Organ Size
  • Tumors
  • Proto-Oncogene Proteins
  • Physical Phenomena
  • Oncology
  216 Scopus citations
• 2012

  Cell crawling mediates collective cell migration to close undamaged epithelial gaps

  Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M. P., Trepat, X. & Ladoux, B., Jul 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pseudopodia
  • Cell Movement
  • Myosin-Light-Chain Kinase
  • Actomyosin
  • rho-Associated Kinases
  123 Scopus citations

• Cells test substrate rigidity by local contractions on submicrometer pillars

  Ghassemi, S., Meacci, G., Liu, S., Gondarenko, A. A., Mathur, A., Roca-Cusachs, P., Sheetz, M. P. & Hone, J., Apr 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5328-5333 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myosins
  • elastomeric
  • Cell Differentiation
  • Growth
  135 Scopus citations

• Finding the weakest link-exploring integrin-mediated mechanical molecular pathways

  Roca-Cusachs, P., Iskratsch, T. & Sheetz, M. P., Jul 1 2012, In: Journal of Cell Science. 125, 13, p. 3025-3038 14 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Integrins
  • Actins
  • Proteins
  • Protein Conformation
  • Cytoskeleton
  159 Scopus citations

• Following nature’s challenges

  Sheetz, M. P. & Kenan, W. R., Oct 2012, In: Nature Medicine. 18, 10, p. 1483-1485 3 p.

  Research output: Contribution to journal › Article › peer-review

• Force-dependent cell signaling in stem cell differentiation

  Yim, E. K. F. & Sheetz, M. P., 2012, In: Stem Cell Research and Therapy. 3, 5, 41.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Cell signaling
  • Stem cells
  • Cell Differentiation
  • Stem Cells
  • rho GTP-Binding Proteins
  91 Scopus citations

• Mechanical feedback between membrane tension and dynamics

  Gauthier, N. C., Masters, T. A. & Sheetz, M., Oct 1 2012, In: Trends in Cell Biology. 22, 10, p. 527-535 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Membranes
  • Architectural Accessibility
  • Cytoskeleton
  • Buffers
  • Cell Membrane
  229 Scopus citations

• Microarray with micro- and nano-topographies enables identification of the optimal topography for directing the differentiation of primary murine neural progenitor cells

  Moe, A. A. K., Suryana, M., Marcy, G., Lim, S. K., Ankam, S., Goh, J. Z. W., Jin, J., Teo, B. K. K., Law, J. B. K., Low, H. Y., Goh, E. L. K., Sheetz, M. P. & Yim, E. K. F., Oct 8 2012, In: Small. 8, 19, p. 3050-3061 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Microarrays
  • Topography
  • Cues
  • Stem Cells
  • Cell Communication
  79 Scopus citations

• Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

  Pan, C. Q., Sudol, M., Sheetz, M. & Low, B. C., Nov 2012, In: Cellular Signalling. 24, 11, p. 2143-2165 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Proteins
  • Cell Plasticity
  • Intercellular Junctions
  • Focal Adhesions
  • Golgi Apparatus
  50 Scopus citations

• Netrin-1 Attracts axons through FAK-dependent mechanotransduction

  Moore Dr., S. W., Zhang, X., Lynch, C. D. & Sheetz, M. P., Aug 22 2012, In: Journal of Neuroscience. 32, 34, p. 11574-11585 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Netrin-1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Axons
  • Growth Cones
  • Crk-Associated Substrate Protein
  55 Scopus citations

• Second-generation covalent TMP-tag for live cell imaging

  Chen, Z., Jing, C., Gallagher, S. S., Sheetz, M. P. & Cornish, V. W., Aug 22 2012, In: Journal of the American Chemical Society. 134, 33, p. 13692-13699 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Thymidine Monophosphate
  • Proteins
  • Imaging techniques
  • Fluorophores
  • Oxidoreductases
  83 Scopus citations

• Spatial-temporal reorganization of activated integrins

  Yu, C. H., Luo, W. & Sheetz, M. P., 2012, In: Cell Adhesion and Migration. 6, 3, p. 280-284 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Integrins
  • Cluster Analysis
  • cyclic arginine-glycine-aspartic acid peptide
  • arginyl-glycyl-aspartic acid
  • Focal Adhesions
  11 Scopus citations

• The lasker awards: Motors take centre stage

  Sheetz, M., Spudich, J. & Vale, R., Nov 2012, In: Nature Cell Biology. 14, 11, p. 1113 1 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• The role of feature curvature in contact guidance

  Mathur, A., Moore, S. W., Sheetz, M. & Hone, J., Jul 1 2012, In: Acta Biomaterialia. 8, 7, p. 2595-2601 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Stress Fibers
  • Topography
  • Tissue Engineering
  • Polarization
  • Fibroblasts
  34 Scopus citations

• T lymphocyte myosin IIA is required for maturation of the immunological synapse

  Kumari, S., Vardhana, S., Cammer, M., Curado, S., Santos, L., Sheetz, M. P. & Dustin, M. L., 2012, In: Frontiers in immunology. 3, AUG, Article 230.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nonmuscle Myosin Type IIA
  • Immunological Synapses
  • T-Cell Antigen Receptor
  • Small Interfering RNA
  • T-Lymphocytes
  51 Scopus citations
• 2011

  Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair

  Moore, S. W. & Sheetz, M. P., Nov 2011, In: Developmental Neurobiology. 71, 11, p. 1090-1101 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Biophysics
  • Cues
  • Neuronal Plasticity
  • Axons
  • Cell Movement
  54 Scopus citations

• Cellular mechanotransduction: Filamin A strains to regulate motility

  Lynch, C. D. & Sheetz, M. P., Nov 22 2011, In: Current Biology. 21, 22, p. R916-R918

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

  • Cellular Mechanotransduction
  • filamin
  • mechanotransduction
  • Filamins
  • microfilament proteins
  6 Scopus citations

• Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization.

  Palma, M., Abramson, J. J., Gorodetsky, A. A., Nuckolls, C., Sheetz, M. P., Wind, S. J. & Hone, J., 2011, In: Methods in molecular biology (Clifton, N.J.). 749, p. 169-185 17 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA
  • Oligonucleotides
  • Proteins
  7 Scopus citations

• Differential mechanical stability of filamin A rod segments

  Chen, H., Zhu, X., Cong, P., Sheetz, M. P., Nakamura, F. & Yan, J., Sep 7 2011, In: Biophysical journal. 101, 5, p. 1231-1237 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Filamins
  • Actins
  • Spectrin
  • Immunoglobulin Domains
  • Proteins
  34 Scopus citations

• Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation

  Yu, C. H., Law, J. B. K., Suryana, M., Low, H. Y. & Sheetz, M. P., Dec 20 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20585-20590 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polymerization
  • Integrins
  • Actins
  • Peptides
  • Myosin Type II
  131 Scopus citations

• Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

  Lynch, C. D., Gauthier, N. C., Biais, N., Lazar, A. M., Roca-Cusachs, P., Yu, C. H. & Sheetz, M. P., Apr 15 2011, In: Molecular Biology of the Cell. 22, 8, p. 1263-1273 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Filamins
  • Actins
  • Stress Fibers
  • Fibroblasts
  • Traction
  44 Scopus citations

• Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin

  Margadant, F., Chew, L. L., Hu, X., Yu, H., Bate, N., Zhang, X. & Sheetz, M., Dec 2011, In: PLoS Biology. 9, 12, e1001223.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • talin
  • mechanotransduction
  • Talin
  • Vinculin
  • Actins
  133 Scopus citations