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• 2020

  New host-directed therapeutics for the treatment of Clostridioides difficile infection

  Andersson, J. A., Peniche, A. G., Galindo, C. L., Boonma, P., Sha, J., Luna, R. A., Savidge, T. C., Chopra, A. K. & Dann, S. M., Mar 1 2020, In: mBio. 11, 2, e00053-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amoxapine
  • Infection
  • Interleukin-33
  • Pharmaceutical Preparations
  • Doxapram
• 2018

  A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague

  Tao, P., Mahalingam, M., Zhu, J., Moayeri, M., Sha, J., Lawrence, W. S., Leppla, S. H., Chopra, A. K. & Rao, V. B., Sep 1 2018, In: mBio. 9, 5, e01926-18.

  Research output: Contribution to journal › Article › peer-review

  • Plague Vaccine
  • Anthrax Vaccines
  • Anthrax
  • Bacteriophage T4
  • Plague
  16 Scopus citations

• Combating multidrug-resistant pathogens with host-directed nonantibiotic therapeutics

  Andersson, J. A., Sha, J., Kirtley, M. L., Reyes, E., Fitts, E. C., Dann, S. M. & Chopra, A. K., Jan 2018, In: Antimicrobial agents and chemotherapy. 62, 1, e01943.

  Research output: Contribution to journal › Article › peer-review

  • Plague
  • Pharmaceutical Preparations
  • Macrophages
  • Acinetobacter baumannii
  • Klebsiella pneumoniae
  8 Scopus citations
• 2017

  A bivalent anthrax-plague vaccine that can protect against two Tier-1 bioterror pathogens, Bacillus anthracis and Yersinia pestis

  Tao, P., Mahalingam, M., Zhu, J., Moayeri, M., Kirtley, M. L., Fitts, E. C., Andersson, J. A., Lawrence, W. S., Leppla, S. H., Chopra, A. K. & Rao, V. B., Jun 26 2017, In: Frontiers in immunology. 8, JUN, 687.

  Research output: Contribution to journal › Article › peer-review

  • Plague Vaccine
  • Anthrax Vaccines
  • Yersinia pestis
  • Bacillus anthracis
  • Anthrax
  15 Scopus citations

• Identification of new virulence factors and vaccine candidates for Yersinia pestis

  Andersson, J. A., Sha, J., Erova, T. E., Fitts, E. C., Ponnusamy, D., Kozlova, E. V., Kirtley, M. L. & Chopra, A. K., Oct 17 2017, In: Frontiers in Cellular and Infection Microbiology. 7, OCT, 448.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plague
  • Virulence Factors
  • Mutagenesis
  • Vaccines
  13 Scopus citations

• Phospholipase A₂-activating protein is associated with a novel form of leukoencephalopathy

  Falik Zaccai, T. C., Savitzki, D., Zivony-Elboum, Y., Vilboux, T., Fitts, E. C., Shoval, Y., Kalfon, L., Samra, N., Keren, Z., Gross, B., Chasnyk, N., Straussberg, R., Mullikin, J. C., Teer, J. K., Geiger, D., Kornitzer, D., Bitterman-Deutsch, O., Samson, A. O., Wakamiya, M., Peterson, J. W. & 7 others, Kirtley, M. L., Pinchuk, I. V., Baze, W. B., Gahl, W. A., Kleta, R., Anikster, Y. & Chopra, A. K., 2017, In: Brain. 140, 2, p. 370-386 17 p.

  Research output: Contribution to journal › Article › peer-review

  • phospholipase A2-activating protein
  • Leukoencephalopathies
  • Protein
  • Dinoprostone
  • Phenotype
  9 Scopus citations

• Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis

  Sim, B. K. L., Li, M., Osorio, M., Wu, Y., Wai, T. T., Peterson, J. W., James, E. R., Chakravarty, S., Gao, L., Xu, R., Kc, N., Stafford, R. E., Lawrence, W. S., Yeager, L. A., Peel, J. E., Sivasubramani, S. K., Chopra, A. K., Filippova, S. & Hoffman, S. L., Dec 1 2017, In: npj Vaccines. 2, 1, 17.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation anthrax
  • anthrax toxin
  • Salmonella typhi
  • Anthrax Vaccines
  • Bacillus anthracis
  7 Scopus citations
• 2016

  A mutated cholera toxin without the ADP-ribosyltransferase activity induces cytokine production and inhibits apoptosis of splenocytes in mice possibly via toll-like receptor-4 signaling

  Liu, T., Wei, Y., Liu, G., Shi, B., Giovanni, S., Peterson, J. W. & Chopra, A. K., Jul 1 2016, In: Molecular Immunology. 75, p. 21-27 7 p.

  Research output: Contribution to journal › Article › peer-review

  • ADP Ribose Transferases
  • Cholera Toxin
  • Toll-Like Receptor 4
  • Cytokines
  • Apoptosis

• A Replication-Defective human type 5 adenovirus-based trivalent vaccine confers complete protection against plague in mice and nonhuman primates

  Sha, J., Kirtley, M. L., Klages, C., Erova, T. E., Telepnev, M., Ponnusamy, D., Fitts, E. C., Baze, W. B., Sivasubramani, S. K., Lawrence, W. S., Patrikeev, I., Peel, J. E., Andersson, J. A., Kozlova, E. V., Tiner, B. L., Peterson, J. W., Mcwilliams, D., Patel, S., Rothe, E., Motin, V. L. & 1 others, Chopra, A. K., Jul 2016, In: Clinical and Vaccine Immunology. 23, 7, p. 586-600 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Adenoviruses
  • Plague
  • Primates
  • Vaccines
  • Antigens
  11 Scopus citations

• Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis

  Ponnusamy, D., Kozlova, E. V., Sha, J., Erova, T. E., Azar, S. R., Fitts, E. C., Kirtley, M. L., Tiner, B. L., Andersson, J. A., Grim, C. J., Isom, R. P., Hasan, N. A., Colwell, R. R. & Chopra, A. K., Jan 19 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 3, p. 722-727 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Exotoxins
  • Necrotizing Fasciitis
  • Coinfection
  • Virulence
  34 Scopus citations

• Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague

  Tiner, B. L., Sha, J., Cong, Y., Kirtley, M. L., Andersson, J. A. & Chopra, A. K., Oct 13 2016, In: npj Vaccines. 1, 16020.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plague
  • Cellular Immunity
  • Immunization
  • Rodentia
  6 Scopus citations

• New insights into autoinducer-2 signaling as a virulence regulator in a mouse model of pneumonic plague

  Fitts, E. C., Andersson, J. A., Kirtley, M. L., Sha, J., Erova, T. E., Chauhan, S., Motin, V. L. & Chopra, A. K., Nov 1 2016, In: mSphere. 1, 6, e00342-16.

  Research output: Contribution to journal › Article › peer-review

  • N-octanoylhomoserine lactone
  • Plague
  • Virulence
  • Yersinia pestis
  • Bacterial Genes
  6 Scopus citations

• New role for FDA-approved drugs in combating antibiotic-resistant bacteria

  Andersson, J. A., Fitts, E. C., Kirtley, M. L., Ponnusamy, D., Peniche, A. G., Dann, S. M., Motin, V. L., Chauhan, S., Rosenzweig, J. A., Sha, J. & Chopra, A. K., Jun 2016, In: Antimicrobial agents and chemotherapy. 60, 6, p. 3717-3729 13 p.

  Research output: Contribution to journal › Article › peer-review

  • United States Food and Drug Administration
  • Yersinia pestis
  • Trifluoperazine
  • Bacteria
  • Anti-Bacterial Agents
  18 Scopus citations

• Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar typhimurium braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

  Erova, T. E., Kirtley, M. L., Fitts, E. C., Ponnusamy, D., Baze, W. B., Andersson, J. A., Cong, Y., Tiner, B. L., Sha, J. & Chopra, A. K., Nov 10 2016, In: Frontiers in Cellular and Infection Microbiology. 6, NOV, 148.

  Research output: Contribution to journal › Article › peer-review

  • Acetyltransferases
  • Salmonella enterica
  • Lipoproteins
  • Serogroup
  • Immunization
  8 Scopus citations
• 2015

  Combinational deletion of three membrane protein-encoding genes highly attenuates Yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague

  Tiner, B. L., Sha, J., Kirtley, M. L., Erova, T. E., Popov, V. L., Baze, W. B., van Lier, C. J., Ponnusamy, D., Andersson, J. A., Motin, V. L., Chauhan, S. & Chopra, A. K., Jan 1 2015, In: Infection and immunity. 83, 4, p. 1318-1338 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plague
  • Membrane Proteins
  • Genes
  • Lethal Dose 50
  12 Scopus citations

• Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages

  van Lier, C. J., Tiner, B. L., Chauhan, S., Motin, V. L., Fitts, E. C., Huante, M. B., Endsley, J. J., Ponnusamy, D., Sha, J. & Chopra, A. K., Mar 1 2015, In: Microbial Pathogenesis. 80, p. 27-38 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plasminogen Activators
  • Lipoproteins
  • Peptide Hydrolases
  • Macrophages
  6 Scopus citations

• High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection

  Ponnusamy, D., Fitts, E. C., Sha, J., Erova, T. E., Kozlova, E. V., Kirtley, M. L., Tiner, B. L., Andersson, J. A. & Chopra, A. K., 2015, In: Infection and immunity. 83, 5, p. 2065-2081 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Lethal Dose 50
  • Virulence Factors
  • Plague
  • Infection
  10 Scopus citations

• Intramuscular immunization of mice with a live-Attenuated triple mutant of yersinia pestis co92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague

  Tiner, B. L., Sha, J., Ponnusamy, D., Baze, W. B., Fitts, E. C., Popov, V. L., Van Lier, C. J., Erova, T. E. & Chopra, A. K., Dec 2015, In: Clinical and Vaccine Immunology. 22, 12, p. 1255-1268 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunization
  • Yersinia pestis
  • Plague
  • Animals
  • Cellular Immunity
  8 Scopus citations
• 2012

  Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

  Suarez, G., Khajanchi, B. K., Sierra, J. C., Erova, T. E., Sha, J. & Chopra, A. K., Sep 15 2012, In: Gene. 506, 2, p. 369-376 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Actins
  • Apoptosis
  • Vibrio
  • Operon
  23 Scopus citations

• Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

  Shniffer, A., Visschedyk, D. D., Ravulapalli, R., Suarez, G., Turgeon, Z. J., Petrie, A. A., Chopra, A. K. & Merrill, A. R., Oct 26 2012, In: Journal of Biological Chemistry. 287, 44, p. 37030-37041 12 p.

  Research output: Contribution to journal › Article › peer-review

  • ADP Ribose Transferases
  • Aeromonas hydrophila
  • Actins
  • Adenosine Diphosphate Ribose
  • Crystal structure
  11 Scopus citations

• DNA adenine methyltransferase (Dam) controls the expression of the cytotoxic enterotoxin (act) gene of Aeromonas hydrophila via tRNA modifying enzyme-glucose-inhibited division protein (GidA)

  Erova, T. E., Kosykh, V. G., Sha, J. & Chopra, A. K., May 1 2012, In: Gene. 498, 2, p. 280-287 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Enterotoxins
  • Adenine
  • Methyltransferases
  • Transfer RNA
  11 Scopus citations

• Impact of QseBC system in c-di-GMP-dependent quorum sensing regulatory network in a clinical isolate SSU of Aeromonas hydrophila

  Kozlova, E. V., Khajanchi, B. K., Popov, V. L., Wen, J. & Chopra, A. K., Sep 2012, In: Microbial Pathogenesis. 53, 3-4, p. 115-124 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Quorum Sensing
  • Cyclic GMP
  • Biofilms
  • Virulence
  20 Scopus citations

• The effect of low shear force on the virulence potential of Yersinia pestis: new aspects that space-like growth conditions and the final frontier can teach us about a formidable pathogen.

  Rosenzweig, J. A. & Chopra, A. K., 2012, In: Frontiers in Cellular and Infection Microbiology. 2, p. 107 1 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Yersinia pestis
  • Weightlessness
  • Virulence
  • Growth
  • Space Flight
  8 Scopus citations

• The future of plague vaccines: Hopes raised by a surrogate, live-attenuated recombinant vaccine candidate

  Rosenzweig, J. A. & Chopra, A. K., Jun 1 2012, In: Expert review of vaccines. 11, 6, p. 659-661 3 p.

  Research output: Contribution to journal › Review article › peer-review

  • Plague Vaccine
  • Yersinia pestis
  • Plague
  • Attenuated Vaccines
  • Synthetic Vaccines
  8 Scopus citations

• The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila

  Khajanchi, B. K., Kozlova, E. V., Sha, J., Popov, V. L. & Chopra, A. K., Jan 2012, In: Microbiology. 158, 1, p. 259-271 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Quorum Sensing
  • Virulence
  • N-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone
  • N-octanoylhomoserine lactone
  44 Scopus citations
• 2011

  Cethromycin-mediated protection against the plague pathogen Yersinia pestis in a rat model of infection and comparison with levofloxacin

  Rosenzweig, J. A., Brackman, S. M., Kirtley, M. L., Sha, J., Erova, T. E., Yeager, L. A., Peterson, J. W., Xu, Z. Q. & Chopra, A. K., Nov 2011, In: Antimicrobial agents and chemotherapy. 55, 11, p. 5034-5042 9 p.

  Research output: Contribution to journal › Article › peer-review

  • cethromycin
  • Yersinia pestis
  • Plague
  • Levofloxacin
  • Infection
  14 Scopus citations

• Characterization of an F1 deletion mutant of Yersinia pestis CO92, pathogenic role of F1 antigen in bubonic and pneumonic plague, and evaluation of sensitivity and specificity of F1 antigen capture-based dipsticks

  Sha, J., Endsley, J. J., Kirtley, M. L., Foltz, S. M., Huante, M. B., Erova, T. E., Kozlova, E. V., Popov, V. L., Yeager, L. A., Zudina, I. V., Motin, V. L., Peterson, J. W., DeBord, K. L. & Chopra, A. K., May 2011, In: Journal of Clinical Microbiology. 49, 5, p. 1708-1715 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plague
  • Sensitivity and Specificity
  • Antigens
  • Homologous Recombination
  24 Scopus citations

• Immunomodulatory and protective Roles of quorum-sensing signaling molecules N-Acyl homoserine lactones during infection of mice with Aeromonas hydrophila

  Khajanchi, B. K., Kirtley, M. L., Brackman, S. M. & Chopra, A. K., Jul 2011, In: Infection and immunity. 79, 7, p. 2646-2657 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Acyl-Butyrolactones
  • Aeromonas hydrophila
  • Quorum Sensing
  • Infection
  • Animals
  32 Scopus citations

• Progress on plague vaccine development

  Rosenzweig, J. A., Jejelowo, O., Sha, J., Erova, T. E., Brackman, S. M., Kirtley, M. L., Van Lier, C. J. & Chopra, A. K., Jul 1 2011, In: Applied Microbiology and Biotechnology. 91, 2, p. 265-286 22 p.

  Research output: Contribution to journal › Review article › peer-review

  • Plague Vaccine
  • Yersinia pestis
  • Plague
  • Vaccines
  • Yersinia pseudotuberculosis
  28 Scopus citations

• Quorum sensing and c-di-GMP-dependent alterations in gene transcripts and virulence-associated phenotypes in a clinical isolate of Aeromonas hydrophila

  Kozlova, E. V., Khajanchi, B. K., Sha, J. & Chopra, A. K., May 2011, In: Microbial Pathogenesis. 50, 5, p. 213-223 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Quorum Sensing
  • Biofilms
  • Virulence
  • Phenotype
  25 Scopus citations

• Ribonucleases and bacterial virulence

  Lawal, A., Jejelowo, O., Chopra, A. K. & Rosenzweig, J. A., Sep 2011, In: Microbial Biotechnology. 4, 5, p. 558-571 14 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Ribonucleases
  • Virulence
  • Bacteria
  • Aeromonas hydrophila
  • Shigella flexneri
  16 Scopus citations