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  • Istvan Boldogh
2020

Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

Hao, W., Wang, J., Zhang, Y., Wang, C., Xia, L., Zhang, W., Zafar, M., Kang, J. Y., Wang, R., Ali Bohio, A., Pan, L., Zeng, X., Wei, M., Boldogh, I. & Ba, X., Jun 1 2020, In : FASEB Journal. 34, 6, p. 7427-7441 15 p.

Research output: Contribution to journalArticle

Open Access

Exercise, redox system and neurodegenerative diseases

Quan, H., Koltai, E., Suzuki, K., Aguiar, A. S., Pinho, R., Boldogh, I., Berkes, I. & Radak, Z., Oct 1 2020, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 10, 165778.

Research output: Contribution to journalReview article

Open Access

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

Dharmalingam, P., Talakatta, G., Mitra, J., Wang, H., Derry, P. J., Nilewski, L. G., McHugh, E. A., Fabian, R. H., Mendoza, K., Vasquez, V., Hegde, P. M., Kakadiaris, E., Roy, T., Boldogh, I., Hegde, V. L., Mitra, S., Tour, J. M., Kent, T. A. & Hegde, M. L., Mar 24 2020, In : ACS Nano. 14, 3, p. 2827-2846 20 p.

Research output: Contribution to journalArticle

3 Scopus citations

Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization

Ke, Y., Lv, X., Fu, X., Zhang, J., Bohio, A. A., Zeng, X., Hao, W., Wang, R., Boldogh, I. & Ba, X., 2020, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

Open Access

The systemic role of SIRT1 in exercise mediated adaptation

Radak, Z., Suzuki, K., Posa, A., Petrovszky, Z., Koltai, E. & Boldogh, I., Aug 2020, In : Redox Biology. 35, 101467.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2019

C-Abl-mediated tyrosine phosphorylation of PARP1 is crucial for expression of proinflammatory genes

Bohio, A. A., Sattout, A., Wang, R., Wang, K., Sah, R. K., Guo, X., Zeng, X., Ke, Y., Boldogh, I. & Ba, X., Sep 15 2019, In : Journal of Immunology. 203, 6, p. 1521-1531 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Epigenetic regulation of TIMP1 expression by 8-oxoguanine DNA glycosylase-1 binding to DNA:RNA hybrid

Pan, L., Wang, H., Luo, J., Zeng, J., Pi, J., Liu, H., Liu, C., Ba, X., Qu, X., Xiang, Y., Boldogh, I. & Qin, X., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 14159-14170 12 p.

Research output: Contribution to journalArticle

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I. & Radak, Z., Jan 1 2019, In : Experimental Gerontology. 115, p. 122-131 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Exercise effects on physiological function during aging

Radak, Z., Torma, F., Berkes, I., Goto, S., Mimura, T., Posa, A., Balogh, L., Boldogh, I., Suzuki, K., Higuchi, M. & Koltai, E., Feb 20 2019, In : Free Radical Biology and Medicine. 132, p. 33-41 9 p.

Research output: Contribution to journalReview article

20 Scopus citations

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M. L., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation

Pázmándi, K., Sütő, M., Fekete, T., Varga, A., Boldizsár, E., Boldogh, I. & Bácsi, A., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 209-220 12 p.

Research output: Contribution to journalArticle

Open Access

Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer

Vlahopoulos, S., Adamaki, M., Khoury, N., Zoumpourlis, V. & Boldogh, I., Feb 2019, In : Pharmacology and Therapeutics. 194, p. 59-72 14 p.

Research output: Contribution to journalReview article

11 Scopus citations

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Brasier, A. R. & Boldogh, I., 2019, In : Drugs in Context. 8, 2019-8-3.

Research output: Contribution to journalReview article

Open Access
2018

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Hao, W., Qi, T., Pan, L., Wang, R., Zhu, B., Aguilera-Aguirre, L., Radak, Z., Hazra, T. K., Vlahopoulos, S. A., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Sep 2018, In : Redox Biology. 18, p. 43-53 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation

Hosoki, K., Jaruga, P., Itazawa, T., Aguilera-Aguirre, L., Coskun, E., Hazra, T. K., Boldogh, I., Dizdaroglu, M. & Sur, S., Dec 2018, In : Clinical and Experimental Allergy. 48, 12, p. 1676-1687 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls

Koltai, E., Bori, Z., Osvath, P., Ihasz, F., Peter, S., Toth, G., Degens, H., Rittweger, J., Boldogh, I. & Radak, Z., Oct 2018, In : Redox Biology. 19, p. 46-51 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos

Wang, R., Li, C., Qiao, P., Xue, Y., Zheng, X., Chen, H., Zeng, X., Liu, W., Boldogh, I. & Ba, X., Jun 1 2018, In : Cell Death and Disease. 9, 6, 628.

Research output: Contribution to journalArticle

14 Scopus citations

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Visnes, T., Cázares-Körner, A., Hao, W., Wallner, O., Masuyer, G., Loseva, O., Mortusewicz, O., Wiita, E., Sarno, A., Manoilov, A., Astorga-Wells, J., Jemth, A. S., Pan, L., Sanjiv, K., Karsten, S., Gokturk, C., Grube, M., Homan, E. J., Hanna, B. M. F., Paulin, C. B. J. & 20 others, Pham, T., Rasti, A., Berglund, U. W., Von Nicolai, C., Benitez-Buelga, C., Koolmeister, T., Ivanic, D., Iliev, P., Scobie, M., Krokan, H. E., Baranczewski, P., Artursson, P., Altun, M., Jensen, A. J., Kalderén, C., Ba, X., Zubarev, R. A., Stenmark, P., Boldogh, I. & Helleday, T., Nov 16 2018, In : Science. 362, 6416, p. 834-839 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

The establishment of methods for free PAR generation and PAR reader detection

Ke, Y., Wang, K., Xu, H., Wang, C., Zhang, J., Zeng, X., Wang, R., Boldogh, I. & Ba, X., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Probes.

Research output: Contribution to journalArticle

1 Scopus citations

The roles of base excision repair enzyme OGG1 in gene expression

Wang, R., Hao, W., Pan, L., Boldogh, I. & Ba, X., Oct 1 2018, In : Cellular and Molecular Life Sciences. 75, 20, p. 3741-3750 10 p.

Research output: Contribution to journalReview article

13 Scopus citations
2017

8-Oxoguanine DNA glycosylase1–driven DNA repair—A paradoxical role in lung aging

German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 51-65 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I., Rao, K. S., Kent, T. A., Mitra, S. & Hegde, M. L., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 163-176 14 p.

Research output: Contribution to journalReview article

10 Scopus citations

Erratum: PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

Ke, Y., Han, Y., Guo, X., Wen, J., Wang, K., Jiang, X., Tian, X., Ba, X., Boldogh, I. & Zeng, X., Mar 31 2017, In : Nature communications. 8, p. 15191 1 p., 15191.

Research output: Contribution to journalArticle

4 Scopus citations

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

Radak, Z., Ishihara, K., Tekus, E., Varga, C., Posa, A., Balogh, L., Boldogh, I. & Koltai, E., Aug 1 2017, In : Redox Biology. 12, p. 285-290 6 p.

Research output: Contribution to journalShort survey

58 Scopus citations

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Pajk, M., Cselko, A., Varga, C., Posa, A., Tokodi, M., Boldogh, I., Goto, S. & Radak, Z., Aug 1 2017, In : Biogerontology. 18, 4, p. 593-600 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Innate mechanism of pollen- and cat dander–induced oxidative stress and DNA damage in the airways

Hosoki, K., Redding, D., Itazawa, T., Chakraborty, A., Tapryal, N., Qian, S., Qi, H., Aguilera-Aguirre, L., Brasier, A. R., Phani, V. S., Hazra, T. K., Boldogh, I. & Sur, S., Nov 2017, In : Journal of Allergy and Clinical Immunology. 140, 5, p. 1436-1439.e5

Research output: Contribution to journalArticle

6 Scopus citations

NF-κB mediates mesenchymal transition, remodeling, and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns

Tian, B., Patrikeev, I., Ochoa, L., Vargas, G., Belanger, K. A. K., Litvinov, J., Boldogh, I., Ameredes, B. T., Motamedi, M. & Brasier, A. R., Apr 2017, In : American journal of respiratory cell and molecular biology. 56, 4, p. 506-520 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

OGG1-DNA interactions facilitate NF-k B binding to DNA targets

Pan, L., Hao, W., Zheng, X., Zeng, X., Ahmed Abbasi, A., Boldogh, I. & Ba, X., Mar 7 2017, In : Scientific reports. 7, 43297.

Research output: Contribution to journalArticle

15 Scopus citations

PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR

Ke, Y., Han, Y., Guo, X., Wen, J., Wang, K., Jiang, X., Tian, X., Ba, X., Boldogh, I. & Zeng, X., Mar 8 2017, In : Nature communications. 8, 14632.

Research output: Contribution to journalArticle

23 Scopus citations

Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation

Aguilera-Aguirre, L., Hao, W., Pan, L., Li, X., Saavedra-Molina, A., Bacsi, A., Radak, Z., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 6, p. L1058-L1068

Research output: Contribution to journalArticle

4 Scopus citations

Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells

Agod, Z., Fekete, T., Budai, M. M., Varga, A., Szabo, A., Moon, H., Boldogh, I., Biro, T., Lanyi, A., Bacsi, A. & Pazmandi, K., Oct 2017, In : Redox Biology. 13, p. 633-645 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reply: Protease plays a role in ragweed pollen-induced neutrophil recruitment and epithelial barrier disruption

Hosoki, K., Brasier, A. R., Kurosky, A., Boldogh, I. & Sur, S., Feb 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 2, p. 272-273 2 p.

Research output: Contribution to journalLetter

1 Scopus citations

SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle

Koltai, E., Bori, Z., Chabert, C., Dubouchaud, H., Naito, H., Machida, S., Davies, K. J. A., Murlasits, Z., Fry, A. C., Boldogh, I. & Radak, Z., Jun 1 2017, In : Journal of Physiology. 595, 11, p. 3361-3376 16 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Facilitation of allergic sensitization and allergic airway inflammation by pollen-induced innate neutrophil recruitment

Hosoki, K., Aguilera-Aguirre, L., Brasier, A. R., Kurosky, A., Boldogh, I. & Sur, S., Jan 2016, In : American journal of respiratory cell and molecular biology. 54, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity

Choudhary, S., Boldogh, I. & Brasier, A. R., Mar 1 2016, In : Journal of Innate Immunity. 8, 2, p. 143-155 13 p.

Research output: Contribution to journalReview article

23 Scopus citations

Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation

Hosoki, K., Boldogh, I., Aguilera-Aguirre, L., Sun, Q., Itazawa, T., Hazra, T., Brasier, A. R., Kurosky, A. & Sur, S., May 1 2016, In : Journal of Allergy and Clinical Immunology. 137, 5, p. 1506-1513.e2

Research output: Contribution to journalArticle

12 Scopus citations

Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation

Hosoki, K., Itazawa, T., Boldogh, I. & Sur, S., 2016, In : Current opinion in allergy and clinical immunology. 16, 1, p. 45-50 6 p.

Research output: Contribution to journalReview article

36 Scopus citations

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T. K., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In : Journal of Biological Chemistry. 291, 49, p. 25553-25566 14 p.

Research output: Contribution to journalArticle

69 Scopus citations

Pathophysiology of bronchoconstriction: Role of oxidatively damaged DNA repair

Bacsi, A., Pan, L., Ba, X. & Boldogh, I., 2016, In : Current opinion in allergy and clinical immunology. 16, 1, p. 59-67 9 p.

Research output: Contribution to journalReview article

10 Scopus citations

Physical exercise, reactive oxygen species and neuroprotection

Radak, Z., Suzuki, K., Higuchi, M., Balogh, L., Boldogh, I. & Koltai, E., Sep 1 2016, In : Free Radical Biology and Medicine. 98, p. 187-196 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma

Belanger, K. A. K., Ameredes, B. T., Boldogh, I. & Aguilera-Aguirre, L., 2016, In : Mediators of inflammation. 2016, 3762561.

Research output: Contribution to journalReview article

4 Scopus citations

The rate of training response to aerobic exercise affects brain function of rats

Marton, O., Koltai, E., Takeda, M., Mimura, T., Pajk, M., Abraham, D., Koch, L. G., Britton, S. L., Higuchi, M., Boldogh, I. & Radak, Z., Oct 1 2016, In : Neurochemistry International. 99, p. 16-23 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha

Batnasan, E., Wang, R., Wen, J., Ke, Y., Li, X., Bohio, A. A., Zeng, X., Huo, H., Han, L., Boldogh, I. & Ba, X., Jan 5 2015, In : Toxicology Letters. 232, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

8-Oxoguanine DNA glycosylase-1-driven DNA base excision repair: Role in asthma pathogenesis

Ba, X., Aguilera-Aguirre, L., Sur, S. & Boldogh, I., Feb 13 2015, In : Current opinion in allergy and clinical immunology. 15, 1, p. 89-97 9 p.

Research output: Contribution to journalReview article

16 Scopus citations

Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1

Hosoki, K., Ying, S., Corrigan, C., Qi, H., Kurosky, A., Jennings, K., Sun, Q., Boldogh, I. & Sur, S., May 2015, In : PloS one. 10, 5, e0126035.

Research output: Contribution to journalArticle

45 Scopus citations

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection

Fang, L., Choudhary, S., Tian, B., Boldogh, I., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R. P. & Brasier, A. R., Jan 1 2015, In : Journal of virology. 89, 5, p. 2628-2642 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51

Qi, W., Wang, R., Chen, H., Wang, X., Xiao, T., Boldogh, I., Ba, X., Han, L. & Zeng, X., 2015, In : Journal of Cell Science. 128, 2, p. 317-330 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment

Vlahopoulos, S. A., Cen, O., Hengen, N., Agan, J., Moschovi, M., Critselis, E., Adamaki, M., Bacopoulou, F., Copland, J. A., Boldogh, I., Karin, M. & Chrousos, G. P., Aug 1 2015, In : Cytokine and Growth Factor Reviews. 26, 4, p. 389-403 15 p.

Research output: Contribution to journalReview article

54 Scopus citations

Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Ziaaldini, M. M., Koltai, E., Csende, Z., Goto, S., Boldogh, I., Taylor, A. W. & Radak, Z., Jul 1 2015, In : Experimental Gerontology. 67, p. 9-14 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development

Zhang, X., He, N., Gu, D., Wickliffe, J., Salazar, J., Boldogh, I. & Xie, J., Oct 20 2015, In : Journal of Genetics and Genomics. 42, 10, p. 589-596 8 p.

Research output: Contribution to journalArticle

3 Scopus citations