Find Research outputs

Search results

• 2020

  A cocrystal structure of dengue capsid protein in complex of inhibitor

  Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Dengue
  • Capsid Proteins
  • Capsid
  • Serogroup

• A Cyclic Phosphoramidate Prodrug of 2=-Deoxy-2=-Fluoro-2=-C-Methylguanosine for the Treatment of Dengue Virus Infection

  Karuna, R., Yokokawa, F., Wang, K., Zhang, J., Xu, H., Wang, G., Ding, M., Chan, W. L., Ghafar, N. A., Leonardi, A., Seh, C. C., Seah, P. G., Liu, W., Srinivasa, R. P. S., Lim, S. P., Lakshminarayana, S. B., Growcott, E., Babu, S., Fenaux, M., Zhong, W. & 4 others, Gu, F., Shi, P. Y., Blasco, F. & Chen, Y. L., Dec 2020, In: Antimicrobial agents and chemotherapy. 64, 12, e00654-20.

  Research output: Contribution to journal › Article › peer-review

  • 8-methylguanosine
  • phosphoramidic acid
  • Dengue Virus
  • Prodrugs
  • triphosphoric acid

• A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

  Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 4059.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • vaccines
  • SARS Virus
  • antibodies
  • Assays
  • Neutralizing Antibodies
  22 Scopus citations

• A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

  Xie, X., Muruato, A. E., Zhang, X., Lokugamage, K. G., Fontes-Garfias, C. R., Zou, J., Liu, J., Ren, P., Balakrishnan, M., Cihlar, T., Tseng, C. T. K., Makino, S., Menachery, V. D., Bilello, J. P. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 5214.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus
  • Coronavirus
  • drugs
  • Screening
  • screening
  6 Scopus citations

• An Infectious cDNA Clone of SARS-CoV-2

  Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., Plante, K. S., Weaver, S. C., Makino, S., LeDuc, J. W., Menachery, V. D. & Shi, P. Y., May 13 2020, In: Cell Host and Microbe. 27, 5, p. 841-848.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Clone Cells
  • SARS Virus
  • DNA
  62 Scopus citations

• Antagonism of Type i Interferon by Severe Acute Respiratory Syndrome Coronavirus 2

  Xia, H. & Shi, P. Y., Dec 2020, In: Journal of Interferon and Cytokine Research. 40, 12, p. 543-548 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Interferons
  • Coronavirus Infections
  • Interferon Type I

• A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice

  Li, N., Zhang, Z. R., Zhang, Y. N., Liu, J., Deng, C. L., Shi, P. Y., Yuan, Z. M., Ye, H. Q. & Zhang, B., Dec 1 2020, In: npj Vaccines. 5, 1, 73.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Japanese Encephalitis Virus
  • West Nile virus
  • Vaccines
  • Flavivirus
  • West Nile Virus Vaccines

• A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

  Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viremia
  • Virulence
  • Epidemics
  • Mutation
  8 Scopus citations

• Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential

  Xu, J., Shi, P. Y., Li, H. & Zhou, J., May 8 2020, In: ACS Infectious Diseases. 6, 5, p. 909-915 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Niclosamide
  • Coronavirus
  • Antiviral Agents
  • Middle East Respiratory Syndrome Coronavirus
  • SARS Virus
  71 Scopus citations

• Construction of stable reporter flaviviruses and their applications

  Baker, C. & Shi, P. Y., Oct 2020, In: Viruses. 12, 10, 1082.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Flavivirus
  • Epidemics
  • Antiviral Agents
  • Vaccines
  • Viruses

• COVID-19 vaccine BNT162b1 elicits human antibody and T_H1 T cell responses

  Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., Brachtendorf, S., Lörks, V., Sikorski, J., Hilker, R., Becker, D., Eller, A. K., Grützner, J., Boesler, C., Rosenbaum, C., Kühnle, M. C. & 22 others, Luxemburger, U., Kemmer-Brück, A., Langer, D., Bexon, M., Bolte, S., Karikó, K., Palanche, T., Fischer, B., Schultz, A., Shi, P. Y., Fontes-Garfias, C., Perez, J. L., Swanson, K. A., Loschko, J., Scully, I. L., Cutler, M., Kalina, W., Kyratsous, C. A., Cooper, D., Dormitzer, P. R., Jansen, K. U. & Türeci, Ö., Oct 22 2020, In: Nature. 586, 7830, p. 594-599 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus
  • Th1 Cells
  • Vaccines
  • Severe Acute Respiratory Syndrome
  • Antibodies
  50 Scopus citations

• Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

  Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Substitution reactions
  • Nitrogen
  • Derivatives
  1 Scopus citations

• Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies

  Vanderheiden, A., Edara, V. V., Floyd, K., Kauffman, R. C., Mantus, G., Anderson, E., Rouphael, N., Edupuganti, S., Shi, P. Y., Menachery, V. D., Wrammert, J. & Suthar, M. S., Dec 2020, In: Current Protocols in Immunology. 131, 1, e116.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus
  • Neutralization Tests
  • Neutralizing Antibodies
  • Vaccines
  • Coronavirus

• Drug repurposing approach to combating coronavirus: Potential drugs and drug targets

  Xu, J., Xue, Y., Zhou, R., Shi, P. Y., Li, H. & Zhou, J., 2020, (Accepted/In press) In: Medicinal Research Reviews.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Drug Repositioning
  • Coronavirus
  • Severe Acute Respiratory Syndrome
  • Pandemics
  • Pharmaceutical Preparations

• Dysregulation of Ephrin receptor and PPAR signaling pathways in neural progenitor cells infected by Zika virus

  Thulasi Raman, S. N., Latreille, E., Gao, J., Zhang, W., Wu, J., Russell, M. S., Walrond, L., Cyr, T., Lavoie, J. R., Safronetz, D., Cao, J., Sauve, S., Farnsworth, A., Chen, W., Shi, P. Y., Wang, Y., Wang, L., Rosu-Myles, M. & Li, X., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2046-2060 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Eph Family Receptors
  • Zika Virus
  • Neural Pathways
  • Microcephaly
  • Peroxisome Proliferator-Activated Receptors

• Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

  Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, Shi, P. Y. & Rajsbaum, R., Sep 17 2020, In: Nature. 585, 7825, p. 414-419 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Ubiquitination
  • Virus Internalization
  • Polyubiquitin
  • Proteins
  6 Scopus citations

• Evasion of Type I Interferon by SARS-CoV-2

  Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y. C., Wang, H., Menachery, V. D., Rajsbaum, R. & Shi, P. Y., Oct 6 2020, In: Cell Reports. 33, 1, 108234.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Interferon Type I
  • Phosphorylation
  • Interferon Regulatory Factor-3
  24 Scopus citations

• Identifying optimal capsid duplication length for the stability of reporter flaviviruses

  Baker, C., Liu, Y., Zou, J., Muruato, A., Xie, X. & Shi, P. Y., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2256-2265 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Flavivirus
  • Capsid
  • Zika Virus
  • Culicidae
  • Viruses

• Inhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the sars-cov-2 spike glycoprotein hrc domain

  Outlaw, V. K., Bovier, F. T., Mears, M. C., Cajimat, M. N., Zhu, Y., Lin, M. J., Addetia, A., Lieberman, N. A. P., Peddu, V., Xie, X., Shi, P. Y., Greninger, A. L., Gellman, S. H., Bente, D. A., Moscona, A. & Porotto, M., Sep 1 2020, In: mBio. 11, 5, p. 1-14 14 p., e01935-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Glycoproteins
  • Lipopeptides
  • Lipids
  1 Scopus citations

• In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

  Lieberman, N. A. P., Peddu, V., Xie, H., Shrestha, L., Huang, M. L., Mears, M. C., Cajimat, M. N., Bente, D. A., Shi, P. Y., Bovier, F., Roychoudhury, P., Jerome, K. R., Moscona, A., Porotto, M. & Greninger, A. L., Sep 2020, In: PLoS Biology. 18, 9, e3000849.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe acute respiratory syndrome coronavirus
  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • viral load
  • Viral Load
  12 Scopus citations

• NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues

  El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Jan 1 2020, In: Journal of virology. 94, 1, e01294-19.

  Research output: Contribution to journal › Article › peer-review

  • Zika virus
  • Japanese encephalitis virus
  • Japanese Encephalitis Virus
  • Zika Virus
  • Dengue virus
  5 Scopus citations

• Peli1 signaling blockade attenuates congenital zika syndrome

  Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 2020, In: PLoS pathogens. 16, 6, e1008538.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Trophoblasts
  • Flavivirus
  • Cell Death
  • Zika Virus Infection
  1 Scopus citations

• Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

  Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Raabe, V., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Walsh, E. E., Frenck, R. & 5 others, Falsey, A. R., Dormitzer, P. R., Gruber, W. C., Şahin, U. & Jansen, K. U., Oct 22 2020, In: Nature. 586, 7830, p. 589-593 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Coronavirus
  • Severe Acute Respiratory Syndrome
  • Vaccines
  • RNA
  • Messenger RNA
  73 Scopus citations

• Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C)

  Rostad, C. A., Chahroudi, A., Mantus, G., Lapp, S. A., Teherani, M., Macoy, L., Tarquinio, K. M., Basu, R. K., Kao, C., Linam, W. M., Zimmerman, M. G., Shi, P-Y., Menachery, V. D., Oster, M. E., Edupuganti, S., Anderson, E. J., Suthar, M. S., Wrammert, J. & Jaggi, P., Dec 1 2020, In: Pediatrics. 146, 6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Serology
  • Child
  • Immunoglobulin G

• Reserve genetic approaches for the development of Zika vaccines and therapeutics

  Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In: Current Opinion in Virology. 44, p. 7-15 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus
  • Vaccines
  • Reverse Genetics
  • Epidemics
  • Antiviral Agents
  2 Scopus citations

• Role of microglia in the dissemination of zika virus from mother to fetal brain

  Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Yolk Sac
  • Microglia
  • Zika Virus Infection
  • Microcephaly
  2 Scopus citations

• Safety and immunogenicity of two RNA-based covid-19 vaccine candidates

  Walsh, E. E., Frenck, R. W., Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Lyke, K. E. & 5 others, Raabe, V., Dormitzer, P. R., Jansen, K. U., Şahin, U. & Gruber, W. C., Dec 17 2020, In: New England Journal of Medicine. 383, 25, p. 2439-2450 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vaccines
  • Severe Acute Respiratory Syndrome
  • RNA
  • Safety
  • Coronavirus
  73 Scopus citations

• Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production

  Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In: Journal of virology. 94, 6

  Research output: Contribution to journal › Article › peer-review

  • Nucleic Acid Repetitive Sequences
  • 3' untranslated regions
  • 3' Untranslated Regions
  • RNA
  • Flavivirus
  3 Scopus citations

• Spike mutation D614G alters SARS-CoV-2 fitness

  Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X., Plante, K. S. & 2 others, Weaver, S. C. & Shi, P. Y., 2020, (Accepted/In press) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus
  • Viral Vaccines
  • Mutation
  • Cricetinae
  • Viruses
  35 Scopus citations

• Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses

  Prasanth, K. R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum, R., Shi, P. Y., Bedford, M. T., Bradrick, S. S., Menachery, V. & Garcia-Blanco, M. A., Oct 2020, In: Antiviral research. 182, 104874.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA topoisomerase III
  • Yellow fever virus
  • SARS Virus
  • Dengue Virus
  • RNA Viruses
  3 Scopus citations

• Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies

  Arora, R., Liew, C. W., Soh, T. S., Otoo, D. A., Seh, C. C., Yue, K., Nilar, S., Wang, G., Yokokawa, F., Noble, C. G., Chen, Y. L., Shi, P. Y., Lescar, J., Smith, T. M., Benson, T. E. & Lim, S. P., Dec 2020, In: Journal of virology. 94, 24, e01130-20.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • RNA Replicase
  • RNA-directed RNA polymerase
  • RNA

• Type I and Type III interferons restrict SARS-CoV-2 infection of human airway epithelial cultures

  Vanderheiden, A., Ralfs, P., Chirkova, T., Upadhyay, A. A., Zimmerman, M. G., Bedoya, S., Aoued, H., Tharp, G. M., Pellegrini, K. L., Manfredi, C., Sorscher, E., Mainou, B., Lobby, J. L., Kohlmeier, J. E., Lowen, A. C., Shi, P. Y., Menachery, V. D., Anderson, L. J., Grakoui, A., Bosinger, S. E. & 1 others, Suthar, M. S., Oct 2020, In: Journal of virology. 94, 19, e00985-20.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Severe acute respiratory syndrome coronavirus
  • interferon type III
  • Coronavirus Infections
  • Severe Acute Respiratory Syndrome
  • interferons
  19 Scopus citations

• Using next generation sequencing to study the genetic diversity of candidate live attenuated zika vaccines

  Collins, N. D., Shan, C., Nunes, B. T. D., Widen, S. G., Shi, P. Y., Barrett, A. D. T. & Sarathy, V. V., Apr 2020, In: Vaccines. 8, 2, 161.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Attenuated Vaccines
  • Genetic Variation
  • Membranes
  • Flaviviridae
  2 Scopus citations

• Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery

  Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In: EBioMedicine. 57, 102838.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Discovery
  • Flavivirus
  • Viruses
  • Serologic Tests
  • Genetic Recombination
  4 Scopus citations

• Vesicular stomatitis virus and DNA vaccines expressing zika virus nonstructural protein 1 induce substantial but not sterilizing protection against zika virus infection

  Li, A., Xue, M., Attia, Z., Yu, J., Lu, M., Shan, C., Liang, X., Gao, T. Z., Shi, P. Y., Peeples, M. E., Boyaka, P. N., Liu, S. L. & Li, J., Sep 2020, In: Journal of virology. 94, 17, e00048-20.

  Research output: Contribution to journal › Article › peer-review

  • Zika virus
  • Zika Virus Infection
  • Zika Virus
  • recombinant vaccines
  • Vesiculovirus

• Zika structural genes determine the virulence of African and Asian lineages

  Nunes, B. T. D., Fontes-Garfias, C. R., Shan, C., Muruato, A. E., Nunes, J. G. C., Burbano, R. M. R., Vasconcelos, P. F. C., Shi, P. Y. & Medeiros, D. B. A., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 1023-1033 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virulence
  • Viruses
  • Epidemics
  • Genes
• 2019

  Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

  Du, S., Liu, Y., Liu, J., Zhao, J., Champagne, C., Tong, L., Zhang, R., Zhang, F., Qin, C. F., Ma, P., Chen, C. H., Liang, G., Liu, Q., Shi, P. Y., Cazelles, B., Wang, P., Tian, H. & Cheng, G., Dec 1 2019, In: Nature communications. 10, 1, 1324.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Aedes
  • viruses
  • Viruses
  • Breeding
  12 Scopus citations

• An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

  Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In: npj Vaccines. 4, 1, 48.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Mutant Proteins
  • Antiviral Agents
  • Attenuated Vaccines
  • Flavivirus
  4 Scopus citations

• Anti-Zika virus RNAi in neural progenitor cells

  Xie, X. & Shi, P. Y., Apr 1 2019, In: Cell Research. 29, 4, p. 261-262 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• A survey of core replacements in indole-based HIV-1 attachment inhibitors

  Wang, T., Wallace, O. B., Zhang, Z., Fang, H., Yang, Z., Robinson, B. A., Spicer, T. P., Gong, Y. F., Blair, W. S., Shi, P. Y., Lin, P. F., Deshpande, M., Meanwell, N. A. & Kadow, J. F., Jun 1 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1423-1429 7 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • HIV-1
  • Antiviral Agents
  • quinoline
  • naphthalene
  6 Scopus citations

• Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

  Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In: mBio. 10, 4, e01372-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virus Internalization
  • Sertoli Cells
  • Antiviral Agents
  • Zika Virus Infection
  20 Scopus citations

• Dengue NS2A Protein Orchestrates Virus Assembly

  Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In: Cell Host and Microbe. 26, 5, p. 606-622.e8

  Research output: Contribution to journal › Article › peer-review

  • Virus Assembly
  • Dengue
  • Virion
  • Polyproteins
  • Nucleocapsid
  17 Scopus citations

• Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5- b]pyridine-7,3′-indoline]-2′,5(3 H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection

  Xu, J., Xie, X., Ye, N., Zou, J., Chen, H., White, M. A., Shi, P. Y. & Zhou, J., Sep 12 2019, In: Journal of medicinal chemistry. 62, 17, p. 7941-7960 20 p.

  Research output: Contribution to journal › Article › peer-review

  • indoline-2,3-dione
  • pyridine
  • Dengue Virus
  • indoline
  • Virus Diseases
  10 Scopus citations

• Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

  Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In: mBio. 10, 2, e00433-19.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Zika Virus
  • Glioblastoma
  • Names
  • Vaccines

• Genetic and biochemical characterizations of Zika virus NS2A protein

  Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virion
  • Molecular Biology
  • Viral Nonstructural Proteins
  • Proteins
  13 Scopus citations

• Genetic stability of live-attenuated Zika vaccine candidates

  Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 2019, In: Antiviral research. 171, 104596.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Attenuated Vaccines
  • Zika Virus Infection
  • Aedes
  • Vero Cells
  4 Scopus citations

• Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

  Collins, N. D., Widen, S. G., Li, L., Swetnam, D. M., Shi, P. Y., Tesh, R. B. & Sarathy, V. V., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Genetic Variation
  • Nucleotides
  • Asian Americans
  • Membranes
  4 Scopus citations

• Maternal vaccination and protective immunity against Zika virus vertical transmission

  Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In: Nature communications. 10, 1, 5677.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • infectious diseases
  • viruses
  • Viruses
  • immunity
  5 Scopus citations

• Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

  Lim, X. N., Shan, C., Marzinek, J. K., Dong, H., Ng, T. S., Ooi, J. S. G., Fibriansah, G., Wang, J., Verma, C. S., Bond, P. J., Shi, P. Y. & Lok, S. M., 2019, In: PLoS pathogens. 15, 9, e1007996.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dengue Virus
  • Serogroup
  • Vaccines
  • Proteins
  • Temperature
  5 Scopus citations

• Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

  Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In: Nucleic acids research. 47, 20, p. e130

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Caps
  • Uridine Diphosphate
  • Viral RNA
  • Flavin-Adenine Dinucleotide
  • Dengue Virus
  18 Scopus citations