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• 2018

  An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

  Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In: Nature communications. 9, 1, 414.

  Research output: Contribution to journal › Article › peer-review

  • interferon
  • Zika Virus
  • viruses
  • Viruses
  • mutations
  95 Scopus citations

• A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

  Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In: Cell Host and Microbe. 24, 4, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Vaccines
  • Infection
  • Attenuated Vaccines
  • Capsid Proteins
  23 Scopus citations

• A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

  Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In: EBioMedicine. 36, p. 92-102 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Attenuated Vaccines
  • Immunity
  • Plasmids
  • Vaccines
  • DNA
  21 Scopus citations

• A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

  Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P. Y. & Qin, C. F., Dec 1 2018, In: Emerging Microbes and Infections. 7, 1, 0006.

  Research output: Contribution to journal › Letter › peer-review
  3 Scopus citations

• A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

  Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P. Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In: Nature communications. 9, 1, 3067.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Polyproteins
  • viruses
  • Viruses
  27 Scopus citations

• Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

  Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In: PloS one. 13, 1, e0189262.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Viruses
  • Methyltransferases
  • methyltransferases
  4 Scopus citations

• Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

  Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In: Nature communications. 9, 1, 673.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Flavivirus
  • Attenuated Vaccines
  • viruses
  45 Scopus citations

• Did Zika Virus Mutate to Cause Severe Outbreaks?

  Rossi, S. L., Ebel, G. D., Shan, C., Shi, P. Y. & Vasilakis, N., Oct 2018, In: Trends in Microbiology. 26, 10, p. 877-885 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus
  • Disease Outbreaks
  • Venezuelan Equine Encephalitis Viruses
  • Chikungunya virus
  • Arboviruses
  12 Scopus citations

• Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent rna polymerase from fragment screening and structure-guided design

  Lim, S. P., Noble, C. G., Nilar, S., Shi, P. Y. & Yokokawa, F., 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 187-198 12 p. (Advances in Experimental Medicine and Biology; vol. 1062).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • RNA Replicase
  • Viruses
  • Dengue
  • DNA-Directed RNA Polymerases
  • Viral RNA
  4 Scopus citations

• Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

  Fei, Z. & Shi, P. Y., Dec 1 2018, In: Nature Materials. 17, 12, p. 1164 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • news

• Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

  Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In: eLife. 7, e39023.

  Research output: Contribution to journal › Article › peer-review

  • Fragile X Mental Retardation Protein
  • Zika Virus
  • Viruses
  • RNA
  • Zika Virus Infection
  17 Scopus citations

• High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

  Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P. Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In: iScience. 1, p. 97-111 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Culicidae
  • Glycosylation
  • Zika Virus Infection
  • Infection
  16 Scopus citations

• Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

  Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In: Immunity. 48, 3, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Protein Stability
  • RNA-Binding Proteins
  • RNA Caps
  • RNA
  • Methylation
  31 Scopus citations

• K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

  Giraldo, M. I., Vargas-Cuartas, O., Gallego-Gomez, J. C., Shi, P. Y., Padilla-Sanabria, L., Castaño-Osorio, J. C. & Rajsbaum, R., Feb 15 2018, In: Virus Research. 246, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Dengue
  • Proteins
  • Ubiquitination
  • Viral Proteins
  9 Scopus citations

• Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

  Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B. H., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S. J., Zhang, W., Aguilar, P. V. & Wang, T., Nov 1 2018, In: Journal of Clinical Investigation. 128, 11, p. 4980-4991 12 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile Fever
  • West Nile virus
  • Microglia
  • Virus Replication
  • Encephalitis
  11 Scopus citations

• Potential Mechanisms for Enhanced Zika Epidemic and Disease

  Xia, H., Xie, X., Shan, C. & Shi, P. Y., May 11 2018, In: ACS Infectious Diseases. 4, 5, p. 656-659 4 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus Infection
  • Epidemics
  • Herd Immunity
  • Flavivirus
  • Mutation
  5 Scopus citations

• Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

  Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P. Y. & Yokokawa, F., Jul 15 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 13, p. 2324-2327 4 p.

  Research output: Contribution to journal › Article › peer-review

  • phosphoramidic acid
  • RNA Replicase
  • Uridine
  • Dengue Virus
  • Structure-Activity Relationship
  8 Scopus citations

• Targeting vesicle size

  Zou, J. & Shi, P. Y., Nov 1 2018, In: Nature Materials. 17, 11, p. 955-956 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • blood-brain barrier
  • Peptides
  • viruses
  • Viruses
  • peptides

• Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

  Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In: mBio. 9, 5, e01683-18.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Glioblastoma
  • Vaccines
  • Glioma
  • Stem Cells
  32 Scopus citations

• Using a virion assembly-defective dengue virus as a vaccine approach

  Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In: Journal of virology. 92, 21, e01002.

  Research output: Contribution to journal › Article › peer-review

  • Defective Viruses
  • Dengue virus
  • Dengue Virus
  • virion
  • Virion
  10 Scopus citations

• Zika virus infection elicits auto-antibodies to C1q

  Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S. L., Shan, C., Shi, P. Y., Beasley, D. W., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In: Scientific reports. 8, 1, 1882.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Antibodies
  • Complement C1q
  • Viral Structures
  10 Scopus citations

• Zika Virus Vaccine: Progress and Challenges

  Shan, C., Xie, X. & Shi, P. Y., Jul 11 2018, In: Cell Host and Microbe. 24, 1, p. 12-17 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus
  • Vaccines
  • Eye Abnormalities
  • Flavivirus
  • Explosive Agents
  36 Scopus citations
• 2017

  A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

  Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S. L., Weaver, S. C., Xie, X. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 145-156 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Inactivated Vaccines
  • Viruses
  • Zika Virus
  • Complementary DNA
  • Clone Cells
  28 Scopus citations

• Adulthood Sequelae of Congenital Zika Virus Infection in Mice

  Zou, J. & Shi, P. Y., Jun 2017, In: EBioMedicine. 20, p. 11-12 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  3 Scopus citations

• A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

  Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In: Nature Medicine. 23, 6, p. 763-767 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Immunity
  • Vaccines
  • Epidemics
  159 Scopus citations

• A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

  Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P. Y., Feb 1 2017, In: EBioMedicine. 16, p. 136-140 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Microspheres
  • Viruses
  • Immunoassay
  • Zika Virus Infection
  58 Scopus citations

• A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

  Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 157-162 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Viruses
  • Assays
  • Neutralizing Antibodies
  • Zika Virus Infection
  • Neutralization Tests
  45 Scopus citations

• A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

  Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In: Nature communications. 8, 1, 676.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • testes
  • pregnancy
  • Zika Virus
  • Attenuated Vaccines
  80 Scopus citations

• A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

  Yuan, L., Huang, X. Y., Liu, Z. Y., Zhang, F., Zhu, X. L., Yu, J. Y., Ji, X., Xu, Y. P., Li, G., Li, C., Wang, H. J., Deng, Y. Q., Wu, M., Cheng, M. L., Ye, Q., Xie, D. Y., Li, X. F., Wang, X., Shi, W., Hu, B. & 3 others, Shi, P. Y., Xu, Z. & Qin, C. F., Nov 17 2017, In: Science. 358, 6365, p. 933-936 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Microcephaly
  • Mutation
  • Epidemics
  • Polynesia
  215 Scopus citations

• Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

  Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In: PLoS pathogens. 13, 7, e1006535.

  Research output: Contribution to journal › Article › peer-review

  • Dengue
  • Culicidae
  • Salivary Glands
  • Immunity
  • RNA
  47 Scopus citations

• Erratum: Zika virus has oncolytic activity against glioblastoma stem cells [The Journal of Experimental Medicine, 214, 10, (2017)] DOI: 10.1084/jem.20171093

  Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P. Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In: Journal of Experimental Medicine. 214, 10, p. 3145 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Zika Virus
  • Biomedical Research
  • Glioblastoma
  • Emotions
  • Stem Cells
  6 Scopus citations

• Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection

  Shan, C., Ortiz, D. A., Yang, Y., Wong, S. J., Kramer, L. D., Shi, P. Y., Loeffelholz, M. J. & Ren, P., Oct 2017, In: Journal of Clinical Microbiology. 55, 10, p. 3028-3036 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Neutralization Tests
  • Dengue Virus
  • Viruses
  24 Scopus citations

• Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

  Liu, Y., Liu, J., Du, S., Shan, C., Nie, K., Zhang, R., Li, X. F., Zhang, R., Wang, T., Qin, C. F., Wang, P., Shi, P. Y. & Cheng, G., May 25 2017, In: Nature. 545, 7655, p. 482-486 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Aedes
  • Culicidae
  • Proteins
  • Epidemics
  193 Scopus citations

• Functional Analysis of Glycosylation of Zika Virus Envelope Protein

  Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In: Cell Reports. 21, 5, p. 1180-1190 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation
  • Viral Envelope Proteins
  • Zika Virus
  • Functional analysis
  • Viruses
  62 Scopus citations

• Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

  Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P. Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In: Antiviral research. 141, p. 38-47 10 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Antiviral Agents
  • Viruses
  • Containment of Biohazards
  • Luciferases
  11 Scopus citations

• Reverse genetics of Zika virus

  Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Zika Virus
  • Reverse Genetics
  • Complementary DNA
  • Clone Cells
  • Hepatitis Delta Virus
  4 Scopus citations

• RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

  Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In: Journal of virology. 91, 4, e01706-16.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Dengue virus
  • Dengue Virus
  • viral proteins
  • Viral Proteins
  29 Scopus citations

• Small Molecules and Antibodies for Zika Therapy

  Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In: Journal of Infectious Diseases. 216, p. S945-S950

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Antibodies
  • Clinical Trials
  • Pregnant Women
  15 Scopus citations

• Understanding zika virus stability and developing a chimeric vaccine through functional analysis

  Xie, X., Yang, Y., Muruato, A. E., Zou, J., Shan, C., Nunes, B. T. D., Medeiros, D. B. A., Vasconcelos, P. F. C., Weaver, S. C., Rossi, S. L. & Shi, P. Y., Jan 1 2017, In: mBio. 8, 1, e02134-16.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Vaccines
  • Viruses
  • Hydrogen
  • Virion
  62 Scopus citations

• Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

  Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., Muruato, A. E., Foreman, B. M., Luo, H., Wang, T., Barrett, A. D., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L., Ciaramella, G., Mysorekar, I. U. & 3 others, Pierson, T. C., Shi, P. Y. & Diamond, M. S., Jul 13 2017, In: Cell. 170, 2, p. 273-283.e12

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Vaccines
  • Glycosylation
  • Fetus
  124 Scopus citations

• West Nile virus NS1 antagonizes interferon beta production by targeting RIG-I and MDA5

  Zhang, H. L., Ye, H. Q., Liu, S. Q., Deng, C. L., Li, X. D., Shi, P. Y. & Zhang, B., Sep 1 2017, In: Journal of virology. 91, 18, e02396-16.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus nonstructural protein 1
  • interferon-beta
  • West Nile virus
  • retinoic acid
  • Interferon-beta
  29 Scopus citations

• Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

  Aliota, M. T., Bassit, L., Bradrick, S. S., Cox, B., Garcia-Blanco, M. A., Gavegnano, C., Friedrich, T. C., Golos, T. G., Griffin, D. E., Haddow, A. D., Kallas, E. G., Kitron, U., Lecuit, M., Magnani, D. M., Marrs, C., Mercer, N., McSweegan, E., Ng, L. F. P., O'Connor, D. H., Osorio, J. E. & 11 others, Ribeiro, G. S., Ricciardi, M., Rossi, S. L., Saade, G., Schinazi, R. F., Schott-Lerner, G. O., Shan, C., Shi, P. Y., Watkins, D. I., Vasilakis, N. & Weaver, S. C., Aug 2017, In: Antiviral research. 144, p. 223-246 24 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Viruses
  • Routine Diagnostic Tests
  • Antiviral Agents
  67 Scopus citations

• Zika virus has oncolytic activity against glioblastoma stem cells

  Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P. Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In: Journal of Experimental Medicine. 214, 10, p. 2843-2857 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Glioblastoma
  • Stem Cells
  • Flavivirus
  • Oncolytic Virotherapy
  77 Scopus citations

• Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model

  Siemann, D. N., Strange, D. P., Maharaj, P. N., Shi, P. Y. & Verma, S., Nov 1 2017, In: Journal of virology. 91, 22, e00623-17.

  Research output: Contribution to journal › Article › peer-review

  • Zika virus
  • Blood-Testis Barrier
  • Zika Virus
  • Sertoli Cells
  • Sertoli cells
  46 Scopus citations
• 2016

  A conserved pocket in the dengue virus polymerase identified through fragment-based screening

  Noble, C. G., Lim, S. P., Arora, R., Yokokawa, F., Nilar, S., Seh, C. C., Wright, S. K., Benson, T. E., Smith, P. W. & Shi, P. Y., Apr 15 2016, In: Journal of Biological Chemistry. 291, 16, p. 8541-8548 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Screening
  • Serogroup
  • Enzyme inhibition
  31 Scopus citations

• Adenosine analog NITD008 is a potent inhibitor of zika virus

  Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X. P., Shi, P. Y. & Qin, C. F., Oct 1 2016, In: Open Forum Infectious Diseases. 3, 4

  Research output: Contribution to journal › Article › peer-review

  • NITD008
  • Zika Virus
  • Adenosine
  • Antiviral Agents
  • Viremia
  82 Scopus citations

• An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

  Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In: Cell Host and Microbe. 19, 6, p. 891-900 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Culicidae
  • Virulence
  • Antiviral Agents
  • Complementary DNA
  162 Scopus citations

• Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

  Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, Ho, C. Y., Wen, Z., Christian, K. M., Shi, P. Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H. & Ming, G. L., May 19 2016, In: Cell. 165, 5, p. 1238-1254 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Organoids
  • Bioreactors
  • Viruses
  • Brain
  783 Scopus citations

• Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

  Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P. Y. & 1 others, Qin, C. F., Oct 1 2016, In: EBioMedicine. 12, p. 170-177 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Primates
  • Animals
  • Spleen
  86 Scopus citations

• Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

  Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In: Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Drug Design
  • Dengue
  • Viral RNA
  • Serogroup
  47 Scopus citations