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• 2020

  Corrigendum: DNA polymerase θ accomplishes translesion synthesis opposite 1,N⁶-ethenodeoxyadenosine with a remarkably high fidelity in human cells

  Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Jan 1 2020, In: Genes & development. 34, 1-2, p. 146 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells

  Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., May 1 2020, In: Journal of Biological Chemistry. 295, 18, p. 5918-5927 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA-Directed DNA Polymerase
  • Cells
  • Catalytic Domain
  • Conformations
  • Base Pairing

• Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

  Malik, R., Kopylov, M., Gomez-Llorente, Y., Jain, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2020, In: Nature Structural and Molecular Biology. 27, 10, p. 913-924 12 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • DNA
  • Holoenzymes
  • Nucleotides
  • Neoplasms
  6 Scopus citations
• 2019

  Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

  Jain, R., Rice, W. J., Malik, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2019, In: Nature Structural and Molecular Biology. 26, 10, p. 955-962 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Holoenzymes
  • DNA-Directed DNA Polymerase
  • DNA
  • Yeasts
  • Exonucleases
  12 Scopus citations

• DNA polymerase θ accomplishes translesion synthesis opposite 1, N ⁶ -ethenodeoxyadenosine with a remarkably high fidelity in human cells

  Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Mar 1 2019, In: Genes and Development. 33, 5-6, p. 282-287 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 1,N(6)-ethenodeoxyadenosine
  • DNA-Directed DNA Polymerase
  • Base Pairing
  • Catalytic Domain
  • Nucleotides
  3 Scopus citations

• Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

  Yoon, J. H., McArthur, M. J., Park, J., Basu, D., Wakamiya, M., Prakash, L. & Prakash, S., Mar 7 2019, In: Cell. 176, 6, p. 1295-1309.e15

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • Skin Neoplasms
  • Skin
  • Mutation
  • Carcinogenesis
  22 Scopus citations

• Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

  Rechkoblit, O., Johnson, R. E., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2019, In: Scientific reports. 9, 1, 16400.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytarabine
  • DNA-Directed DNA Polymerase
  • Nucleosides
  • Acute Myeloid Leukemia
  • Mutagenesis
  1 Scopus citations

• Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine

  Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 13 2019, In: Journal of Biological Chemistry. 294, 50, p. 19048-19054 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytarabine
  • DNA-Directed DNA Polymerase
  • Nucleosides
  • DNA
  • Acute Myeloid Leukemia
  1 Scopus citations
• 2018

  Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

  Yoon, J. H., Hodge, R. P., Hackfeld, L. C., Park, J., Choudhury, J. R., Prakash, S. & Prakash, L., Feb 23 2018, In: Journal of Biological Chemistry. 293, 8, p. 2949-2958 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Acrolein
  • DNA Adducts
  • Nucleotides
  • 1,N2-propano-2'-deoxyguanosine
  • Aldehydes
  3 Scopus citations

• Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

  Rechkoblit, O., Choudhury, J. R., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2018, In: Scientific reports. 8, 1, 12702.

  Research output: Contribution to journal › Article › peer-review

  • Cytarabine
  • DNA-Directed DNA Polymerase
  • Nucleosides
  • Deoxyribose
  • Deoxycytidine
  5 Scopus citations
• 2017

  Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-l

  Jain, R., Choudhury, J. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Mar 8 2017, In: Scientific reports. 7, 43904.

  Research output: Contribution to journal › Article › peer-review

  • 2'-deoxycytidine 5'-triphosphate
  • thymidine 5'-triphosphate
  • 2'-deoxyadenosine
  • DNA-Directed DNA Polymerase
  • Nucleotides
  8 Scopus citations

• Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

  Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Nov 10 2017, In: Journal of Biological Chemistry. 292, 45, p. 18682-18688 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-deaza-3-methyladenine
  • DNA Adducts
  • DNA-Directed DNA Polymerase
  • Nucleotides
  • Cells
  11 Scopus citations
• 2016

  Human DNA polymerase α in binary complex with a DNA:DNA template-primer

  Coloma, J., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 1 2016, In: Scientific reports. 6, 23784.

  Research output: Contribution to journal › Article › peer-review

  • DNA Primers
  • DNA-Directed DNA Polymerase
  • DNA
  • RNA primers
  • Eukaryota
  14 Scopus citations

• Response to Burgers et al.

  Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Feb 18 2016, In: Molecular cell. 61, 4, p. 494-495 2 p.

  Research output: Contribution to journal › Letter › peer-review
  5 Scopus citations

• Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

  Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Oct 2016, In: Science Advances. 2, 10, e1601317.

  Research output: Contribution to journal › Article › peer-review

  • DNA Primase
  • DNA-Directed DNA Polymerase
  • DNA Primers
  • Enzymes
  • DNA
  32 Scopus citations
• 2013

  The Architecture of Yeast DNA Polymerase ζ

  Gómez-Llorente, Y., Malik, R., Jain, R., Choudhury, J. R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 17 2013, In: Cell Reports. 5, 1, p. 79-86 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Yeast
  • DNA-Directed DNA Polymerase
  • Catalytic Domain
  • Yeasts
  • Electron microscopy
  22 Scopus citations
• 2011

  DNA synthesis across an abasic lesion by yeast Rev1 DNA polymerase

  Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Feb 11 2011, In: Journal of Molecular Biology. 406, 1, p. 18-28 11 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • Arginine
  • Nucleotides
  • Yeasts
  • 2'-deoxycytidine 5'-triphosphate
  26 Scopus citations

• PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication

  Acharya, N., Klassen, R., Johnson, R. E., Prakash, L. & Prakash, S., Nov 1 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 17927-17932 6 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • Proliferating Cell Nuclear Antigen
  • DNA Replication
  • Yeasts
  • Amino Acid Motifs
  43 Scopus citations

• Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast

  Gangavarapu, V., Maria, S. R. S., Prakash, S. & Prakash, L., 2011, In: mBio. 2, 3, e00079-11.

  Research output: Contribution to journal › Article › peer-review

  • Protein Kinases
  • Yeasts
  • DNA-Directed DNA Polymerase
  • DNA Replication
  • Saccharomyces cerevisiae
  13 Scopus citations

• Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer

  Vasquez-Del Carpio, R., Silverstein, T. D., Lone, S., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 29 2011, In: Journal of Molecular Biology. 408, 2, p. 252-261 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Pyrimidine Dimers
  • DNA-Directed DNA Polymerase
  • Nucleotides
  • Pyrimidines
  • DNA
  14 Scopus citations