Find Research Outputs

Search results

• 2020

  Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection

  Rumfield, C., Hyseni, I., McBride, J. W., Walker, D. H. & Fang, R., Mar 23 2020, In: Infection and immunity. 88, 4

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Toll-Like Receptor 4
  • Interleukin-1
  • Immunity
  • Macrophages

• A single mutation (V64G) within the ring domain of Z attenuates junin virus

  Hallam, S. J., Manning, J. T., Maruyama, J., Seregin, A., Huang, C., Walker, D. H., de la Torre, J. C. & Paessler, S., Sep 2020, In: PLoS neglected tropical diseases. 14, 9, p. 1-15 15 p., e0008555.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • New World Arenaviruses
  • Junin virus
  • Mutation
  • Arenaviridae
  • Fever

• Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes

  Luo, T., Patel, J. G., Zhang, X., Walker, D. H. & McBride, J. W., Dec 1 2020, In: npj Vaccines. 5, 1, 85.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ehrlichia chaffeensis
  • Protein Conformation
  • Epitopes
  • Antibodies
  • Proteins

• Human monocytic ehrlichiosis, Mexico City, Mexico

  Alcántara-Rodríguez, V. E., Sánchez-Montes, S., Contreras, H., Colunga-Salas, P., Fierro-Flores, L., Avalos, S., Rodríguez-Rangel, F., Becker, I. & Walker, D. H., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3016-3019 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Mexico
  • Ehrlichia canis
  • Ehrlichia
  • Infection

• Human rickettsiosis caused by rickettsia parkeri strain Atlantic rainforest, Urabá, Colombia

  Arboleda, M., Acevedo-Gutiérrez, L. Y., Ávila, A., Ospina, D., Díaz, F. J., Walker, D. H. & Rodas, J. D., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3048-3050 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Rainforest
  • Rickettsia
  • Colombia
  • vpr Genes
  • Gene Amplification

• Perspective Piece: Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue

  Sarathy, V. V. & Walker, D. H., Sep 2020, In: American Journal of Tropical Medicine and Hygiene. 103, 3, p. 970-975 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Scrub Typhus
  • Disease Vectors
  • Dengue
  • Orientia tsutsugamushi
  • Zoonoses

• Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections

  Zhao, Y., Fang, R., Zhang, J., Zhang, Y., Bechelli, J., Smalley, C., Valbuena, G., Walker, D. H., Oteo, J. A. & Brasier, A. R., Feb 2020, In: American Journal of Pathology. 190, 2, p. 306-322 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Spotted Fever Group Rickettsiosis
  • Rickettsia conorii
  • Proteomics
  • Boutonneuse Fever
  • Infection
  3 Scopus citations

• Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead

  Narra, H. P., Sahni, A., Walker, D. H. & Sahni, S. K., Jun 2020, In: Future Microbiology. 15, 9, p. 753-765 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Arthropod Vectors
  • resmethrin
  • Rickettsia
  • Antitoxins
  • Host-Pathogen Interactions
  1 Scopus citations

• The guinea pig model for tick-borne spotted fever rickettsioses: A second look

  Stokes, J. V., Walker, D. H. & Varela-Stokes, A. S., Nov 2020, In: Ticks and Tick-borne Diseases. 11, 6, 101538.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • rickettsial diseases
  • Spotted Fever Group Rickettsiosis
  • Ticks
  • fever
  • ticks
• 2018

  Analysis of health-Care charges in murine typhus: Need for improved clinical recognition and diagnostics for acute disease

  Vohra, R. F., Walker, D. H. & Blanton, L. S., 2018, In: American Journal of Tropical Medicine and Hygiene. 98, 6, p. 1594-1598 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Acute Disease
  • Delivery of Health Care
  • Human Influenza
  • Rickettsia typhi
  5 Scopus citations

• Chlamydial, Mycoplasmal, Rickettsial, and Ehrlichial Diseases

  Walker, D. H., 2018, Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Inc., p. 315-326 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2017

  A review of the global epidemiology of scrub typhus

  Xu, G., Walker, D. H., Jupiter, D., Melby, P. C. & Arcari, C. M., Nov 3 2017, In: PLoS neglected tropical diseases. 11, 11, e0006062.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Epidemiology
  • Orientia tsutsugamushi
  • Public Health
  • Neglected Diseases
  73 Scopus citations

• CD8⁺T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

  Xu, G., Mendell, N. L., Liang, Y., Shelite, T. R., Goez-Rivillas, Y., Soong, L., Bouyer, D. H. & Walker, D. H., Jul 19 2017, In: PLoS neglected tropical diseases. 11, 7, e0005763.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • T-Lymphocytes
  • Bacterial Load
  • Immunity
  15 Scopus citations

• Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium

  Sahni, A., Patel, J., Narra, H. P., Schroeder, C. L. C., Walker, D. H. & Sahni, S. K., Aug 2017, In: PloS one. 12, 8, e0183181.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor receptor 1
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Receptor, Fibroblast Growth Factor, Type 1
  • fibroblast growth factor receptors
  9 Scopus citations

• Flea-Borne Rickettsioses and Rickettsiae

  Blanton, L. S. & Walker, D. H., Jan 2017, In: American Journal of Tropical Medicine and Hygiene. 96, 1, p. 53-56 4 p.

  Research output: Contribution to journal › Review article › peer-review

  • Siphonaptera
  • Rickettsia felis
  • Rickettsia typhi
  • Ecology
  • Uncertainty
  32 Scopus citations

• Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka

  Premaratna, R., Blanton, L. S., Samaraweera, D. N., de Silva, G. N. N., Chandrasena, N. T. G. A., Walker, D. H. & de Silva, H. J., Jan 13 2017, In: BMC Infectious Diseases. 17, 1, 67.

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Sri Lanka
  • Genotype
  • Real-Time Polymerase Chain Reaction
  • Fever
  7 Scopus citations

• Mechanisms of immunity to rickettsia and implications for vaccine development

  Walker, D., Jan 1 2017, In: Revista Colombiana de Ciencias Pecuarias. 30, p. 262-263 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • vaccine development
  • fever
  • immunity

• Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection

  Mendell, N. L., Bouyer, D. H. & Walker, D. H., Mar 10 2017, In: PLoS neglected tropical diseases. 11, 3, e0005453.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Infection
  • Trombiculidae
  • Heterologous Immunity
  10 Scopus citations

• Rickettsiae as Emerging Infectious Agents

  Fang, R., Blanton, L. S. & Walker, D. H., Jun 2017, In: Clinics in Laboratory Medicine. 37, 2, p. 383-400 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • Arthropod Vectors
  • Epidemic Louse-Borne Typhus
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Epidemiology
  25 Scopus citations

• Time to Worry about Anthrax Again

  Keim, P. S., Walker, D. H. & Zilinskas, R. A., Mar 14 2017, In: Scientific American. 316, 4, p. 70-75 6 p.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations
• 2016

  An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

  Soong, L., Mendell, N. L., Olano, J. P., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T. R., Valbuena, G., Walker, D. H. & Bouyer, D. H., Aug 1 2016, In: PLoS neglected tropical diseases. 10, 8, e0004884.

  Research output: Contribution to journal › Article › peer-review

  • Immunological Models
  • Scrub Typhus
  • Infection
  • Orientia tsutsugamushi
  • Interleukin-9
  15 Scopus citations

• Editorial: Changing dynamics of human-rickettsial interactions

  Walker, D. H., Jan 2016, In: American Journal of Tropical Medicine and Hygiene. 94, 1, p. 3-4 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  5 Scopus citations

• Ehrlichioses: An important one health opportunity

  Saito, T. B. & Walker, D. H., Sep 1 2016, In: Veterinary Sciences. 3, 3, 20.

  Research output: Contribution to journal › Review article › peer-review

  • ehrlichiosis
  • Ehrlichiosis
  • Ehrlichia
  • T-Lymphocytes
  • Health
  11 Scopus citations

• Endothelial Activation and Injury: The Mechanisms of Rickettsial Vasculiti

  Sahni, A., Narra, H. P., Walker, D. H. & Sahni, S. K., Jan 1 2016, Vascular Responses to Pathogens. Elsevier Inc., p. 111-122 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Wounds and Injuries
  • Infection
  • Rickettsia Infections
  • Arthropod Vectors
  • Rickettsia
  5 Scopus citations

• Endothelial cell proteomic response to Rickettsia conorii infection reveals activation of the Janus Kinase (JAK)-signal transducer and activator of transcription (STAT)-inferferon stimulated gene (ISG)15 pathway and reprogramming plasma membrane integrin/cadherin signaling

  Zhao, Y., Valbuena, G., Walker, D. H., Gazi, M., Hidalgo, M., DeSousa, R., Oteo, J. A., Goez, Y. & Brasier, A. R., Jan 2016, In: Molecular and Cellular Proteomics. 15, 1, p. 289-304 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Boutonneuse Fever
  • Endothelial cells
  • Cell membranes
  • Proteomics
  • Janus Kinases
  10 Scopus citations

• Epidemiology, molecular biology, and pathogenic mechanisms of Ehrlichia infections

  Yu, X. J. & Walker, D., Jan 1 2016, Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development. Springer International Publishing, p. 225-240 16 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Ehrlichia
  • Ehrlichiosis
  • Molecular Biology
  • Epidemiology
  • Pattern Recognition Receptors
  1 Scopus citations

• Fatal monocytic ehrlichiosis in woman, Mexico, 2013

  Sosa-Gutierrez, C. G., Solorzano-Santos, F., Walker, D. H., Torres, J., Serrano, C. A. & Gordillo-Perez, G., May 2016, In: Emerging infectious diseases. 22, 5, p. 871-874 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Mexico
  • Ehrlichia chaffeensis
  • Fever
  • Tick Bites
  8 Scopus citations

• MyD88 mediates instructive signaling in dendritic cells and protective inflammatory response during rickettsial infection

  Bechelli, J., Smalley, C., Zhao, X., Judy, B., Valdes, P., Walker, D. H. & Fang, R., Apr 1 2016, In: Infection and immunity. 84, 4, p. 883-893 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendritic Cells
  • Interleukin-1
  • Infection
  • Bone Marrow
  • Rickettsia
  12 Scopus citations

• Opossums and cat fleas: New insights in the ecology of murine typhus in Galveston, Texas

  Blanton, L. S., Idowu, B. M., Tatsch, T. N., Henderson, J. M., Bouyer, D. H. & Walker, D. H., Aug 2016, In: American Journal of Tropical Medicine and Hygiene. 95, 2, p. 457-461 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ctenocephalides
  • Endemic Flea-Borne Typhus
  • Siphonaptera
  • Opossums
  • Ecology
  31 Scopus citations

• Rickettsia

  Walker, D., Oct 6 2016, International Encyclopedia of Public Health. Elsevier Inc., p. 370-377 8 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Coxiella
  • Rickettsia
  • Neorickettsia
  • Endemic Flea-Borne Typhus
  • Anaplasma
  2 Scopus citations

• Rickettsia australis activates inflammasome in human and murine macrophages

  Smalley, C., Bechelli, J., Rockx-Brouwer, D., Saito, T., Azar, S. R., Ismail, N., Walker, D. H. & Fang, R., Jun 2016, In: PloS one. 11, 6, e0157231.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia australis
  • inflammasomes
  • Macrophages
  • Rickettsia
  • Inflammasomes
  13 Scopus citations

• Scrub typhus - Scientific neglect, ever-widening impact

  Walker, D. H., Sep 8 2016, In: New England Journal of Medicine. 375, 10, p. 913-915 3 p.

  Research output: Contribution to journal › Short survey › peer-review
  32 Scopus citations

• Value of autopsy emphasized in the case report of a single patient with middle east respiratory syndrome

  Walker, D. H., Mar 1 2016, In: American Journal of Pathology. 186, 3, p. 507-510 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Coronavirus Infections
  • Communicable Diseases
  • Autopsy
  7 Scopus citations
• 2015

  An animal model of a newly emerging human ehrlichiosis

  Saito, T. B., Thirumalapura, N. R., Shelite, T. R., Rockx-Brouwer, D., Popov, V. L. & Walker, D. H., Feb 1 2015, In: Journal of Infectious Diseases. 211, 3, p. 452-461 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Ehrlichiosis
  • Animal Models
  • Infection
  • Clinical Chemistry
  14 Scopus citations

• A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis

  Saito, T. B. & Walker, D. H., Sep 15 2015, In: Journal of Infectious Diseases. 212, 6, p. 968-977 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Ticks
  • Ehrlichia
  • Nymph
  • Larva
  13 Scopus citations

• Case report: An unusual cutaneous manifestation in a patient with murine typhus

  Blanton, L. S., Lea, A. S., Kelly, B. C. & Walker, D. H., Dec 2015, In: American Journal of Tropical Medicine and Hygiene. 93, 6, p. 1164-1167 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Skin Manifestations
  • Rickettsia typhi
  • Siphonaptera
  • Mites
  9 Scopus citations

• Fever and rash after a safari

  Damavandy, A. A., Rojek, N. W., Dugan, E. M., Walker, D. & Norton, S. A., Jan 1 2015, In: Journal of the American Academy of Dermatology. 72, 1, p. e5-e6

  Research output: Contribution to journal › Article › peer-review

• Permissive and protective roles for neutrophils in leishmaniasis

  Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In: Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • Parasites
  • Neutrophils
  • Leishmania
  • Infection
  32 Scopus citations

• Reemergence of murine typhus in galveston, texas, usa, 2013

  Blanton, L. S., Vohra, R. F., Bouyer, D. H. & Walker, D. H., 2015, In: Emerging infectious diseases. 21, 3, p. 484-486 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Rickettsia typhi
  • Public Health
  • Physicians
  24 Scopus citations

• Rickettsia massiliae and rickettsia conorii israeli spotted fever strain differentially regulate endothelial cell responses

  Bechelli, J., Smalley, C., Milhano, N., Walker, D. H. & Fang, R., Sep 22 2015, In: PloS one. 10, 9, e0138830.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia massiliae
  • Rickettsia conorii
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Rickettsia
  5 Scopus citations

• The role of CD8 T lymphocytes in rickettsial infections

  Walker, D. H. & Dumler, J. S., May 26 2015, In: Seminars in Immunopathology. 37, 3, p. 289-299 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • T-Lymphocytes
  • Infection
  • Anaplasmosis
  • Ehrlichiosis
  • Immunity
  17 Scopus citations

• The role of Rhipicephalus sanguineus sensu lato saliva in the dissemination of Rickettsia conorii in C3H/HeJ mice

  Milhano, N., Saito, T. B., Bechelli, J., Fang, R., Vilhena, M., De Sousa, R. & Walker, D. H., Sep 1 2015, In: Medical and Veterinary Entomology. 29, 3, p. 225-229 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia conorii
  • Rhipicephalus sanguineus
  • tick
  • saliva
  • Ticks
  9 Scopus citations
• 2014

  After malaria is controlled, what's next?

  Walker, D. H., Jul 2014, In: American Journal of Tropical Medicine and Hygiene. 91, 1, p. 7-10 4 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations

• A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

  Shelite, T. R., Saito, T. B., Mendell, N. L., Gong, B., Xu, G., Soong, L., Valbuena, G., Bouyer, D. H. & Walker, D. H., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e2966.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Infection
  • Inbred C57BL Mouse
  • Trombiculidae
  25 Scopus citations

• Diseases Caused by Fungi

  Walker, D. H. & McGinnis, M. R., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 217-221 5 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Mycoses
  • Fungi
  • Fungal Structures
  • Histoplasma
  • Arthrodermataceae

• Ehrlichia

  Thirumalapura, N. R. & Walker, D., Nov 26 2014, Molecular Medical Microbiology: Second Edition. Elsevier Ltd, Vol. 3. p. 2011-2032 22 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Ehrlichia
  • Ehrlichiosis
  • Ehrlichia chaffeensis
  • Peptidoglycan
  • Liver

• Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae

  Dumler, J. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2227-2233.e3

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  9 Scopus citations

• Inactivation of sam-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain

  Liu, Y., Wu, B., Weinstock, G., Walker, D. H. & Yu, X. J., Nov 20 2014, In: PloS one. 9, 11, e113285.

  Research output: Contribution to journal › Article › peer-review

  • typhus vaccine
  • Rickettsia prowazekii
  • Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, Skeletal Abnormalities
  • typhus
  • Phthiraptera
  4 Scopus citations

• Interactions of Pathogens with the Host

  Walker, D., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 214-216 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Host-Pathogen Interactions
  • Infection
  • Meningoencephalitis
  • Asymptomatic Infections
  • Lymphatic Vessels

• Omplete genome sequence of Ehrlichia muris strain AS145^T, a model monocytotropic Ehrlichia strain

  Thirumalapura, N. R., Qin, X., Kuriakose, J. A. & Walker, D., 2014, In: Genome Announcements. 2, 1, e01234-13.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Ehrlichiosis
  • Genome
  • Japan
  • Infection
  5 Scopus citations