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• 2020

  Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection

  Rumfield, C., Hyseni, I., McBride, J. W., Walker, D. H. & Fang, R., Mar 23 2020, In: Infection and immunity. 88, 4

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Toll-Like Receptor 4
  • Interleukin-1
  • Immunity
  • Macrophages

• A single mutation (V64G) within the ring domain of Z attenuates junin virus

  Hallam, S. J., Manning, J. T., Maruyama, J., Seregin, A., Huang, C., Walker, D. H., de la Torre, J. C. & Paessler, S., Sep 2020, In: PLoS neglected tropical diseases. 14, 9, p. 1-15 15 p., e0008555.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • New World Arenaviruses
  • Junin virus
  • Mutation
  • Arenaviridae
  • Fever

• Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes

  Luo, T., Patel, J. G., Zhang, X., Walker, D. H. & McBride, J. W., Dec 1 2020, In: npj Vaccines. 5, 1, 85.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ehrlichia chaffeensis
  • Protein Conformation
  • Epitopes
  • Antibodies
  • Proteins

• Human monocytic ehrlichiosis, Mexico City, Mexico

  Alcántara-Rodríguez, V. E., Sánchez-Montes, S., Contreras, H., Colunga-Salas, P., Fierro-Flores, L., Avalos, S., Rodríguez-Rangel, F., Becker, I. & Walker, D. H., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3016-3019 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Mexico
  • Ehrlichia canis
  • Ehrlichia
  • Infection

• Human rickettsiosis caused by rickettsia parkeri strain Atlantic rainforest, Urabá, Colombia

  Arboleda, M., Acevedo-Gutiérrez, L. Y., Ávila, A., Ospina, D., Díaz, F. J., Walker, D. H. & Rodas, J. D., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3048-3050 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Rainforest
  • Rickettsia
  • Colombia
  • vpr Genes
  • Gene Amplification

• Perspective Piece: Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue

  Sarathy, V. V. & Walker, D. H., Sep 2020, In: American Journal of Tropical Medicine and Hygiene. 103, 3, p. 970-975 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Scrub Typhus
  • Disease Vectors
  • Dengue
  • Orientia tsutsugamushi
  • Zoonoses

• Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections

  Zhao, Y., Fang, R., Zhang, J., Zhang, Y., Bechelli, J., Smalley, C., Valbuena, G., Walker, D. H., Oteo, J. A. & Brasier, A. R., Feb 2020, In: American Journal of Pathology. 190, 2, p. 306-322 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Spotted Fever Group Rickettsiosis
  • Rickettsia conorii
  • Proteomics
  • Boutonneuse Fever
  • Infection
  3 Scopus citations

• Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead

  Narra, H. P., Sahni, A., Walker, D. H. & Sahni, S. K., Jun 2020, In: Future Microbiology. 15, 9, p. 753-765 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Arthropod Vectors
  • resmethrin
  • Rickettsia
  • Antitoxins
  • Host-Pathogen Interactions
  1 Scopus citations

• The guinea pig model for tick-borne spotted fever rickettsioses: A second look

  Stokes, J. V., Walker, D. H. & Varela-Stokes, A. S., Nov 2020, In: Ticks and Tick-borne Diseases. 11, 6, 101538.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • rickettsial diseases
  • Spotted Fever Group Rickettsiosis
  • Ticks
  • fever
  • ticks
• 2019

  A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri atlantic rainforest strain

  Londoño, A. F., Mendell, N. L., Walker, D. H. & Bouyer, D. H., Jun 2019, In: PLoS neglected tropical diseases. 13, 6, e0007054.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rainforest
  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • Containment of Biohazards
  • Infection
  2 Scopus citations

• A cluster of cases of rocky mountain spotted fever in an area of Colombia not known to be endemic for this disease

  Londoño, A. F., Arango-Ferreira, C., Acevedo-Gutiérrez, L. Y., Paternina, L. E., Montes, C., Ruiz, I., Labruna, M. B., Díaz, F. J., Walker, D. H. & Rodas, J. D., 2019, In: American Journal of Tropical Medicine and Hygiene. 101, 2, p. 336-342 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Rocky Mountain Spotted Fever
  • Endemic Diseases
  • Colombia
  • Rickettsia rickettsii
  • Molecular Diagnostic Techniques
  2 Scopus citations

• Atg5 supports Rickettsia australis infection in macrophages in vitro and in vivo

  Bechelli, J., Vergara, L., Smalley, C., Buzhdygan, T. P., Bender, S., Zhang, W., Liu, Y., Popov, V. L., Wang, J., Garg, N., Hwang, S., Walker, D. H. & Fang, R., Jan 1 2019, In: Infection and immunity. 87, 1, e00651.

  Research output: Contribution to journal › Article › peer-review

  • Spotted Fever Group Rickettsiosis
  • Macrophages
  • In Vitro Techniques
  • Rickettsia
  • Interleukin-1
  9 Scopus citations

• Burkholderia pseudomallei ΔtonB Δhcp1 live attenuated vaccine strain elicits full protective immunity against aerosolized melioidosis infection

  Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Kilgore, P. B., Ross, B. N., Walker, D. H., Endsley, J. J. & Torresa, A. G., Jan 1 2019, In: mSphere. 4, 1, e00570-18.

  Research output: Contribution to journal › Article › peer-review

  • Melioidosis
  • Burkholderia pseudomallei
  • Attenuated Vaccines
  • Burkholderia mallei
  • Immunity
  10 Scopus citations

• Ehrlichia chaffeensis outer membrane protein 1-specific human antibody-mediated immunity is defined by intracellular TRIM21-dependent innate immune activation and extracellular neutralization

  Velayutham, T. S., Kumar, S., Zhang, X., Kose, N., Walker, D. H., Winslow, G., Crowe, J. E. & McBride, J. W., Dec 1 2019, In: Infection and immunity. 87, 12, e00383-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ehrlichia chaffeensis
  • Ehrlichia
  • Membrane Proteins
  • Immunity
  • Autophagy
  3 Scopus citations

• Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

  Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Walker, D. H., Endsley, J. J. & Torres, A. G., Jul 2019, In: PLoS neglected tropical diseases. 13, 7, e0007578.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Burkholderia mallei
  • Glanders
  • Melioidosis
  • Attenuated Vaccines
  • Humoral Immunity
  3 Scopus citations

• Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection

  Sahni, A., Fang, R., Sahni, S. K. & Walker, D. H., 2019, In: Annual Review of Pathology: Mechanisms of Disease. 14, p. 127-152 26 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia Infections
  • Actins
  • Endothelial Cells
  • Infection
  • Rickettsia
  11 Scopus citations

• Rickettsiae Within the Fleas of Feral Cats in Galveston, Texas

  Blanton, L. S., Vohra, R. F., Fistein, L., Quade, B., Walker, D. H. & Bouyer, D. H., Sep 2019, In: Vector-Borne and Zoonotic Diseases. 19, 9, p. 647-651 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ctenocephalides
  • feral
  • Siphonaptera
  • Rickettsia typhi
  • Endemic Flea-Borne Typhus
  7 Scopus citations

• Seek and you shall find — Unknown pathogens?

  Vasilakis, N. & Walker, D. H., May 30 2019, In: New England Journal of Medicine. 380, 22, p. 2174-2175 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Sequelae of Lassa fever: Postviral cerebellar ataxia

  Ezeomah, C., Adoga, A., Ihekweazu, C., Paessler, S., Cisneros, I., Tomori, O. & Walker, D., Dec 1 2019, In: Open Forum Infectious Diseases. 6, 12

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Lassa Fever
  • Cerebellar Ataxia
  • Ataxia
  • Antiviral Agents
  • Lassa virus
  1 Scopus citations

• Susceptibility of Rickettsia rickettsii to Tigecycline in a Cell Culture Assay and Animal Model for Rocky Mountain Spotted Fever

  Blanton, L. S., Wilson, N. M., Quade, B. R. & Walker, D. H., 2019, In: American Journal of Tropical Medicine and Hygiene. 101, 5, p. 1091-1095 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia rickettsii
  • Rocky Mountain Spotted Fever
  • Tigecycline
  • Cell Culture Techniques
  • Animal Models
  1 Scopus citations

• Vector Tick Transmission Model of Spotted Fever Rickettsiosis

  Saito, T. B., Bechelli, J., Smalley, C., Karim, S. & Walker, D. H., Jan 2019, In: American Journal of Pathology. 189, 1, p. 115-123 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Spotted Fever Group Rickettsiosis
  • Ticks
  • Infection
  • Rickettsia Infections
  • Bacterial Load
  4 Scopus citations

• Whole-genome sequence of rickettsia parkeri strain atlantic rainforest, isolated from a colombian tick

  Londoño, A. F., Mendell, N. L., Valbuena, G. A., Routh, A. L., Wood, T. G., Widen, S. G., Rodas, J. D., Walker, D. H. & Bouyer, D. H., Sep 26 2019, In: Microbiology Resource Announcements. 8, 39, e00684-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rainforest
  • Rickettsia
  • Ticks
  • Genome
  • Colombia
• 2018

  Analysis of health-Care charges in murine typhus: Need for improved clinical recognition and diagnostics for acute disease

  Vohra, R. F., Walker, D. H. & Blanton, L. S., 2018, In: American Journal of Tropical Medicine and Hygiene. 98, 6, p. 1594-1598 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Acute Disease
  • Delivery of Health Care
  • Human Influenza
  • Rickettsia typhi
  5 Scopus citations

• Chlamydial, Mycoplasmal, Rickettsial, and Ehrlichial Diseases

  Walker, D. H., 2018, Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Inc., p. 315-326 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2015

  An animal model of a newly emerging human ehrlichiosis

  Saito, T. B., Thirumalapura, N. R., Shelite, T. R., Rockx-Brouwer, D., Popov, V. L. & Walker, D. H., Feb 1 2015, In: Journal of Infectious Diseases. 211, 3, p. 452-461 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Ehrlichiosis
  • Animal Models
  • Infection
  • Clinical Chemistry
  14 Scopus citations

• A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis

  Saito, T. B. & Walker, D. H., Sep 15 2015, In: Journal of Infectious Diseases. 212, 6, p. 968-977 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Ticks
  • Ehrlichia
  • Nymph
  • Larva
  13 Scopus citations

• Case report: An unusual cutaneous manifestation in a patient with murine typhus

  Blanton, L. S., Lea, A. S., Kelly, B. C. & Walker, D. H., Dec 2015, In: American Journal of Tropical Medicine and Hygiene. 93, 6, p. 1164-1167 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Skin Manifestations
  • Rickettsia typhi
  • Siphonaptera
  • Mites
  9 Scopus citations

• Fever and rash after a safari

  Damavandy, A. A., Rojek, N. W., Dugan, E. M., Walker, D. & Norton, S. A., Jan 1 2015, In: Journal of the American Academy of Dermatology. 72, 1, p. e5-e6

  Research output: Contribution to journal › Article › peer-review

• Permissive and protective roles for neutrophils in leishmaniasis

  Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In: Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • Parasites
  • Neutrophils
  • Leishmania
  • Infection
  32 Scopus citations

• Reemergence of murine typhus in galveston, texas, usa, 2013

  Blanton, L. S., Vohra, R. F., Bouyer, D. H. & Walker, D. H., 2015, In: Emerging infectious diseases. 21, 3, p. 484-486 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Rickettsia typhi
  • Public Health
  • Physicians
  24 Scopus citations

• Rickettsia massiliae and rickettsia conorii israeli spotted fever strain differentially regulate endothelial cell responses

  Bechelli, J., Smalley, C., Milhano, N., Walker, D. H. & Fang, R., Sep 22 2015, In: PloS one. 10, 9, e0138830.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia massiliae
  • Rickettsia conorii
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Rickettsia
  5 Scopus citations

• The role of CD8 T lymphocytes in rickettsial infections

  Walker, D. H. & Dumler, J. S., May 26 2015, In: Seminars in Immunopathology. 37, 3, p. 289-299 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • T-Lymphocytes
  • Infection
  • Anaplasmosis
  • Ehrlichiosis
  • Immunity
  17 Scopus citations

• The role of Rhipicephalus sanguineus sensu lato saliva in the dissemination of Rickettsia conorii in C3H/HeJ mice

  Milhano, N., Saito, T. B., Bechelli, J., Fang, R., Vilhena, M., De Sousa, R. & Walker, D. H., Sep 1 2015, In: Medical and Veterinary Entomology. 29, 3, p. 225-229 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia conorii
  • Rhipicephalus sanguineus
  • tick
  • saliva
  • Ticks
  9 Scopus citations
• 2014

  After malaria is controlled, what's next?

  Walker, D. H., Jul 2014, In: American Journal of Tropical Medicine and Hygiene. 91, 1, p. 7-10 4 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations

• A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

  Shelite, T. R., Saito, T. B., Mendell, N. L., Gong, B., Xu, G., Soong, L., Valbuena, G., Bouyer, D. H. & Walker, D. H., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e2966.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Infection
  • Inbred C57BL Mouse
  • Trombiculidae
  25 Scopus citations

• Diseases Caused by Fungi

  Walker, D. H. & McGinnis, M. R., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 217-221 5 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Mycoses
  • Fungi
  • Fungal Structures
  • Histoplasma
  • Arthrodermataceae

• Ehrlichia

  Thirumalapura, N. R. & Walker, D., Nov 26 2014, Molecular Medical Microbiology: Second Edition. Elsevier Ltd, Vol. 3. p. 2011-2032 22 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Ehrlichia
  • Ehrlichiosis
  • Ehrlichia chaffeensis
  • Peptidoglycan
  • Liver

• Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae

  Dumler, J. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2227-2233.e3

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  9 Scopus citations

• Inactivation of sam-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain

  Liu, Y., Wu, B., Weinstock, G., Walker, D. H. & Yu, X. J., Nov 20 2014, In: PloS one. 9, 11, e113285.

  Research output: Contribution to journal › Article › peer-review

  • typhus vaccine
  • Rickettsia prowazekii
  • Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, Skeletal Abnormalities
  • typhus
  • Phthiraptera
  4 Scopus citations

• Interactions of Pathogens with the Host

  Walker, D., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 214-216 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Host-Pathogen Interactions
  • Infection
  • Meningoencephalitis
  • Asymptomatic Infections
  • Lymphatic Vessels

• Omplete genome sequence of Ehrlichia muris strain AS145^T, a model monocytotropic Ehrlichia strain

  Thirumalapura, N. R., Qin, X., Kuriakose, J. A. & Walker, D., 2014, In: Genome Announcements. 2, 1, e01234-13.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Ehrlichiosis
  • Genome
  • Japan
  • Infection
  5 Scopus citations

• Pathogenesis of Infectious Diseases and Mechanisms of Immunity

  McBride, J. & Walker, D., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 59-72 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Communicable Diseases
  • Immunity
  • Vaccines
  • Host-Pathogen Interactions
  • Antibodies

• Principles of Diagnosis of Infectious Diseases

  Walker, D., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 222-225 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Communicable Diseases
  • Inclusion Bodies
  • Viruses
  • Nucleic Acids
  • Fungi

• Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs

  Milhano, N., Popov, V., Vilhena, M., Bouyer, D. H., de Sousa, R. & Walker, D. H., Oct 1 2014, In: Ticks and Tick-borne Diseases. 5, 6, p. 709-714 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia massiliae
  • Rhipicephalus sanguineus
  • Rickettsia
  • Ticks
  • ticks
  6 Scopus citations

• "rickettsia amblyommii" Induces cross protection against lethal rocky mountain spotted fever in a guinea pig model

  Blanton, L. S., Mendell, N. L., Walker, D. H. & Bouyer, D. H., Aug 1 2014, In: Vector-Borne and Zoonotic Diseases. 14, 8, p. 557-562 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia rickettsii
  • Rocky Mountain Spotted Fever
  • Cross Protection
  • Rickettsia
  • Guinea Pigs
  18 Scopus citations

• Rickettsiae and ehrlichiae within a city park: Is the urban dweller at risk?

  Blanton, L. S., Walker, D. H. & Bouyer, D. H., Feb 1 2014, In: Vector-Borne and Zoonotic Diseases. 14, 2, p. 168-170 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Ticks
  • Ehrlichiosis
  • Ehrlichia chaffeensis
  • Dermacentor
  13 Scopus citations

• Rickettsia felis and changing paradigms about pathogenic rickettsiae

  Labruna, M. B. & Walker, D. H., Oct 1 2014, In: Emerging infectious diseases. 20, 10, p. 1768-1769 2 p.

  Research output: Contribution to journal › Letter › peer-review
  21 Scopus citations

• Rickettsia prowazekii (Epidemic or Louse-Borne Typhus)

  Blanton, L. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2217-2220.e1

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)

  Walker, D. H. & Blanton, L. S., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2198-2205 8 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  4 Scopus citations

• Rickettsia typhi (Murine Typhus)

  Blanton, L. S., Dumler, J. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2221-2224.e2

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  5 Scopus citations