Find Research outputs

Search results

• 2017

  A Sensitive in Vitro High-Throughput Screen to Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface

  Liu, G., Nash, P. J., Johnson, B., Pietzsch, C., Ilagan, M. X. G., Bukreyev, A., Basler, C. F., Bowlin, T. L., Moir, D. T., Leung, D. W. & Amarasinghe, G. K., Mar 10 2017, In: ACS Infectious Diseases. 3, 3, p. 190-198 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ebolavirus
  • Nucleoproteins
  • Viral Proteins
  • Virus Replication
  • Disease Outbreaks
  12 Scopus citations

• Ebola virus binding to Tim-1 on T lymphocytes induces a cytokine storm

  Younan, P., Iampietro, M., Nishida, A., Ramanathan, P., Santos, R. I., Dutta, M., Lubaki, N. M., Koup, R. A., Katze, M. G. & Bukreyev, A., Sep 1 2017, In: mBio. 8, 5, e00845-17.

  Research output: Contribution to journal › Article › peer-review

  • Ebolavirus
  • Virus Attachment
  • Cytokines
  • T-Lymphocytes
  • Ebola Hemorrhagic Fever
  41 Scopus citations

• Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection

  Iampietro, M., Younan, P., Nishida, A., Dutta, M., Lubaki, N. M., Santos, R. I., Koup, R. A., Katze, M. G. & Bukreyev, A., May 2017, In: PLoS pathogens. 13, 5, e1006397.

  Research output: Contribution to journal › Article › peer-review

  • Ebolavirus
  • Glycoproteins
  • T-Lymphocytes
  • Infection
  • Cell Death
  29 Scopus citations

• Implementation of objective PASC-derived taxon demarcation criteria for official classification of filoviruses

  Bào, Y., Amarasinghe, G. K., Basler, C. F., Bavari, S., Bukreyev, A., Chandran, K., Dolnik, O., Dye, J. M., Ebihara, H., Formenty, P., Hewson, R., Kobinger, G. P., Leroy, E. M., Mühlberger, E., Netesov, S. V., Patterson, J. L., Paweska, J. T., Smither, S. J., Takada, A., Towner, J. S. & 3 others, Volchkov, V. E., Wahl-Jensen, V. & Kuhn, J. H., May 11 2017, In: Viruses. 9, 5, 106.

  Research output: Contribution to journal › Letter › peer-review

  • Filoviridae
  • Genome
  • Software Design
  • Information Centers
  • Nucleic Acid Databases
  9 Scopus citations

• Innate immune responses of bat and human cells to filoviruses: Commonalities and distinctions

  Kuzmin, I. V., Schwarz, T. M., Ilinykh, P. A., Jordan, I., Ksiazek, T. G., Sachidanandam, R., Basler, C. F. & Bukreyev, A., Apr 1 2017, In: Journal of virology. 91, 8, e02471-16.

  Research output: Contribution to journal › Article › peer-review

  • Filoviridae
  • Chiroptera
  • interferons
  • innate immunity
  • Innate Immunity
  25 Scopus citations

• Possibility and challenges of conversion of current virus species names to Linnaean binomials

  Postler, T. S., Clawson, A. N., Amarasinghe, G. K., Basler, C. F., Bavari, S., Benko, M., Blasdell, K. R., Briese, T., Buchmeier, M. J., Bukreyev, A., Calisher, C. H., Chandran, K., Charrel, R., Clegg, C. S., Collins, P. L., De La Torre, J. C., DeRisi, J. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R. & 52 others, Dye, J. M., Easton, A. J., Emonet, S., Formenty, P., Fouchier, R. A. M., Ghedin, E., Gonzalez, J. P., Harrach, B., Hewson, R., Horie, M., Jiāng, D., Kobinger, G., Kondo, H., Kropinski, A. M., Krupovic, M., Kurath, G., Lamb, R. A., Leroy, E. M., Lukashevich, I. S., Maisner, A., Mushegian, A. R., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Peters, C. J., Radoshitzky, S. R., Rima, B. K., Romanowski, V., Rubbenstroth, D., Sabanadzovic, S., Sanfaçon, H., Salvato, M. S., Schwemmle, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, L. F., Varsani, A., Whitfield, A. E., Murilo Zerbini, F. & Kuhn, J. H., May 1 2017, In: Systematic Biology. 66, 3, p. 463-473 11 p.

  Research output: Contribution to journal › Article › peer-review

  • virus
  • Names
  • Mononegavirales
  • Arenaviridae
  • Viruses
  11 Scopus citations

• Taxonomy of the order Mononegavirales: update 2017

  Amarasinghe, G. K., Bào, Y., Basler, C. F., Bavari, S., Beer, M., Bejerman, N., Blasdell, K. R., Bochnowski, A., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Collins, P. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Fang, Q. & 53 others, Formenty, P., Fouchier, R. A. M., Ghedin, E., Harding, R. M., Hewson, R., Higgins, C. M., Hong, J., Horie, M., James, A. P., Jiāng, D., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Li, M., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Pearson, M. N., Randall, R. E., Revill, P. A., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Smither, S. J., Song, Q., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, B., Wang, D., Wang, F., Wang, L. F., Werren, J. H., Whitfield, A. E., Yan, Z., Ye, G. & Kuhn, J. H., Aug 1 2017, In: Archives of virology. 162, 8, p. 2493-2504 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mononegavirales
  • Names
  • Pneumovirus
  • Rhabdoviridae
  • Viruses
  135 Scopus citations

• Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing ebola virus immune evasion

  Luthra, P., Aguirre, S., Yen, B. C., Pietzsch, C. A., Sanchez-Aparicio, M. T., Tigabu, B., Morlock, L. K., García-Sastre, A., Leung, D. W., Williams, N. S., Fernandez-Sesma, A., Bukreyev, A. & Basler, C. F., Mar 1 2017, In: mBio. 8, 2, e00368-17.

  Research output: Contribution to journal › Article › peer-review

  • Topoisomerase II Inhibitors
  • Ebolavirus
  • Immune Evasion
  • Interferons
  • DNA Damage
  36 Scopus citations
• 2016

  Chimeric filoviruses for identification and characterization of monoclonal antibodies

  Ilinykh, P. A., Shen, X., Flyak, A. I., Kuzmina, N., Ksiazek, T. G., Crowe, J. E. & Bukreyev, A., Apr 1 2016, In: Journal of virology. 90, 8, p. 3890-3901 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Filoviridae
  • monoclonal antibodies
  • Monoclonal Antibodies
  • Ebolavirus
  • Glycoproteins
  22 Scopus citations

• Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

  Flyak, A. I., Shen, X., Murin, C. D., Turner, H. L., David, J. A., Fusco, M. L., Lampley, R., Kose, N., Ilinykh, P. A., Kuzmina, N., Branchizio, A., King, H., Brown, L., Bryan, C., Davidson, E., Doranz, B. J., Slaughter, J. C., Sapparapu, G., Klages, C., Ksiazek, T. G. & 4 others, Saphire, E. O., Ward, A. B., Bukreyev, A. & Crowe, J. E., Jan 28 2016, In: Cell. 164, 3, p. 392-405 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Ebolavirus
  • Viruses
  • Neutralizing Antibodies
  • Antibody Formation
  • Infection
  102 Scopus citations

• High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication

  Edwards, M. R., Pietzsch, C., Vausselin, T., Shaw, M. L., Bukreyev, A. & Basler, C. F., Jan 8 2016, In: ACS Infectious Diseases. 1, 8, p. 380-387 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ebolavirus
  • Virus Replication
  • High-Throughput Screening Assays
  • Filoviridae
  • Inosine Monophosphate
  37 Scopus citations

• Proteoform-specific insights into cellular proteome regulation

  Norris, E. L., Headlam, M. J., Dave, K. A., Smith, D. D., Bukreyev, A., Singh, T., Jayakody, B. A., Chappell, K. J., Collins, P. L. & Gorman, J. J., Oct 2016, In: Molecular and Cellular Proteomics. 15, 10, p. 3297-3320 24 p.

  Research output: Contribution to journal › Article › peer-review

  • Human respiratory syncytial virus
  • Viruses
  • Proteome
  • Proteolysis
  • Host Microbial Interactions
  2 Scopus citations

• Taxonomy of the order Mononegavirales: update 2016

  Afonso, C. L., Amarasinghe, G. K., Bányai, K., Bào, Y., Basler, C. F., Bavari, S., Bejerman, N., Blasdell, K. R., Briand, F. X., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Chéng, J., Clawson, A. N., Collins, P. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Dürrwald, R. & 63 others, Dye, J. M., Easton, A. J., Ebihara, H., Farkas, S. L., Freitas-Astúa, J., Formenty, P., Fouchier, R. A. M., Fù, Y., Ghedin, E., Goodin, M. M., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lenardon, S., Leroy, E. M., Li, C. X., Lin, X. D., Liú, L., Longdon, B., Marton, S., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Randall, R. E., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Shi, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tian, J. H., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Verbeek, M., Volchkov, V. E., Wahl-Jensen, V., Walsh, J. A., Walker, P. J., Wang, D., Wang, L. F., Wetzel, T., Whitfield, A. E., Xiè, J., Yuen, K. Y., Zhang, Y. Z. & Kuhn, J. H., Aug 1 2016, In: Archives of virology. 161, 8, p. 2351-2360 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mononegavirales
  • Pneumovirinae
  • Aprepitant
  • Viruses
  268 Scopus citations

• The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses

  Lubaki, N. M., Younan, P., Santos, R. I., Meyer, M., Iampietro, M., Koup, R. A. & Bukreyev, A., Dec 8 2016, In: PLoS pathogens. 12, 12, e1006031.

  Research output: Contribution to journal › Article › peer-review

  • Ebolavirus
  • Interferons
  • Ebola Hemorrhagic Fever
  • Cytomegalovirus
  • Dendritic Cells
  21 Scopus citations

• Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

  Rialdi, A., Campisi, L., Zhao, N., Lagda, A. C., Pietzsch, C., Ho, J. S. Y., Martinez-Gil, L., Fenouil, R., Chen, X., Edwards, M., Metreveli, G., Jordan, S., Peralta, Z., Munoz-Fontela, C., Bouvier, N., Merad, M., Jin, J., Weirauch, M., Heinz, S., Benner, C. & 5 others, Van Bakel, H., Basler, C., García-Sastre, A., Bukreyev, A. & Marazzi, I., May 27 2016, In: Science. 352, 6289, 7993.

  Research output: Contribution to journal › Article › peer-review

  • Microbial Genes
  • Ebolavirus
  • Gene Expression
  • Inflammation
  • RNA Polymerase II
  65 Scopus citations
• 2015

  Adapting high-throughput screening methods and assays for biocontainment laboratories

  Rasmussen, L., Tigabu, B., White, E. L., Bostwick, R., Tower, N., Bukreyev, A., Rockx, B., Leduc, J. W. & Noah, J. W., Feb 1 2015, In: Assay and Drug Development Technologies. 13, 1, p. 44-54 11 p.

  Research output: Contribution to journal › Article › peer-review

  • High-Throughput Screening Assays
  • Containment of Biohazards
  • Drug Discovery
  • Nipah Virus
  • Ebolavirus
  5 Scopus citations

• Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

  Meyer, M., Garron, T., Lubaki, N. M., Mire, C. E., Fenton, K. A., Klages, C., Olinger, G. G., Geisbert, T. W., Collins, P. L. & Bukreyev, A., Aug 3 2015, In: Journal of Clinical Investigation. 125, 8, p. 3241-3255 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Ebola Vaccines
  • Ebolavirus
  • Primates
  • Vaccines
  • Aerosols
  45 Scopus citations

• Different temporal effects of Ebola virus VP35 and VP24 proteins on global gene expression in human dendritic cells

  Ilinykh, P. A., Lubaki, N. M., Widen, S. G., Renn, L. A., Theisen, T. C., Rabin, R. L., Wood, T. G. & Bukreyev, A., 2015, In: Journal of virology. 89, 15, p. 7567-7583 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Ebola virus VP24 protein
  • filovirus VP35 protein
  • Ebolavirus
  • dendritic cells
  • Dendritic Cells
  32 Scopus citations

• Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus

  Flyak, A. I., Ilinykh, P. A., Murin, C. D., Garron, T., Shen, X., Fusco, M. L., Hashiguchi, T., Bornholdt, Z. A., Slaughter, J. C., Sapparapu, G., Klages, C., Ksiazek, T. G., Ward, A. B., Saphire, E. O., Bukreyev, A. & Crowe, J. E., Feb 26 2015, In: Cell. 160, 5, p. 893-903 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Marburgvirus
  • Viruses
  • Glycoproteins
  • Neutralizing Antibodies
  • Antibodies
  89 Scopus citations

• Partial attenuation of respiratory syncytial virus with a deletion of a small hydrophobic gene is associated with elevated interleukin-1β responses

  Russell, R. F., McDonald, J. U., Ivanova, M., Zhong, Z., Bukreyev, A. & Tregoning, J. S., 2015, In: Journal of virology. 89, 17, p. 8974-8981 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • interleukin-1
  • Respiratory Syncytial Viruses
  • Interleukin-1
  • Genes
  34 Scopus citations
• 2013

  Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection

  Tregoning, J. S., Wang, B. L., McDonald, J. U., Yamaguchi, Y., Harker, J. A., Goritzka, M., Johansson, C., Bukreyev, A., Collins, P. L. & Openshaw, P. J., Apr 2 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5576-5581 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Natural Killer Cells
  • Interferons
  • Antibody Formation
  25 Scopus citations

• The Lack of Maturation of Ebola Virus-Infected Dendritic Cells Results from the Cooperative Effect of at Least Two Viral Domains

  Lubaki, N. M., Ilinykh, P., Pietzsch, C., Tigabu, B., Freiberg, A. N., Koup, R. A. & Bukreyev, A., 2013, In: Journal of virology. 87, 22, p. 12506 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  6 Scopus citations

• Virus nomenclature below the species level: A standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae

  Kuhn, J. H., Bao, Y., Bavari, S., Becker, S., Bradfute, S., Brister, J. R., Bukreyev, A. A., Caì, Y., Chandran, K., Davey, R. A., Dolnik, O., Dye, J. M., Enterlein, S., Gonzalez, J. P., Formenty, P., Freiberg, A. N., Hensley, L. E., Honko, A. N., Ignatyev, G. M., Jahrling, P. B. & 30 others, Johnson, K. M., Klenk, H. D., Kobinger, G., Lackemeyer, M. G., Leroy, E. M., Lever, M. S., Lofts, L. L., Mühlberger, E., Netesov, S. V., Olinger, G. G., Palacios, G., Patterson, J. L., Paweska, J. T., Pitt, L., Radoshitzky, S. R., Ryabchikova, E. I., Saphire, E. O., Shestopalov, A. M., Smither, S. J., Sullivan, N. J., Swanepoel, R., Takada, A., Towner, J. S., van der Groen, G., Volchkov, V. E., Wahl-Jensen, V., Warren, T. K., Warfield, K. L., Weidmann, M. & Nichol, S. T., Jun 2013, In: Archives of virology. 158, 6, p. 1425-1432 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Filoviridae
  • Laboratory Animals
  • Terminology
  • Viruses
  • Ebolavirus
  40 Scopus citations

• Virus nomenclature below the species level: A standardized nomenclature for natural variants of viruses assigned to the family Filoviridae

  Kuhn, J. H., Bao, Y., Bavari, S., Becker, S., Bradfute, S., Brister, J. R., Bukreyev, A. A., Chandran, K., Davey, R. A., Dolnik, O., Dye, J. M., Enterlein, S., Hensley, L. E., Honko, A. N., Jahrling, P. B., Johnson, K. M., Kobinger, G., Leroy, E. M., Lever, M. S., Mühlberger, E. & 17 others, Netesov, S. V., Olinger, G. G., Palacios, G., Patterson, J. L., Paweska, J. T., Pitt, L., Radoshitzky, S. R., Saphire, E. O., Smither, S. J., Swanepoel, R., Towner, J. S., van der Groen, G., Volchkov, V. E., Wahl-Jensen, V., Warren, T. K., Weidmann, M. & Nichol, S. T., Jan 2013, In: Archives of virology. 158, 1, p. 301-311 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Filoviridae
  • Terminology
  • Names
  • Viruses
  • Ebolavirus
  73 Scopus citations
• 2012

  The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways

  Hastie, M. L., Headlam, M. J., Patel, N. B., Bukreyev, A. A., Buchholz, U. J., Dave, K. A., Norris, E. L., Wright, C. L., Spann, K. M., Collins, P. L. & Gorman, J. J., May 2012, In: Molecular and Cellular Proteomics. 11, 5, p. 108-127 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Human respiratory syncytial virus
  • Interferon Type I
  • Viruses
  • Interferon-gamma
  • Vero Cells
  39 Scopus citations

• The secreted g protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement

  Bukreyev, A., Yang, L. & Collins, P. L., Oct 2012, In: Journal of virology. 86, 19, p. 10880-10884 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Human orthopneumovirus
  • Human respiratory syncytial virus
  • Respiratory syncytial virus
  • macrophages
  • complement
  29 Scopus citations