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• 2013

  Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

  Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 2013, In: Journal of virology. 87, 9, p. 5291-5295 5 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Dengue virus
  • RNA-directed RNA polymerase
  • Dengue Virus
  • Serogroup
  70 Scopus citations

• Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

  Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In: Journal of virology. 87, 10, p. 5755-5768 14 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • RNA-directed RNA polymerase
  • Enterovirus
  • crystal structure
  • Picornaviridae
  45 Scopus citations

• Detection and quantification of flavivirus NS5 methyl-transferase activities

  Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Flavivirus
  • Thin Layer Chromatography
  • Transferases
  • mRNA guanylyltransferase
  • Fluorescence Polarization
  5 Scopus citations

• Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

  Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 2013, In: Antiviral research. 97, 2, p. 198-205 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Antiviral Agents
  • Viruses
  • Vero Cells
  • Complementary DNA
  33 Scopus citations

• Difficulties and advancements in developing drugs for the treatment of dengue fever

  Noble, C. G. & Shi, P. Y., 2013, In: Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

  Research output: Contribution to journal › Review article › peer-review

  • Dengue
  • Dengue Virus
  • Antiviral Agents
  • Pharmaceutical Preparations
  • Culicidae
  1 Scopus citations

• Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

  Yeung, K. S., Qiu, Z., Xue, Q., Fang, H., Yang, Z., Zadjura, L., D'Arienzo, C. J., Eggers, B. J., Riccardi, K., Shi, P. Y., Gong, Y. F., Browning, M. R., Gao, Q., Hansel, S., Santone, K., Lin, P. F., Meanwell, N. A. & Kadow, J. F., Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 198-202 5 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • HIV-1
  • Antiviral Agents
  • Pharmacokinetics
  • Amides
  37 Scopus citations

• Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

  Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, Kadow, J. F., Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • Rats
  • Assays
  • Substitution reactions
  • HIV-1
  29 Scopus citations

• Membrane topology and function of dengue virus NS2A protein

  Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In: Journal of virology. 87, 8, p. 4609-4622 14 p.

  Research output: Contribution to journal › Article › peer-review

  • virus protein 2A
  • Dengue virus
  • Dengue Virus
  • topology
  • Flavivirus
  118 Scopus citations

• NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

  Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In: Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear magnetic resonance
  • Dengue
  • Peptide Hydrolases
  • Dengue Virus
  • Viruses
  69 Scopus citations

• Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

  Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In: Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Virus Diseases
  • Brain
  • Antiviral Agents
  • Renilla Luciferases
  9 Scopus citations

• Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

  Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In: Journal of virology. 87, 10, p. 5812-5819 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Viral RNA
  • methylation
  • Methylation
  • vaccines
  67 Scopus citations

• Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

  Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In: PLoS pathogens. 9, 8, e1003521.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Vaccines
  • Attenuated Vaccines
  • Methyltransferases
  • Macaca
  • Viruses
  79 Scopus citations

• Report of the fifth symposium on emerging viral diseases

  Zhang, B. & Shi, P. Y., Apr 2013, In: Virologica Sinica. 28, 2, p. 63-64 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Ten years of dengue drug discovery: Progress and prospects

  Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., 2013, In: Antiviral research. 100, 2, p. 500-519 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • Dengue Virus
  • Dengue
  • Drug Discovery
  • balapiravir
  • celgosivir
  241 Scopus citations

• Testing Antiviral Compounds in a Dengue Mouse Model

  Schul, W., Yip, A. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 269-281 13 p. (Methods in Molecular Biology; vol. 1030).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Dengue Virus
  • Dengue
  • Antiviral Agents
  • Virus Diseases
  • Active Immunotherapy
  3 Scopus citations

• West Nile virus drug discovery

  Lim, S. P. & Shi, P. Y., Dec 3 2013, In: Viruses. 5, 12, p. 2977-3006 30 p.

  Research output: Contribution to journal › Review article › peer-review

  • West Nile virus
  • Drug Discovery
  • Antiviral Agents
  • Antibodies
  • Flaviviridae
  27 Scopus citations
• 2012

  2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase

  Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In: PLoS pathogens. 8, 4, e1002642.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Methyltransferases
  • Adenosine
  • Methylation
  • 2'-O-methyladenosine
  85 Scopus citations

• Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

  Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 2012, In: Journal of virology. 86, 24, p. 13662-13671 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Picornaviridae
  • RNA
  • mutation
  • Mutation
  32 Scopus citations

• Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice

  Pesko, K. N., Fitzpatrick, K. A., Ryan, E. M., Shi, P. Y., Zhang, B., Lennon, N. J., Newman, R. M., Henn, M. R. & Ebel, G. D., May 25 2012, In: Virology. 427, 1, p. 10-17 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Culicidae
  • Birds
  • Genome
  • 4-(2-(4-isopropylbenzamido)ethoxy)benzoic acid
  • Population
  24 Scopus citations

• Ligand-bound structures of the dengue virus protease reveal the active conformation

  Noble, C. G., Seh, C. C., Chao, A. T. & Shi, P. Y., Jan 2012, In: Journal of virology. 86, 1, p. 438-446 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • ligands
  • Peptide Hydrolases
  • proteinases
  166 Scopus citations

• Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

  Van Slyke, G. A., Ciota, A. T., Willsey, G. G., Jaeger, J., Shi, P. Y. & Kramer, L. D., May 25 2012, In: Virology. 427, 1, p. 18-24 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Flaviviridae
  • RNA Replicase
  • West Nile virus
  • Flavivirus
  • Point Mutation
  21 Scopus citations

• Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1

  Zou, G., Kukkaro, P., Lok, S. M., Ng, J. K. W., Tan, G. K., Hanson, B. J., Alonso, S., MacAry, P. A. & Shi, P. Y., Sep 1 2012, In: Antiviral research. 95, 3, p. 216-223 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Serogroup
  • Antibodies
  • Viral Envelope Proteins
  • Viruses
  11 Scopus citations

• Structural biology of dengue virus enzymes: Towards rational design of therapeutics

  Noble, C. G. & Shi, P. Y., Nov 1 2012, In: Antiviral research. 96, 2, p. 115-126 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Dengue Virus
  • Methyltransferases
  • Dengue
  • Enzymes
  • Peptide Hydrolases
  78 Scopus citations

• Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

  Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In: Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribonucleosides
  • indole
  • Antiviral Agents
  • stannane
  • Cross Reactions
  37 Scopus citations

• Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

  Simmons, C. P., Wolbers, M., Nguyen, M. N., Whitehorn, J., Shi, P. Y., Young, P., Petric, R., Nguyen, V. V. C., Farrar, J. & Wills, B., Sep 2012, In: PLoS neglected tropical diseases. 6, 9, e1752.

  Research output: Contribution to journal › Article › peer-review
  25 Scopus citations

• The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation

  Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G. & Lok, S. M., Nov 23 2012, In: Journal of Biological Chemistry. 287, 48, p. 40525-40534 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Viruses
  • Dengue
  • Membrane Proteins
  • Exosomes
  • Dengue Virus
  32 Scopus citations

• The structural basis for serotype-specific neutralization of dengue virus by a human antibody

  Teoh, E. P., Kukkaro, P., Teo, E. W., Lim, A. P. C., Tan, T. T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V. A., Leo, Y. S., Chan, S. H., Smith, K. G. C., Chan, A. H. Y., Zou, G., Ooi, E. E., Kemeny, D. M., Tan, G. K., Ng, J. K. W., Ng, M. L., Alonso, S. & 5 others, Fisher, D., Shi, P. Y., Hanson, B. J., Lok, S. M. & MacAry, P. A., Jun 20 2012, In: Science Translational Medicine. 4, 139, 139ra83.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Serogroup
  • Antibodies
  • Immunity
  • Cryoelectron Microscopy
  165 Scopus citations

• U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication

  Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 2012, In: Antiviral research. 93, 1, p. 191-198 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
  • Anticholesteremic Agents
  • Virus Internalization
  • Dengue Virus
  • Virus Replication
  72 Scopus citations