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• 2016

  The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

  Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In: EBioMedicine. 6, p. 42-49 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oligomers
  • Toxicity
  • Amyloid
  • Immunotherapy
  • Conformations
  252 Scopus citations
• 2015

  A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

  Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In: eLife. 4, MAY, p. 1-46 46 p., e07558.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-1
  • Oligomers
  • Spinocerebellar Ataxias
  • Scaffolds
  • Drive
  16 Scopus citations

• Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease

  Bodani, R. U., Sengupta, U., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Gerson, J. E., Rudra, J. & Kayed, R., Dec 16 2015, In: ACS Chemical Neuroscience. 6, 12, p. 1981-1989 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Amyloid
  • Alzheimer Disease
  • Poisons
  • Peptides
  13 Scopus citations

• Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

  Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In: eLife. 4, DECEMBER2015, e10891.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-1
  • Immunization
  • Oligomers
  • Spinocerebellar Ataxias
  • Passive Immunization
  9 Scopus citations

• Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

  Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In: Biological Psychiatry. 78, 10, p. 672-683 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • alpha-Synuclein
  • Antibodies
  • Brain
  • Lewy Body Disease
  86 Scopus citations

• Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

  Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In: Neurobiology of Disease. 82, p. 540-551 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleic Acids
  • Neurons
  • Induced Hyperthermia
  • Alzheimer Disease
  • Pathology
  34 Scopus citations

• Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

  Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In: Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Immunotherapy
  • Alzheimer Disease
  • Memory Disorders
  • Pathology
  82 Scopus citations

• The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

  Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In: Aging cell. 14, 5, p. 715-724 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Proteasome Endopeptidase Complex
  • Neurodegenerative Diseases
  • Ubiquitin
  • Sumoylation
  • Amyloidogenic Proteins
  38 Scopus citations
• 2013

  Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

  Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In: Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer Disease
  • Tauopathies
  • Brain
  • Tacrolimus Binding Proteins
  • tau Proteins
  128 Scopus citations

• Design of metastable β-sheet oligomers from natively unstructured peptide

  Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In: ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Prion Proteins
  • Amyloid
  • Peptides
  • Antibodies
  9 Scopus citations

• Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

  Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In: Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Toxicity
  • Amyloid
  • Oligomers
  • Conformations
  • Neoplasms
  48 Scopus citations

• Formation and propagation of tau oligomeric seeds

  Gerson, J. E. & Kayed, R., Sep 11 2013, In: Frontiers in Neurology. 4 JUL, Article 93.

  Research output: Contribution to journal › Review article › peer-review

  • Seeds
  • Tauopathies
  • Neurofibrillary Tangles
  • Poisons
  • Exocytosis
  66 Scopus citations

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., 2013, In: Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

  Research output: Contribution to journal › Review article › peer-review

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  210 Scopus citations

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., Feb 15 2013, Alzheimer's Disease: Advances for a New Century. IOS Press, p. 67-78 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  2 Scopus citations

• Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

  Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Tauopathies
  • Rats
  • Traumatic Brain Injury
  • Brain
  90 Scopus citations

• Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

  Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In: Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocytosis
  • Neurons
  • Tauopathies
  • Conformations
  • Molecular weight
  273 Scopus citations

• Tau aggregates as immunotherapeutic targets

  Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Toxicity
  • Tauopathies
  • Neurodegenerative diseases
  30 Scopus citations
• 2012

  Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In: Scientific reports. 2, 700.

  Research output: Contribution to journal › Article › peer-review

  • Pathology
  • Brain
  • Alzheimer Disease
  • Amyloid angiopathy
  • Genetically Modified Animals
  256 Scopus citations

• Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

  Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In: Frontiers in Neurology. JAN, Article 5.

  Research output: Contribution to journal › Article › peer-review

  • Amyloidosis
  • Skin
  • Brain
  • Protein Aggregates
  • Amyloid Plaques
  10 Scopus citations

• Differential activation of the ER stress factor XBP1 by oligomeric assemblies

  Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In: Neurochemical Research. 37, 8, p. 1707-1717 11 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Box Binding Protein 1
  • Factor X
  • Oligomers
  • Amyloid
  • Chemical activation
  25 Scopus citations

• Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In: FASEB Journal. 26, 5, p. 1946-1959 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Agglomeration
  • Alzheimer Disease
  • Brain
  236 Scopus citations

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  17 Scopus citations

• Tau protein: Function and pathology

  Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In: International Journal of Alzheimer's Disease. 707482.

  Research output: Contribution to journal › Editorial › peer-review
  6 Scopus citations

• Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

  Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Vaccination
  • Cognition
  • Hemorrhage
  • Vaccines
  29 Scopus citations

• α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

  Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Oligomers
  • Calcineurin
  • Long-Term Potentiation
  • Memory
  63 Scopus citations