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• 2015

  Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

  Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In: Free Radical Biology and Medicine. 89, p. 20-33 14 p.

  Research output: Contribution to journal › Article › peer-review

  • 8-hydroxyguanine
  • DNA Glycosylases
  • Airway Remodeling
  • Gene Expression Profiling
  • DNA Repair
  24 Scopus citations
• 2014

  8-Oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors

  Ba, X., Bacsi, A., Luo, J., Aguilera-Aguirre, L., Zeng, X., Radak, Z., Brasier, A. R. & Boldogh, I., Mar 1 2014, In: Journal of Immunology. 192, 5, p. 2384-2394 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 8-hydroxyguanine
  • DNA Glycosylases
  • Transcription Factors
  • Gene Expression
  • Guanine
  56 Scopus citations

• 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

  Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In: Free Radical Biology and Medicine. 73, p. 430-438 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 8-hydroxyguanine
  • DNA Glycosylases
  • rho GTP-Binding Proteins
  • Polymerization
  • Muscle
  37 Scopus citations

• ATM regulates NF-κB-dependent immediate-early genes via RelA ser 276 phosphorylation coupled to CDK9 promoter recruitment

  Fang, L., Choudhary, S., Zhao, Y., Edeh, C. B., Yang, C., Boldogh, I. & Brasier, A. R., Jul 29 2014, In: Nucleic acids research. 42, 13, p. 8416-8432 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Ataxia Telangiectasia
  • Immediate-Early Genes
  • Phosphorylation
  • Cyclin-Dependent Kinase 9
  • Double-Stranded DNA Breaks
  34 Scopus citations

• Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

  Torma, F., Bori, Z., Koltai, E., Felszeghy, K., Vacz, G., Koch, L., Britton, S., Boldogh, I. & Radak, Z., Aug 2014, In: Brain Research Bulletin. 107, p. 54-60 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain-Derived Neurotrophic Factor
  • Feeding Behavior
  • Short-Term Memory
  • Hippocampus
  • Organelle Biogenesis
  2 Scopus citations

• Effects of diabetes on oxidative and nitrosative stress in kidney mitochondria from aged rats

  Pérez-Gallardo, R. V., Noriega-Cisneros, R., Esquivel-Gutiérrez, E., Calderón-Cortés, E., Cortés-Rojo, C., Manzo-Avalos, S., Campos-García, J., Salgado-Garciglia, R., Montoya-Pérez, R., Boldogh, I. & Saavedra-Molina, A., Dec 9 2014, In: Journal of Bioenergetics and Biomembranes. 46, 6, p. 511-518 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Nitrosative Stress
  • Mitochondria
  • Oxidative Stress
  • Experimental Diabetes Mellitus
  • Aconitate Hydratase
  23 Scopus citations

• Exercise increases markers of spermatogenesis in rats selectively bred for low running capacity

  Torma, F., Koltai, E., Nagy, E., Ziaaldini, M. M., Posa, A., Koch, L. G., Britton, S. L., Boldogh, I. & Radak, Z., Dec 10 2014, In: PloS one. 9, 12, e11407.

  Research output: Contribution to journal › Article › peer-review

  • Rats
  • Spermatogenesis
  • Running
  • spermatogenesis
  • exercise
  13 Scopus citations

• Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model

  Csillag, A., Kumar, B. V., Szabó, K., Szilasi, M., Papp, Z., Szilasi, M. E., Pázmándi, K., Boldogh, I., Rajnavölgyi, É., Bácsi, A. & László, J. F., Jun 6 2014, In: Journal of the Royal Society Interface. 11, 95, 20140097.

  Research output: Contribution to journal › Article › peer-review

  • Magnetic Fields
  • Magnetic fields
  • ragweed pollen
  • Inflammation
  • Reactive Oxygen Species
  12 Scopus citations

• Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes

  Menon, R., Polettini, J., Syed, T. A., Saade, G. R. & Boldogh, I., Jan 1 2014, In: American Journal of Reproductive Immunology. 72, 1, p. 75-84 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 8-hydroxyguanine
  • Extraembryonic Membranes
  • Smoke
  • Tobacco Products
  • Preterm Premature Rupture of the Membranes
  27 Scopus citations

• Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro

  Menon, R., Boldogh, I., Hawkins, H. K., Woodson, M., Polettini, J., Syed, T. A., Fortunato, S. J., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Jun 2014, In: American Journal of Pathology. 184, 6, p. 1740-1751 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Premature Rupture Fetal Membranes
  • Oxidative Stress
  • Membranes
  • Premature Birth
  • In Vitro Techniques
  112 Scopus citations

• Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

  Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In: Journal of Immunology. 193, 9, p. 4643-4653 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 8-hydroxyguanine
  • DNA Glycosylases
  • Inflammation
  • DNA
  • 7,8-dihydro-8-oxoguanine
  60 Scopus citations

• NEIL2 Protects against Oxidative DNA damage induced by sidestream smoke in human cells

  Sarker, A. H., Chatterjee, A., Williams, M., Lin, S., Havel, C., Jacob, P., Boldogh, I., Hazra, T. K., Talbot, P. & Hang, B., Mar 3 2014, In: PloS one. 9, 3, e90261.

  Research output: Contribution to journal › Article › peer-review

  • smoke
  • DNA damage
  • Cells
  • Smoke
  • DNA Damage
  21 Scopus citations

• New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

  Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I., Rao, K. S., Mitra, S. & Hegde, M. L., Sep 1 2014, In: Biomolecules. 4, 3, p. 678-703 26 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genes
  • Metals
  • Repair
  • Reactive Oxygen Species
  • Inhibition (Psychology)
  21 Scopus citations

• Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

  Pazmandi, K., Agod, Z., Kumar, B. V., Szabo, A., Fekete, T., Sogor, V., Veres, A., Boldogh, I., Rajnavolgyi, E., Lanyi, A. & Bacsi, A., 2014, In: Free Radical Biology and Medicine. 77, p. 281-290 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendritic Cells
  • Mitochondrial DNA
  • Oxidative stress
  • Molecules
  • 8-hydroxyguanine
  28 Scopus citations

• Systems biology approaches to understanding epithelial mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma

  Ijaz, T., Pazdrak, K., Kalita, M., Konig, R., Choudhary, S., Tian, B., Boldogh, I. & Brasier, A. R., Jun 2 2014, In: World Allergy Organization Journal. 7, 1, 13.

  Research output: Contribution to journal › Review article › peer-review

  • Systems Biology
  • Epithelial-Mesenchymal Transition
  • Asthma
  • Extracellular Matrix
  • Myofibroblasts
  55 Scopus citations

• The redox-associated adaptive response of brain to physical exercise

  Radak, Z., Ihasz, F., Koltai, E., Goto, S., Taylor, A. W. & Boldogh, I., Jan 2014, In: Free Radical Research. 48, 1, p. 84-92 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oxidation-Reduction
  • Brain
  • Exercise
  • Reactive Oxygen Species
  • Metabolism
  31 Scopus citations

• The role of 8-oxoguanine DNA glycosylase-1 in inflammation

  Ba, X., Aguilera-Aguirre, L., Rashid, Q. T. A. N., Bacsi, A., Radak, Z., Sur, S., Hosoki, K., Hegde, M. L. & Boldogh, I., Sep 23 2014, In: International journal of molecular sciences. 15, 9, p. 16975-16997 23 p.

  Research output: Contribution to journal › Review article › peer-review

  • 8-hydroxyguanine
  • DNA Glycosylases
  • DNA
  • deoxyribonucleic acid
  • Inflammation
  54 Scopus citations
• 2013

  8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1

  Hajas, G., Bacsi, A., Aguilera-Aguirre, L., Hegde, M. L., Tapas, K. H., Sur, S., Radak, Z., Ba, X. & Boldogh, I., 2013, In: Free Radical Biology and Medicine. 61, p. 384-394 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell signaling
  • 8-hydroxyguanine
  • DNA Glycosylases
  • Monomeric GTP-Binding Proteins
  • DNA Repair
  59 Scopus citations

• Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

  German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T. K., Hegde, M. L., Ba, X. & Boldogh, I., Oct 2013, In: DNA Repair. 12, 10, p. 856-863 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell signaling
  • 8-hydroxyguanine
  • DNA Glycosylases
  • DNA Repair
  • Chemical activation
  46 Scopus citations

• Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair

  Sarga, L., Hart, N., Koch, L. G., Britton, S. L., Hajas, G., Boldogh, I., Ba, X. & Radak, Z., Nov 12 2013, In: Neuroscience. 252, p. 326-336 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 8-hydroxyguanine
  • DNA Glycosylases
  • Spatial Memory
  • Running
  • Post Translational Protein Processing
  18 Scopus citations

• Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

  Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In: PloS one. 8, 2, e57442.

  Research output: Contribution to journal › Article › peer-review

  • Aldehyde Reductase
  • phosphatidylinositol 3-kinase
  • Airway Remodeling
  • Phosphatidylinositol 3-Kinases
  • mice
  27 Scopus citations

• Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

  Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In: DNA Repair. 12, 1, p. 18-26 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 8-hydroxyguanine
  • DNA Glycosylases
  • Pneumonia
  • Epithelium
  • Down-Regulation
  50 Scopus citations

• Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes

  Noriega-Cisneros, R., Cortés-Rojo, C., Manzo-Avalos, S., Clemente-Guerrero, M., Calderón-Cortés, E., Salgado-Garciglia, R., Montoya-Pérez, R., Boldogh, I. & Saavedra-Molina, A., Nov 2013, In: Mitochondrion. 13, 6, p. 835-840 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Nitrosative Stress
  • Lipid Peroxidation
  • Oxidative Stress
  • Diabetes Mellitus
  • Aconitate Hydratase
  17 Scopus citations

• Novel recombinant human lactoferrin: Differential activation of oxidative stress related gene expression

  Kruzel, M. L., Actor, J. K., Zimecki, M., Wise, J., Płoszaj, P., Mirza, S., Kruzel, M., Hwang, S. A., Ba, X. & Boldogh, I., Dec 2013, In: Journal of Biotechnology. 168, 4, p. 666-675 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Lactoferrin
  • Gene expression
  • Human Milk
  • Cells
  28 Scopus citations

• Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

  Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3090-E3099

  Research output: Contribution to journal › Article › peer-review

  • DNA Glycosylases
  • Human Genome
  • DNA Replication
  • S Phase
  • 5-hydroxyuracil
  58 Scopus citations

• Redox-regulating sirtuins in aging, caloric restriction, and exercise

  Radak, Z., Koltai, E., Taylor, A. W., Higuchi, M., Kumagai, S., Ohno, H., Goto, S. & Boldogh, I., May 2013, In: Free Radical Biology and Medicine. 58, p. 87-97 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Caloric Restriction
  • Sirtuins
  • Oxidation-Reduction
  • Aging of materials
  • NAD
  68 Scopus citations

• Senescence of primary amniotic cells via oxidative DNA damage

  Menon, R., Boldogh, I., Urrabaz-Garza, R., Polettini, J., Syed, T. A., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Dec 27 2013, In: PloS one. 8, 12, e83416.

  Research output: Contribution to journal › Article › peer-review

  • cigarettes
  • DNA damage
  • smoke
  • amnion
  • DNA Damage
  59 Scopus citations

• Systems approaches to modeling chronic mucosal inflammation

  Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., 2013, In: BioMed Research International. 2013, 505864.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells
  • Epithelial-Mesenchymal Transition
  • Mucous Membrane
  • Pulmonary diseases
  • Amantadine
  29 Scopus citations