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  • Lynn Soong
2011

Differential, type i interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver

Desai, M. M., Gong, B., Chan, T., Davey, R. A., Soong, L., Kolokoltsov, A. A. & Sun, J., Aug 2011, In : Gastroenterology. 141, 2, p. 674-685.e6

Research output: Contribution to journalArticle

27 Scopus citations

Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes

Wang, Y., Chen, Y., Xin, L., Beverley, S. M., Carlsen, E. D., Popov, V., Chang, K. P., Wang, M. & Soong, L., Mar 2011, In : Infection and immunity. 79, 3, p. 1124-1133 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

IFNα/β and autophagy: Tug-of-war between HCV and the host

Sun, J., Desai, M. M., Soong, L. & Ou, J. H. J., Nov 2011, In : Autophagy. 7, 11, p. 1394-1396 3 p.

Research output: Contribution to journalShort survey

13 Scopus citations

Multistrain influenza protection induced by a nanoparticulate mucosal immunotherapeutic

Tai, W., Roberts, L., Seryshev, A., Gubatan, J. M., Bland, C. S., Zabriskie, R., Kulkarni, S., Soong, L., Mbawuike, I., Gilbert, B., Kheradmand, F. & Corry, D. B., Mar 1 2011, In : Mucosal Immunology. 4, 2, p. 197-207 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice

Yan, J., Jie, Z., Hou, L., Wanderley, J. L., Soong, L., Gupta, S., Qiu, S., Chan, T. & Sun, J., May 2011, In : Hepatology. 53, 5, p. 1455-1467 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host

Xu, W., Xin, L., Soong, L. & Zhang, K., Aug 2011, In : Infection and immunity. 79, 8, p. 3377-3387 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

The magnitude of CD4+ T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice

Xin, L., Wanderley, J. L., Wang, Y., Vargas-Inchaustegui, D. A. & Soong, L., Mar 2011, In : Parasite Immunology. 33, 3, p. 170-180 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Exposure of phosphatidylserine on leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity

França-Costa, J., Wanderley, J. L. M., Deolindo, P., Zarattini, J. B., Costa, J., Soong, L., Barcinski, M. A., Barral, A. & Borges, V. M., May 4 2012, In : PloS one. 7, 5, e36595.

Research output: Contribution to journalArticle

26 Scopus citations

Functional interferon system is required for clearance of Lassa virus

Yun, N. E., Poussard, A. L., Seregin, A. V., Walker, A. G., Smith, J. K., Aronson, J. F., Smith, J. N., Soong, L. & Paessler, S., Mar 2012, In : Journal of virology. 86, 6, p. 3389-3392 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis

Soong, L., Henard, C. A. & Melby, P. C., Nov 2012, In : Seminars in Immunopathology. 34, 6, p. 735-751 17 p.

Research output: Contribution to journalReview article

67 Scopus citations

Subversion and utilization of host innate defense by Leishmania amazonensis

Soong, L., 2012, In : Frontiers in immunology. 3, MAR, Article 58.

Research output: Contribution to journalReview article

36 Scopus citations

Systemic treatment with cpg-b after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (ido)

Xin, L., Shelite, T. R., Gong, B., Mendell, N. L., Soong, L., Fang, R. & Walker, D. H., Mar 28 2012, In : PloS one. 7, 3, e34062.

Research output: Contribution to journalArticle

16 Scopus citations
2013

A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco

Hamdi, S., Ejghal, R., Idrissi, M., Ezzikouri, S., Hida, M., Soong, L., Amarouch, H. & Lemrani, M., Jan 1 2013, In : Infection, Genetics and Evolution. 13, 1, p. 162-167 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis

Hou, L., Jie, Z., Desai, M., Liang, Y., Soong, L., Wang, T. & Sun, J., Jan 15 2013, In : Journal of Immunology. 190, 2, p. 621-629 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

IL-33 induces nuocytes and modulates liver injury in viral hepatitis

Liang, Y., Jie, Z., Hou, L., Aguilar-Valenzuela, R., Vu, D., Soong, L. & Sun, J., Jun 1 2013, In : Journal of Immunology. 190, 11, p. 5666-5675 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis

Eaves-Pyles, T., Patel, J., Arigi, E., Cong, Y., Cao, A., Garg, N., Dhiman, M., Pyles, R. B., Arulanandam, B., Miller, A. L., Popov, V. L., Soong, L., Carlsen, E. D., Coletta, C., Szabo, C. & Almeida, I. C., 2013, In : Molecular Medicine. 19, 1, p. 263-275 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Interferon gamma in leishmaniasis

Kima, P. E. & Soong, L., 2013, In : Frontiers in immunology. 4, JUN, Article 156.

Research output: Contribution to journalShort survey

43 Scopus citations

Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms

Carlsen, E. D., Hay, C., Henard, C. A., Popov, V., Garg, N. J. & Soong, L., Nov 2013, In : Infection and immunity. 81, 11, p. 3966-3974 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Phosphatidylserine exposure on the surface of Leishmania amazonensis amastigotes modulates in vivo infection and dendritic cell function

Wanderley, J. L. M., Thorpe, P. E., Barcinski, M. A. & Soong, L., Mar 2013, In : Parasite Immunology. 35, 3-4, p. 109-119 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

Almahariq, M., Mei, F. C., Wang, H., Cao, A. T., Yao, S., Soong, L., Sun, J., Cong, Y., Chen, J. & Cheng, X., Jan 15 2015, In : Biochemical Journal. 465, p. 295-303 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

Liang, Y., Jie, Z., Hou, L., Yi, P., Wang, W., Kwota, Z., Salvato, M., de Waal Malefyt, R., Soong, L. & Sun, J., 2015, (Accepted/In press) In : European Journal of Immunology.

Research output: Contribution to journalArticle

19 Scopus citations

Interactions between Neutrophils and Leishmania braziliensis Amastigotes Facilitate Cell Activation and Parasite Clearance

Carlsen, E. D., Jie, Z., Liang, Y., Henard, C. A., Hay, C., Sun, J., De Matos Guedes, H. & Soong, L., Jul 22 2015, In : Journal of Innate Immunity. 7, 4, p. 354-363 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Permissive and protective roles for neutrophils in leishmaniasis

Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In : Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Type 1 interferon-induced IL-7 maintains CD8 + T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis

Hou, L., Jie, Z., Liang, Y., Desai, M., Soong, L. & Sun, J., Mar 1 2015, In : Cellular and Molecular Immunology. 12, 2, p. 213-221 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

Soong, L., Mendell, N. L., Olano, J. P., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T. R., Valbuena, G., Walker, D. H. & Bouyer, D. H., Aug 1 2016, In : PLoS neglected tropical diseases. 10, 8, e0004884.

Research output: Contribution to journalArticle

14 Scopus citations

IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice

Shelite, T. R., Liang, Y., Wang, H., Mendell, N. L., Trent, B. J., Sun, J., Gong, B., Xu, G., Hu, H., Bouyer, D. H. & Soong, L., Mar 4 2016, In : PLoS neglected tropical diseases. 10, 3, e0004467.

Research output: Contribution to journalArticle

18 Scopus citations

MTOR mediates IL-23 induction of neutrophil IL-17 and IL-22 production

Chen, F., Cao, A., Yao, S., Evans-Marin, H. L., Liu, H., Wu, W., Carlsen, E. D., Dann, S. M., Soong, L., Sun, J., Zhao, Q. & Cong, Y., May 15 2016, In : Journal of Immunology. 196, 10, p. 4390-4399 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

Liu, F., Fan, X., Auclair, S., Ferguson, M., Sun, J., Soong, L., Hou, W., Redfield, R. R., Birx, D. L., Ratto-Kim, S., Robb, M. L., Kim, J. H., Michael, N. L. & Hu, H., Jun 2016, In : PLoS pathogens. 12, 6, e1005663.

Research output: Contribution to journalArticle

13 Scopus citations

The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury

Gaziova, I., Jackson, D., Boor, P. J., Carter, D., Cruz-Monserrate, Z., Elferink, C. J., Joshi, A. D., Kaphalia, B., Logsdon, C. D., De Castro, K. P., Soong, L., Tao, X., Qiu, S. & Elferink, L. A., Oct 2016, In : PloS one. 11, 10, 0165485.

Research output: Contribution to journalArticle

1 Scopus citations
2017

CD8+T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

Xu, G., Mendell, N. L., Liang, Y., Shelite, T. R., Goez-Rivillas, Y., Soong, L., Bouyer, D. H. & Walker, D. H., Jul 19 2017, In : PLoS neglected tropical diseases. 11, 7, e0005763.

Research output: Contribution to journalArticle

13 Scopus citations

Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action

Chen, J., Liang, Y., Yi, P., Xu, L., Hawkins, H. K., Rossi, S. L., Soong, L., Cai, J., Menon, R. & Sun, J., Nov 7 2017, In : Cell Reports. 21, 6, p. 1588-1599 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Priming and activation of inflammasome by canarypox virus vector alvac via the CGAS/IFI16-sting-type I IFN pathway and AIM2 sensor

Liu, F., Niu, Q., Fan, X., Liu, C., Zhang, J., Wei, Z., Hou, W., Kanneganti, T. D., Robb, M. L., Kim, J. H., Michael, N. L., Sun, J., Soong, L. & Hu, H., Nov 1 2017, In : Journal of Immunology. 199, 9, p. 3293-3305 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis

Jie, Z., Liang, Y., Yi, P., Tang, H., Soong, L., Cong, Y., Zhang, K. & Sun, J., May 1 2017, In : Journal of Immunology. 198, 9, p. 3448-3460 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Splenic CD4+ T cells in progressive visceral leishmaniasis show a mixed effector-regulatory phenotype and impair macrophage effector function through inhibitory receptor expression

Medina-Colorado, A. A., Osorio, E. Y., Saldarriaga, O. A., Travi, B. L., Kong, F., Spratt, H., Soong, L. & Melby, P. C., Jan 2017, In : PloS one. 12, 1, e0169496.

Research output: Contribution to journalArticle

13 Scopus citations

The burden of leishmaniasis in Iran, acquired from the global burden of disease during 1990-2010

Badirzadeh, A., Mohebali, M., Asadgol, Z., Soong, L., Zeinali, M., Mokhayeri, Y., Shirzadi, M. R. & Spotin, A., Sep 1 2017, In : Asian Pacific Journal of Tropical Disease. 7, 9, p. 513-518 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice

Soong, L., Shelite, H. T. R., Xing, Y., Kodakandla, H., Liang, Y., Trent, B. J., Horton, P., Smith, K. C., Zhao, Z., Sun, J., Bouyer, D. H. & Cai, J., Jul 24 2017, In : PLoS neglected tropical diseases. 11, 7, e0005765.

Research output: Contribution to journalArticle

4 Scopus citations

Viral retinopathy in experimental models of zika infection

Zhao, Z., Yang, M., Azar, S. R., Soong, L., Weaver, S. C., Sun, J., Chen, Y., Rossi, S. L. & Cai, J., Aug 2017, In : Investigative Ophthalmology and Visual Science. 58, 10, p. 4075-4085 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2018

Developmental Defects Associated with DNA Copy Number Gain of Chromosome 2q33.1: A Case Report and Review of Literature

Gupta, A., Yo, J., Huang, G., Soong, L. & Dong, J., Mar 21 2018, In : Lab Medicine. 49, 2, p. 160-164 5 p.

Research output: Contribution to journalArticle

Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection

Auclair, S., Liu, F., Niu, Q., Hou, W., Churchyard, G., Morgan, C., Frahm, N., Nitayaphan, S., Pitisuthithum, P., Rerks-Ngarm, S., Kimata, J. T., Soong, L., Franchini, G., Robb, M., Kim, J., Michael, N. & Hu, H., Feb 2018, In : PLoS pathogens. 14, 2, e1006888.

Research output: Contribution to journalArticle

12 Scopus citations

Dysregulated Th1 immune and vascular responses in scrub typhus pathogenesis

Soong, L., Feb 15 2018, In : Journal of Immunology. 200, 4, p. 1233-1240 8 p.

Research output: Contribution to journalReview article

5 Scopus citations

Imported leishmaniasis cases in Cuba (2006-2016): What have we learned

Montalvo, A. M., Fraga, J., Blanco, O., González, D., Monzote, L., Soong, L. & Capó, V., Aug 7 2018, In : Tropical Diseases, Travel Medicine and Vaccines. 4, 1, 7.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

CD4+ T cell-dependent macrophage activation modulates sustained ps exposure on intracellular amastigotes of leishmania amazonensis

Wanderley, J. L. M., Deolindo, P., Carlsen, E., Portugal, A. B., DaMatta, R. A., Barcinski, M. A. & Soong, L., 2019, In : Frontiers in Cellular and Infection Microbiology. 9, APR, 105.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
7 Scopus citations

Immunotherapy using anti-PD-1 and anti-PD-L1 in Leishmania amazonensis-infected BALB/c mice reduce parasite load

da Fonseca-Martins, A. M., Ramos, T. D., Pratti, J. E. S., Firmino-Cruz, L., Gomes, D. C. O., Soong, L., Saraiva, E. M. & de Matos Guedes, H. L., Dec 1 2019, In : Scientific reports. 9, 1, 20275.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection

Trent, B., Fisher, J. & Soong, L., Sep 6 2019, In : Frontiers in Microbiology. 10, 2065.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2020

Annexin a2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and ebola virus infections

Su, Z., Chang, Q., Drelich, A., Shelite, T., Judy, B., Liu, Y., Xiao, J., Zhou, C., He, X., Jin, Y., Saito, T., Tang, S., Soong, L., Wakamiya, M., Fang, X., Bukreyev, A., Ksiazek, T., Russell, W. K. & Gong, B., Jul 2020, In : PLoS neglected tropical diseases. 14, 7, p. 1-30 30 p., e0007960.

Research output: Contribution to journalArticle

Open Access

Epigenetic suppression of HIV in myeloid cells by the BRD4-selective small molecule modulator ZL0580

Alamer, E., Zhong, C., Liu, Z., Niu, Q., Long, F., Guo, L., Gelman, B. B., Soong, L., Zhou, J. & Hu, H., Jun 1 2020, In : Journal of virology. 94, 11, e01880-19.

Research output: Contribution to journalArticle

2 Scopus citations

Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway

Lu, Y., Li, C. F., Ping, N. N., Sun, Y. Y., Wang, Z., Zhao, G. X., Yuan, S. H., Zibrila, A. I., Soong, L. & Liu, J. J., May 1 2020, In : Journal of Biochemical and Molecular Toxicology. 34, 5, e22467.

Research output: Contribution to journalArticle

2 Scopus citations

IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice

Liang, Y., Yi, P., Ru, W., Jie, Z., Wang, H., Ghanayem, T., Wang, X., Alamer, E., Liu, J., Hu, H., Soong, L., Cai, J. & Sun, J., Aug 25 2020, In : Journal of neuroinflammation. 17, 1, 249.

Research output: Contribution to journalArticle

Open Access

Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection

Trent, B., Liang, Y., Xing, Y., Esqueda, M., Wei, Y., Cho, N. H., Kim, H. I., Kim, Y. S., Shelite, T. R., Cai, J., Sun, J., Bouyer, D. H., Liu, J. & Soong, L., Mar 1 2020, In : PLoS neglected tropical diseases. 14, 3, p. e0007675

Research output: Contribution to journalArticle

Open Access
1 Scopus citations