Find Research outputs

Search results

• 2011

  Methods for biomarker verification and assay development

  Zhao, Y. & Brasier, A. R., Jul 2011, In: Current Proteomics. 8, 2, p. 138-152 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Biomarkers
  • Assays
  • Proteomics
  • Mass spectrometry
  • Dilution
  3 Scopus citations

• Quantification of activated NF-κB/RelA complexes using ssDNA aptamer affinity - Stable isotope dilution - Selected reaction monitoring - Mass spectrometry

  Zhao, Y., Widen, S. G., Jamaluddin, M., Tian, B., Wood, T. G., Edeh, C. B. & Brasier, A. R., Jun 2011, In: Molecular and Cellular Proteomics. 10, 6

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Dilution
  • Isotopes
  • Assays
  • Mass Spectrometry
  37 Scopus citations
• 2012

  Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways

  Denner, L. A., Rodriguez-Rivera, J., Haidacher, S. J., Jahrling, J. B., Carmical, J. R., Hernandez, C. M., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Wood, T. G. & Dineley, K. T., Nov 21 2012, In: Journal of Neuroscience. 32, 47, p. 16725-16735 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Rosiglitazone
  • Peroxisome Proliferator-Activated Receptors
  • Extracellular Signal-Regulated MAP Kinases
  • Mitogen-Activated Protein Kinases
  • Protein Kinases
  84 Scopus citations

• Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner

  Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Poussard, A. L., Walker, A. G., Brasier, A. R., Zhao, Y., Tian, B., de la Torre, J. C. & Paessler, S., May 2012, In: PLoS neglected tropical diseases. 6, 5, e1659.

  Research output: Contribution to journal › Article › peer-review

  • Interferon Type I
  • Virus Diseases
  • Viruses
  • Interferons
  • Arenavirus
  43 Scopus citations
• 2013

  Applications of selected reaction monitoring (SRM)-mass spectrometry (MS) for quantitative measurement of signaling pathways

  Zhao, Y. & Brasier, A. R., Jun 15 2013, In: Methods. 61, 3, p. 313-322 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Mass spectrometry
  • Assays
  • Isotopes
  • Dilution
  • Mass Spectrometry
  40 Scopus citations

• CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

  Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. P. & Brasier, A. R., Jun 2013, In: Journal of virology. 87, 12, p. 7075-7092 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin-Dependent Kinase 9
  • Respiratory syncytial virus
  • Interferon Regulatory Factor-3
  • Respiratory Syncytial Virus Infections
  • cyclin-dependent kinase
  41 Scopus citations

• Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics

  Wu, P., Zhao, Y., Haidacher, S. J., Wang, E., Parsley, M. O., Gao, J., Sadygov, R. G., Starkey, J. M., Luxon, B. A., Spratt, H., Dewitt, D. S., Prough, D. S. & Denner, L., May 1 2013, In: Journal of neurotrauma. 30, 9, p. 775-788 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Proteomics
  • Hippocampus
  • Calcineurin
  • Knowledge Bases
  18 Scopus citations

• Inducible Tumor Necrosis Factor (TNF) receptor-associated factor-1 expression couples the canonical to the non-canonical NF-κB pathway in TNF stimulation

  Choudhary, S., Kalita, M., Fang, L., Patel, K. V., Tian, B., Zhao, Y., Edeh, C. B. & Brasier, A. R., May 17 2013, In: Journal of Biological Chemistry. 288, 20, p. 14612-14623 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
  • TNF Receptor-Associated Factor 1
  • Phosphotransferases
  • Tumor Necrosis Factor-alpha
  • Ligases
  29 Scopus citations

• Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry

  Zhao, Y., Tian, B., Edeh, C. B. & Brasier, A. R., Jun 2013, In: Molecular and Cellular Proteomics. 12, 6, p. 1513-1529 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Innate Immunity
  • Mass Spectrometry
  • Double-Stranded RNA
  • Chemical activation
  29 Scopus citations
• 2015

  Improved detection of invasive pulmonary aspergillosis arising during leukemia treatment using a panel of host response proteins and fungal antigens

  Brasier, A. R., Zhao, Y., Spratt, H. M., Wiktorowicz, J. E., Ju, H., Wheat, L. J., Baden, L., Stafford, S., Wu, Z., Issa, N., Caliendo, A. M., Denning, D. W., Soman, K., Clancy, C. J., Nguyen, M. H., Sugrue, M. W., Alexander, B. D. & Wingard, J. R., Nov 1 2015, In: PloS one. 10, 11, 0143165.

  Research output: Contribution to journal › Article › peer-review

  • fungal antigens
  • Fungal Antigens
  • Invasive Pulmonary Aspergillosis
  • aspergillosis
  • leukemia
  15 Scopus citations

• Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks

  Desai, P., Yang, J., Tian, B., Sun, H., Kalita, M., Ju, H., Paulucci-Holthauzen, A., Zhao, Y., Brasier, A. R. & Sadygov, R. G., Jul 1 2015, In: Cellular Signalling. 27, 7, p. 1413-1425 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial-Mesenchymal Transition
  • HSP27 Heat-Shock Proteins
  • Vitamin K 3
  • Glycogen Synthase Kinase 3
  • Airway Remodeling
  18 Scopus citations

• Molecular classification of outcomes from dengue virus -3 infections

  Brasier, A. R., Zhao, Y., Wiktorowicz, J. E., Spratt, H. M., Nascimento, E. J. M., Cordeiro, M. T., Soman, K. V., Ju, H., Recinos, A., Stafford, S., Wu, Z., Marques, E. T. A. & Vasilakis, N., Mar 1 2015, In: Journal of Clinical Virology. 64, p. 97-106 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Severe Dengue
  • Dengue Virus
  • Dengue
  • Virus Diseases
  • Heuristics
  10 Scopus citations

• Systematic determination of human cyclin dependent kinase (CDK)-9 interactome identifies novel functions in RNA splicing mediated by the DEAD Box (DDX)-5/17 RNA helicases

  Yang, J., Zhao, Y., Kalita, M., Li, X., Jamaluddin, M., Tian, B., Edeh, C. B., Wiktorowicz, J. E., Kudlicki, A. & Brasier, A. R., Oct 1 2015, In: Molecular and Cellular Proteomics. 14, 10, p. 2701-2721 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin-Dependent Kinase 9
  • RNA Helicases
  • RNA Splicing
  • RNA
  • Isotope Labeling
  18 Scopus citations
• 2016

  BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation

  Tian, B., Zhao, Y., Sun, H., Zhang, Y., Yang, J. & Brasier, A. R., 2016, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 6, p. L1183-L1201

  Research output: Contribution to journal › Article › peer-review

  • Immediate-Early Genes
  • Pulmonary Fibrosis
  • Epithelial-Mesenchymal Transition
  • Transcription Factor RelA
  • Fibrosis
  39 Scopus citations

• Endothelial cell proteomic response to Rickettsia conorii infection reveals activation of the Janus Kinase (JAK)-signal transducer and activator of transcription (STAT)-inferferon stimulated gene (ISG)15 pathway and reprogramming plasma membrane integrin/cadherin signaling

  Zhao, Y., Valbuena, G., Walker, D. H., Gazi, M., Hidalgo, M., DeSousa, R., Oteo, J. A., Goez, Y. & Brasier, A. R., Jan 2016, In: Molecular and Cellular Proteomics. 15, 1, p. 289-304 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Boutonneuse Fever
  • Endothelial cells
  • Cell membranes
  • Proteomics
  • Janus Kinases
  10 Scopus citations

• Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

  Zhao, Y., Tian, B., Sadygov, R., Zhang, Y. & Brasier, A. R., Oct 4 2016, In: Journal of Proteomics. 148, p. 126-138 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteomics
  • Epithelial-Mesenchymal Transition
  • Tumor Necrosis Factor-alpha
  • Transforming Growth Factor beta
  • Epithelial Cells
  14 Scopus citations

• Qualification and verification of protein biomarker candidates

  Zhao, Y. & Brasier, A. R., 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 919. p. 493-514 22 p. (Advances in Experimental Medicine and Biology; vol. 919).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Biomarkers
  • Proteins
  • Pipelines
  • United States Food and Drug Administration
  • Industry
  8 Scopus citations
• 2018

  Central role of the NF-κB pathway in the Scgb1a1-expressing epithelium in mediating respiratory syncytial virus-induced airway inflammation

  Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Wakamiya, M., Garofalo, R. P. & Brasier, A. R., Jun 1 2018, In: Journal of virology. 92, 11, e00441-18.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Knockout Mice
  • Interferons
  13 Scopus citations

• Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

  Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Apr 24 2018, In: Cell Reports. 23, 4, p. 1138-1151 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells
  • Histone Acetyltransferases
  • Molecules
  • Chemokines
  • Chemical activation
  18 Scopus citations

• The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

  Tian, B., Widen, S. G., Yang, J., Wood, T. G., Kudlicki, A., Zhao, Y. & Brasier, A. R., Oct 19 2018, In: Journal of Biological Chemistry. 293, 42, p. 16528-16545 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells
  • Epithelial-Mesenchymal Transition
  • Genes
  • Transforming Growth Factors
  • Cadherins
  13 Scopus citations
• 2019

  Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

  Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In: Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

  Research output: Contribution to journal › Article › peer-review

  • Dander
  • Cats
  • Myofibroblasts
  • Inflammation
  • Airway Remodeling
  14 Scopus citations

• Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

  Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In: Journal of Proteomics. 205, 103415.

  Research output: Contribution to journal › Article › peer-review

  • Airway Remodeling
  • Bronchoalveolar Lavage Fluid
  • Homeostasis
  • Pericytes
  • Blood Vessels
  10 Scopus citations

• Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation to Maintain Proteostasis and Extracellular Matrix Production

  Zhang, J., Jamaluddin, M., Zhang, Y., Widen, S. G., Sun, H., Brasier, A. R. & Zhao, Y., Sep 6 2019, In: Journal of Proteome Research. 18, 9, p. 3447-3460 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation
  • Proteostasis
  • Extracellular Matrix Proteins
  • X-Box Binding Protein 1
  • Epithelial-Mesenchymal Transition
  4 Scopus citations