Find Research Outputs

Search results

• 2011

  Annexin A2 mediates Up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells

  Sarkar, S., Swiercz, R., Kantara, C., Hajjar, K. A. & Singh, P., Feb 2011, In: Gastroenterology. 140, 2, p. 583-595.e4

  Research output: Contribution to journal › Article › peer-review

  • big gastrin
  • Annexins
  • Catenins
  • HEK293 Cells
  • Stem Cells
  45 Scopus citations
• 2012

  Clathrin mediates endocytosis of progastrin and activates MAPKs: Role of cell surface annexin A2

  Sarkar, S., Kantara, C. & Singh, P., Apr 1 2012, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 7, p. G712-G722

  Research output: Contribution to journal › Article › peer-review

  • big gastrin
  • Annexin A2
  • Clathrin
  • Endocytosis
  • Down-Regulation
  13 Scopus citations

• Distinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection

  Chandrakesan, P., Ahmed, I., Chinthalapally, A., Singh, P., Awasthi, S., Anant, S. & Umar, S., Feb 2012, In: Infection and immunity. 80, 2, p. 753-767 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Colitis
  • Bacterial Infections
  • Hyperplasia
  • keratinocyte-derived chemokines
  • Citrobacter rodentium
  24 Scopus citations

• Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: Phenotypic differences between transformed and nontransformed stem cells

  Sarkar, S., Kantara, C., Ortiz, I., Swiercz, R., Kuo, J., Davey, R., Escobar, K., Ullrich, R. & Singh, P., Oct 1 2012, In: International Journal of Cancer. 131, 7, p. E1088-E1099

  Research output: Contribution to journal › Article › peer-review

  • big gastrin
  • Stem Cells
  • Epithelial Cells
  • Phosphotransferases
  • Catenins
  16 Scopus citations

• Progastrin peptides increase the risk of developing colonic tumors: Impact on colonic stem cells

  Singh, P., Sarkar, S., Kantara, C. & Maxwell, C., Dec 2012, In: Current Colorectal Cancer Reports. 8, 4, p. 277-289 13 p.

  Research output: Contribution to journal › Article › peer-review

  • big gastrin
  • Aberrant Crypt Foci
  • Gastrins
  • Polyps
  • Intercellular Signaling Peptides and Proteins
  14 Scopus citations
• 2013

  Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

  Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In: Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Biomolecular Nuclear Magnetic Resonance
  • Nuclear magnetic resonance spectroscopy
  • Extracellular Fluid
  • Sulfhydryl Compounds
  • Oxidation
  36 Scopus citations
• 2016

  CD90⁺ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer

  Huynh, P. T., Beswick, E. J., Coronado, Y. A., Johnson, P., O'Connell, M. R., Watts, T., Singh, P., Qiu, S., Morris, K., Powell, D. W. & Pinchuk, I. V., Apr 15 2016, In: International Journal of Cancer. 138, 8, p. 1971-1981 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplastic Stem Cells
  • Stromal Cells
  • Colorectal Neoplasms
  • Interleukin-6
  • Inflammation
  40 Scopus citations

• Epigenetic regulation of human DCLK-1 gene during coloncarcinogenesis: Clinical and mechanistic implications

  Singh, P., O'Connell, M. & Shubhashish, S., Sep 1 2016, In: Stem Cell Investigation. 2016, SEP, 51.

  Research output: Contribution to journal › Review article › peer-review

  • Epigenomics
  • CpG Islands
  • Colorectal Neoplasms
  • Carcinogenesis
  • Tumor Suppressor Genes
  12 Scopus citations
• 2017

  A novel antibody against cancer stem cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy

  Sarkar, S., Popov, V. L., O'Connell, M. R., Stevenson, H. L., Lee, B. S., Obeid, R. A., Luthra, G. K. & Singh, P., Oct 1 2017, In: Laboratory Investigation. 97, 10, p. 1245-1261 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplastic Stem Cells
  • Colonoscopy
  • Colonic Neoplasms
  • Protein Isoforms
  • Biomarkers
  15 Scopus citations

• FOXD3 regulates csc marker, dclk1-s, and invasive potential: Prognostic implications in colon cancer

  Sarkar, S., O'Connell, M. R., Okugawa, Y., Lee, B. S., Toiyama, Y., Kusunoki, M., Daboval, R. D., Goel, A. & Singh, P., Dec 2017, In: Molecular Cancer Research. 15, 12, p. 1678-1691 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Colonic Neoplasms
  • Phosphotransferases
  • Colon
  • Adenocarcinoma
  • Adenoma
  10 Scopus citations

• Hormonal effects on gastrointestinal cancer growth

  Townsend, C., Singh, P. & Thompson, J. C., Jan 1 2017, Growth of the Gastrointestinal Tract: Gastrointestinal Hormones and Growth Factors. CRC Press, p. 207-221 15 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Gastrointestinal Neoplasms
  • Tumors
  • Stomach Neoplasms
  • Growth
  • Neoplasms
• 2019

  Inhibition of LEF1-mediated DCLK1 by niclosamide attenuates colorectal cancer stemness

  Park, S. Y., Kim, J. Y., Choi, J. H., Kim, J. H., Lee, C. J., Singh, P., Sarkar, S., Baek, J. H. & Nam, J. S., Feb 15 2019, In: Clinical Cancer Research. 25, 4, p. 1415-1429 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoid Enhancer-Binding Factor 1
  • Niclosamide
  • Colorectal Neoplasms
  • Phosphotransferases
  • Neoplastic Stem Cells
  14 Scopus citations