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• 2019

  Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

  Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In: Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

  Research output: Contribution to journal › Article › peer-review

  • Dander
  • Cats
  • Myofibroblasts
  • Inflammation
  • Airway Remodeling
  14 Scopus citations

• Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

  Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In: Journal of Proteomics. 205, 103415.

  Research output: Contribution to journal › Article › peer-review

  • Airway Remodeling
  • Bronchoalveolar Lavage Fluid
  • Homeostasis
  • Pericytes
  • Blood Vessels
  10 Scopus citations

• Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation to Maintain Proteostasis and Extracellular Matrix Production

  Zhang, J., Jamaluddin, M., Zhang, Y., Widen, S. G., Sun, H., Brasier, A. R. & Zhao, Y., Sep 6 2019, In: Journal of Proteome Research. 18, 9, p. 3447-3460 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation
  • Proteostasis
  • Extracellular Matrix Proteins
  • X-Box Binding Protein 1
  • Epithelial-Mesenchymal Transition
  4 Scopus citations
• 2018

  Central role of the NF-κB pathway in the Scgb1a1-expressing epithelium in mediating respiratory syncytial virus-induced airway inflammation

  Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Wakamiya, M., Garofalo, R. P. & Brasier, A. R., Jun 1 2018, In: Journal of virology. 92, 11, e00441-18.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Knockout Mice
  • Interferons
  13 Scopus citations

• Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

  Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Apr 24 2018, In: Cell Reports. 23, 4, p. 1138-1151 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells
  • Histone Acetyltransferases
  • Molecules
  • Chemokines
  • Chemical activation
  18 Scopus citations

• The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

  Tian, B., Widen, S. G., Yang, J., Wood, T. G., Kudlicki, A., Zhao, Y. & Brasier, A. R., Oct 19 2018, In: Journal of Biological Chemistry. 293, 42, p. 16528-16545 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells
  • Epithelial-Mesenchymal Transition
  • Genes
  • Transforming Growth Factors
  • Cadherins
  13 Scopus citations
• 2017

  BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

  Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Garofalo, R. P. & Brasier, A. R., 2017, In: Journal of virology. 91, 6, e00007-17.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections
  • Interferons
  • inflammation
  • Respiratory Syncytial Viruses
  31 Scopus citations

• Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

  Ijaz, T., Jamaluddin, M., Zhao, Y., Zhang, Y., Jay, J., Finnerty, C. C., Herndon, D. N., Tilton, R. G. & Brasier, A. R., 2017, In: Cell Death and Disease. 8, 2, e2606.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin-Dependent Kinase 9
  • Myofibroblasts
  • Fibroblasts
  • Hypertrophic Cicatrix
  • Collagen
  21 Scopus citations

• Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

  Zhao, Y., Tilton, R., Brasier, A., Ijaz, T., Finnerty, C., Herndon, D., Tilton, R. & Jamaluddin, M., Feb 9 2017, In: Cell Death and Disease.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin-Dependent Kinase 9
  • Myofibroblasts
  • Fibroblasts
  • Hypertrophic Cicatrix
  • Collagen

• Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

  Maroto, R., Zhao, Y., Jamaluddin, M., Popov, V. L., Wang, H., Kalubowilage, M., Zhang, Y., Luisi, J., Sun, H., Culbertson, C. T., Bossmann, S. H., Motamedi, M. & Brasier, A. R., Dec 1 2017, In: Journal of Extracellular Vesicles. 6, 1, 1359478.

  Research output: Contribution to journal › Article › peer-review

  • Exosomes
  • Temperature
  • Bronchoalveolar Lavage Fluid
  • Proteins
  • Dynamic Light Scattering
  54 Scopus citations

• Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women

  Chondronikola, M., Asghar, R., Zhang, X., Dillon, E. L., Durham, W. J., Wu, Z., Porter, C., Camacho-Hughes, M., Zhao, Y., Brasier, A. R., Volpi, E., Sheffield-Moore, M., Abate, N., Sidossis, L. & Tuvdendorj, D., Oct 2017, In: Clinical Nutrition. 36, 5, p. 1310-1319 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Carnitine
  • Blood Cells
  • Palmitates
  • Insulin Resistance
  • Hyperinsulinism
  2 Scopus citations

• Quantitative Assessment of the Effects of Trypsin Digestion Methods on Affinity Purification-Mass Spectrometry-based Protein-Protein Interaction Analysis

  Zhang, Y., Sun, H., Zhang, J., Brasier, A. R. & Zhao, Y., Aug 4 2017, In: Journal of Proteome Research. 16, 8, p. 3068-3082 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Purification
  • Trypsin
  • Digestion
  • Mass Spectrometry
  12 Scopus citations

• Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples

  Zhao, Y., Zhang, Y., Sun, H., Maroto, R. & Brasier, A. R., Aug 4 2017, In: Journal of Proteome Research. 16, 8, p. 2983-2992 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-nitrotyrosine
  • Chemical analysis
  • Peptides
  • Nitration
  • Tyrosine
  5 Scopus citations

• Systematic analysis of cell-type differences in the epithelial secretome reveals insights into the pathogenesis of respiratory syncytial virus-induced lower respiratory tract infections

  Zhao, Y., Jamaluddin, M., Zhang, Y., Sun, H., Ivanciuc, T., Garofalo, R. P. & Brasier, A. R., Apr 15 2017, In: Journal of Immunology. 198, 8, p. 3345-3364 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Viruses
  • Respiratory Tract Infections
  • Trachea
  • Proteins
  • Human respiratory syncytial virus
  25 Scopus citations
• 2016

  BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation

  Tian, B., Zhao, Y., Sun, H., Zhang, Y., Yang, J. & Brasier, A. R., 2016, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 6, p. L1183-L1201

  Research output: Contribution to journal › Article › peer-review

  • Immediate-Early Genes
  • Pulmonary Fibrosis
  • Epithelial-Mesenchymal Transition
  • Transcription Factor RelA
  • Fibrosis
  39 Scopus citations

• Endothelial cell proteomic response to Rickettsia conorii infection reveals activation of the Janus Kinase (JAK)-signal transducer and activator of transcription (STAT)-inferferon stimulated gene (ISG)15 pathway and reprogramming plasma membrane integrin/cadherin signaling

  Zhao, Y., Valbuena, G., Walker, D. H., Gazi, M., Hidalgo, M., DeSousa, R., Oteo, J. A., Goez, Y. & Brasier, A. R., Jan 2016, In: Molecular and Cellular Proteomics. 15, 1, p. 289-304 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Boutonneuse Fever
  • Endothelial cells
  • Cell membranes
  • Proteomics
  • Janus Kinases
  10 Scopus citations

• Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

  Zhao, Y., Tian, B., Sadygov, R., Zhang, Y. & Brasier, A. R., Oct 4 2016, In: Journal of Proteomics. 148, p. 126-138 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteomics
  • Epithelial-Mesenchymal Transition
  • Tumor Necrosis Factor-alpha
  • Transforming Growth Factor beta
  • Epithelial Cells
  14 Scopus citations

• Qualification and verification of protein biomarker candidates

  Zhao, Y. & Brasier, A. R., 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 919. p. 493-514 22 p. (Advances in Experimental Medicine and Biology; vol. 919).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Biomarkers
  • Proteins
  • Pipelines
  • United States Food and Drug Administration
  • Industry
  8 Scopus citations
• 2015

  Improved detection of invasive pulmonary aspergillosis arising during leukemia treatment using a panel of host response proteins and fungal antigens

  Brasier, A. R., Zhao, Y., Spratt, H. M., Wiktorowicz, J. E., Ju, H., Wheat, L. J., Baden, L., Stafford, S., Wu, Z., Issa, N., Caliendo, A. M., Denning, D. W., Soman, K., Clancy, C. J., Nguyen, M. H., Sugrue, M. W., Alexander, B. D. & Wingard, J. R., Nov 1 2015, In: PloS one. 10, 11, 0143165.

  Research output: Contribution to journal › Article › peer-review

  • fungal antigens
  • Fungal Antigens
  • Invasive Pulmonary Aspergillosis
  • aspergillosis
  • leukemia
  15 Scopus citations

• Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks

  Desai, P., Yang, J., Tian, B., Sun, H., Kalita, M., Ju, H., Paulucci-Holthauzen, A., Zhao, Y., Brasier, A. R. & Sadygov, R. G., Jul 1 2015, In: Cellular Signalling. 27, 7, p. 1413-1425 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial-Mesenchymal Transition
  • HSP27 Heat-Shock Proteins
  • Vitamin K 3
  • Glycogen Synthase Kinase 3
  • Airway Remodeling
  18 Scopus citations

• Molecular classification of outcomes from dengue virus -3 infections

  Brasier, A. R., Zhao, Y., Wiktorowicz, J. E., Spratt, H. M., Nascimento, E. J. M., Cordeiro, M. T., Soman, K. V., Ju, H., Recinos, A., Stafford, S., Wu, Z., Marques, E. T. A. & Vasilakis, N., Mar 1 2015, In: Journal of Clinical Virology. 64, p. 97-106 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Severe Dengue
  • Dengue Virus
  • Dengue
  • Virus Diseases
  • Heuristics
  10 Scopus citations

• Systematic determination of human cyclin dependent kinase (CDK)-9 interactome identifies novel functions in RNA splicing mediated by the DEAD Box (DDX)-5/17 RNA helicases

  Yang, J., Zhao, Y., Kalita, M., Li, X., Jamaluddin, M., Tian, B., Edeh, C. B., Wiktorowicz, J. E., Kudlicki, A. & Brasier, A. R., Oct 1 2015, In: Molecular and Cellular Proteomics. 14, 10, p. 2701-2721 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin-Dependent Kinase 9
  • RNA Helicases
  • RNA Splicing
  • RNA
  • Isotope Labeling
  18 Scopus citations
• 2014

  ATM regulates NF-κB-dependent immediate-early genes via RelA ser 276 phosphorylation coupled to CDK9 promoter recruitment

  Fang, L., Choudhary, S., Zhao, Y., Edeh, C. B., Yang, C., Boldogh, I. & Brasier, A. R., Jul 29 2014, In: Nucleic acids research. 42, 13, p. 8416-8432 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Ataxia Telangiectasia
  • Immediate-Early Genes
  • Phosphorylation
  • Cyclin-Dependent Kinase 9
  • Double-Stranded DNA Breaks
  34 Scopus citations

• Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

  Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B., Dineley, K. T. & Denner, L., Jan 20 2014, In: Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

  Research output: Contribution to journal › Article › peer-review

  • PPAR gamma
  • Dentate Gyrus
  • Alzheimer Disease
  • Memory
  • SNARE Proteins
  43 Scopus citations

• Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: Coordinated dynamics emerging from cell-level noise

  Bertolusso, R., Tian, B., Zhao, Y., Vergara, L., Sabree, A., Iwanaszko, M., Lipniacki, T., Brasier, A. R. & Kimmel, M., Apr 7 2014, In: PloS one. 9, 4, e93396.

  Research output: Contribution to journal › Article › peer-review

  • Double-Stranded RNA
  • double-stranded RNA
  • innate immunity
  • Innate Immunity
  • Noise
  22 Scopus citations

• Erratum: Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: Coordinated dynamics emerging from cell-level noise (PLoS ONE 9, 4 (e93396) DOI:10.1371/journal.pone.0093396)

  Bertolusso, R., Tian, B., Zhao, Y., Vergara, L. & Sabree, A., Jul 11 2014, In: PloS one. 9, 7, e103019.

  Research output: Contribution to journal › Comment/debate › peer-review

• Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

  Ray, S., Zhao, Y., Jamaluddin, M., Edeh, C. B., Lee, C. & Brasier, A. R., Jul 2014, In: Cellular Signalling. 26, 7, p. 1445-1455 11 p.

  Research output: Contribution to journal › Article › peer-review

  • STAT3 Transcription Factor
  • Ubiquitination
  • Apoptosis
  • Proteins
  • Ubiquitin
  30 Scopus citations

• Measurement of the innate immune response in the airway

  Brasier, A. R. & Zhao, Y., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 233-254 22 p. (Advances in Experimental Medicine and Biology; vol. 795).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Innate Immunity
  • Genes
  • RNA Helicases
  • Pathogens
  • Cell membranes
  1 Scopus citations

• Measurement of the innate immune response in the airway

  Brasier, A. R. & Zhao, Y., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 233-254 22 p. (Advances in Experimental Medicine and Biology; vol. 795).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Innate Immunity
  • Genes
  • RNA Helicases
  • Pathogens
  • Cell membranes

• Modulation of gene expression regulated by the transcription factor nf-κb/rela

  Li, X., Zhao, Y., Tian, B., Jamaluddin, M., Mitra, A., Yang, J., Rowicka, M., Brasier, A. R. & Kudlicki, A., Apr 25 2014, In: Journal of Biological Chemistry. 289, 17, p. 11927-11944 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Transcription Factor RelA
  • DNA-Binding Proteins
  • Gene expression
  • Modulators
  • Modulation
  21 Scopus citations

• Translational studies in older men using testosterone to treat sarcopenia

  Urban, R., Dillon, E., Choudhary, S., Zhao, Y., Horstman, A. M., Tilton, R. & Sheffield-Moore, M., 2014, In: Transactions of the American Clinical and Climatological Association. 125

  Research output: Contribution to journal › Article › peer-review

  • Sarcopenia
  • Testosterone
  • Muscles
  • Inflammation
  • Skeletal Muscle
  21 Scopus citations
• 2012

  Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways

  Denner, L. A., Rodriguez-Rivera, J., Haidacher, S. J., Jahrling, J. B., Carmical, J. R., Hernandez, C. M., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Wood, T. G. & Dineley, K. T., Nov 21 2012, In: Journal of Neuroscience. 32, 47, p. 16725-16735 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Rosiglitazone
  • Peroxisome Proliferator-Activated Receptors
  • Extracellular Signal-Regulated MAP Kinases
  • Mitogen-Activated Protein Kinases
  • Protein Kinases
  84 Scopus citations

• Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner

  Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Poussard, A. L., Walker, A. G., Brasier, A. R., Zhao, Y., Tian, B., de la Torre, J. C. & Paessler, S., May 2012, In: PLoS neglected tropical diseases. 6, 5, e1659.

  Research output: Contribution to journal › Article › peer-review

  • Interferon Type I
  • Virus Diseases
  • Viruses
  • Interferons
  • Arenavirus
  43 Scopus citations
• 2011

  Methods for biomarker verification and assay development

  Zhao, Y. & Brasier, A. R., Jul 2011, In: Current Proteomics. 8, 2, p. 138-152 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Biomarkers
  • Assays
  • Proteomics
  • Mass spectrometry
  • Dilution
  3 Scopus citations

• Quantification of activated NF-κB/RelA complexes using ssDNA aptamer affinity - Stable isotope dilution - Selected reaction monitoring - Mass spectrometry

  Zhao, Y., Widen, S. G., Jamaluddin, M., Tian, B., Wood, T. G., Edeh, C. B. & Brasier, A. R., Jun 2011, In: Molecular and Cellular Proteomics. 10, 6

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Dilution
  • Isotopes
  • Assays
  • Mass Spectrometry
  37 Scopus citations