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• 2014

  Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection

  Kolli, D., Gupta, M. R., Sbrana, E., Velayutham, T. S., Chao, H., Casola, A. & Garofalo, R. P., Oct 1 2014, In: American journal of respiratory cell and molecular biology. 51, 4, p. 502-515 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Alveolar Macrophages
  • Metapneumovirus
  • Respiratory Syncytial Virus Infections
  • Viruses
  • Infection
  52 Scopus citations

• Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity

  Mehta, R., Scheffler, M., Tapia, L., Aideyan, L., Patel, K. D., Jewell, A. M., Avadhanula, V., Mei, M., Garofalo, R. P. & Piedra, P. A., Nov 1 2014, In: Influenza and other respiratory viruses. 8, 6, p. 617-625 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bronchiolitis
  • Caspases
  • L-Lactate Dehydrogenase
  • Caspase 3
  • Child
  11 Scopus citations

• Paramyxovirus infection regulates T cell responses by BDCA-1⁺and BDCA-3⁺ myeloid dendritic cells

  Gupta, M. R., Kolli, D., Molteni, C., Casola, A. & Garofalo, R. P., Jun 11 2014, In: PloS one. 9, 6, e99227.

  Research output: Contribution to journal › Article › peer-review

  • Human metapneumovirus
  • Dendritic Cells
  • Respiratory syncytial virus
  • T-cells
  • Metapneumovirus
  5 Scopus citations
• 2015

  Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection

  Fang, L., Choudhary, S., Tian, B., Boldogh, I., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R. P. & Brasier, A. R., 2015, In: Journal of virology. 89, 5, p. 2628-2642 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Respirovirus
  • Factor VII
  • Ataxia Telangiectasia
  • retinoic acid
  • Gene Amplification
  20 Scopus citations

• Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

  Sawant, K. V., Xu, R., Cox, R., Hawkins, H., Sbrana, E., Kolli, D., Garofalo, R. P. & Rajarathnam, K., Oct 16 2015, In: Journal of Innate Immunity. 7, 6, p. 647-658 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Neutrophils
  • Lung
  • Neutrophil Infiltration
  • Interleukin-8B Receptors
  46 Scopus citations

• Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus

  Deng, J., Chen, Y., Liu, G., Ren, J., Go, C., Ivanciuc, T., Deepthi, K., Casola, A., Garofalo, R. P. & Bao, X., Aug 1 2015, In: Journal of General Virology. 96, 8, p. 2104-2113 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Metapneumovirus
  • Antiviral Agents
  • Immunity
  • Proteins
  • Infection
  6 Scopus citations

• Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

  Komaravelli, N., Tian, B., Ivanciuc, T., Mautemps, N., Brasier, A. R., Garofalo, R. P. & Casola, A., 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 391-403 13 p.

  Research output: Contribution to journal › Article › peer-review

  • NF-E2-Related Factor 2
  • Respiratory Syncytial Virus Infections
  • Viruses
  • Antioxidants
  • Down-Regulation
  37 Scopus citations

• Role of hydrogen sulfide in paramyxovirus infections

  Li, H., Ma, Y., Escaffre, O., Ivanciuc, T., Komaravelli, N., Kelley, J. P., Coletta, C., Szabo, C., Rockx, B., Garofalo, R. P. & Casola, A., 2015, In: Journal of virology. 89, 10, p. 5557-5568 12 p.

  Research output: Contribution to journal › Article › peer-review

  • GYY 4137
  • Respiratory syncytial virus
  • Respirovirus
  • Hydrogen Sulfide
  • hydrogen sulfide
  27 Scopus citations
• 2017

  BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

  Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Garofalo, R. P. & Brasier, A. R., 2017, In: Journal of virology. 91, 6, e00007-17.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections
  • Interferons
  • inflammation
  • Respiratory Syncytial Viruses
  31 Scopus citations

• Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

  Bazhanov, N., Escaffre, O., Freiberg, A. N., Garofalo, R. P. & Casola, A., Jan 20 2017, In: Scientific reports. 7, 41029.

  Research output: Contribution to journal › Article › peer-review

  • GYY 4137
  • Hydrogen Sulfide
  • RNA Viruses
  • Antiviral Agents
  • Human Influenza
  18 Scopus citations

• Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

  Yang, J., Tian, B., Sun, H., Garofalo, R. P. & Brasier, A. R., Jun 5 2017, In: Nature Microbiology. 2, 17086.

  Research output: Contribution to journal › Article › peer-review

  • interferon type III
  • Interferon Regulatory Factor-1
  • Zinc Finger E-box-Binding Homeobox 1
  • Epithelial-Mesenchymal Transition
  • Respiratory Tract Infections
  18 Scopus citations

• Hydrogen sulfide: A novel player in airway development, pathophysiology of respiratory diseases, and antiviral defenses

  Bazhanov, N., Ansar, M., Ivanciuc, T., Garofalo, R. P. & Casola, A., Oct 2017, In: American journal of respiratory cell and molecular biology. 57, 4, p. 403-410 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cystathionine
  • Pulmonary diseases
  • Hydrogen Sulfide
  • Antiviral Agents
  • Lung Diseases
  34 Scopus citations

• Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein ‐ ring finger protein 4 dependent pathway

  Komaravelli, N., Ansar, M., Garofalo, R. P. & Casola, A., Dec 2017, In: Free Radical Biology and Medicine. 113, p. 494-504 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Promyelocytic Leukemia Protein
  • NF-E2-Related Factor 2
  • Respiratory Syncytial Viruses
  • Viruses
  • Fingers
  14 Scopus citations

• Systematic analysis of cell-type differences in the epithelial secretome reveals insights into the pathogenesis of respiratory syncytial virus-induced lower respiratory tract infections

  Zhao, Y., Jamaluddin, M., Zhang, Y., Sun, H., Ivanciuc, T., Garofalo, R. P. & Brasier, A. R., Apr 15 2017, In: Journal of Immunology. 198, 8, p. 3345-3364 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Viruses
  • Respiratory Tract Infections
  • Trachea
  • Proteins
  • Human respiratory syncytial virus
  25 Scopus citations

• The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-Associated bronchiolitis

  Piedra, F. A., Mei, M., Avadhanula, V., Mehta, R., Aideyan, L., Garofalo, R. P. & Piedra, P. A., Mar 2017, In: PloS one. 12, 3, e0172953.

  Research output: Contribution to journal › Article › peer-review

  • bronchiolitis
  • Respiratory syncytial virus
  • Bronchiolitis
  • Respiratory Syncytial Viruses
  • Viruses
  21 Scopus citations
• 2018

  Central role of the NF-κB pathway in the Scgb1a1-expressing epithelium in mediating respiratory syncytial virus-induced airway inflammation

  Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Wakamiya, M., Garofalo, R. P. & Brasier, A. R., Jun 1 2018, In: Journal of virology. 92, 11, e00441-18.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Knockout Mice
  • Interferons
  13 Scopus citations

• Exchange proteins directly activated by cAMP and their roles in respiratory syncytial virus infection

  Choi, E. J., Ren, Y., Chen, Y., Liu, S., Wu, W., Ren, J., Wang, P., Garofalo, R. P., Zhou, J. & Bao, X., Nov 1 2018, In: Journal of virology. 92, 22, e01200-18.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • infection
  • 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile
  3 Scopus citations

• Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

  Joseph, P. R. B., Sawant, K. V., Iwahara, J., Garofalo, R. P., Desai, U. R. & Rajarathnam, K., Dec 1 2018, In: Scientific reports. 8, 1, 12289.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Lysine
  • Chemokines
  • Arginine
  • Neutrophils
  3 Scopus citations

• Proinflammatory effects of respiratory syncytial virus-induced epithelial HMGB1 on human innate immune cell activation

  Rayavara, K., Kurosky, A., Stafford, S. J., Garg, N. J., Brasier, A. R., Garofalo, R. P. & Hosakote, Y. M., Nov 1 2018, In: Journal of Immunology. 201, 9, p. 2832-2841 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Viruses
  • p38 Mitogen-Activated Protein Kinases
  • Epithelial Cells
  • Chemokines
  • Cytokines
  8 Scopus citations

• Protective role of nuclear factor erythroid 2-related factor 2 against respiratory syncytial virus and human metapneumovirus infections

  Ivanciuc, T., Sbrana, E., Casola, A. & Garofalo, R. P., Apr 23 2018, In: Frontiers in immunology. 9, APR, 854.

  Research output: Contribution to journal › Article › peer-review

  • Metapneumovirus
  • Respiratory Syncytial Viruses
  • Antioxidants
  • Airway Obstruction
  • Enzymes
  9 Scopus citations
• 2019

  Antiviral and immunomodulatory activity of silver nanoparticles in experimental rsv infection

  Morris, D., Ansar, M., Speshock, J., Ivanciuc, T., Qu, Y., Casola, A. & Garofalo, R., Aug 2019, In: Viruses. 11, 8, 732.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Viruses
  • Silver
  • Nanoparticles
  • Antiviral Agents
  • Respiratory Syncytial Virus Infections
  18 Scopus citations

• Cigarette Smoke Condensate Exposure Changes RNA Content of Extracellular Vesicles Released from Small Airway Epithelial Cells

  Corsello, T., Kudlicki, A. S., Garofalo, R. P. & Casola, A., Dec 17 2019, In: Cells. 8, 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracellular Vesicles
  • Smoke
  • Tobacco Products
  • Epithelial Cells
  • RNA

• Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke

  Ivanciuc, T., Sbrana, E., Casola, A. & Garofalo, R. P., Jul 1 2019, In: Pediatric Research. 86, 1, p. 39-46 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Lyases
  • Smoke
  • Tobacco
  • Virus Diseases
  3 Scopus citations
• 2020

  A polymorphism in the catalase gene promoter confers protection against severe RSV bronchiolitis

  Chambliss, J. M., Ansar, M., Kelley, J. P., Spratt, H., Garofalo, R. P. & Casola, A., Jan 3 2020, In: Viruses. 12, 1, , 57.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bronchiolitis
  • Respiratory Syncytial Viruses
  • Catalase
  • NF-E2-Related Factor 2
  • Antioxidants
  3 Scopus citations

• Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H₂S Biogenesis and the Effects Are Transmitted Transgenerationally

  Singh, S. P., Devadoss, D., Manevski, M., Sheybani, A., Ivanciuc, T., Exil, V., Agarwal, H., Raizada, V., Garofalo, R. P., Chand, H. S. & Sopori, M. L., Jul 28 2020, In: Frontiers in immunology. 11, 1628.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gasotransmitters
  • Cystathionine
  • Smoke
  • Tobacco Products
  • Lyases
  2 Scopus citations

• HIF-1α modulates core metabolism and virus replication in primary airway epithelial cells infected with respiratory syncytial virus

  Morris, D. R., Qu, Y., Agrawal, A., Garofalo, R. P. & Casola, A., Oct 2020, In: Viruses. 12, 10, 1088.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hypoxia-Inducible Factor 1
  • Respiratory Syncytial Viruses
  • Virus Replication
  • Respiratory Syncytial Virus Infections
  • endothelial PAS domain-containing protein 1

• Increased Lung Catalase Activity Confers Protection Against Experimental RSV Infection

  Ansar, M., Ivanciuc, T., Garofalo, R. P. & Casola, A., Dec 1 2020, In: Scientific reports. 10, 1, 3653.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • catalase-polyethylene glycol
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Catalase
  • Lung
  4 Scopus citations

• Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

  Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In: Journal of Leukocyte Biology.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Chemokines
  • Personnel Selection
  • Neutrophil Activation

• Respiratory syncytial virus infection induces chromatin remodeling to activate growth factor and extracellular matrix secretion pathways

  Xu, X., Qiao, D., Mann, M., Garofalo, R. P. & Brasier, A. R., Aug 2020, In: Viruses. 12, 8, 804.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Virus Infections
  • Chromatin Assembly and Disassembly
  • Secretory Pathway
  • Chromatin
  • Extracellular Matrix
  1 Scopus citations

• Selective blockade of TNFR1 improves clinical disease and bronchoconstriction in experimental RSV infection

  Morris, D. R., Ansar, M., Ivanciuc, T., Qu, Y., Casola, A. & Garofalo, R. P., Oct 17 2020, In: Viruses. 12, 10, 1176.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptors, Tumor Necrosis Factor, Type I
  • Respiratory Syncytial Virus Infections
  • Bronchoconstriction
  • Respiratory Syncytial Viruses
  • Receptors, Tumor Necrosis Factor, Type II