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  • Xuping Xie
2019

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2015

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

41 Scopus citations
2018

A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In : Cell Host and Microbe. 24, 4, p. 487-499.e5

Research output: Contribution to journalArticle

20 Scopus citations

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In : EBioMedicine. 36, p. 92-102 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Zika Virus Replicons for Drug Discovery

Xie, X., Zou, J., Shan, C., Yang, Y., Kum, D. B., Dallmeier, K., Neyts, J. & Shi, P. Y., Oct 1 2016, In : EBioMedicine. 12, p. 156-160 5 p.

Research output: Contribution to journalArticle

41 Scopus citations
2018

Zika Virus Vaccine: Progress and Challenges

Shan, C., Xie, X. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

33 Scopus citations
2015

Determinants of dengue virus NS4A protein oligomerization

Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In : Journal of virology. 89, 12, p. 6171-6183 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., El Sahili, A., Chan, G. K. Y., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K. F., Dong, H., Xie, X., Shi, P. Y. & Yokokawa, F., Aug 2016, In : PLoS pathogens. 12, 8, e1005737.

Research output: Contribution to journalArticle

59 Scopus citations

A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P-Y., Nov 29 2016, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

53 Scopus citations
2020

Evasion of Type I Interferon by SARS-CoV-2

Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y. C., Wang, H., Menachery, V. D., Rajsbaum, R. & Shi, P. Y., Oct 6 2020, In : Cell Reports. 33, 1, 108234.

Research output: Contribution to journalArticle

Open Access
2016

Zika Virus: Diagnosis, Therapeutics, and Vaccine

Shan, C., Xie, X., Barrett, A., Garcia-Blanco, M., Tesh, R. B., Vasconcelos, P. F. D. C., Vasilakis, N., Weaver, S. & Shi, P-Y., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 170-172 3 p.

Research output: Contribution to journalArticle

53 Scopus citations
2020

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, Shi, P. Y. & Rajsbaum, R., Sep 17 2020, In : Nature. 585, 7825, p. 414-419 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Restriction of Zika Virus by Host Innate Immunity

Xie, X., Shan, C. & Shi, P. Y., May 11 2016, In : Cell Host and Microbe. 19, 5, p. 566-567 2 p.

Research output: Contribution to journalShort survey

18 Scopus citations
2018

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In : Nature communications. 9, 1, 414.

Research output: Contribution to journalArticle

86 Scopus citations
2016

Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease

Akiyama, B. M., Laurence, H. M., Massey, A. R., Costantino, D. A., Xie, X., Yang, Y., Shi, P-Y., Nix, J. C., Beckham, J. D. & Kieft, J. S., Dec 2 2016, In : Science. 354, 6316, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

91 Scopus citations

Adenosine analog NITD008 is a potent inhibitor of zika virus

Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X. P., Shi, P. Y. & Qin, C. F., 2016, In : Open Forum Infectious Diseases. 3, 4

Research output: Contribution to journalArticle

77 Scopus citations
2020

A cocrystal structure of dengue capsid protein in complex of inhibitor

Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.

Research output: Contribution to journalArticle

2015

Mapping the interactions between the NS4B and NS3 proteins of dengue virus

Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3471-3483 13 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

Grant, D., Tan, G. K., Qing, M., Ng, J. K. W., Yip, A., Zou, G., Xie, X., Yuan, Z. Y., Schreiber, J., Schul, W., Shi, P. Y. & Alonso, S., Aug 2011, In : Journal of virology. 85, 15, p. 7775-7787 13 p.

Research output: Contribution to journalArticle

64 Scopus citations
2015

Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly

Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., 2015, In : Journal of virology. 89, 2, p. 1298-1313 16 p.

Research output: Contribution to journalArticle

50 Scopus citations
2020

A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Potential Mechanisms for Enhanced Zika Epidemic and Disease

Xia, H., Xie, X., Shan, C. & Shi, P-Y., May 11 2018, In : ACS Infectious Diseases. 4, 5, p. 656-659 4 p.

Research output: Contribution to journalReview article

5 Scopus citations

Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In : mBio. 9, 5, e01683-18.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

Xie, X., Zou, J., Wang, Q. Y., Noble, C. G., Lescar, J. & Shi, P. Y., Feb 1 2014, In : Virology. 450-451, p. 250-257 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Inhibition of japanese encephalitis virus infection by flavivirus recombinant e protein domain III

Fan, J., Liu, Y., Xie, X., Zhang, B. & Yuan, Z., Jun 1 2013, In : Virologica Sinica. 28, 3, p. 152-160 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Using a virion assembly-defective dengue virus as a vaccine approach

Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In : Journal of virology. 92, 21, e01002.

Research output: Contribution to journalArticle

8 Scopus citations
2020

Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses

Kambham, R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum Gorodezky, R., Shi, P. Y., Bedford, M. T., Bradrick, S., Menachery, V. & Garcia-Blanco, M., Oct 2020, In : Antiviral research. 182, 104874.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In : mBio. 10, 2, e00433-19.

Research output: Contribution to journalComment/debate

Open Access
2020

Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery

Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In : EBioMedicine. 57, 102838.

Research output: Contribution to journalArticle

Open Access
2011

A translation inhibitor that suppresses dengue virus in vitro and in vivo

Wang, Q. Y., Kondreddi, R. R., Xie, X., Rao, R., Nilar, S., Xu, H. Y., Qing, M., Chang, D., Dong, H., Yokokawa, F., Lakshminarayana, S. B., Goh, A., Schul, W., Kramer, L., Keller, T. H. & Shi, P. Y., Sep 2011, In : Antimicrobial agents and chemotherapy. 55, 9, p. 4072-4080 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
2019

Genetic and biochemical characterizations of Zika virus NS2A protein

Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

10 Scopus citations

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2064-2066 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations
2018

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

15 Scopus citations
2020

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In : Nature communications. 11, 1, 4059.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Zika virus NS2A-mediated virion assembly

Zhang, X., Xie, X., Xia, H., Zou, J., Huang, L., Popov, V. L., Chen, X. & Shi, P. Y., 2019, In : mBio. 10, 5, e02375-19.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2013

Membrane topology and function of dengue virus NS2A protein

Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In : Journal of virology. 87, 8, p. 4609-4622 14 p.

Research output: Contribution to journalArticle

112 Scopus citations

Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In : Journal of virology. 87, 10, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

65 Scopus citations
2018

Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In : PloS one. 13, 1, e0189262.

Research output: Contribution to journalArticle

2 Scopus citations
2016

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In : Cell Host and Microbe. 19, 6, p. 891-900 10 p.

Research output: Contribution to journalArticle

150 Scopus citations
2019
5 Scopus citations
2014

Dimerization of flavivirus NS4B protein

Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In : Journal of virology. 88, 6, p. 3379-3391 13 p.

Research output: Contribution to journalArticle

40 Scopus citations
2020
2015

Characterization of Dengue virus NS4A and NS4B protein interaction

Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In : Journal of virology. 89, 7, p. 3455-3470 16 p.

Research output: Contribution to journalArticle

65 Scopus citations
2019

Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In : mBio. 10, 4, e01372-19.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2012

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication

Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 1 2012, In : Antiviral research. 93, 1, p. 191-198 8 p.

Research output: Contribution to journalArticle

70 Scopus citations
2015

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P-Y. & Kang, C., Dec 1 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Inhibition of dengue virus by targeting viral NS4B protein

Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 2011, In : Journal of virology. 85, 21, p. 11183-11195 13 p.

Research output: Contribution to journalArticle

88 Scopus citations
2019

Anti-Zika virus RNAi in neural progenitor cells

Xie, X. & Shi, P. Y., Apr 1 2019, In : Cell Research. 29, 4, p. 261-262 2 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2020

Role of microglia in the dissemination of zika virus from mother to fetal brain

Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In : PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.

Research output: Contribution to journalArticle

Open Access