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Author

  • Fernanda Laezza
2014

Role of the axonal initial segment in psychiatric disorders: Function, dysfunction, and intervention

Hsu, W. C. J., Nilsson, C. L. & Laezza, F., 2014, In : Frontiers in Psychiatry. 5, AUG, Article 109.

Research output: Contribution to journalReview article

26 Scopus citations
2011
53 Scopus citations
2015

Quantification of Histone Modifications by Parallel-Reaction Monitoring: A Method Validation

Sowers, J. L., Mirfattah, B., Xu, P., Tang, H., Park, I. Y., Walker, C., Wu, P., Laezza, F., Sowers, L. C. & Zhang, K., Oct 6 2015, In : Analytical Chemistry. 87, 19, p. 10006-10014 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2017

Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell

Crofton, E. J., Nenov, M. N., Zhang, Y., Scala, F., Page, S. A., McCue, D. L., Li, D., Hommel, J. D., Laezza, F. & Green, T. A., May 1 2017, In : Neuropharmacology. 117, p. 49-60 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2018

Automated sorting of neuronal trees in fluorescent images of neuronal networks using NeuroTreeTracer

Kayasandik, C., Negi, P., Laezza, F., Papadakis, M. & Labate, D., Dec 1 2018, In : Scientific reports. 8, 1, 6450.

Research output: Contribution to journalArticle

5 Scopus citations
2019

Emerging roles of Fgf14 in behavioral control

Hoxha, E., Marcinnò, A., Montarolo, F., Masante, L., Balbo, I., Ravera, F., Laezza, F. & Tempia, F., Jan 1 2019, In : Behavioural Brain Research. 356, p. 257-265 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2020

Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability

Singh, A. K., Wadsworth, P. A., Tapia, C. M., Aceto, G., Ali, S. R., Chen, H., D'Ascenzo, M., Zhou, J. & Laezza, F., Jul 1 2020, In : Physiological reports. 8, 14, e14505.

Research output: Contribution to journalArticle

Open Access
2015

Impaired firing properties of dentate granule neurons in an Alzheimer’s disease animal model are rescued by PPARγ agonism

Nenov, M. N., Tempia, F., Denner, L., Dineley, K. T. & Laezza, F., Mar 15 2015, In : Journal of neurophysiology. 113, 6, p. 1712-1726 15 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Control of neuronal ion channel function by glycogen synthase kinase-3: New prospective for an old kinase

Wildburger, N. C. & Laezza, F., Jun 20 2012, In : Frontiers in Molecular Neuroscience. JUNE 2012

Research output: Contribution to journalReview article

20 Scopus citations

Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex

Shavkunov, A., Panova, N., Prasai, A., Veselenak, R., Bourne, N., Stoilova-McPhie, S. & Laezza, F., Apr 1 2012, In : Assay and Drug Development Technologies. 10, 2, p. 148-160 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2020

JAK2 regulates Nav1.6 channel function via FGF14Y158 phosphorylation

Wadsworth, P. A., Singh, A. K., Nguyen, N., Dvorak, N. M., Tapia, C. M., Russell, W. K., Stephan, C. & Laezza, F., Oct 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 10, 118786.

Research output: Contribution to journalArticle

2017

Intracellular fibroblast growth factor 14: Emerging risk factor for brain disorders

Re, J. D., Wadsworth, P. A. & Laezza, F., Apr 19 2017, In : Frontiers in Cellular Neuroscience. 11, 103.

Research output: Contribution to journalArticle

21 Scopus citations
2018
10 Scopus citations
2020

Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels

Aceto, G., Colussi, C., Leone, L., Fusco, S., Rinaudo, M., Scala, F., Green, T. A., Laezza, F., D'Ascenzo, M. & Grassi, C., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8143-8153 11 p.

Research output: Contribution to journalArticle

2014

Modulation of the FGF14: FGF14 homodimer interaction through short peptide fragments

Ali, S., Shavkunov, A., Panova, N., Stoilova-McPhie, S. & Laezza, F., Jan 1 2014, In : CNS and Neurological Disorders - Drug Targets. 13, 9, p. 1559-1570 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2020

Bidirectional modulation of the voltage-gated sodium (Nav1.6) channel by rationally designed peptidomimetics

Dvorak, N. M., Wadsworth, P. A., Wang, P., Chen, H., Zhou, J. & Laezza, F., Aug 2020, In : Molecules. 25, 15, 3365.

Research output: Contribution to journalArticle

Open Access
2014

Thermal property and assessment of biocompatibility of poly(lactic-co- glycolic) acid/graphene nanocomposites

Adhikari, A. R., Rusakova, I., Haleh, A., Luisi, J., Panova, N. I., Laezza, F. & Chu, W. K., Jan 1 2014, In : Journal of Applied Physics. 115, 5, 054701.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (Nav1.2) macromolecular complex in mammalian brain

Wildburger, N. C., Ali, S. R., Hsu, W. C. J., Shavkunov, A. S., Nenov, M. N., Lichti, C. F., LeDuc, R. D., Mostovenko, E., Panova-Elektronova, N. I., Emmett, M. R., Nilsson, C. L. & Laezza, F., May 1 2015, In : Molecular and Cellular Proteomics. 14, 5, p. 1288-1300 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Split-luciferase complementation assay to detect channel-protein interactions in live cells

Shavkunov, A. S., Ali, S. R., Panova-Elektronova, N. I. & Laezza, F., Apr 9 2015, Protein-Protein Interactions: Methods and Applications: Second Edition. Springer New York, p. 497-514 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Control of neuronal ion channel function by glycogen synthase kinase-3: New prospective for an old kinase

Wildburger, N. C. & Laezza, F., Jul 16 2012, In : Frontiers in Molecular Neuroscience. JULY 2012

Research output: Contribution to journalReview article

15 Scopus citations
2017

Consequences of acute Nav1.1 exposure to deltamethrin

James, T. F., Nenov, M. N., Tapia, C. M., Lecchi, M., Koshy, S., Green, T. A. & Laezza, F., May 2017, In : NeuroToxicology. 60, p. 150-160 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019

Imaging of the Axon Initial Segment

Di Re, J., Kayasandik, C., Botello-Lins, G., Labate, D. & Laezza, F., 2019, In : Current Protocols in Neuroscience. 89, 1, e78.

Research output: Contribution to journalArticle

2014

Integrative biological analysis for neuropsychopharmacology

Emmett, M. R., Kroes, R. A., Moskal, J. R., Conrad, C. A., Priebe, W., Laezza, F., Meyer-Baese, A. & Nilsson, C. L., Jan 2014, In : Neuropsychopharmacology. 39, 1, p. 5-23 19 p.

Research output: Contribution to journalReview article

16 Scopus citations
2013

Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior

Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In : Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.

Research output: Contribution to journalArticle

25 Scopus citations

The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)

Shavkunov, A. S., Wildburger, N. C., Nenov, M. N., James, T. F., Buzhdygan, T. P., Panova-Elektronova, N. I., Green, T. A., Veselenak, R. L., Bourne, N. & Laezza, F., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19370-19385 16 p.

Research output: Contribution to journalArticle

57 Scopus citations
2015

Split-luciferase complementation assay to detect channel–protein interactions in live cells

Shavkunov, A. S., Ali, S. R., Panova-Elektronova, N. I. & Laezza, F., 2015, In : Methods in Molecular Biology. 1278, p. 497-514 18 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B., Dineley, K. T. & Denner, L., Jan 20 2014, In : Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Efficient processing of fluorescence images using directional multiscale representations

Damanik, D., Ruzhansky, M., Vougalter, V., Wong, M. W., Labate, D., Laezza, F., Negi, P., Ozcan, B. & Papadakis, M., 2014, In : Mathematical Modelling of Natural Phenomena. 9, 5, p. 177-193 17 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses

Sallam, H. S., Tumurbaatar, B., Zhang, W. R., Tuvdendorj, D., Chandalia, M., Tempia, F., Laezza, F., Taglialatela, G. & Abate, N., Apr 2015, In : Journal of neurochemistry. 133, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Automated detection of soma location and morphology in neuronal network cultures

Ozcan, B., Negi, P., Laezza, F., Papadakis, M. & Labate, D., Apr 8 2015, In : PloS one. 10, 4, e0121886.

Research output: Contribution to journalArticle

12 Scopus citations

Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation

Hsu, W. C., Nenov, M. N., Shavkunov, A., Panova, N., Zhan, M. & Laezza, F., Feb 6 2015, In : PloS one. 10, 2, e0117246.

Research output: Contribution to journalArticle

31 Scopus citations

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3

Scala, F., Fusco, S., Ripoli, C., Piacentini, R., Li Puma, D. D., Spinelli, M., Laezza, F., Grassi, C. & D'Ascenzo, M., Feb 1 2015, In : Neurobiology of Aging. 36, 2, p. 886-900 15 p.

Research output: Contribution to journalArticle

34 Scopus citations
2019

Erratum: GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels (Cerebral Cortex (bhy042) DOI: 10.1093/cercor/bhy042)

Aceto, G., Re, A., Mattera, A., Leone, L., Colussi, C., Rinaudo, M., Scala, F., Gironi, K., Barbati, S. A., Fusco, S., Green, T., Laezza, F., D'Ascenzo, M. & Grassi, C., 2019, In : Cerebral Cortex. 29, 12, p. 5315 1 p.

Research output: Contribution to journalComment/debate

Open Access

Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions

Alshammari, T. K., Alghamdi, H., Green, T. A., Niazy, A., Alkahdar, L., Alrasheed, N., Alhosaini, K., Alswayyed, M., Elango, R., Laezza, F., Alshammari, M. A. & Yacoub, H., Oct 1 2019, In : PloS one. 14, 10, e0222818.

Research output: Contribution to journalArticle

Open Access
2015

Parallel fiber to purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27

Tempia, F., Hoxha, E., Negro, G., Alshammari, M. A., Alshammari, T. K., Panova-Elektronova, N. & Laezza, F., Jun 4 2015, In : Frontiers in Cellular Neuroscience. 9, June, p. 1-10 10 p., A205.

Research output: Contribution to journalArticle

24 Scopus citations
2019

GSK3β modulates timing-dependent long-term depression through direct phosphorylation of Kv4.2 channels

Aceto, G., Re, A., Mattera, A., Leone, L., Colussi, C., Rinaudo, M., Scala, F., Gironi, K., Barbati, S. A., Fusco, S., Green, T., Laezza, F., D'Ascenzo, M. & Grassi, C., May 2019, In : Cerebral Cortex. 29, 5, p. 1851-1865 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

The Nav1.2 channel is regulated by GSK3

James, T. F., Nenov, M. N., Wildburger, N. C., Lichti, C. F., Luisi, J., Vergara, F., Panova-Electronova, N. I., Nilsson, C. L., Rudra, J. S., Green, T. A., Labate, D. & Laezza, F., Apr 2015, In : Biochimica et Biophysica Acta - General Subjects. 1850, 4, p. 832-844 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2018

Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

Ali, S. R., Liu, Z., Nenov, M. N., Folorunso, O., Singh, A., Scala, F., Chen, H., James, T. F., Alshammari, M., Panova-Elektronova, N. I., White, M. A., Zhou, J. & Laezza, F., May 16 2018, In : ACS chemical neuroscience. 9, 5, p. 976-987 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2019

High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex

Wadsworth, P. A., Folorunso, O., Nguyen, N., Singh, A. K., D’Amico, D., Powell, R. T., Brunell, D., Allen, J., Stephan, C. & Laezza, F., Dec 1 2019, In : Scientific reports. 9, 1, 16890.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sex-specific proteomic changes induced by genetic deletion of fibroblast growth factor 14 (FGF14), a regulator of neuronal ion channels

Sowers, M. L., Di Re, J., Wadsworth, P. A., Shavkunov, A. S., Lichti, C., Zhang, K. & Laezza, F., Mar 1 2019, In : Proteomes. 7, 1, 5.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2020

Effects of Deltamethrin Acute Exposure on Nav1.6 Channels and Medium Spiny Neurons of the Nucleus Accumbens

Tapia, C. M., Folorunso, O., Singh, A. K., McDonough, K. & Laezza, F., Jul 2020, In : Toxicology. 440, 152488.

Research output: Contribution to journalArticle

2017

PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease

Hsu, W. C. J., Wildburger, N. C., Haidacher, S. J., Nenov, M. N., Folorunso, O., Singh, A. K., Chesson, B. C., Franklin, W. F., Cortez, I., Sadygov, R. G., Dineley, K. T., Rudra, J. S., Taglialatela, G., Lichti, C. F., Denner, L. & Laezza, F., Sep 2017, In : Experimental Neurology. 295, p. 1-17 17 p.

Research output: Contribution to journalArticle

19 Scopus citations
2020

Broader phenotypic traits and widespread brain hypometabolism in spinocerebellar ataxia 27

Paucar, M., Lundin, J., Alshammari, T., Bergendal, Lindefeldt, M., Alshammari, M., Solders, G., Di Re, J., Savitcheva, I., Granberg, T., Laezza, F., Iwarsson, E. & Svenningsson, P., Jul 1 2020, In : Journal of Internal Medicine. 288, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2011

Induction and expression rules of synaptic plasticity in hippocampal interneurons

Laezza, F. & Dingledine, R., Apr 2011, In : Neuropharmacology. 60, 5, p. 720-729 10 p.

Research output: Contribution to journalReview article

15 Scopus citations
2018

Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway

Scala, F., Nenov, M. N., Crofton, E. J., Singh, A. K., Folorunso, O., Zhang, Y., Chesson, B. C., Wildburger, N. C., James, T. F., Alshammari, M. A., Alshammari, T. K., Elfrink, H., Grassi, C., Kasper, J. M., Smith, A. E., Hommel, J. D., Lichti, C. F., Rudra, J. S., D'Ascenzo, M., Green, T. A. & 1 others, Laezza, F., Apr 10 2018, In : Cell Reports. 23, 2, p. 555-567 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2019

Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions

Liu, Z., Wadsworth, P., Singh, A. K., Chen, H., Wang, P., Folorunso, O., Scaduto, P., Ali, S. R., Laezza, F. & Zhou, J., Feb 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

A harmonic analysis view on neuroscience imaging

Hernandez-Herrera, P., Jiménez, D., Kakadiaris, I. A., Koutsogiannis, A., Labate, D., Laezza, F. & Papadakis, M., Jan 1 2013, Applied and Numerical Harmonic Analysis. 9780817683788 ed. Springer International Publishing, p. 423-450 28 p. (Applied and Numerical Harmonic Analysis; no. 9780817683788).

Research output: Chapter in Book/Report/Conference proceedingChapter