Find Research Outputs

Search results

• 2015

  Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  Staloch, D., Gao, X., Liu, K., Xu, M., Feng, X., Aronson, J. F., Falzon, M., Greeley, G. H., Rastellini, C., Chao, C., Hellmich, M. R., Cao, Y. & Ko, T. C., Oct 3 2015, In: Journal of Molecular Medicine. 93, 10, p. 1085-1093 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Pancreatitis
  • Bone Morphogenetic Proteins
  • Transforming Growth Factors
  • Pancreatic Stellate Cells
  • Mouse Grem1 protein
  22 Scopus citations
• 2012

  Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells

  Kim, S. O., Ives, K. L., Wang, X., Davey, R. A., Chao, C. & Hellmich, M. R., Sep 28 2012, In: Journal of Biological Chemistry. 287, 40, p. 33377-33388 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-raf
  • Secretagogues
  • Acinar Cells
  • Cholecystokinin
  • Ethanol
  8 Scopus citations

• Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis

  Bhatia, V., Kim, S. O. K., Aronson, J. F., Chao, C., Hellmich, M. R. & Falzon, M., Apr 10 2012, In: Regulatory Peptides. 175, 1-3, p. 49-60 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Parathyroid Hormone-Related Protein
  • Pancreatitis
  • Ceruletide
  • Acinar Cells
  • Procollagen
  15 Scopus citations
• 2013

  Lymph node involvement in immunohistochemistry-based molecular classifications of breast cancer

  Howland, N. K., Driver, T. D., Sedrak, M. P., Wen, X., Dong, W., Hatch, S., Eltorky, M. A. & Chao, C., Dec 2013, In: Journal of Surgical Research. 185, 2, p. 697-703 7 p.

  Research output: Contribution to journal › Article › peer-review

  • human ERBB2 protein
  • Lymph Nodes
  • Immunohistochemistry
  • Breast Neoplasms
  • Neoplasm Metastasis
  31 Scopus citations
• 2011

  Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells

  Wen, X., Chao, C., Ives, K. & Hellmich, M. R., Jul 11 2011, In: BMC Molecular Biology. 12, 29.

  Research output: Contribution to journal › Article › peer-review

  • Bombesin
  • Cyclooxygenase 2
  • Prostatic Neoplasms
  • Phosphatidylinositol 3-Kinases
  • NF-kappa B
  8 Scopus citations
• 2019

  Apigenin Decreases Acinar Cell Damage in Pancreatitis

  Mrazek, A. A., Bhatia, V., Falzon, M., Spratt, H., Chao, C. & Hellmich, M. R., May 1 2019, In: Pancreas. 48, 5, p. 711-718 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apigenin
  • Acinar Cells
  • Pancreatitis
  • Parathyroid Hormone-Related Protein
  • Transforming Growth Factors
  2 Scopus citations
• 2013

  Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

  Szabo, C., Coletta, C., Chao, C., Módis, K., Szczesny, B., Papapetropoulos, A. & Hellmich, M. R., Jul 23 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 30, p. 12474-12479 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Hydrogen Sulfide
  • Energy Metabolism
  • Colonic Neoplasms
  • Cell Proliferation
  319 Scopus citations
• 2012

  Overview of Personalized Medicine in GI Cancers

  Chao, C., Sep 2012, In: Journal of Gastrointestinal Surgery. 16, 9, p. 1641-1644 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Gastrointestinal Neoplasms
  • Precision Medicine
  • Tumor Biomarkers
  • Drug Therapy
  • Neoplasms
  2 Scopus citations
• 2016

  Cystathionine-β-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach

  Chao, C., Zatarain, J. R., Ding, Y., Coletta, C., Mrazek, A. A., Druzhyna, N., Johnson, P., Chen, H., Hellmich, J. L., Asimakopoulou, A., Yanagi, K., Olah, G., Szoleczky, P., Törö, G., Bohanon, F. J., Cheema, M., Lewis, R., Eckelbarger, D., Ahmad, A., Módis, K. & 6 others, Untereiner, A., Szczesny, B., Papapetropoulos, A., Zhou, J., Hellmich, M. R. & Szabo, C., 2016, In: Molecular Medicine. 22, p. 361-379 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Aminooxyacetic Acid
  • Cystathionine
  • Prodrugs
  • Colonic Neoplasms
  • Neoplasms
  24 Scopus citations
• 2013

  Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy

  Cao, Y., Yang, W., Tyler, M. A., Gao, X., Duan, C., Kim, S. O., Aronson, J. F., Popov, V., Takahashi, H., Saito, H., Evers, B. M., Chao, C., Hellmich, M. R. & Ko, T. C., Mar 2013, In: Pancreas. 42, 2, p. 301-307 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ceruletide
  • Autophagy
  • Pancreatitis
  • Bone Morphogenetic Proteins
  • Acinar Cells
  12 Scopus citations
• 2016

  Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

  Druzhyna, N., Szczesny, B., Olah, G., Módis, K., Asimakopoulou, A., Pavlidou, A., Szoleczky, P., Gerö, D., Yanagi, K., Törö, G., López-García, I., Myrianthopoulos, V., Mikros, E., Zatarain, J. R., Chao, C., Papapetropoulos, A., Hellmich, M. R. & Szabo, C., Nov 1 2016, In: Pharmacological Research. 113, p. 18-37 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Benserazide
  • Cystathionine
  • Investigational Therapies
  • Inhibitory Concentration 50
  • Colonic Neoplasms
  29 Scopus citations
• 2015

  Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivos

  Almahariq, M., Chao, C., Mei, F. C., Hellmich, M. R., Patrikeev, I., Motamedi, M. & Cheng, X., Feb 1 2015, In: Molecular pharmacology. 87, 2, p. 142-149 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms
  • Adenocarcinoma
  • Pharmacology
  • Neoplasm Metastasis
  • Proteins
  28 Scopus citations

• The therapeutic potential of cystathionine β-Synthetase/hydrogen sulfide inhibition in cancer

  Hellmich, M. R., Coletta, C., Chao, C. & Szabo, C., Feb 10 2015, In: Antioxidants and Redox Signaling. 22, 5, p. 424-448 25 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cystathionine beta-Synthase
  • Hydrogen Sulfide
  • Cells
  • Tumors
  • Energy Metabolism
  114 Scopus citations
• 2013

  BMP2 inhibits TGF-β-induced pancreatic stellate cell activation and extracellular matrix formation

  Gao, X., Cao, Y., Yang, W., Duan, C., Aronson, J. F., Rastellini, C., Chao, C., Hellmich, M. R. & Ko, T. C., 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 9, p. G804-G813

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cells
  • Transforming Growth Factors
  • Extracellular Matrix
  • Ceruletide
  • Bone Morphogenetic Proteins
  41 Scopus citations
• 2015

  Apigenin inhibits pancreatic stellate cell activity in pancreatitis

  Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M. R., Jun 1 2015, In: Journal of Surgical Research. 196, 1, p. 8-16 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cells
  • Apigenin
  • Pancreatitis
  • Chronic Pancreatitis
  • Fibrosis
  23 Scopus citations
• 2016

  Isolation of CD 90+ fibroblast/myofibroblasts from human frozen gastrointestinal specimens

  Johnson, P., Beswick, E. J., Chao, C., Powell, D. W., Hellmich, M. R. & Pinchuk, I. V., Jan 31 2016, In: Journal of Visualized Experiments. 2016, 107, e53691.

  Research output: Contribution to journal › Article › peer-review

  • Fibroblasts
  • Myofibroblasts
  • Tissue
  • Immunohistochemistry
  • Flow cytometry
  9 Scopus citations
• 2012

  CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133-cells

  Chao, C., Carmical, J. R., Ives, K. L., Wood, T. G., Aronson, J. F., Gomez, G. A., Djukom, C. D. & Hellmich, M. R., Mar 2012, In: Laboratory Investigation. 92, 3, p. 420-436 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Microenvironment
  • Colonic Neoplasms
  • Fibroblasts
  • Carcinoma
  • Genes
  32 Scopus citations

• Indications for sentinel lymph node biopsy in multifocal and multicentric breast cancer

  Moody, L. C., Wen, X., Washington, T. M. & Chao, C., Sep 2012, In: Surgery (United States). 152, 3, p. 389-396 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sentinel Lymph Node Biopsy
  • Breast Neoplasms
  • Contraindications
  • Meta-Analysis
  • Validation Studies
  15 Scopus citations
• 2018

  Medical Students’ Evaluation of Scientific Evidence and Their Justifications for Their Clinical Decisions: a Pilot Study

  Cestone, C., Lewis, R., Aronson, J. F. & Chao, C., Dec 15 2018, In: Medical Science Educator. 28, 4, p. 587-590 4 p.

  Research output: Contribution to journal › Article › peer-review

  • clinical decisions
  • Medical Students
  • medical student
  • Clinical Decision-Making
  • evaluation
• 2012

  Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin

  Chao, C. & Hellmich, M. R., Dec 1 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 115-154 40 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  2 Scopus citations
• 2013

  Quality of post-treatment surveillance of early stage breast cancer in Texas

  Parmar, A. D., Sheffield, K. M., Vargas, G., Han, Y., Chao, C. & Riall, T. S., Aug 2013, In: Surgery (United States). 154, 2, p. 214-225 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mammography
  • Positron-Emission Tomography
  • Breast Neoplasms
  • Positron Emission Tomography Computed Tomography
  • Magnetic Resonance Imaging
  10 Scopus citations
• 2011

  Malignant phyllodes tumor of the breast: A case report

  Al-Zoubaidi, M., Qiu, S., Bonnen, M., Joyner, M., Roehl, K., Silva, C. & Chao, C., 2011, In: Open Breast Cancer Journal. 3, p. 45-48 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Phyllodes Tumor
  • Breast Neoplasms
  • Stromal Cells
  • Breast
  2 Scopus citations
• 2017

  Patient-derived xenografts from colorectal carcinoma: A temporal and hierarchical study of murine stromal cell replacement

  Chao, C., Widen, S. G., Wood, T. G., Zatarain, J. R., Johnson, P., Gajjar, A., Gomez, G., Qiu, S., Thompson, J., Spratt, H. & Hellmich, M. R., Jul 2017, In: Anticancer Research. 37, 7, p. 3405-3412 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Time and Motion Studies
  • Stromal Cells
  • Heterografts
  • Colorectal Neoplasms
  • Nude Mice
  11 Scopus citations

• Upregulation of cystathionine-β-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis

  Phillips, CN. M., Zatarain, J. R., Nicholls, M. E., Porter, C., Widen, S. G., Thanki, K., Johnson, P., Jawad, M. U., Moyer, M. P., Randall, J. W., Hellmich, J. L., Maskey, M., Qiu, S., Wood, T. G., Druzhyna, N., Szczesny, B., Módis, K., Szabo, C., Chao, C. & Hellmich, M. R., Nov 1 2017, In: Cancer Research. 77, 21, p. 5741-5754 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Carcinogenesis
  • Epithelium
  • Up-Regulation
  • Genes
  28 Scopus citations