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  • Bing Tian
2013

Systems approaches to modeling chronic mucosal inflammation

Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., Nov 18 2013, In : BioMed Research International. 2013, 505864.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-ΚB/RelA signaling network in type II epithelial mesenchymal transition

Tian, B., Li, X., Kalita, M., Widen, S. G., Yang, J., Bhavnani, S. K., Dang, B., Kudlicki, A., Sinha, M., Kong, F., Wood, T. G., Luxon, B. & Brasier, A. R., Jul 18 2015, In : BMC Genomics. 16, 1, 529.

Research output: Contribution to journalArticle

41 Scopus citations
2019

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In : Journal of Proteomics. 205, 103415.

Research output: Contribution to journalArticle

8 Scopus citations
2018

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

Tian, B., Widen, S. G., Yang, J., Wood, T. G., Kudlicki, A., Zhao, Y. & Brasier, A. R., Oct 19 2018, In : Journal of Biological Chemistry. 293, 42, p. 16528-16545 18 p.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Poussard, A. L., Walker, A. G., Brasier, A. R., Zhao, Y., Tian, B., de la Torre, J. C. & Paessler, S., May 2012, In : PLoS neglected tropical diseases. 6, 5, e1659.

Research output: Contribution to journalArticle

43 Scopus citations
2019

Efficacy of novel highly specific bromodomain-containing protein 4 inhibitors in innate inflammation–driven airway remodeling

Tian, B., Liu, Z., Litvinov, J., Maroto, R., Jamaluddin, M., Rytting, E., Patrikeev, I., Ochoa, L., Vargas, G., Motamedi, M., Ameredes, B. T., Zhou, J. & Brasier, A. R., Jan 2019, In : American journal of respiratory cell and molecular biology. 60, 1, p. 68-83 16 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

Komaravelli, N., Tian, B., Ivanciuc, T., Mautemps, N., Brasier, A. R., Garofalo, R. P. & Casola, A., 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 391-403 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry

Zhao, Y., Tian, B., Edeh, C. B. & Brasier, A. R., Jun 2013, In : Molecular and Cellular Proteomics. 12, 6, p. 1513-1529 17 p.

Research output: Contribution to journalArticle

29 Scopus citations
2018

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Apr 24 2018, In : Cell Reports. 23, 4, p. 1138-1151 14 p.

Research output: Contribution to journalArticle

16 Scopus citations
2017

BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Garofalo, R. P. & Brasier, A. R., 2017, In : Journal of virology. 91, 6, e00007-17.

Research output: Contribution to journalArticle

25 Scopus citations
2018

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. R. & Zhou, J., May 10 2018, In : European journal of medicinal chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2011

RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection

Brasier, A. R., Tian, B., Jamaluddin, M., Kalita, M. K., Garofalo, R. P. & Lu, M., Nov 2011, In : Journal of virology. 85, 22, p. 11752-11769 18 p.

Research output: Contribution to journalArticle

63 Scopus citations
2015

Systematic determination of human cyclin dependent kinase (CDK)-9 interactome identifies novel functions in RNA splicing mediated by the DEAD Box (DDX)-5/17 RNA helicases

Yang, J., Zhao, Y., Kalita, M., Li, X., Jamaluddin, M., Tian, B., Edeh, C. B., Wiktorowicz, J. E., Kudlicki, A. & Brasier, A. R., Oct 1 2015, In : Molecular and Cellular Proteomics. 14, 10, p. 2701-2721 21 p.

Research output: Contribution to journalArticle

18 Scopus citations

A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells

Xie, G., Luo, H., Tian, B., Mann, B., Bao, X., McBride, J., Tesh, R., Barrett, A. D. & Wang, T., Feb 11 2015, In : Vaccine. 33, 7, p. 869-878 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011
36 Scopus citations
2020

Bisphenol A Activates an Innate Viral Immune Response Pathway

Sowers, M. L., Tang, H., Tian, B., Goldblum, R., Midoro-Horiuti, T. & Zhang, K., Feb 7 2020, In : Journal of Proteome Research. 19, 2, p. 644-654 11 p.

Research output: Contribution to journalArticle

2019

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2013

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. P. & Brasier, A. R., Jun 2013, In : Journal of virology. 87, 12, p. 7075-7092 18 p.

Research output: Contribution to journalArticle

41 Scopus citations
2011

High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway

Choudhary, S., Rosenblatt, K. P., Fang, L., Tian, B., Wu, Z. H. & Brasier, A. R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37187-37195 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Two-step cross-linking for analysis of protein-chromatin interactions

Tian, B., Yang, J. & Brasier, A. R., 2012, Transcriptional Regulation: Methods and Protocols. Vancura, A. (ed.). p. 105-120 16 p. (Methods in Molecular Biology; vol. 809).

Research output: Chapter in Book/Report/Conference proceedingChapter

59 Scopus citations
2017

NF-κB mediates mesenchymal transition, remodeling, and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns

Tian, B., Patrikeev, I., Ochoa, L., Vargas, G., Belanger, K. A. K., Litvinov, J., Boldogh, I., Ameredes, B. T., Motamedi, M. & Brasier, A. R., Apr 2017, In : American journal of respiratory cell and molecular biology. 56, 4, p. 506-520 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Targeting Chromatin Remodeling in Inflammation and Fibrosis

Yang, J., Tian, B. & Brasier, A. R., 2017, Advances in Protein Chemistry and Structural Biology. Academic Press Inc., p. 1-36 36 p. (Advances in Protein Chemistry and Structural Biology; vol. 107).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Proteome analysis of hypoxic glioblastoma cells reveals sequential metabolic adaptation of one-carbon metabolic pathways

Zhang, K., Xu, P., Sowers, J. L., Machuca, D. F., Mirfattah, B., Herring, J., Tang, H., Chen, Y., Tian, B., Brasier, A. R. & Sowers, L. C., Nov 2017, In : Molecular and Cellular Proteomics. 16, 11, p. 1906-1921 16 p.

Research output: Contribution to journalArticle

5 Scopus citations
13 Scopus citations
2016

Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

Zhao, Y., Tian, B., Sadygov, R., Zhang, Y. & Brasier, A. R., Oct 4 2016, In : Journal of Proteomics. 148, p. 126-138 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2020

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

Liu, Z., Chen, H., Wang, P., Li, Y., Wold, E. A., Leonard, P. G., Joseph, S., Brasier, A. R., Tian, B., Tian, B., Zhou, J., Zhou, J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5242-5256 15 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016
3 Scopus citations
2017

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of medicinal chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

96 Scopus citations
2020

Peli1 signaling blockade attenuates congenital zika syndrome

Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 2020, In : PLoS pathogens. 16, 6, e1008538.

Research output: Contribution to journalArticle

Open Access
2016
37 Scopus citations
2015

Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks

Desai, P., Yang, J., Tian, B., Sun, H., Kalita, M., Ju, H., Paulucci-Holthauzen, A., Zhao, Y., Brasier, A. R. & Sadygov, R. G., Jul 1 2015, In : Cellular Signalling. 27, 7, p. 1413-1425 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images

Kalita, M. K., Sargsyan, K., Tian, B., Paulucci-Holthauzen, A., Najm, H. N., Debusschere, B. J. & Brasier, A. R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37741-37757 17 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Inducible Tumor Necrosis Factor (TNF) receptor-associated factor-1 expression couples the canonical to the non-canonical NF-κB pathway in TNF stimulation

Choudhary, S., Kalita, M., Fang, L., Patel, K. V., Tian, B., Zhao, Y., Edeh, C. B. & Brasier, A. R., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14612-14623 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 20-33 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
2019

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In : Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

Research output: Contribution to journalArticle

13 Scopus citations
2018

Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia

Graber, T. G., Rawls, B. L., Tian, B., Durham, W. J., Brightwell, C. R., Brasier, A. R., Rasmussen, B. B. & Fry, C. S., Jun 2018, In : Experimental Gerontology. 106, p. 88-100 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing

Ochoa, L. F., Kholodnykh, A., Villarreal, P., Tian, B., Pal, R., Freiberg, A. N., Brasier, A. R., Motamedi, M. & Vargas, G., Dec 1 2018, In : Scientific reports. 8, 1, 13348.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection

Fang, L., Choudhary, S., Tian, B., Boldogh, I., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R. P. & Brasier, A. R., Jan 1 2015, In : Journal of virology. 89, 5, p. 2628-2642 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
2018

Central role of the NF-κB pathway in the Scgb1a1-expressing epithelium in mediating respiratory syncytial virus-induced airway inflammation

Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Wakamiya, M., Garofalo, R. P. & Brasier, A., Jun 1 2018, In : Journal of Virology. 92, 11, e00441-18.

Research output: Contribution to journalArticle

11 Scopus citations