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  • Yuhui Yin
2015

Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

Meyer, A. J., Garry, D. J., Hall, B., Byrom, M. M., McDonald, H. G., Yang, X., Yin, Y. W. & Ellington, A. D., Jul 7 2015, In : Nucleic acids research. 43, 15, p. 7480-7488 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2020

Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles

Singh, A., Pandey, M., Nandakumar, D., Raney, K. D., Yin, Y. W. & Patel, S. S., Mar 16 2020, In : EMBO Journal. 39, 6, e103367.

Research output: Contribution to journalArticle

Open Access
2016

The yeast mitochondrial RNA polymerase and transcription factor complex catalyzes efficient priming of DNA synthesis on single-stranded DNA

Ramachandran, A., Nandakumar, D., Deshpande, A. P., Lucas, T. P., R-Bhojappa, R., Tang, G. Q., Raney, K., Yin, Y. & Patel, S. S., Aug 5 2016, In : Journal of Biological Chemistry. 291, 32, p. 16828-16839 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Structural insight on processivity, human disease and antiviral drug toxicity

Yin, Y. W., Feb 2011, In : Current Opinion in Structural Biology. 21, 1, p. 83-91 9 p.

Research output: Contribution to journalReview article

2 Scopus citations
2020

Structural Energy Landscapes and Plasticity of the Microstates of Apo Escherichia coli cAMP Receptor Protein

Chkheidze, R., Evangelista, W., White, M. A., Yin, Y. W. & Lee, J. C., Feb 4 2020, In : Biochemistry. 59, 4, p. 460-470 11 p.

Research output: Contribution to journalArticle

2015

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

Sohl, C. D., Szymanski, M. R., Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S. & Yin, Y. W., Jul 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 28, p. 8596-8601 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Yeast mitochondrial transcription factor Mtf1 determines the precision of promoter-directed initiation of RNA polymerase Rpo41

Yang, X., Chang, H. R. & Yin, Y. W., Sep 2 2015, In : PloS one. 10, 9, e0136879.

Research output: Contribution to journalArticle

4 Scopus citations
2016

The DNA polymerase gamma R953C mutant is associated with antiretroviral therapy-induced mitochondrial toxicity

Li, M., Mislak, A. C., Foli, Y., Agbosu, E., Bose, V., Bhandari, S., Szymanski, M. R., Shumate, C. K., Yin, Y. W., Anderson, K. S. & Paintsil, E., Sep 1 2016, In : Antimicrobial agents and chemotherapy. 60, 9, p. 5608-5611 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

Szymanski, M. R., Kuznetsov, V. B., Shumate, C., Meng, Q., Lee, Y. S., Patel, G., Patel, S. & Yin, Y. W., 2015, In : EMBO Journal. 34, 14, p. 1959-1970 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Selective inhibition of bacterial tryptophanyl-tRNA synthetases by indolmycin is mechanism-based

Williams, T. L., Yin, Y. W. & Carter, C. W., Jan 1 2016, In : Journal of Biological Chemistry. 291, 1, p. 255-265 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2019

Networked Communication between Polymerase and Exonuclease Active Sites in Human Mitochondrial DNA Polymerase

Sowers, M. L., Anderson, A. P. P., Wrabl, J. O. & Yin, Y. W., Jul 10 2019, In : Journal of the American Chemical Society. 141, 27, p. 10821-10829 9 p.

Research output: Contribution to journalArticle

2017

A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

Szymanski, M. R., Yu, W., Gmyrek, A. M., White, M. A., Molineux, I. J., Lee, J. C. & Yin, Y. W., 2017, In : Nature communications. 8, 14959.

Research output: Contribution to journalArticle

8 Scopus citations
2018
12 Scopus citations
2020

Transcription polymerase-catalyzed emergence of novel RNA replicons

Jain, N., Blauch, L. R., Szymanski, M. R., Das, R., Tang, S. K. Y., Yin, Y. W. & Fire, A. Z., Apr 10 2020, In : Science. 368, 6487, eaay0688.

Research output: Contribution to journalArticle

1 Scopus citations
2019
3 Scopus citations
2020

Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity

Anderson, A. P., Luo, X., Russell, W. & Yin, Y. W., Jan 24 2020, In : Nucleic acids research. 48, 2, p. 817-829 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations