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  • Rakez Kayed
2016

Oligomer Formation and Cross-Seeding: The New Frontier

Farmer, K., Gerson, J. E. & Kayed, R., 2016, (Accepted/In press) In : Israel Journal of Chemistry.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Oligomeric tau-targeted immunotherapy in Tg4510 mice

Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In : Alzheimer's Research and Therapy. 9, 1, 46.

Research output: Contribution to journalArticle

5 Scopus citations

Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls

Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In : Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In : Protein Science. 27, 11, p. 1901-1909 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart

Troncone, L., Luciani, M., Coggins, M., Wilker, E. H., Ho, C. Y., Codispoti, K. E., Frosch, M. P., Kayed, R. & del Monte, F., Dec 6 2016, In : Journal of the American College of Cardiology. 68, 22, p. 2395-2407 13 p.

Research output: Contribution to journalArticle

52 Scopus citations
2018

Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

Research output: Contribution to conferenceAbstract

2016

Therapeutic approaches targeting pathological tau aggregates

Gerson, J. & Kayed, R., Jul 1 2016, In : Current Pharmaceutical Design. 22, 26, p. 4028-4039 12 p.

Research output: Contribution to journalReview article

7 Scopus citations
2014

Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles

Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Mark Estes, D., Barrett, A. D. T., Dineley, K. T., Jackson, G. R. & Kayed, R., 2014, In : Journal of Neuroscience. 34, 12, p. 4260-4272 13 p.

Research output: Contribution to journalArticle

150 Scopus citations
2016

Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity

Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In : Scientific reports. 6, 35865.

Research output: Contribution to journalArticle

8 Scopus citations
2012

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 1 2012, In : Journal of neurochemistry. 120, 3, p. 440-452 13 p.

Research output: Contribution to journalArticle

61 Scopus citations
2016

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In : EBioMedicine. 6, p. 42-49 8 p.

Research output: Contribution to journalArticle

220 Scopus citations
2019

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In : Scientific reports. 9, 1, 19011.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2020

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In : Progress in Neurobiology. 184, 101716.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations
2017

Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In : Aging and Disease. 8, 3, p. 257-266 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2018

Azure C Targets and Modulates Toxic Tau Oligomers

Lo Cascio, F. & Kayed, R., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1657

Research output: Contribution to journalMeeting Abstract

2017
15 Scopus citations
2018

Preparation and characterization of tau oligomer strains

Sengupta, U., Carretero-Murillo, M. & Kayed, R., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2015

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In : Aging cell. 14, 5, p. 715-724 10 p.

Research output: Contribution to journalReview article

35 Scopus citations
2016

Advances in tau immunotherapy

Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2019

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In : Nature. 575, 7784, p. 669-673 5 p.

Research output: Contribution to journalArticle

56 Scopus citations
2017

Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo

Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations
2019

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2014

Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L. & Kayed, R., Apr 15 2014, In : Biochemical Pharmacology. 88, 4, p. 468-478 11 p.

Research output: Contribution to journalReview article

77 Scopus citations
2020

Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In : Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.

Research output: Contribution to journalArticle

Open Access
2018

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In : Molecular Neurodegeneration. 13, 1, 13.

Research output: Contribution to journalArticle

17 Scopus citations
2015

A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In : eLife. 4, MAY, p. 1-46 46 p., e07558.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., Nov 7 2012, In : Scientific reports. 2, 700.

Research output: Contribution to journalArticle

239 Scopus citations

Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In : Frontiers in Neurology. JAN, Article 5.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Tau aggregates as immunotherapeutic targets

Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In : Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2019

Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

Sengupta, U. & Kayed, R., Jan 1 2019, In : Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2013

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Jan 1 2013, In : Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

Research output: Contribution to journalReview article

193 Scopus citations
2020

Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies

Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In : Cell Death and Disease. 11, 5, 314.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2016

Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In : Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2014

Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds

Castillo-Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A. & Kayed, R., 2014, In : Journal of Alzheimer's Disease. 40, S1, p. S97-S111

Research output: Contribution to journalArticle

87 Scopus citations
2020

Advances and considerations in AD tau-targeted immunotherapy

Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In : Neurobiology of Disease. 134, 104707.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations
2015

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In : Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

Research output: Contribution to journalArticle

78 Scopus citations
2014

Characterization of tau oligomeric seeds in progressive supranuclear palsy

Gerson, J. E., Sengupta, U., Lasagna-Reeves, C. A., Guerrero-Muñoz, M. J., Troncoso, J. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 73.

Research output: Contribution to journalArticle

42 Scopus citations
2019

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
2012

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations
2014

Advances in therapeutics for neurodegenerative tauopathies: Moving toward the specific targeting of the most toxic tau species

Gerson, J. E., Castillo-Carranza, D. L. & Kayed, R., Sep 17 2014, In : ACS chemical neuroscience. 5, 9, p. 752-769 18 p.

Research output: Contribution to journalReview article

34 Scopus citations
2018

Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In : npj Vaccines. 3, 1, 9.

Research output: Contribution to journalArticle

22 Scopus citations
2015

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In : Neurobiology of Disease. 82, p. 540-551 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In : eLife. 4, DECEMBER2015, e10891.

Research output: Contribution to journalArticle

9 Scopus citations
2018
10 Scopus citations
2012

Tau protein: Function and pathology

Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In : International Journal of Alzheimer's Disease. 707482.

Research output: Contribution to journalEditorial

6 Scopus citations
2016

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

Kim, Y., Choi, H., Lee, W., Park, H., Kam, T. I., Hong, S. H., Nah, J., Jung, S., Shin, B., Lee, H., Choi, T. Y., Choo, H., Kim, K. K., Choi, S. Y., Kayed, R. & Jung, Y. K., Mar 1 2016, In : Neurobiology of Disease. 87, p. 19-28 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Tau Immunotherapy for Alpha-Synucleinopathy

Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1442

Research output: Contribution to journalMeeting Abstract