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• 2018

  Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation

  Oláh, G., Módis, K., Törö, G., Hellmich, M. R., Szczesny, B. & Szabo, C., Mar 2018, In: Biochemical Pharmacology. 149, p. 186-204 19 p.

  Research output: Contribution to journal › Article › peer-review

  • carbon sulfide
  • Gasotransmitters
  • Cell proliferation
  • Hydrogen Sulfide
  • HCT116 Cells
  28 Scopus citations
• 2015

  Hydrogen sulfide and cancer

  Hellmich, M. R. & Szabo, C., 2015, In: Handbook of Experimental Pharmacology. 230, p. 233-241 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydrogen Sulfide
  • Tumors
  • Energy Metabolism
  • Cells
  • Tissue
  86 Scopus citations
• 2016

  Isolation of CD 90+ fibroblast/myofibroblasts from human frozen gastrointestinal specimens

  Johnson, P., Beswick, E. J., Chao, C., Powell, D. W., Hellmich, M. R. & Pinchuk, I. V., Jan 31 2016, In: Journal of Visualized Experiments. 2016, 107, e53691.

  Research output: Contribution to journal › Article › peer-review

  • Fibroblasts
  • Myofibroblasts
  • Tissue
  • Immunohistochemistry
  • Flow cytometry
  9 Scopus citations
• 2017

  Patient-derived xenografts from colorectal carcinoma: A temporal and hierarchical study of murine stromal cell replacement

  Chao, C., Widen, S. G., Wood, T. G., Zatarain, J. R., Johnson, P., Gajjar, A., Gomez, G., Qiu, S., Thompson, J., Spratt, H. & Hellmich, M. R., Jul 2017, In: Anticancer Research. 37, 7, p. 3405-3412 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Time and Motion Studies
  • Stromal Cells
  • Heterografts
  • Colorectal Neoplasms
  • Nude Mice
  11 Scopus citations
• 2012

  Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin

  Chao, C. & Hellmich, M. R., Dec 1 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 115-154 40 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  2 Scopus citations
• 2017

  Upregulation of cystathionine-β-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis

  Phillips, CN. M., Zatarain, J. R., Nicholls, M. E., Porter, C., Widen, S. G., Thanki, K., Johnson, P., Jawad, M. U., Moyer, M. P., Randall, J. W., Hellmich, J. L., Maskey, M., Qiu, S., Wood, T. G., Druzhyna, N., Szczesny, B., Módis, K., Szabo, C., Chao, C. & Hellmich, M. R., Nov 1 2017, In: Cancer Research. 77, 21, p. 5741-5754 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Carcinogenesis
  • Epithelium
  • Up-Regulation
  • Genes
  28 Scopus citations
• 2016

  Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

  Szczesny, B., Marcatti, M., Zatarain, J. R., Druzhyna, N., Wiktorowicz, J. E., Nagy, P., Hellmich, M. R. & Szabo, C., Nov 3 2016, In: Scientific reports. 6, 36125.

  Research output: Contribution to journal › Article › peer-review

  • Hydrogen Sulfide
  • Adenocarcinoma of Lung
  • Mitochondrial DNA
  • DNA Repair
  • Energy Metabolism
  43 Scopus citations
• 2015

  Apigenin inhibits pancreatic stellate cell activity in pancreatitis

  Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M. R., Jun 1 2015, In: Journal of Surgical Research. 196, 1, p. 8-16 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cells
  • Apigenin
  • Pancreatitis
  • Chronic Pancreatitis
  • Fibrosis
  23 Scopus citations

• Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivos

  Almahariq, M., Chao, C., Mei, F. C., Hellmich, M. R., Patrikeev, I., Motamedi, M. & Cheng, X., Feb 1 2015, In: Molecular pharmacology. 87, 2, p. 142-149 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms
  • Adenocarcinoma
  • Pharmacology
  • Neoplasm Metastasis
  • Proteins
  28 Scopus citations

• The therapeutic potential of cystathionine β-Synthetase/hydrogen sulfide inhibition in cancer

  Hellmich, M. R., Coletta, C., Chao, C. & Szabo, C., Feb 10 2015, In: Antioxidants and Redox Signaling. 22, 5, p. 424-448 25 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cystathionine beta-Synthase
  • Hydrogen Sulfide
  • Cells
  • Tumors
  • Energy Metabolism
  114 Scopus citations
• 2012

  Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells

  Kim, S. O., Ives, K. L., Wang, X., Davey, R. A., Chao, C. & Hellmich, M. R., Sep 28 2012, In: Journal of Biological Chemistry. 287, 40, p. 33377-33388 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-raf
  • Secretagogues
  • Acinar Cells
  • Cholecystokinin
  • Ethanol
  8 Scopus citations
• 2015

  The Multidisciplinary Translational Team (MTT) Model for Training and Development of Translational Research Investigators

  Ameredes, B. T., Hellmich, M. R., Cestone, C. M., Wooten, K. C., Ottenbacher, K. J., Chonmaitree, T., Anderson, K. E. & Brasier, A. R., Oct 2015, In: Clinical and translational science. 8, 5, p. 533-541 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Translational Medical Research
  • Research Personnel
  • Interdisciplinary Research
  • Mentoring
  • Health
  12 Scopus citations

• Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  Staloch, D., Gao, X., Liu, K., Xu, M., Feng, X., Aronson, J. F., Falzon, M., Greeley, G. H., Rastellini, C., Chao, C., Hellmich, M. R., Cao, Y. & Ko, T. C., Oct 3 2015, In: Journal of Molecular Medicine. 93, 10, p. 1085-1093 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Pancreatitis
  • Bone Morphogenetic Proteins
  • Transforming Growth Factors
  • Pancreatic Stellate Cells
  • Mouse Grem1 protein
  22 Scopus citations
• 2016

  Cystathionine-β-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach

  Chao, C., Zatarain, J. R., Ding, Y., Coletta, C., Mrazek, A. A., Druzhyna, N., Johnson, P., Chen, H., Hellmich, J. L., Asimakopoulou, A., Yanagi, K., Olah, G., Szoleczky, P., Törö, G., Bohanon, F. J., Cheema, M., Lewis, R., Eckelbarger, D., Ahmad, A., Módis, K. & 6 others, Untereiner, A., Szczesny, B., Papapetropoulos, A., Zhou, J., Hellmich, M. R. & Szabo, C., 2016, In: Molecular Medicine. 22, p. 361-379 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Aminooxyacetic Acid
  • Cystathionine
  • Prodrugs
  • Colonic Neoplasms
  • Neoplasms
  24 Scopus citations
• 2018

  Drug resistance induces the upregulation of H₂S-producing enzymes in HCT116 colon cancer cells

  Untereiner, A. A., Pavlidou, A., Druzhyna, N., Papapetropoulos, A., Hellmich, M. R. & Szabo, C., Mar 2018, In: Biochemical Pharmacology. 149, p. 174-185 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cells
  • Fluorouracil
  • Drug Resistance
  • Colonic Neoplasms
  • Up-Regulation
  28 Scopus citations
• 2017

  H₂S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells

  Untereiner, A. A., Oláh, G., Módis, K., Hellmich, M. R. & Szabo, C., Jul 15 2017, In: Biochemical Pharmacology. 136, p. 86-98 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Energy Metabolism
  • GYY 4137
  • L-Lactate Dehydrogenase
  • Cells
  • Colonic Neoplasms
  26 Scopus citations
• 2020

  3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

  Abdollahi Govar, A., Törő, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. & Módis, K., Feb 1 2020, In: British Journal of Pharmacology. 177, 4, p. 866-883 18 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-mercaptopyruvic acid
  • Energy Metabolism
  • Endothelial Cells
  • Hydrogen Sulfide
  • Small Interfering RNA
  7 Scopus citations
• 2016

  Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

  Druzhyna, N., Szczesny, B., Olah, G., Módis, K., Asimakopoulou, A., Pavlidou, A., Szoleczky, P., Gerö, D., Yanagi, K., Törö, G., López-García, I., Myrianthopoulos, V., Mikros, E., Zatarain, J. R., Chao, C., Papapetropoulos, A., Hellmich, M. R. & Szabo, C., Nov 1 2016, In: Pharmacological Research. 113, p. 18-37 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Benserazide
  • Cystathionine
  • Investigational Therapies
  • Inhibitory Concentration 50
  • Colonic Neoplasms
  29 Scopus citations
• 2012

  CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133-cells

  Chao, C., Carmical, J. R., Ives, K. L., Wood, T. G., Aronson, J. F., Gomez, G. A., Djukom, C. D. & Hellmich, M. R., Mar 2012, In: Laboratory Investigation. 92, 3, p. 420-436 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Microenvironment
  • Colonic Neoplasms
  • Fibroblasts
  • Carcinoma
  • Genes
  32 Scopus citations

• Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis

  Bhatia, V., Kim, S. O. K., Aronson, J. F., Chao, C., Hellmich, M. R. & Falzon, M., Apr 10 2012, In: Regulatory Peptides. 175, 1-3, p. 49-60 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Parathyroid Hormone-Related Protein
  • Pancreatitis
  • Ceruletide
  • Acinar Cells
  • Procollagen
  15 Scopus citations