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• 2016

  Ehrlichia chaffeensis exploits canonical and noncanonical host Wnt signaling pathways to stimulate phagocytosis and promote intracellular survival

  Luo, T., Dunphy, P. S., Lina, T. T. & McBride, J. W., Mar 1 2016, In: Infection and immunity. 84, 3, p. 686-700 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Wnt Signaling Pathway
  • Tandem Repeat Sequences
  • Phagocytosis
  • Catenins
  26 Scopus citations

• The Prostaglandin E₂-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation

  Wang, X., Shaw, D. K., Hammond, H. L., Sutterwala, F. S., Rayamajhi, M., Shirey, K. A., Perkins, D. J., Bonventre, J. V., Velayutham, T. S., Evans, S. M., Rodino, K. G., VieBrock, L., Scanlon, K. M., Carbonetti, N. H., Carlyon, J. A., Miao, E. A., McBride, J. W., Kotsyfakis, M. & Pedra, J. H. F., Aug 2016, In: PLoS pathogens. 12, 8, e1005803.

  Research output: Contribution to journal › Article › peer-review

  • Anaplasma phagocytophilum
  • Inflammasomes
  • Dinoprostone
  • Anaplasmosis
  • Interleukin-18
  15 Scopus citations
• 2018

  Ehrlichia chaffeensis TRP32 nucleomodulin function and localization is regulated by NEDD4L-mediated ubiquitination

  Farris, T. R., Zhu, B., Wang, J. Y. & McBride, J. W., Jan 11 2018, In: Frontiers in Cellular and Infection Microbiology. 7, JAN, 534.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Ubiquitination
  • Lysine
  • Ubiquitin-Protein Ligases
  • Ligases
  4 Scopus citations

• Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response

  Kibler, C. E., Milligan, S. L., Farris, T. R., Zhu, B., Mitra, S. & McBride, J. W., Nov 2018, In: PloS one. 13, 11, e0205983.

  Research output: Contribution to journal › Article › peer-review

  • MYND Domains
  • Ehrlichia chaffeensis
  • Signal transduction
  • Genes
  • signal transduction
  6 Scopus citations
• 2013

  Genetic diversity of Ehrlichia canis in Brazil

  Aguiar, D. M., Zhang, X., Melo, A. L. T., Pacheco, T. A., Meneses, A. M. C., Zanutto, M. S., Horta, M. C., Santarém, V. A., Camargo, L. M. A., McBride, J. W. & Labruna, M. B., 2013, In: Veterinary Microbiology. 164, 3-4, p. 315-321 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia canis
  • Genetic Variation
  • Brazil
  • Genotype
  • genetic variation
  34 Scopus citations

• Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

  Dunphy, P. S., Luo, T. & McBride, J. W., Dec 1 2013, In: Microbes and Infection. 15, 14-15, p. 1005-1016 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Ehrlichia
  • Tandem Repeat Sequences
  • Phagocytes
  • Gram-Negative Bacteria
  18 Scopus citations
• 2019

  Bacterial manipulation of wnt signaling: A host-pathogen tug-of-wnt

  Rogan, M. R., Patterson, L. L., Wang, J. Y. & McBride, J. W., 2019, In: Frontiers in immunology. 10, OCT, 2390.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Wnt Signaling Pathway
  • Bacterial Infections
  • Viral Tropism
  • Organogenesis
  • Survival
  4 Scopus citations
• 2017

  Ehrlichia chaffeensis tandem repeat effector targets differentially influence infection

  Luo, T., Dunphy, P. S. & McBride, J. W., May 12 2017, In: Frontiers in Cellular and Infection Microbiology. 7, MAY, 178.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Tandem Repeat Sequences
  • Infection
  • Proteins
  • Morula
  6 Scopus citations
• 2016

  Rapid identification of ubiquitination and SUMOylation target sites by microfluidic peptide array

  Zhu, B., Farris, T. R., Milligan, S. L., Chen, H., Zhu, R., Hong, A., Zhou, X., Gao, X. & McBride, J. W., Mar 1 2016, In: Biochemistry and Biophysics Reports. 5, p. 430-438 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sumoylation
  • Microfluidics
  • Ubiquitination
  • Ubiquitin
  • Identification (control systems)
  10 Scopus citations
• 2014

  A novel Ehrlichia genotype strain distinguished by the TRP36 gene naturally infects cattle in Brazil and causes clinical manifestations associated with ehrlichiosis

  Aguiar, D. M., Ziliani, T. F., Zhang, X., Melo, A. L. T., Braga, Í. A., Witter, R., Freitas, L. C., Rondelli, A. L. H., Luis, M. A., Sorte, E. C. B., Jaune, F. W., Santarém, V. A., Horta, M. C., Pescador, C. A., Colodel, E. M., Soares, H. S., Pacheco, R. C., Onuma, S. S. M., Labruna, M. B. & McBride, J. W., Sep 2014, In: Ticks and Tick-borne Diseases. 5, 5, p. 537-544 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • ehrlichiosis
  • Ehrlichiosis
  • Brazil
  • Cattle
  39 Scopus citations
• 2016

  Ehrlichia chaffeensis TRP32 is a nucleomodulin that directly regulates expression of host genes governing differentiation and proliferation

  Farris, T. R., Dunphy, P. S., Zhu, B., Kibler, C. E. & McBride, J. W., 2016, In: Infection and immunity. 84, 11, p. 3182-3194 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Gene Expression
  • trityrosine
  • Genes
  • MicroRNAs
  13 Scopus citations
• 2019

  Ehrlichia chaffeensis outer membrane protein 1-specific human antibody-mediated immunity is defined by intracellular TRIM21-dependent innate immune activation and extracellular neutralization

  Velayutham, T. S., Kumar, S., Zhang, X., Kose, N., Walker, D. H., Winslow, G., Crowe, J. E. & McBride, J. W., Dec 1 2019, In: Infection and immunity. 87, 12, e00383-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ehrlichia chaffeensis
  • Ehrlichia
  • Membrane Proteins
  • Immunity
  • Autophagy
  3 Scopus citations
• 2014

  Ehrlichia chaffeensis exploits Host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival

  Dunphy, P. S., Luo, T. & McBride, J. W., 2014, In: Infection and immunity. 82, 10, p. 4154-4168 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Sumoylation
  • Ubiquitin
  • Survival
  • Tandem Repeat Sequences
  36 Scopus citations

• Advances in vaccines, diagnostics and pathobiology

  McBride, J. W., 2014, Ehrlichia.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2016

  Ehrlichia chaffeensis TRP120 activates canonical notch signaling to downregulate TLR2/4 expression and promote intracellular survival

  Lina, T. T., Dunphy, P. S., Luo, T. & McBride, J. W., Jul 1 2016, In: mBio. 7, 4, e00672-16.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Down-Regulation
  • ADAM17 Protein
  21 Scopus citations
• 2018

  Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain

  Klema, V. J., Sepuru, K. M., Füllbrunn, N., Farris, T. R., Dunphy, P. S., McBride, J. W., Rajarathnam, K. & Choi, K. H., Apr 2018, In: PloS one. 13, 4, e0194891.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Tandem Repeat Sequences
  • tandem repeat sequences
  • DNA
  • Proteins
  5 Scopus citations

• Ehrlichia chaffeensis TRP120 effector targets and recruits host polycomb group proteins for degradation to promote intracellular infection

  Mitra, S., Dunphy, P. S., Das, S., Zhu, B., Luo, T. & McBride, J. W., Apr 1 2018, In: Infection and immunity. 86, 4, e00845-17.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Polycomb-Group Proteins
  • Polycomb Repressive Complex 1
  • Proteolysis
  • Protein Isoforms
  6 Scopus citations
• 2017

  Engineering of obligate intracellular bacteria: Progress, challenges and paradigms

  McClure, E. E., Chávez, A. S. O., Shaw, D. K., Carlyon, J. A., Ganta, R. R., Noh, S. M., Wood, D. O., Bavoil, P. M., Brayton, K. A., Martinez, J. J., McBride, J. W., Valdivia, R. H., Munderloh, U. G. & Pedra, J. H. F., Sep 1 2017, In: Nature Reviews Microbiology. 15, 9, p. 544-558 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Bacteria
  • Coxiella
  • Anaplasma
  • Ehrlichia
  • Rickettsia
  40 Scopus citations
• 2018

  Ehrlichia chaffeensis TRP75 interacts with host cell targets involved in homeostasis, cytoskeleton organization, and apoptosis regulation to promote infection

  Luo, T., Mitra, S. & McBride, J. W., Mar 1 2018, In: mSphere. 3, 2, 14718.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ehrlichia chaffeensis
  • Cytoskeleton
  • Homeostasis
  • Apoptosis
  • Tandem Repeat Sequences
  2 Scopus citations
• 2017

  Ehrlichia chaffeensis TRP120 moonlights as a HECT E3 ligase involved in selfand host ubiquitination to influence protein interactions and stability for intracellular survival

  Zhu, B., Das, S., Mitra, S., Farris, T. R. & McBride, J. W., Sep 1 2017, In: Infection and immunity. 85, 9, e00290-17.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Protein Stability
  • Ubiquitin-Protein Ligases
  • Ubiquitination
  • Ubiquitin
  9 Scopus citations

• Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis

  Ismail, N. & McBride, J. W., Jun 2017, In: Clinics in Laboratory Medicine. 37, 2, p. 317-340 24 p.

  Research output: Contribution to journal › Review article › peer-review

  • Anaplasmosis
  • Ehrlichiosis
  • Tick-Borne Diseases
  • Anaplasma
  • Macrophages
  58 Scopus citations
• 2016

  Hacker within! Ehrlichia chaffeensis effector driven phagocyte reprogramming strategy

  Lina, T. T., Farris, T., Luo, T., Mitra, S., Zhu, B. & McBride, J. W., May 31 2016, In: Frontiers in Cellular and Infection Microbiology. 6, MAY, 58.

  Research output: Contribution to journal › Review article › peer-review

  • Ehrlichia chaffeensis
  • Phagocytes
  • Ehrlichia
  • Ehrlichiosis
  • Ankyrin Repeat
  17 Scopus citations

• Detection of genotype-specific Ehrlichia canis exposure in Brazilian dogs by TRP36 peptide ELISA

  Aguiar, D. M., Zhang, X., Braga, I. A., Taques, I. I. G. G. & McBride, J. W., Feb 2016, In: Ticks and Tick-borne Diseases. 7, 1, p. 142-145 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia canis
  • enzyme-linked immunosorbent assay
  • dogs
  • Genotype
  • Dogs
  10 Scopus citations
• 2013

  Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis

  Thirumalapura, N. R., Crocquet-Valdes, P. A., Saito, T. B., Thomas, S., McBride, J. W. & Walker, D. H., Dec 5 2013, In: Vaccine. 31, 50, p. 5960-5967 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • ehrlichiosis
  • Ehrlichiosis
  • Tandem Repeat Sequences
  • Ehrlichia chaffeensis
  4 Scopus citations
• 2015

  A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells

  Xie, G., Luo, H., Tian, B., Mann, B., Bao, X., McBride, J., Tesh, R., Barrett, A. D. & Wang, T., Feb 11 2015, In: Vaccine. 33, 7, p. 869-878 10 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • cytokines
  • macrophages
  • Macrophages
  • Cytokines
  4 Scopus citations
• 2014

  Pathogenesis of Infectious Diseases and Mechanisms of Immunity

  McBride, J. & Walker, D., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 59-72 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Communicable Diseases
  • Immunity
  • Vaccines
  • Host-Pathogen Interactions
  • Antibodies