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• 2017

  Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

  Brix, K. A., Brody, D. L., Grimes, J. B., Yitzhak, A., Agoston, D., Aldag, M., Armstrong, R., Arun, P., Audette, M., Babcock, D., Balaban, C., Banton, R., Bellgowan, P., Borkholder, D., Broglio, S., Brokaw, E., Cantu, R., Carr, W., Chapman, S., Cmarik, J. & 96 others, Colder, B., Colombe, J., Cook, D., Cozzarelli, T., Da Silva, U. O., Daphalapurkar, N., Dardzinski, B., DeGraba, T., DeMar, J., DeWitt, D., Dickstein, D., Duckworth, J., Elder, G., Fazel-Rezai, R., Fine, M., Fiskum, G., Fournier, A., Ganpule, S., Gill, J., Glenn, J. F., Greene, C., Greig, N., Haering, C., Harrington, J., Hein, A., Helmick, K., Hicks, R., Hinds, S., Hoffman, S., Horkayne-Szakaly, I., Iacono, D., Ishii, E., Jones, R. V., Karami, G., Krawczyk, D., Labutta, R., Latta, R., Lattimore, T., Leggieri, M., Leonessa, F., Lin, A., Ling, G., Long, M., Lu, K. P., Panker, S. M., McCabe, J., Merkle, A., Montenigro, P., Mueller, G. P., Ng, L., Nigam, S., O'Donnell, J., Okonkwo, D., Pauli, I., Perl, D., Peskind, E., Pfister, B., Philippens, M., Piehler, T., Proctor, J., Przekwas, A., Qashu, F., Raskind, M., Razumovsky, A., Reifman, J., Reyes, P., Rigby, P., Risling, M., Robinson, M., Rooks, T., Rosen, C., Rosseau, G., Sammons-Jackson, W., Santago, A., Shoge, R., Sours, C., Stone, J., Templin, M., Tepe, V., Thielen, P., Thomas, M., Timmes, T., Tortella, F., Tucker, L., Tweedie, D., Hamm, D. V., Christie Vu, B., Wang, Y., West, T., Wilde, E., Willis, A., Wu, J., Zai, L., Zander, N., Zheng, J. & Ziejewski, M., Sep 2017, In: Journal of neurotrauma. 34, S1, p. S18-S25

  Research output: Contribution to journal › Article › peer-review

  • Chronic Traumatic Encephalopathy
  • Traumatic Brain Injury
  • Sports
  • Blast Injuries
  • Neuropathology
  7 Scopus citations
• 2015

  A rodent model of mild traumatic brain blast injury

  Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. Y., Prough, D., Dewitt, D. S., Spratt, H. & Hulsebosch, C. E., Apr 1 2015, In: Journal of Neuroscience Research. 93, 4, p. 549-561 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Blast Injuries
  • Brain Concussion
  • Rodentia
  • Brain Injuries
  • Righting Reflex
  36 Scopus citations
• 2018

  Impact & blast traumatic brain injury: Implications for therapy

  Yamamoto, S., DeWitt, D. S. & Prough, D. S., 2018, In: Molecules. 23, 2, 245.

  Research output: Contribution to journal › Review article › peer-review

  • brain damage
  • blasts
  • Traumatic Brain Injury
  • therapy
  • Brain
  13 Scopus citations

• Erratum to: Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury (Scientific Reports, (2017), 7, 1, (6645), 10.1038/s41598-017-06341-6)

  Boone, D. K., Weisz, H. A., Bi, M., Falduto, M. T., Torres, K. E. O., Willey, H. E., Volsko, C. M., Kumar, A. M., Micci, M. A., Dewitt, D. S., Prough, D. S. & Hellmich, H. L., Dec 1 2018, In: Scientific reports. 8, 1, 14994.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Essential Genes
  • Traumatic Brain Injury
  • MicroRNAs
  • Cell Death
• 2017

  Persistent Behavioral Deficits in Rats after Parasagittal Fluid Percussion Injury

  Sell, S., Johnson, K., Dewitt, D. & Prough, D., Mar 1 2017, In: Journal of Neurotrauma. 34, 5, p. 1086-1096 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Percussion
  • Traumatic Brain Injury
  • Wounds and Injuries
  • Memory Disorders
  • Short-Term Memory
  18 Scopus citations
• 2016

  Stochastic fluctuations in gene expression in aging hippocampal neurons could be exacerbated by traumatic brain injury

  Shearer, J., Boone, D., Weisz, H., Jennings, K., Uchida, T., Parsley, M., DeWitt, D., Prough, D. & Hellmich, H., Apr 1 2016, In: Aging Clinical and Experimental Research. 28, 2, p. 363-367 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Neurons
  • Gene Expression
  • Cognitive Dysfunction
  • Cell Survival
  1 Scopus citations
• 2018

  Pre-clinical testing of therapies for traumatic brain injury

  DeWitt, D. S., Hawkins, B. E., Dixon, C. E., Kochanek, P. M., Armstead, W., Bass, C. R., Bramlett, H. M., Buki, A., Dietrich, W. D., Ferguson, A. R., Hall, E. D., Hayes, R. L., Hinds, S. R., Laplaca, M. C., Long, J. B., Meaney, D. F., Mondello, S., Noble-Haeusslein, L. J., Poloyac, S. M., Prough, D. S. & 8 others, Robertson, C. S., Saatman, K. E., Shultz, S. R., Shear, D. A., Smith, D. H., Valadka, A. B., Vandevord, P. & Zhang, L., Dec 1 2018, In: Journal of neurotrauma. 35, 23, p. 2737-2754 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Consensus
  • Research Personnel
  • Guidelines
  • Investigational Therapies
  35 Scopus citations
• 2017

  Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury

  Boone, D. K., Weisz, H. A., Bi, M., Falduto, M. T., Torres, K. E. O., Willey, H. E., Volsko, C. M., Kumar, A. M., Micci, M. A., Dewitt, D. S., Prough, D. S. & Hellmich, H. L., Dec 1 2017, In: Scientific reports. 7, 1, 6645.

  Research output: Contribution to journal › Article › peer-review

  • Essential Genes
  • Traumatic Brain Injury
  • MicroRNAs
  • Cell Death
  • Genes
  13 Scopus citations
• 2015

  Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain

  Patel, J. P., Sowers, M. L., Herring, J. L., Theruvathu, J. A., Emmett, M. R., Hawkins, B. E., Zhang, K., Dewitt, D. S., Prough, D. S. & Sowers, L. C., Dec 21 2015, In: Chemical Research in Toxicology. 28, 12, p. 2352-2363 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolism
  • DNA Damage
  • Brain
  • Rodentia
  • DNA
  5 Scopus citations
• 2018

  Proteomic changes in traumatic brain injury: Experimental approaches

  Sowers, J. L., Wu, P., Zhang, K., DeWitt, D. S. & Prough, D. S., 2018, In: Current opinion in neurology. 31, 6, p. 709-717 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Traumatic Brain Injury
  • Proteomics
  • Theoretical Models
  • Proteome
  • Mass Spectrometry
  4 Scopus citations

• Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant

  López-García, I., Gerő, D., Szczesny, B., Szoleczky, P., Olah, G., Módis, K., Zhang, K., Gao, J., Wu, P., Sowers, L. C., DeWitt, D., Prough, D. S. & Szabo, C., 2018, In: British Journal of Pharmacology. 175, 2, p. 284-300 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Rifampin
  • Neuroprotective Agents
  • Wounds and Injuries
  • In Vitro Techniques
  • Neurons
  9 Scopus citations
• 2016

  Human neural stem cell transplantation-mediated alteration of microglial/macrophage phenotypes after traumatic brain injury

  Gao, J., Grill, R. J., Dunn, T. J., Bedi, S., Labastida, J. A., Hetz, R. A., Xue, H., Thonhoff, J. R., Dewitt, D. S., Prough, D. S., Cox, C. S. & Wu, P., 2016, In: Cell Transplantation. 25, 10, p. 1863-1877 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • Stem cells
  • Microglia
  • Neural Stem Cells
  • Stem Cell Transplantation
  23 Scopus citations
• 2015

  Pathway-Focused PCR Array Profiling of Enriched Populations of Laser Capture Microdissected Hippocampal Cells after Traumatic Brain Injury

  Boone, D. R., Micci, M. A., Taglialatela, I. G., Hellmich, J. L., Weisz, H. A., Bi, M., Prough, D. S., DeWitt, D. S. & Hellmich, H. L., May 2015, In: PloS one. 10, 5, e0127287.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Neurons
  • Brain
  • neurons
  • Lasers
  21 Scopus citations
• 2018

  Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma

  Esenaliev, R. O., Petrov, I. Y., Petrov, Y., Guptarak, J., Boone, D. R., Mocciaro, E., Weisz, H., Parsley, M. A., Sell, S. L., Hellmich, H., Ford, J. M., Pogue, C., Dewitt, D., Prough, D. S. & Micci, M. A., Jul 2018, In: Journal of neurotrauma. 35, 13, p. 1510-1522 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Laser Therapy
  • Lasers
  • Caspase 3
  • Brain-Derived Neurotrophic Factor
  • Microglia
  13 Scopus citations
• 2016

  Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

  Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Cognitive Dysfunction
  • Pathology
  • Brain
  • Neurodegenerative Diseases
  39 Scopus citations
• 2018

  Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular, Histopathological, and Behavioral Outcomes in Rats

  Rodriguez, U. A., Zeng, Y., Deyo, D., Parsley, M. A., Hawkins, B. E., Prough, D. S. & DeWitt, D. S., Jan 15 2018, In: Journal of neurotrauma. 35, 2, p. 375-392 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion
  • Traumatic Brain Injury
  • penicillamine methyl ester
  • Blood Vessels
  • Perfusion
  24 Scopus citations
• 2017

  Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury

  Boone, D. R., Leek, J. M., Falduto, M. T., Torres, K. E. O., Sell, S. L., Parsley, M. A., Cowart, J. C., Uchida, T., Micci, M. A., DeWitt, D. S., Prough, D. S. & Hellmich, H. L., Oct 2017, In: PloS one. 12, 10, e0185943.

  Research output: Contribution to journal › Article › peer-review

  • Dependoparvovirus
  • glutathione peroxidase GPX1
  • neuronal nitric oxide synthase
  • Nitric Oxide Synthase Type I
  • Dependovirus
  4 Scopus citations
• 2016

  Inflammatory cytokine receptor blockade in a rodent model of mild traumatic brain injury

  Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. Y., Prough, D., Dewitt, D. S., Paulucci-Holthauzen, A. A., Werrbach-Perez, K. & Hulsebosch, C. E., Jan 2016, In: Journal of Neuroscience Research. 94, 1, p. 27-38 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion
  • Cytokine Receptors
  • Interleukin 1 Receptor Antagonist Protein
  • Rodentia
  • Tumor Necrosis Factor-alpha
  10 Scopus citations