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  • Pei-Yong Shi
2015

The search for nucleoside/nucleotide analog inhibitors of dengue virus

Chen, Y. L., Yokokawa, F. & Shi, P-Y., Aug 10 2015, In : Antiviral Research. 122, p. 12-19 8 p., 3670.

Research output: Contribution to journalArticle

40 Scopus citations

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P-Y. & Kang, C., Dec 1 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2016

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

Zhang, P. T., Shan, C., Li, X. D., Liu, S. Q., Deng, C. L., Ye, H. Q., Shang, B. D., Shi, P-Y., Lv, M., Shen, B. F., Qin, C. F. & Zhang, B., Jan 4 2016, In : Virus Research. 211, p. 17-24 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

Li, X. D., Li, X. F., Ye, H. Q., Deng, C. L., Ye, Q., Shan, C., Shang, B. D., Xu, L. L., Li, S. H., Cao, S. B., Yuan, Z. M., Shi, P. Y., Qin, C. F. & Zhang, B., 2014, In : Journal of General Virology. 95, PART 4, p. 806-815 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2016

A conserved pocket in the dengue virus polymerase identified through fragment-based screening

Noble, C. G., Lim, S. P., Arora, R., Yokokawa, F., Nilar, S., Seh, C. C., Wright, S. K., Benson, T. E., Smith, P. W. & Shi, P-Y., Apr 15 2016, In : Journal of Biological Chemistry. 291, 16, p. 8541-8548 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2019

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

Lim, X. N., Shan, C., Marzinek, J. K., Dong, H., Ng, T. S., Ooi, J. S. G., Fibriansah, G., Wang, J., Verma, C. S., Bond, P. J., Shi, P. Y. & Lok, S. M., 2019, In : PLoS pathogens. 15, 9, e1007996.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2013

Membrane topology and function of dengue virus NS2A protein

Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In : Journal of virology. 87, 8, p. 4609-4622 14 p.

Research output: Contribution to journalArticle

111 Scopus citations
2018

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In : EBioMedicine. 36, p. 92-102 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2019

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2015

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

41 Scopus citations
2014

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

Xie, X., Zou, J., Wang, Q. Y., Noble, C. G., Lescar, J. & Shi, P. Y., Feb 1 2014, In : Virology. 450-451, p. 250-257 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P. Y., Huber, T., Lescar, J., Luo, D. & Vasudevan, S. G., Jan 1 2015, In : Journal of virology. 89, 20, p. 10717-10721 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia

Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In : Infection, Genetics and Evolution. 32, p. 165-177 13 p.

Research output: Contribution to journalArticle

42 Scopus citations
2011

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 2011, In : Antiviral research. 89, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

62 Scopus citations
2018

Targeting vesicle size

Zou, J. & Shi, P. Y., Nov 1 2018, In : Nature Materials. 17, 11, p. 955-956 2 p.

Research output: Contribution to journalComment/debate

2011

Anti-infectives: Can cellular screening deliver?

Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In : Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

Research output: Contribution to journalReview article

22 Scopus citations
2015

Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases

Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P-Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In : Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.

Research output: Contribution to journalLetter

4 Scopus citations
2016

Flavivirus Entry Inhibitors

Wang, Q. Y. & Shi, P-Y., Jan 8 2016, In : ACS Infectious Diseases. 1, 9, p. 428-434 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Detection and quantification of flavivirus NS5 methyl-transferase activities

Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
2019

Strategies for Zika drug discovery

Zou, J. & Shi, P. Y., Apr 2019, In : Current Opinion in Virology. 35, p. 19-26 8 p.

Research output: Contribution to journalReview article

12 Scopus citations
2013

Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, Kadow, J. F., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
2014

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

Fu, Y., Yip, A., Seah, P. G., Blasco, F., Shi, P. Y. & Hervé, M., Jan 1 2014, In : Antiviral research. 110, p. 151-157 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2017

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., Muruato, A. E., Foreman, B. M., Luo, H., Wang, T., Barrett, A. D., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L., Ciaramella, G., Mysorekar, I. U. & 3 others, Pierson, T. C., Shi, P. Y. & Diamond, M. S., Jul 13 2017, In : Cell. 170, 2, p. 273-283.e12

Research output: Contribution to journalArticle

110 Scopus citations
2018

Using a virion assembly-defective dengue virus as a vaccine approach

Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In : Journal of virology. 92, 21, e01002.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In : Antiviral research. 119, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In : Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.

Research output: Contribution to journalArticle

67 Scopus citations
2017

Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P-Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In : Antiviral Research. 141, p. 38-47 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G. & Luo, D., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-27 27 p., e1004682.

Research output: Contribution to journalArticle

95 Scopus citations
2018

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

13 Scopus citations
2019

Genetic and biochemical characterizations of Zika virus NS2A protein

Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P. Y. & Qin, C. F., Dec 1 2018, In : Emerging Microbes and Infections. 7, 1, 0006.

Research output: Contribution to journalLetter

2 Scopus citations

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P-Y. & Yokokawa, F., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Zika Virus: Diagnosis, Therapeutics, and Vaccine

Shan, C., Xie, X., Barrett, A., Garcia-Blanco, M., Tesh, R. B., Vasconcelos, P. F. D. C., Vasilakis, N., Weaver, S. & Shi, P-Y., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 170-172 3 p.

Research output: Contribution to journalArticle

53 Scopus citations
2014

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus

Song, K. Y., Zhao, H., Jiang, Z. Y., Li, X. F., Deng, Y. Q., Jiang, T., Zhu, S. Y., Shi, P. Y., Zhang, B., Zhang, F. C., Qin, E. D. & Qin, C. F., Feb 18 2014, In : BMC Microbiology. 14, 1, 44.

Research output: Contribution to journalArticle

11 Scopus citations

Dimerization of flavivirus NS4B protein

Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In : Journal of virology. 88, 6, p. 3379-3391 13 p.

Research output: Contribution to journalArticle

40 Scopus citations
2012

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 2012, In : Journal of virology. 86, 24, p. 13662-13671 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2019

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In : Nucleic acids research. 47, 20, p. e130

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2014

Live attenuated vaccine: The first clinically approved dengue vaccine?

Fink, K. & Shi, P. Y., Feb 1 2014, In : Expert review of vaccines. 13, 2, p. 185-188 4 p.

Research output: Contribution to journalReview article

14 Scopus citations

Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

Wang, P., Li, L. F., Wang, Q. Y., Shang, L. Q., Shi, P. Y. & Yin, Z., Jul 2014, In : ChemMedChem. 9, 7, p. 1522-1533 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
2012

2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase

Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In : PLoS pathogens. 8, 4, e1002642.

Research output: Contribution to journalArticle

79 Scopus citations
2016

A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P-Y., Nov 29 2016, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

53 Scopus citations
2013

Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In : Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Small Molecules and Antibodies for Zika Therapy

Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In : Journal of Infectious Diseases. 216, p. S945-S950

Research output: Contribution to journalReview article

14 Scopus citations

Adulthood Sequelae of Congenital Zika Virus Infection in Mice

Zou, J. & Shi, P. Y., Jun 2017, In : EBioMedicine. 20, p. 11-12 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
2013

A multidimensional platform for the purification of non-coding RNA species

Chionh, Y. H., Ho, C. H., Pruksakorn, D., Ramesh Babu, I., Ng, C. S., Hia, F., McBee, M. E., Su, D., Pang, Y. L. J., Gu, C., Dong, H., Prestwich, E. G., Shi, P. Y., Preiser, P. R., Alonso, S. & Dedon, P. C., Sep 2013, In : Nucleic acids research. 41, 17, p. e168

Research output: Contribution to journalArticle

23 Scopus citations
2011

Small molecule inhibitors that selectively block dengue virus methyltransferase

Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, Keller, T. H. & Shi, P. Y., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.

Research output: Contribution to journalArticle

103 Scopus citations
2016

Adenosine analog NITD008 is a potent inhibitor of zika virus

Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X. P., Shi, P. Y. & Qin, C. F., 2016, In : Open Forum Infectious Diseases. 3, 4

Research output: Contribution to journalArticle

76 Scopus citations
2017

Zika virus has oncolytic activity against glioblastoma stem cells

Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P. Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In : Journal of Experimental Medicine. 214, 10, p. 2843-2857 15 p.

Research output: Contribution to journalArticle

61 Scopus citations

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In : PLoS pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

36 Scopus citations
2011

Dengue drug discovery

Shi, P. Y., Yin, Z., Nilar, S. & Keller, T. H., Oct 31 2011, Third World Diseases. Elliot, R. (ed.). p. 243-276 34 p. (Topics in Medicinal Chemistry; vol. 7).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations