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  • Istvan Boldogh
2015

Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Ziaaldini, M. M., Koltai, E., Csende, Z., Goto, S., Boldogh, I., Taylor, A. W. & Radak, Z., Jul 1 2015, In : Experimental Gerontology. 67, p. 9-14 6 p.

Research output: Contribution to journalArticle

41 Scopus citations
2011

Apoptosis induced by persistent single-strand breaks in mitochondrial genome: Critical role of EXOG (5′-exo/endonuclease) in their repair

Tann, A. W., Boldogh, I., Meiss, G., Qian, W., Van Houten, B., Mitra, S. & Szczesny, B., Sep 16 2011, In : Journal of Biological Chemistry. 286, 37, p. 31975-31983 9 p.

Research output: Contribution to journalArticle

101 Scopus citations
2015

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2019

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Brasier, A. R. & Boldogh, I., 2019, In : Drugs in Context. 8, 2019-8-3.

Research output: Contribution to journalReview article

Open Access
2017

Innate mechanism of pollen- and cat dander–induced oxidative stress and DNA damage in the airways

Hosoki, K., Redding, D., Itazawa, T., Chakraborty, A., Tapryal, N., Qian, S., Qi, H., Aguilera-Aguirre, L., Brasier, A. R., Phani, V. S., Hazra, T. K., Boldogh, I. & Sur, S., Nov 2017, In : Journal of Allergy and Clinical Immunology. 140, 5, p. 1436-1439.e5

Research output: Contribution to journalArticle

5 Scopus citations
2013

8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1

Hajas, G., Bacsi, A., Aguilera-Aguirre, L., Hegde, M. L., Tapas, K. H., Sur, S., Radak, Z., Ba, X. & Boldogh, I., 2013, In : Free Radical Biology and Medicine. 61, p. 384-394 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
2018

The establishment of methods for free PAR generation and PAR reader detection

Ke, Y., Wang, K., Xu, H., Wang, C., Zhang, J., Zeng, X., Wang, R., Boldogh, I. & Ba, X., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Probes.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 20-33 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3090-E3099

Research output: Contribution to journalArticle

56 Scopus citations
2015

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha

Batnasan, E., Wang, R., Wen, J., Ke, Y., Li, X., Bohio, A. A., Zeng, X., Huo, H., Han, L., Boldogh, I. & Ba, X., Jan 5 2015, In : Toxicology Letters. 232, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Systems approaches to modeling chronic mucosal inflammation

Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., Nov 18 2013, In : BioMed Research International. 2013, 505864.

Research output: Contribution to journalArticle

27 Scopus citations
2020

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

Dharmalingam, P., Talakatta, G., Mitra, J., Wang, H., Derry, P. J., Nilewski, L. G., McHugh, E. A., Fabian, R. H., Mendoza, K., Vasquez, V., Hegde, P. M., Kakadiaris, E., Roy, T., Boldogh, I., Hegde, V. L., Mitra, S., Tour, J. M., Kent, T. A. & Hegde, M. L., Mar 24 2020, In : ACS Nano. 14, 3, p. 2827-2846 20 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Visnes, T., Cázares-Körner, A., Hao, W., Wallner, O., Masuyer, G., Loseva, O., Mortusewicz, O., Wiita, E., Sarno, A., Manoilov, A., Astorga-Wells, J., Jemth, A. S., Pan, L., Sanjiv, K., Karsten, S., Gokturk, C., Grube, M., Homan, E. J., Hanna, B. M. F., Paulin, C. B. J. & 20 others, Pham, T., Rasti, A., Berglund, U. W., Von Nicolai, C., Benitez-Buelga, C., Koolmeister, T., Ivanic, D., Iliev, P., Scobie, M., Krokan, H. E., Baranczewski, P., Artursson, P., Altun, M., Jensen, A. J., Kalderén, C., Ba, X., Zubarev, R. A., Stenmark, P., Boldogh, I. & Helleday, T., Nov 16 2018, In : Science. 362, 6416, p. 834-839 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2015

Innate responses to pollen allergens

Hosoki, K., Boldogh, I. & Sur, S., Feb 13 2015, In : Current opinion in allergy and clinical immunology. 15, 1, p. 79-88 10 p.

Research output: Contribution to journalReview article

16 Scopus citations
2019

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M. L., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

The redox-associated adaptive response of brain to physical exercise

Radak, Z., Ihasz, F., Koltai, E., Goto, S., Taylor, A. W. & Boldogh, I., Jan 1 2014, In : Free Radical Research. 48, 1, p. 84-92 9 p.

Research output: Contribution to journalReview article

30 Scopus citations
2013

Redox-regulating sirtuins in aging, caloric restriction, and exercise

Radak, Z., Koltai, E., Taylor, A. W., Higuchi, M., Kumagai, S., Ohno, H., Goto, S. & Boldogh, I., May 2013, In : Free Radical Biology and Medicine. 58, p. 87-97 11 p.

Research output: Contribution to journalReview article

65 Scopus citations

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In : DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z., Bacsi, A., Sur, S., Hazra, T. K. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

Research output: Contribution to journalArticle

83 Scopus citations
2014

Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model

Csillag, A., Kumar, B. V., Szabó, K., Szilasi, M., Papp, Z., Szilasi, M. E., Pázmándi, K., Boldogh, I., Rajnavölgyi, É., Bácsi, A. & László, J. F., Jun 6 2014, In : Journal of the Royal Society Interface. 11, 95, 20140097.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Physical exercise, reactive oxygen species and neuroprotection

Radak, Z., Suzuki, K., Higuchi, M., Balogh, L., Boldogh, I. & Koltai, E., Sep 1 2016, In : Free Radical Biology and Medicine. 98, p. 187-196 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2015

The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD

Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

Research output: Contribution to journalArticle

22 Scopus citations
2011

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. V. & Srivastava, S. K., Nov 3 2011, In : Respiratory Research. 12, 145.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats

Marton, O., Koltai, E., Takeda, M., Koch, L. G., Britton, S. L., Davies, K. J. A., Boldogh, I. & Radak, Z., Jan 1 2015, In : Pflugers Archiv European Journal of Physiology. 467, 4, p. 779-788 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Effects of diabetes on oxidative and nitrosative stress in kidney mitochondria from aged rats

Pérez-Gallardo, R. V., Noriega-Cisneros, R., Esquivel-Gutiérrez, E., Calderón-Cortés, E., Cortés-Rojo, C., Manzo-Avalos, S., Campos-García, J., Salgado-Garciglia, R., Montoya-Pérez, R., Boldogh, I. & Saavedra-Molina, A., Dec 9 2014, In : Journal of Bioenergetics and Biomembranes. 46, 6, p. 511-518 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro

Menon, R., Boldogh, I., Hawkins, H. K., Woodson, M., Polettini, J., Syed, T. A., Fortunato, S. J., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Jun 2014, In : American Journal of Pathology. 184, 6, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

104 Scopus citations
2015

Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1

Hosoki, K., Ying, S., Corrigan, C., Qi, H., Kurosky, A., Jennings, K., Sun, Q., Boldogh, I. & Sur, S., May 2015, In : PloS one. 10, 5, e0126035.

Research output: Contribution to journalArticle

44 Scopus citations
2017

Reply: Protease plays a role in ragweed pollen-induced neutrophil recruitment and epithelial barrier disruption

Hosoki, K., Brasier, A. R., Kurosky, A., Boldogh, I. & Sur, S., Feb 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 2, p. 272-273 2 p.

Research output: Contribution to journalLetter

2012

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells

Pazmandi, K., Magyarics, Z., Boldogh, I., Csillag, A., Rajnavolgyi, E. & Bacsi, A., Feb 1 2012, In : Free Radical Biology and Medicine. 52, 3, p. 635-645 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

Radak, Z., Ishihara, K., Tekus, E., Varga, C., Posa, A., Balogh, L., Boldogh, I. & Koltai, E., Aug 1 2017, In : Redox Biology. 12, p. 285-290 6 p.

Research output: Contribution to journalShort survey

57 Scopus citations
2014

The role of 8-oxoguanine DNA glycosylase-1 in inflammation

Ba, X., Aguilera-Aguirre, L., Rashid, Q. T. A. N., Bacsi, A., Radak, Z., Sur, S., Hosoki, K., Hegde, M. L. & Boldogh, I., Sep 23 2014, In : International journal of molecular sciences. 15, 9, p. 16975-16997 23 p.

Research output: Contribution to journalReview article

49 Scopus citations
2017

Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation

Aguilera-Aguirre, L., Hao, W., Pan, L., Li, X., Saavedra-Molina, A., Bacsi, A., Radak, Z., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 6, p. L1058-L1068

Research output: Contribution to journalArticle

4 Scopus citations
2019

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I. & Radak, Z., Jan 1 2019, In : Experimental Gerontology. 115, p. 122-131 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2017

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Pajk, M., Cselko, A., Varga, C., Posa, A., Tokodi, M., Boldogh, I., Goto, S. & Radak, Z., Aug 1 2017, In : Biogerontology. 18, 4, p. 593-600 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2020

The systemic role of SIRT1 in exercise mediated adaptation

Radak, Z., Suzuki, K., Posa, A., Petrovszky, Z., Koltai, E. & Boldogh, I., Aug 2020, In : Redox Biology. 35, 101467.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Exercise, redox system and neurodegenerative diseases

Quan, H., Koltai, E., Suzuki, K., Aguiar, A. S., Pinho, R., Boldogh, I., Berkes, I. & Radak, Z., Oct 1 2020, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 10, 165778.

Research output: Contribution to journalReview article

Open Access
2013

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In : PloS one. 8, 2, e57442.

Research output: Contribution to journalArticle

27 Scopus citations
2019

Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation

Pázmándi, K., Sütő, M., Fekete, T., Varga, A., Boldizsár, E., Boldogh, I. & Bácsi, A., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 209-220 12 p.

Research output: Contribution to journalArticle

Open Access
2017

NF-κB mediates mesenchymal transition, remodeling, and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns

Tian, B., Patrikeev, I., Ochoa, L., Vargas, G., Belanger, K. A. K., Litvinov, J., Boldogh, I., Ameredes, B., Motamedi, M. & Brasier, A. R., Apr 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 4, p. 506-520 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2019

Exercise effects on physiological function during aging

Radak, Z., Torma, F., Berkes, I., Goto, S., Mimura, T., Posa, A., Balogh, L., Boldogh, I., Suzuki, K., Higuchi, M. & Koltai, E., Feb 20 2019, In : Free Radical Biology and Medicine. 132, p. 33-41 9 p.

Research output: Contribution to journalReview article

18 Scopus citations
2014

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2016

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T. K., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In : Journal of Biological Chemistry. 291, 49, p. 25553-25566 14 p.

Research output: Contribution to journalArticle

65 Scopus citations

The rate of training response to aerobic exercise affects brain function of rats

Marton, O., Koltai, E., Takeda, M., Mimura, T., Pajk, M., Abraham, D., Koch, L. G., Britton, S. L., Higuchi, M., Boldogh, I. & Radak, Z., Oct 1 2016, In : Neurochemistry International. 99, p. 16-23 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

C-Abl-mediated tyrosine phosphorylation of PARP1 is crucial for expression of proinflammatory genes

Bohio, A. A., Sattout, A., Wang, R., Wang, K., Sah, R. K., Guo, X., Zeng, X., Ke, Y., Boldogh, I. & Ba, X., Sep 15 2019, In : Journal of Immunology. 203, 6, p. 1521-1531 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Epigenetic regulation of TIMP1 expression by 8-oxoguanine DNA glycosylase-1 binding to DNA:RNA hybrid

Pan, L., Wang, H., Luo, J., Zeng, J., Pi, J., Liu, H., Liu, C., Ba, X., Qu, X., Xiang, Y., Boldogh, I. & Qin, X., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 14159-14170 12 p.

Research output: Contribution to journalArticle

2018

OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos

Wang, R., Li, C., Qiao, P., Xue, Y., Zheng, X., Chen, H., Zeng, X., Liu, W., Boldogh, I. & Ba, X., Jun 1 2018, In : Cell Death and Disease. 9, 6, 628.

Research output: Contribution to journalArticle

12 Scopus citations
2017

OGG1-DNA interactions facilitate NF-k B binding to DNA targets

Pan, L., Hao, W., Zheng, X., Zeng, X., Ahmed Abbasi, A., Boldogh, I. & Ba, X., Mar 7 2017, In : Scientific Reports. 7, 43297.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development

Zhang, X., He, N., Gu, D., Wickliffe, J., Salazar, J., Boldogh, I. & Xie, J., Oct 20 2015, In : Journal of Genetics and Genomics. 42, 10, p. 589-596 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells

Agod, Z., Fekete, T., Budai, M. M., Varga, A., Szabo, A., Moon, H., Boldogh, I., Biro, T., Lanyi, A., Bacsi, A. & Pazmandi, K., Oct 2017, In : Redox Biology. 13, p. 633-645 13 p.

Research output: Contribution to journalArticle

11 Scopus citations