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  • Pei-Yong Shi
2019
4 Scopus citations
2012

Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice

Pesko, K. N., Fitzpatrick, K. A., Ryan, E. M., Shi, P. Y., Zhang, B., Lennon, N. J., Newman, R. M., Henn, M. R. & Ebel, G. D., May 25 2012, In : Virology. 427, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2020

Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery

Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In : EBioMedicine. 57, 102838.

Research output: Contribution to journalArticle

Open Access
2019

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

Jackman, J. A., Shi, P-Y. & Cho, N. J., Nov 1 2019, In : ACS Infectious Diseases. 5, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Zika Virus: Diagnosis, Therapeutics, and Vaccine

Shan, C., Xie, X., Barrett, A., Garcia-Blanco, M., Tesh, R. B., Vasconcelos, P. F. D. C., Vasilakis, N., Weaver, S. & Shi, P-Y., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 170-172 3 p.

Research output: Contribution to journalArticle

53 Scopus citations
2019

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In : Nucleic acids research. 47, 20, p. e130

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2020

Peli1 signaling blockade attenuates congenital zika syndrome

Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 1 2020, In : PLoS pathogens. 16, 6, p. e1008538

Research output: Contribution to journalArticle

Open Access
2015

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign

Smith, T. M., Lim, S. P., Yue, K., Busby, S. A., Arora, R., Seh, C. C., Kirk Wright, S., Nutiu, R., Niyomrattanakit, P., Wan, K. F., Beer, D., Shi, P. Y. & Benson, T. E., Jan 30 2015, In : Journal of Biomolecular Screening. 20, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 1 2012, In : Journal of virology. 86, 24, p. 13662-13671 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2016

A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P-Y., Nov 29 2016, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

53 Scopus citations
2014

Dimerization of flavivirus NS4B protein

Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In : Journal of virology. 88, 6, p. 3379-3391 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
2013

A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities

Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2014

Live attenuated vaccine: The first clinically approved dengue vaccine?

Fink, K. & Shi, P. Y., Feb 1 2014, In : Expert review of vaccines. 13, 2, p. 185-188 4 p.

Research output: Contribution to journalReview article

13 Scopus citations
2017

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In : PLoS pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

36 Scopus citations
2013

Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In : Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model

Siemann, D. N., Strange, D. P., Maharaj, P. N., Shi, P-Y. & Verma, S., Nov 1 2017, In : Journal of Virology. 91, 22, e00623-17.

Research output: Contribution to journalArticle

35 Scopus citations

Small Molecules and Antibodies for Zika Therapy

Xie, X., Zou, J., Shan, C. & Shi, P-Y., Jan 1 2017, In : Journal of Infectious Diseases. 216, p. S945-S950

Research output: Contribution to journalReview article

14 Scopus citations

Understanding zika virus stability and developing a chimeric vaccine through functional analysis

Xie, X., Yang, Y., Muruato, A. E., Zou, J., Shan, C., Nunes, B. T. D., Medeiros, D. B. A., Vasconcelos, P. F. C., Weaver, S. C., Rossi, S. L. & Shi, P. Y., Jan 1 2017, In : mBio. 8, 1, e02134-16.

Research output: Contribution to journalArticle

58 Scopus citations
2011

Inhibition of dengue virus by targeting viral NS4B protein

Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 1 2011, In : Journal of virology. 85, 21, p. 11183-11195 13 p.

Research output: Contribution to journalArticle

82 Scopus citations
2017

West Nile virus NS1 antagonizes interferon beta production by targeting RIG-I and MDA5

Zhang, H. L., Ye, H. Q., Liu, S. Q., Deng, C. L., Li, X. D., Shi, P-Y. & Zhang, B., Sep 1 2017, In : Journal of Virology. 91, 18, e02396-16.

Research output: Contribution to journalArticle

26 Scopus citations
2012

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2018

Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

Fei, Z. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

2014

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells

Fu, Y., Chen, Y. L., Herve, M., Gu, F., Shi, P. Y. & Blasco, F., Feb 2014, In : Journal of Virological Methods. 196, p. 18-24 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Adenosine analog NITD008 is a potent inhibitor of zika virus

Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X., Shi, P-Y. & Qin, C. F., 2016, In : Open Forum Infectious Diseases. 3, 4, ofw175.

Research output: Contribution to journalArticle

75 Scopus citations
2018

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In : Nature communications. 9, 1, 414.

Research output: Contribution to journalArticle

76 Scopus citations
2017

A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S., Weaver, S., Xie, X. & Shi, P-Y., Jan 4 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

23 Scopus citations
2013

West Nile virus drug discovery

Lim, S. P. & Shi, P. Y., Dec 3 2013, In : Viruses. 5, 12, p. 2977-3006 30 p.

Research output: Contribution to journalReview article

26 Scopus citations

Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In : Journal of virology. 87, 10, p. 5755-5768 14 p.

Research output: Contribution to journalArticle

42 Scopus citations
2019

Anti-Zika virus RNAi in neural progenitor cells

Xie, X. & Shi, P. Y., Apr 1 2019, In : Cell Research. 29, 4, p. 261-262 2 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2016

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

Zhang, P. T., Shan, C., Li, X. D., Liu, S. Q., Deng, C. L., Ye, H. Q., Shang, B. D., Shi, P-Y., Lv, M., Shen, B. F., Qin, C. F. & Zhang, B., Jan 4 2016, In : Virus Research. 211, p. 17-24 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P-Y., Apr 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 4, p. 2086-2093 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 1 2013, In : Journal of virology. 87, 10, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
2018

Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In : mBio. 9, 5, e01683-18.

Research output: Contribution to journalArticle

18 Scopus citations
2012

Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

Van Slyke, G. A., Ciota, A. T., Willsey, G. G., Jaeger, J., Shi, P. Y. & Kramer, L. D., May 25 2012, In : Virology. 427, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2016

Therapeutic potential of spirooxindoles as antiviral agents

Ye, N., Chen, H., Wold, E. A., Shi, P-Y. & Zhou, J., Jun 10 2016, In : ACS Infectious Diseases. 2, 6, p. 382-392 11 p.

Research output: Contribution to journalReview article

159 Scopus citations
2014

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

Noble, C. G., Li, S. H., Dong, H., Chew, S. H. & Shi, P. Y., Nov 2014, In : Antiviral research. 111, p. 78-81 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 1 2011, In : Antiviral research. 89, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

60 Scopus citations
2015

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In : Antiviral research. 119, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Anti-infectives: Can cellular screening deliver?

Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In : Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

Research output: Contribution to journalReview article

22 Scopus citations
2016

Zika virus: History, emergence, biology, and prospects for control

Weaver, S., Costa, F., Garcia-Blanco, M., Ko, A. I., Ribeiro, G. S., Saade, G., Shi, P-Y. & Vasilakis, N., Jun 1 2016, In : Antiviral Research. 130, p. 69-80 12 p.

Research output: Contribution to journalArticle

342 Scopus citations
2013

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In : Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
2016

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, Ho, C. Y., Wen, Z., Christian, K. M., Shi, P-Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H. & Ming, G. L., May 19 2016, In : Cell. 165, 5, p. 1238-1254 17 p.

Research output: Contribution to journalArticle

650 Scopus citations

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Apr 14 2016, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

145 Scopus citations
2017

Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P-Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In : Antiviral Research. 141, p. 38-47 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Difficulties and advancements in developing drugs for the treatment of dengue fever

Noble, C. G. & Shi, P. Y., Jan 1 2013, In : Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

Research output: Contribution to journalReview article

1 Scopus citations
2017

Erratum: Zika virus has oncolytic activity against glioblastoma stem cells [The Journal of Experimental Medicine, 214, 10, (2017)] DOI: 10.1084/jem.20171093

Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P-Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In : Journal of Experimental Medicine. 214, 10, 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
2016

Zika virus epidemic in Brazil. I. Fatal disease in adults: Clinical and laboratorial aspects

Azevedo, R. S. S., Araujo, M. T., Martins Filho, A. J., Oliveira, C. S., Nunes, B. T. D., Cruz, A. C. R., Nascimento, A. G. P. A. C., Medeiros, R. C., Caldas, C. A. M., Araujo, F. C., Quaresma, J. A. S., Vasconcelos, B. C. B., Queiroz, M. G. L., da Rosa, E. S. T., Henriques, D. F., Silva, E. V. P., Chiang, J. O., Martins, L. C., Medeiros, D. B. A., Lima, J. A. & 7 others, Nunes, M. R. T., Cardoso, J. F., Silva, S. P., Shi, P. Y., Tesh, R. B., Rodrigues, S. G. & Vasconcelos, P. F. C., Dec 1 2016, In : Journal of Clinical Virology. 85, p. 56-64 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2015

Therapeutics for Neglected Infectious Diseases: Progress and Challenge

Shi, P. Y., Smith, P. W. & Diagana, T. T., Jan 8 2015, In : ACS Infectious Diseases. 1, 1, p. 76-78 3 p.

Research output: Contribution to journalShort survey

7 Scopus citations
2019

Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

Du, S., Liu, Y., Liu, J., Zhao, J., Champagne, C., Tong, L., Zhang, R., Zhang, F., Qin, C. F., Ma, P., Chen, C. H., Liang, G., Liu, Q., Shi, P. Y., Cazelles, B., Wang, P., Tian, H. & Cheng, G., Dec 1 2019, In : Nature communications. 10, 1, 1324.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S. L., Shan, C., Shi, P. Y., Beasley, D. W., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific reports. 8, 1, 1882.

Research output: Contribution to journalArticle

9 Scopus citations