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  • Pei-Yong Shi
2015

Therapeutics for Neglected Infectious Diseases: Progress and Challenge

Shi, P. Y., Smith, P. W. & Diagana, T. T., Jan 8 2015, In : ACS Infectious Diseases. 1, 1, p. 76-78 3 p.

Research output: Contribution to journalShort survey

7 Scopus citations
2019

Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In : mBio. 10, 2, e00433-19.

Research output: Contribution to journalComment/debate

Open Access
2018

Zika Virus Vaccine: Progress and Challenges

Shan, C., Xie, X. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

31 Scopus citations
2016

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In : Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

Research output: Contribution to journalArticle

42 Scopus citations
2013

Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 1 2013, In : Antiviral research. 97, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2016

Zika virus epidemic in Brazil. I. Fatal disease in adults: Clinical and laboratorial aspects

Azevedo, R. S. S., Araujo, M. T., Martins Filho, A. J., Oliveira, C. S., Nunes, B. T. D., Cruz, A. C. R., Nascimento, A. G. P. A. C., Medeiros, R. C., Caldas, C. A. M., Araujo, F. C., Quaresma, J. A. S., Vasconcelos, B. C. B., Queiroz, M. G. L., da Rosa, E. S. T., Henriques, D. F., Silva, E. V. P., Chiang, J. O., Martins, L. C., Medeiros, D. B. A., Lima, J. A. & 7 others, Nunes, M. R. T., Cardoso, J. F., Silva, S. P., Shi, P. Y., Tesh, R. B., Rodrigues, S. G. & Vasconcelos, P. F. C., Dec 1 2016, In : Journal of Clinical Virology. 85, p. 56-64 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2019

Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections

Furuya, A. K. M., Hunt, D., St. George, K., Dupuis, A. P., Kramer, L. D., Shi, P-Y. & Wong, S., Apr 15 2019, In : Clinical Science. 133, 7, p. 859-867 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In : Nature Medicine. 23, 6, p. 763-767 5 p.

Research output: Contribution to journalArticle

143 Scopus citations
2019

Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In : mBio. 10, 4, e01372-19.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2011

Corrigendum to "Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes" [Virology 404 (2010) 89-95]

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Feb 20 2011, In : Virology. 410, 2, p. 437 1 p.

Research output: Contribution to journalComment/debate

2013

Report of the fifth symposium on emerging viral diseases

Zhang, B. & Shi, P. Y., Apr 2013, In : Virologica Sinica. 28, 2, p. 63-64 2 p.

Research output: Contribution to journalEditorial

A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities

Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2014

Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development

Caillet-Saguy, C., Lim, S. P., Shi, P. Y., Lescar, J. & Bressanelli, S., May 2014, In : Antiviral research. 105, 1, p. 8-16 9 p.

Research output: Contribution to journalReview article

34 Scopus citations
2013

Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 2013, In : Journal of virology. 87, 9, p. 5291-5295 5 p.

Research output: Contribution to journalArticle

66 Scopus citations
2015

Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors

Zou, B., Chan, W. L., Ding, M., Leong, S. Y., Nilar, S., Seah, P. G., Liu, W., Karuna, R., Blasco, F., Yip, A., Chao, A., Susila, A., Dong, H., Wang, Q. Y., Xu, H. Y., Chan, K., Wan, K. F., Gu, F., Diagana, T. T., Wagner, T. & 3 others, Dix, I., Shi, P. Y. & Smith, P. W., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir

Chen, Y. L., Ghafar, N. A., Karuna, R., Fu, Y., Lim, S. P., Schul, W., Gu, F., Herve, M., Yokohama, F., Wang, G., Cerny, D., Fink, K., Blasco, F. & Shi, P. Y., Feb 1 2014, In : Journal of virology. 88, 3, p. 1740-1747 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2020

Reserve genetic approaches for the development of Zika vaccines and therapeutics

Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In : Current Opinion in Virology. 44, p. 7-15 9 p.

Research output: Contribution to journalReview article

An Infectious cDNA Clone of SARS-CoV-2

Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., Plante, K. S., Weaver, S. C., Makino, S., LeDuc, J. W., Menachery, V. D. & Shi, P. Y., May 13 2020, In : Cell Host and Microbe. 27, 5, p. 841-848.e3

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2014

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

Whitehorn, J., Yacoub, S., Anders, K. L., Macareo, L. R., Cassetti, M. C., Nguyen Van, V. C., Shi, P. Y., Wills, B. & Simmons, C. P., Aug 28 2014, In : PLoS neglected tropical diseases. 8, 8, e3025.

Research output: Contribution to journalArticle

44 Scopus citations
2011

The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry

Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 1 2011, In : Journal of virology. 85, 10, p. 5159-5171 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2018

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In : Nature communications. 9, 1, 673.

Research output: Contribution to journalArticle

40 Scopus citations

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In : Nature communications. 9, 1, 414.

Research output: Contribution to journalArticle

79 Scopus citations
2014

Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry

Hsieh, S. C., Wu, Y. C., Zou, G., Nerurkar, V. R., Shi, P. Y. & Wang, W. K., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33149-33160 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2019

Genetic stability of live-attenuated Zika vaccine candidates

Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 2019, In : Antiviral research. 171, 104596.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Ligand-bound structures of the dengue virus protease reveal the active conformation

Noble, C. G., Seh, C. C., Chao, A. T. & Shi, P. Y., Jan 1 2012, In : Journal of virology. 86, 1, p. 438-446 9 p.

Research output: Contribution to journalArticle

161 Scopus citations
2015

Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P. Y., Apr 1 2015, In : Antimicrobial agents and chemotherapy. 59, 4, p. 2086-2093 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2016

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P. Y. & 1 others, Qin, C. F., Oct 1 2016, In : EBioMedicine. 12, p. 170-177 8 p.

Research output: Contribution to journalArticle

83 Scopus citations
2013

West Nile virus drug discovery

Lim, S. P. & Shi, P. Y., Dec 3 2013, In : Viruses. 5, 12, p. 2977-3006 30 p.

Research output: Contribution to journalReview article

26 Scopus citations
2012

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

Simmons, C. P., Wolbers, M., Nguyen, M. N., Whitehorn, J., Shi, P. Y., Young, P., Petric, R., Nguyen, V. V. C., Farrar, J. & Wills, B., Sep 2012, In : PLoS neglected tropical diseases. 6, 9, e1752.

Research output: Contribution to journalArticle

25 Scopus citations
2018

Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

Fei, Z. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

2011

The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In : Journal of virology. 85, 4, p. 1900-1905 6 p.

Research output: Contribution to journalArticle

51 Scopus citations
2015

Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly

Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., 2015, In : Journal of virology. 89, 2, p. 1298-1313 16 p.

Research output: Contribution to journalArticle

49 Scopus citations
2011

A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-Dependent RNA polymerase

Niyomrattanakit, P., Abas, S. N., Lim, C. C., Beer, D., Shi, P. Y. & Chen, Y. L., Feb 1 2011, In : Journal of Biomolecular Screening. 16, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2020

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In : Nature communications. 11, 1, 4059.

Research output: Contribution to journalArticle

Open Access
2011

Nonconsensus west nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo

Ebel, G. D., Fitzpatrick, K. A., Lim, P. Y., Bennett, C. J., Deardorff, E. R., Kramer, G. V. S. J., Zhou, Y., Shi, P. Y. & Bernard, K. A., Dec 2011, In : Journal of virology. 85, 23, p. 12605-12613 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Development of a stable Gaussia luciferase enterovirus 71 reporter virus

Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In : Journal of Virological Methods. 219, p. 62-66 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mapping the interactions between the NS4B and NS3 proteins of dengue virus

Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3471-3483 13 p.

Research output: Contribution to journalArticle

43 Scopus citations
2017

A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P-Y., Mar 1 2017, In : EBioMedicine. 17, p. 157-162 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In : Nature communications. 8, 1, 676.

Research output: Contribution to journalArticle

70 Scopus citations
2014

Flavivirus RNA methylation

Dong, H., Fink, K., Züst, R., Lim, S. P., Qin, C. F. & Shi, P. Y., 2014, In : Journal of General Virology. 95, PART 4, p. 763-778 16 p.

Research output: Contribution to journalReview article

63 Scopus citations

Unraveling a flavivirus enigma

Shi, P. Y., Jan 1 2014, In : Science. 343, 6173, p. 849-850 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations
2013

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In : PLoS pathogens. 9, 8, e1003521.

Research output: Contribution to journalArticle

76 Scopus citations
2017

Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model

Siemann, D. N., Strange, D. P., Maharaj, P. N., Shi, P-Y. & Verma, S., Nov 1 2017, In : Journal of Virology. 91, 22, e00623-17.

Research output: Contribution to journalArticle

36 Scopus citations
2019

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

Jackman, J. A., Shi, P-Y. & Cho, N. J., Nov 1 2019, In : ACS Infectious Diseases. 5, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

Collins, N. D., Widen, S. G., Li, L., Swetnam, D. M., Shi, P. Y., Tesh, R. B. & Sarathy, V. V., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2016

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W. K., Yoon, K. J., Shan, C., Huang, L., Qin, Z. & 10 others, Christian, K. M., Shi, P. Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G. L. & Jin, P., Oct 14 2016, In : Nucleic acids research. 44, 18, p. 8610-8620 11 p.

Research output: Contribution to journalArticle

84 Scopus citations
2011

Functional analysis of two cavities in flavivirus NS5 polymerase

Zou, G., Chen, Y. L., Dong, H., Lim, C. C., Yap, L. J., Yau, Y. H., Shochat, S. G., Lescar, J. & Shi, P. Y., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14362-14372 11 p.

Research output: Contribution to journalArticle

79 Scopus citations
2019

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

6 Scopus citations

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2064-2066 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations