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  • Michael Sheetz
2013

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Higuchi, S., Lin, Q., Wang, J., Lim, T. K., Joshi, S. B., Anand, G. S., Chung, M. C. M., Sheetz, M. & Fujita, H., Mar 1 2013, In : Journal of Bioscience and Bioengineering. 115, 3, p. 320-325 6 p.

Research output: Contribution to journalArticle

33 Scopus citations
2017

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Wang, Y. H., Hariharan, A., Bastianello, G., Toyama, Y., Shivashankar, G. V., Foiani, M. & Sheetz, M. P., Dec 1 2017, In : Nature communications. 8, 1, 2118.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2016

α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M. R., Iskratsch, T., Mathur, A., Ghassemi, S., Gauthier, N., Tabdanov, E., Lohner, J., Gondarenko, A., Chander, A. C., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M., Nov 7 2016, In : Molecular Biology of the Cell. 27, 22, p. 3471-3479 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cooperative vinculin binding to talin mapped by time-resolved super resolution microscopy

Hu, X., Jing, C., Xu, X., Nakazawa, N., Cornish, V. W., Margadant, F. M. & Sheetz, M., Jul 13 2016, In : Nano Letters. 16, 7, p. 4062-4068 7 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2017

Polymer fiber-based models of connective tissue repair and healing

Lee, N. M., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W. N. & Lu, H. H., Jan 1 2017, In : Biomaterials. 112, p. 303-312 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Erratum: Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions (Developmental cell (2018) 44 3 (326-336.e3) PII: S1534-5807(18)30409-X)

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Jun 4 2018, In : Developmental cell. 45, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations
2012

Cells test substrate rigidity by local contractions on submicrometer pillars

Ghassemi, S., Meacci, G., Liu, S., Gondarenko, A. A., Mathur, A., Roca-Cusachs, P., Sheetz, M. & Hone, J., Apr 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5328-5333 6 p.

Research output: Contribution to journalArticle

Open Access
125 Scopus citations
2015

Early events in cell spreading as a model for quantitative analysis of biomechanical events

Wolfenson, H., Iskratsch, T. & Sheetz, M., Aug 2 2015, In : Biophysical Journal. 107, 11, p. 2508-2514 7 p.

Research output: Contribution to journalReview article

Open Access
24 Scopus citations
2016

Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate

Sonam, S., Sathe, S. R., Yim, E. K. F., Sheetz, M. & Lim, C. T., Feb 16 2016, In : Scientific reports. 6, 20415.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
2012

Mechanical feedback between membrane tension and dynamics

Gauthier, N. C., Masters, T. A. & Sheetz, M., Oct 1 2012, In : Trends in Cell Biology. 22, 10, p. 527-535 9 p.

Research output: Contribution to journalReview article

215 Scopus citations
2019

Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading

Kalappurakkal, J. M., Anilkumar, A. A., Patra, C., van Zanten, T. S., Sheetz, M. & Mayor, S., Jun 13 2019, In : Cell. 177, 7, p. 1738-1756.e23

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2016

Mechanosensing Controlled Directly by Tyrosine Kinases

Yang, B., Lieu, Z. Z., Wolfenson, H., Hameed, F. M., Bershadsky, A. D. & Sheetz, M., Sep 14 2016, In : Nano Letters. 16, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

Nakazawa, N., Sathe, A. R., Shivashankar, G. V. & Sheetz, M., Nov 1 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 44, p. E6813-E6822

Research output: Contribution to journalArticle

Open Access
19 Scopus citations
2012

Second-generation covalent TMP-tag for live cell imaging

Chen, Z., Jing, C., Gallagher, S. S., Sheetz, M. & Cornish, V. W., Aug 22 2012, In : Journal of the American Chemical Society. 134, 33, p. 13692-13699 8 p.

Research output: Contribution to journalArticle

82 Scopus citations
2017

Spatial control of biological ligands on surfaces applied to T cell activation

Cai, H., Depoil, D., Muller, J., Sheetz, M., Dustin, M. L. & Wind, S. J., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 307-331 25 p. (Methods in Molecular Biology; vol. 1584).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2012

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M. P., Trepat, X. & Ladoux, B., Jul 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

Microarray with micro- and nano-topographies enables identification of the optimal topography for directing the differentiation of primary murine neural progenitor cells

Moe, A. A. K., Suryana, M., Marcy, G., Lim, S. K., Ankam, S., Goh, J. Z. W., Jin, J., Teo, B. K. K., Law, J. B. K., Low, H. Y., Goh, E. L. K., Sheetz, M. & Yim, E. K. F., Oct 8 2012, In : Small. 8, 19, p. 3050-3061 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Spatial-temporal reorganization of activated integrins

Yu, C. H., Luo, W. & Sheetz, M., Jan 1 2012, In : Cell Adhesion and Migration. 6, 3, p. 280-284 5 p.

Research output: Contribution to journalReview article

Open Access
11 Scopus citations
2018

Correction to: Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus (Oncogene, (2007), 26, 26, (3878-3891), 10.1038/sj.onc.1210162)

Karni-Schmidt, O., Friedler, A., Zupnick, A., McKinney, K., Mattia, M., Beckerman, R., Bouvet, P., Sheetz, M., Fersht, A. & Prives, C., Aug 30 2018, In : Oncogene. 37, 35, p. 4901-4902 2 p.

Research output: Contribution to journalComment/debate

Open Access
2015

Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

Yu, C. H., Rafiq, N. B. M., Cao, F., Zhou, Y., Krishnasamy, A., Biswas, K. H., Ravasio, A., Chen, Z., Wang, Y. H., Kawauchi, K., Jones, G. E. & Sheetz, M. P., Oct 28 2015, In : Nature communications. 6, 8672.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations
2013

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

Gupta, P., Gauthier, N. C., Cheng-Han, Y., Zuanning, Y., Pontes, B., Ohmstede, M., Martin, R., Knölker, H. J., Döbereiner, H. G., Krendel, M. & Sheetz, M., Jan 1 2013, In : Biology Open. 2, 12, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
2014

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M. P., Apr 2014, In : Journal of Cell Science. 127, 7, p. 1394-1405 12 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations
2016

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

Santos, L. C., Blair, D. A., Kumari, S., Cammer, M., Iskratsch, T., Herbin, O., Alexandropoulos, K., Dustin, M. L. & Sheetz, M. P., Nov 1 2016, In : Immunology and Cell Biology. 94, 10, p. 981-993 13 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2018

Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Feb 5 2018, In : Developmental cell. 44, 3, p. 326-336.e3

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
2016

Mechanical confinement triggers glioma linear migration dependent on formin FHOD3

Monzo, P., Chong, Y. K., Guetta-Terrier, C., Krishnasamy, A., Sathe, S. R., Yim, E. K. F., Ng, W. H., Ang, B. T., Tang, C., Ladoux, B., Gauthier, N. C. & Sheetz, M., Apr 15 2016, In : Molecular Biology of the Cell. 27, 8, p. 1246-1261 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

Saxena, M., Changede, R., Hone, J., Wolfenson, H. & Sheetz, M., Dec 13 2017, In : Nano Letters. 17, 12, p. 7242-7251 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2018

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Cai, H., Muller, J., Depoil, D., Mayya, V., Sheetz, M., Dustin, M. L. & Wind, S. J., Jul 1 2018, In : Nature Nanotechnology. 13, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2012

The lasker awards: Motors take centre stage

Sheetz, M., Spudich, J. & Vale, R., Nov 1 2012, In : Nature Cell Biology. 14, 11, 1 p.

Research output: Contribution to journalEditorial

Open Access
2011

Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization.

Palma, M., Abramson, J. J., Gorodetsky, A. A., Nuckolls, C., Sheetz, M., Wind, S. J. & Hone, J., Jan 1 2011, In : Methods in molecular biology (Clifton, N.J.). 749, p. 169-185 17 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Force-dependent cell signaling in stem cell differentiation

Yim, E. K. F. & Sheetz, M., Nov 6 2012, In : Stem Cell Research and Therapy. 3, 5, 41.

Research output: Contribution to journalReview article

Open Access
86 Scopus citations
2016

F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback

Masters, T. A., Sheetz, M. & Gauthier, N. C., Apr 1 2016, In : Cytoskeleton. 73, 4, p. 180-196 17 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility

Zaburdaev, V., Biais, N., Schmiedeberg, M., Eriksson, J., Jonsson, A. B., Sheetz, M. & Weitz, D. A., Oct 7 2014, In : Biophysical Journal. 107, 7, p. 1523-1531 9 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations
2011

Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair

Moore, S. W. & Sheetz, M., Nov 1 2011, In : Developmental Neurobiology. 71, 11, p. 1090-1101 12 p.

Research output: Contribution to journalArticle

50 Scopus citations
2019

Large and reversible myosin-dependent forces in rigidity sensing

Lohner, J., Rupprecht, J. F., Hu, J., Mandriota, N., Saxena, M., de Araujo, D. P., Hone, J., Sahin, O., Prost, J. & Sheetz, M., Jul 1 2019, In : Nature Physics. 15, 7, p. 689-695 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Finding the weakest link-exploring integrin-mediated mechanical molecular pathways

Roca-Cusachs, P., Iskratsch, T. & Sheetz, M., Jul 1 2012, In : Journal of Cell Science. 125, 13, p. 3025-3038 14 p.

Research output: Contribution to journalComment/debate

Open Access
152 Scopus citations
2016

Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains

Sathe, A. R., Shivashankar, G. V. & Sheetz, M., May 15 2016, In : Journal of Cell Science. 129, 10, p. 1981-1988 8 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2013

Toward a modular analysis of cell mechanosensing and mechanotransduction: A manual for cell mechanics

Dubin-Thaler, B. J. & Sheetz, M., Jan 1 2013, Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues. Cambridge University Press, Vol. 9780521895231. p. 181-195 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading

Rangamani, P., Fardin, M. A., Xiong, Y., Lipshtat, A., Rossier, O., Sheetz, M. & Iyengar, R., Feb 16 2011, In : Biophysical Journal. 100, 4, p. 845-857 13 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2015

Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

Changede, R., Xu, X., Margadant, F. & Sheetz, M., Jan 1 2015, In : Developmental Cell. 35, 5, p. 614-621 8 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations
2013

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces

Yu, C. H., Rafiq, N. B. M., Krishnasamy, A., Hartman, K. L., Jones, G. E., Bershadsky, A. D. & Sheetz, M., Dec 12 2013, In : Cell Reports. 5, 5, p. 1456-1468 13 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations
2017

EGFR and HER2 activate rigidity sensing only on rigid matrices

Saxena, M., Liu, S., Yang, B., Hajal, C., Changede, R., Hu, J., Wolfenson, H., Hone, J. & Sheetz, M., Jul 1 2017, In : Nature Materials. 16, 7, p. 775-781 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

Yan, J., Yao, M., Goult, B. T. & Sheetz, M. P., 2015, In : Cellular and Molecular Bioengineering. 8, 1, p. 151-159 9 p.

Research output: Contribution to journalReview article

Open Access
49 Scopus citations
2016

Formin DAAM1 organizes actin filaments in the cytoplasmic nodal actin network

Luo, W., Lieu, Z. Z., Manser, E., Bershadsky, A. D. & Sheetz, M. P., Oct 2016, In : PloS one. 11, 10, e0163915.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2013

Bifunctional nanoarrays for probing the immune response at the single-molecule level

Cai, H., Depoil, D., Palma, M., Sheetz, M., Dustin, M. L. & Wind, S. J., Nov 1 2013, In : Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures. 31, 6, 6F902.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level

Schvartzman, M., Palma, M., Sable, J., Abramson, J., Hu, X., Sheetz, M. & Wind, S. J., Mar 9 2011, In : Nano Letters. 11, 3, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

148 Scopus citations
2015

Cyclic stretching of soft substrates induces spreading and growth

Cui, Y., Hameed, F. M., Yang, B., Lee, K., Pan, C. Q., Park, S. & Sheetz, M., Feb 23 2015, In : Nature communications. 6, 6333.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations
2011

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

Lynch, C. D., Gauthier, N. C., Biais, N., Lazar, A. M., Roca-Cusachs, P., Yu, C. H. & Sheetz, M., Apr 15 2011, In : Molecular Biology of the Cell. 22, 8, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2019

A tale of two states: Normal and transformed, with and without rigidity sensing

Sheetz, M., Jan 1 2019, In : Annual Review of Cell and Developmental Biology. 35, p. 169-190 22 p.

Research output: Contribution to journalReview article

1 Scopus citations
2020

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

Doss, B. L., Pan, M., Gupta, M., Grenci, G., Mège, R. M., Lim, C. T., Sheetz, M. P., Voituriez, R. & Ladoux, B., Jun 9 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 12817-12825 9 p.

Research output: Contribution to journalArticle

2017

Molecular stretching modulates mechanosensing pathways

Hu, X., Margadant, F. M., Yao, M. & Sheetz, M. P., Jul 1 2017, In : Protein Science. 26, 7, p. 1337-1351 15 p.

Research output: Contribution to journalReview article

22 Scopus citations