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  • Jia Zhou
2013

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

Almahariq, M., Tsalkova, T., Mei, F. C., Chen, H., Zhou, J., Sastry, S. K., Schwede, F. & Cheng, X., Jan 2013, In : Molecular pharmacology. 83, 1, p. 122-128 7 p.

Research output: Contribution to journalArticle

131 Scopus citations
2020

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

Liu, Z., Chen, H., Wang, P., Li, Y., Wold, E. A., Leonard, P. G., Joseph, S., Brasier, A. R., Tian, B., Tian, B., Zhou, J., Zhou, J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5242-5256 15 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019
4 Scopus citations
4 Scopus citations
2017

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Li, Z., Brecher, M., Deng, Y. Q., Zhang, J., Sakamuru, S., Liu, B., Huang, R., Koetzner, C. A., Allen, C. A., Jones, S. A., Chen, H., Zhang, N. N., Tian, M., Gao, F., Lin, Q., Banavali, N., Zhou, J., Boles, N., Xia, M., Kramer, L. D. & 2 others, Qin, C. F. & Li, H., Aug 1 2017, In : Cell Research. 27, 8, p. 1046-1064 19 p.

Research output: Contribution to journalArticle

52 Scopus citations
2016

Hydrogen sulfide contributes to retinal neovascularization in Ischemia-Induced retinopathy

Gersztenkorn, D., Coletta, C., Zhu, S., Ha, Y., Liu, H., Tie, H., Zhou, J., Szabo, C., Zhang, W. & Motamedi, M., Jun 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, p. 3002-3009 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2019

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In : Journal of Proteomics. 205, 103415.

Research output: Contribution to journalArticle

6 Scopus citations

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2017

YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway

Chen, Z., Wu, Q., Ding, Y., Zhou, W., Liu, R., Chen, H., Zhou, J., Feng, J. & Chen, C., Jan 1 2017, In : Theranostics. 7, 8, p. 2339-2349 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journalArticle

15 Scopus citations
2018

Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Xu, J., Wold, E. A., Ding, Y., Shen, Q. & Zhou, J., Jan 1 2018, In : Molecules. 23, 2, 474.

Research output: Contribution to journalReview article

28 Scopus citations
2014

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

Chen, H., Yang, Z., Ding, C., Xiong, A., Wild, C., Wang, L., Ye, N., Cai, G., Flores, R. M., Ding, Y., Shen, Q. & Zhou, J., Jul 23 2014, In : European journal of medicinal chemistry. 82, p. 195-203 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2019

Recent advances in developing K-ras plasma membrane localization inhibitors

Ye, N., Xu, Q., Li, W., Wang, P. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 23, p. 2114-2127 14 p.

Research output: Contribution to journalReview article

2 Scopus citations
2014

Development of a concise synthetic approach to access oroxin A

Chen, H., He, G., Li, C., Dong, L., Xie, X., Wu, J., Gao, Y. & Zhou, J., 2014, In : RSC Advances. 4, 85, p. 45151-45154 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: Synthesis of dihydropyran-fused diterpenoids

Ding, C., Wang, L., Chen, H., Wild, C., Ye, N., Ding, Y., Wang, T., White, M. A., Shen, Q. & Zhou, J., Nov 14 2014, In : Organic and Biomolecular Chemistry. 12, 42, p. 8442-8452 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
2018

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease

Li, Z., Sakamuru, S., Huang, R., Brecher, M., Koetzner, C. A., Zhang, J., Chen, H., Qin, C. F., Zhang, Q. Y., Zhou, J., Kramer, L. D., Xia, M. & Li, H., Feb 1 2018, In : Antiviral Research. 150, p. 217-225 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist

Chen, H., Ding, C., Wild, C., Liu, H., Wang, T., White, M. A., Cheng, X. & Zhou, J., Mar 20 2013, In : Tetrahedron Letters. 54, 12, p. 1546-1549 4 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells

Bohanon, F. J., Wang, X., Graham, B. M., Prasai, A., Vasudevan, S. J., Ding, C., Ding, Y., Radhakrishnan, G., Rastellini, C., Zhou, J. & Radhakrishnan, R., Sep 7 2015, In : Molecular and Cellular Biochemistry. 410, 1-2, p. 293-300 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2018

Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer

Lin, Y., Liu, R., Zhao, P., Ye, J., Zheng, Z., Huang, J., Zhang, Y., Gao, Y., Chen, H., Liu, S., Zhou, J., Chen, C. & Chen, H., Feb 25 2018, In : European Journal of Medicinal Chemistry. 146, p. 354-367 14 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Therapeutic potential of spirooxindoles as antiviral agents

Ye, N., Chen, H., Wold, E. A., Shi, P-Y. & Zhou, J., Jun 10 2016, In : ACS Infectious Diseases. 2, 6, p. 382-392 11 p.

Research output: Contribution to journalReview article

159 Scopus citations
2018

GPCR Allosteric Modulators: Mechanistic Advantages and Therapeutic Applications

Wold, E. A. & Zhou, J., Jan 1 2018, In : Current Topics in Medicinal Chemistry. 18, 23, p. 2002-2006 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Scaffold repurposing of old drugs towards new cancer drug discovery

Chen, H., Wu, J., Gao, Y., Chen, H. & Zhou, J., Aug 1 2016, In : Current Topics in Medicinal Chemistry. 16, 19, p. 2107-2114 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

Chen, H., Gao, Y., Wu, J., Chen, Y., Chen, B., Hu, J. & Zhou, J., Nov 1 2014, In : Cancer Letters. 354, 1, p. 5-11 7 p.

Research output: Contribution to journalShort survey

61 Scopus citations
2018

Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions

Liu, Z., Wadsworth, P., Singh, A. K., Chen, H., Wang, P., Folorunso, O., Scaduto, P., Ali, S. R., Laezza, F. & Zhou, J., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

3 Scopus citations

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. & Zhou, J., May 10 2018, In : European Journal of Medicinal Chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Identification and characterization of small molecules as potent and specific EPAC2 antagonists

Chen, H., Tsalkova, T., Chepurny, O. G., Mei, F. C., Holz, G. G., Cheng, X. & Zhou, J., Feb 14 2013, In : Journal of medicinal chemistry. 56, 3, p. 952-962 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012

NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia

Feng, J. F., Gurkoff, G. G., Van, K. C., Song, M., Lowe, D. A., Zhou, J. & Lyeth, B. G., Aug 21 2012, In : Brain Research. 1469, p. 144-152 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2019

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In : Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

Research output: Contribution to journalArticle

10 Scopus citations
2014

Transcription factor STAT3 as a novel molecular target for cancer prevention

Xiong, A., Yang, Z., Shen, Y., Zhou, J. & Shen, Q., Jun 2014, In : Cancers. 6, 2, p. 926-957 32 p.

Research output: Contribution to journalReview article

154 Scopus citations
2019

HFIP-promoted Michael reactions: direct para-selective C-H activation of anilines with maleimides

Li, B., Mao, Q., Zhou, J., Liu, F. & Ye, N., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 8, p. 2242-2246 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Suppression of the growth and invasion of human head and neck squamous cell carcinomas via regulating STAT3 signaling and the miR-21/β-catenin axis with HJC0152

Wang, Y., Wang, S., Wu, Y., Ren, Y., Li, Z., Yao, X., Zhang, C., Ye, N., Jing, C., Dong, J., Zhang, K., Sun, S., Zhao, M., Guo, W., Qu, X., Qiao, Y., Chen, H., Kong, L., Jin, R., Wang, X. & 4 others, Zhang, L., Zhou, J., Shen, Q. & Zhou, X., Apr 2017, In : Molecular Cancer Therapeutics. 16, 4, p. 578-590 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Modulation of Bax and mTOR for cancer therapeutics

Li, R., Ding, C., Zhang, J., Xie, M., Park, D., Ding, Y., Chen, G., Zhang, G., Gilbert-Ross, M., Zhou, W., Marcus, A. I., Sun, S. Y., Chen, Z. G., Sica, G. L., Ramalingam, S. S., Magis, A. T., Fu, H., Khuri, F. R., Curran, W. J., Owonikoko, T. K. & 3 others, Shin, D. M., Zhou, J. & Deng, X., Jun 1 2017, In : Cancer Research. 77, 11, p. 3001-3012 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M., Jun 1 2015, In : Journal of Surgical Research. 196, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2019

Applications of bioorthogonal chemistry in tumor-targeted drug discovery

Liu, G., Wold, E. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 11, p. 892-897 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Small Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.

Sampson, C. M., Kasper, J., Felsing, D., Raval, S., Ye, N., P, W., Rytting, E., Zhou, J., Allen, J. & Hommel, J., Aug 23 2018, In : Pharmacology Research and Perspectives. 6, (5):e00425. , doi: 10.1002/prp2.425.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2012

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators

Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In : ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Discovery and development of natural product oridonin-inspired anticancer agents

Ding, Y., Ding, C., Ye, N., Liu, Z., Wold, E. A., Chen, H., Wild, C., Shen, Q. & Zhou, J., Oct 21 2016, In : European Journal of Medicinal Chemistry. 122, p. 102-117 16 p.

Research output: Contribution to journalReview article

66 Scopus citations
2019

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Evolutions in fragment-based drug design: The deconstruction-reconstruction approach

Chen, H., Zhou, X., Wang, A., Zheng, Y., Gao, Y. & Zhou, J., Jan 2015, In : Drug Discovery Today. 20, 1, p. 105-113 9 p.

Research output: Contribution to journalReview article

66 Scopus citations
2016

Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors

Wild, C. T., Zhu, Y., Na, Y., Mei, F., Ynalvez, M. A., Chen, H., Cheng, X. & Zhou, J., May 12 2016, In : ACS Medicinal Chemistry Letters. 7, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

STAT3 inhibition suppresses hepatic stellate cell fibrogenesis: HJC0123, a potential therapeutic agent for liver fibrosis

Lopez, O. N., Bohanon, F. J., Wang, X., Ye, N., Gorgun, T., Rojas-Khalil, Y., Chen, H., Chen, H., Zhou, J. & Radhakrishnan, R., 2016, In : RSC Advances. 6, 102, p. 100652-100663 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Medicinal chemistry in oncology: New approaches and future trends

Zhou, J., 2015, In : Current topics in medicinal chemistry. 15, 8, 1 p.

Research output: Contribution to journalEditorial

2019

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

Liu, G., Yin, T., Kim, H., Ding, C., Yu, Z., Wang, H., Chen, H., Yan, R., Wold, E. A., Zou, H., Liu, X., Ding, Y., Shen, Q. & Zhou, J., Sep 15 2019, In : European journal of medicinal chemistry. 178, p. 589-605 17 p.

Research output: Contribution to journalArticle

2017

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of Medicinal Chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

86 Scopus citations
2017

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

Liu, Z., Zhu, Y., Chen, H., Wang, P., Mei, F. C., Ye, N., Cheng, X. & Zhou, J., Dec 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5163-5166 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Gpcr drug discovery: Emerging targets, novel approaches and future trends

Zhou, J. & Wild, C., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1363-1364 2 p.

Research output: Contribution to journalEditorial

Open Access

Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

5 Scopus citations
2013

Overcoming synthetic challenges of oridonin a-ring structural diversification: Regio- and stereoselective installation of azides and 1,2,3-triazoles at the c-1, c-2, or c-3 position

Ding, C., Zhang, Y., Chen, H., Wild, C., Wang, T., White, M. A., Shen, Q. & Zhou, J., Jul 19 2013, In : Organic Letters. 15, 14, p. 3718-3721 4 p.

Research output: Contribution to journalArticle

39 Scopus citations
2019

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S-J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In : Life Sciences. 221, p. 1-12 12 p.

Research output: Contribution to journalArticle

1 Scopus citations