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  • Jia Zhou
2017

Fragment-based drug design: Strategic advances and lessons learned

Chen, H., Zhou, X., Gao, Y., Chen, H. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 212-232 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

Liu, Z., Zhu, Y., Chen, H., Wang, P., Mei, F. C., Ye, N., Cheng, X. & Zhou, J., Dec 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5163-5166 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N′-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists

Ye, N., Zhu, Y., Chen, H., Liu, Z., Mei, F. C., Wild, C., Chen, H., Cheng, X. & Zhou, J., Jul 17 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 6033-6047 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Li, Z., Brecher, M., Deng, Y. Q., Zhang, J., Sakamuru, S., Liu, B., Huang, R., Koetzner, C. A., Allen, C. A., Jones, S. A., Chen, H., Zhang, N. N., Tian, M., Gao, F., Lin, Q., Banavali, N., Zhou, J., Boles, N., Xia, M., Kramer, L. D. & 2 others, Qin, C. F. & Li, H., Aug 1 2017, In : Cell Research. 27, 8, p. 1046-1064 19 p.

Research output: Contribution to journalArticle

53 Scopus citations
2019

Synthesis and pharmacological evaluation of non-catechol G protein biased and unbiased dopamine D1 receptor agonists

Wang, P., Felsing, D., Chen, H., Raval, S., Allen, J. & Zhou, J., May 9 2019, In : ACS Medicinal Chemistry Letters. 10.1021/acsmedchemlett.9b00050, p. 792-799 8 p., 10.1021/acsmedchemlett.9b00050.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2014

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

Chen, H., Mrazek, A. A., Wang, X., Ding, C., Ding, Y., Porro, L. J., Liu, H., Chao, C., Hellmich, M. R. & Zhou, J., Jul 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 13, p. 3393-3404 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2018

AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence

Hu, X., Tian, X., Guo, X., He, Y., Chen, H., Zhou, J. & Wang, Z. J., Jul 15 2018, In : Neuropharmacology. 137, p. 50-58 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Antifibrosis effect of novel oridonin analog CYD0618 via suppression of the NF-κB pathway

Cummins, C. B., Wang, X., Xu, J., Hughes, B. D., Ding, Y., Chen, H., Zhou, J. & Radhakrishnan, R. S., Dec 2018, In : Journal of Surgical Research. 232, p. 283-292 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Development of a concise synthetic approach to access oroxin A

Chen, H., He, G., Li, C., Dong, L., Xie, X., Wu, J., Gao, Y. & Zhou, J., 2014, In : RSC Advances. 4, 85, p. 45151-45154 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2020

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling

Brasier, A. R. & Zhou, J., Jan 2020, In : Drug Discovery Today. 25, 1, p. 126-132 7 p.

Research output: Contribution to journalReview article

3 Scopus citations
2018

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease

Li, Z., Sakamuru, S., Huang, R., Brecher, M., Koetzner, C. A., Zhang, J., Chen, H., Qin, C. F., Zhang, Q. Y., Zhou, J., Kramer, L. D., Xia, M. & Li, H., Feb 1 2018, In : Antiviral Research. 150, p. 217-225 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Small Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.

Sampson, C. M., Kasper, J., Felsing, D., Raval, S., Ye, N., P, W., Rytting, E., Zhou, J., Allen, J. & Hommel, J., Aug 23 2018, In : Pharmacology Research and Perspectives. 6, (5):e00425. , doi: 10.1002/prp2.425.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2015

Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells

Bohanon, F. J., Wang, X., Graham, B. M., Prasai, A., Vasudevan, S. J., Ding, C., Ding, Y., Radhakrishnan, G. L., Rastellini, C., Zhou, J. & Radhakrishnan, R. S., Sep 7 2015, In : Molecular and Cellular Biochemistry. 410, 1-2, p. 293-300 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Small-molecule Bax agonists for cancer therapy

Xin, M., Li, R., Xie, M., Park, D., Owonikoko, T. K., Sica, G. L., Corsino, P. E., Zhou, J., Ding, C., White, M. A., Magis, A. T., Ramalingam, S. S., Curran, W. J., Khuri, F. R. & Deng, X., Jan 1 2014, In : Nature communications. 5, 4935.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations

STAT3 modulation to enhance motor neuron differentiation in human neural stem cells

Natarajan, R., Singal, V., Benes, R., Gao, J., Chan, H., Chen, H., Yu, Y., Zhou, J. & Wu, P., Jun 19 2014, In : PloS one. 9, 6, e100405.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

Bohanon, F. J., Wang, X., Graham, B. M., Ding, C., Ding, Y., Radhakrishnan, G., Rastellini, C., Zhou, J. & Radhakrishnan, R., Dec 1 2015, In : Journal of Surgical Research. 199, 2, p. 441-449 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis

Bohanon, F. J., Wang, X., Ding, C., Ding, Y., Radhakrishnan, G. L., Rastellini, C., Zhou, J. & Radhakrishnan, R. S., Jul 2014, In : Journal of Surgical Research. 190, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

45 Scopus citations
2020

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Liu, X., Xu, J., Zhou, J. & Shen, Q., 2020, (Accepted/In press) In : Genes and Diseases.

Research output: Contribution to journalReview article

Open Access
2014

Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis

Qi, C., Zhou, Q., Li, B., Yang, Y., Cao, L., Ye, Y., Li, J., Ding, Y., Wang, H., Wang, J., He, X., Zhang, Q., Lan, T., Lee, K. K. H., Li, W., Song, X., Zhou, J., Yang, X. & Wang, L., 2014, In : Oncotarget. 5, 20, p. 9966-9979 14 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2018

Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

Ali, S. R., Liu, Z., Nenov, M. N., Folorunso, O., Singh, A., Scala, F., Chen, H., James, T. F., Alshammari, M., Panova-Elektronova, N. I., White, M. A., Zhou, J. & Laezza, F., May 16 2018, In : ACS chemical neuroscience. 9, 5, p. 976-987 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Chen, H., Wang, C. Z., Ding, C., Wild, C., Copits, B., Swanson, G. T., Johnson, K. M. & Zhou, J., Feb 2013, In : ChemMedChem. 8, 2, p. 226-230 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
2018

Exchange protein directly activated by cAMP modulates ebola virus uptake into vascular endothelial cells

Drelich, A., Judy, B., He, X., Chang, Q., Yu, S., Li, X., Lu, F., Wakamiya, M., Popov, V., Zhou, J., Ksiazek, T. & Gong, B., Oct 16 2018, In : Viruses. 10, 10, 563.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI

Feng, J. F., Van, K. C., Gurkoff, G. G., Kopriva, C., Olszewski, R. T., Song, M., Sun, S., Xu, M., Neale, J. H., Yuen, P. W., Lowe, D. A., Zhou, J. & Lyeth, B. G., Jun 13 2011, In : Brain Research. 1395, p. 62-73 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Discovery of O-alkylamino-tethered niclosamide derivatives as potent and orally bioavailable anticancer agents

Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q. & Zhou, J., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 180-185 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Identification and characterization of small molecules as potent and specific EPAC2 antagonists

Chen, H., Tsalkova, T., Chepurny, O. G., Mei, F. C., Holz, G. G., Cheng, X. & Zhou, J., Feb 14 2013, In : Journal of medicinal chemistry. 56, 3, p. 952-962 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2018

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

Wang, P. & Zhou, J., Jan 1 2018, In : Current Topics in Medicinal Chemistry. 18, 16, p. 1354-1356 3 p.

Research output: Contribution to journalReview article

17 Scopus citations

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis

Li, D., Wang, H., Ding, Y., Zhang, Z., Zheng, Z., Dong, J., Kim, H., Meng, X., Zhou, Q., Zhou, J., Fang, L. & Shen, Q., Jun 28 2018, In : Cancer Letters. 424, p. 97-108 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2020

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5159-5184 26 p.

Research output: Contribution to journalArticle

2015

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 "Therapeutic Window"

Zhu, Y., Chen, H., Boulton, S., Mei, F., Ye, N., Melacini, G., Zhou, J. & Cheng, X., Mar 23 2015, In : Scientific reports. 5, 9344.

Research output: Contribution to journalArticle

62 Scopus citations
2019

HFIP-promoted Michael reactions: direct para-selective C-H activation of anilines with maleimides

Li, B., Mao, Q., Zhou, J., Liu, F. & Ye, N., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 8, p. 2242-2246 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

Wang, P., Liu, Z., Chen, H., Ye, N., Cheng, X. & Zhou, J., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1633-1639 7 p.

Research output: Contribution to journalReview article

21 Scopus citations
2014

Transcription factor STAT3 as a novel molecular target for cancer prevention

Xiong, A., Yang, Z., Shen, Y., Zhou, J. & Shen, Q., Jun 2014, In : Cancers. 6, 2, p. 926-957 32 p.

Research output: Contribution to journalReview article

158 Scopus citations

Allosteric Modulation of G Protein-Coupled Receptors: An Emerging Approach of Drug Discovery

Wild, C., Cunningham, K. A. & Zhou, J., Feb 13 2014, In : Austin Journal of Pharmacology and Therapeutics. 2, p. 3

Research output: Contribution to journalArticle

2013

Oridonin ring A-based diverse constructions of enone functionality: Identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis

Ding, C., Zhang, Y., Chen, H., Yang, Z., Wild, C., Ye, N., Ester, C. D., Xiong, A., White, M. A., Shen, Q. & Zhou, J., Nov 14 2013, In : Journal of medicinal chemistry. 56, 21, p. 8814-8825 12 p.

Research output: Contribution to journalArticle

51 Scopus citations
2018

Luteolin-mediated inhibition of hepatic stellate cell activation via suppression of the STAT3 pathway

Cummins, C. B., Wang, X., Nunez Lopez, O., Graham, G., Tie, H. Y., Zhou, J. & Radhakrishnan, R. S., Jun 2018, In : International journal of molecular sciences. 19, 6, 1567.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist

Chen, H., Ding, C., Wild, C., Liu, H., Wang, T., White, M. A., Cheng, X. & Zhou, J., Mar 20 2013, In : Tetrahedron Letters. 54, 12, p. 1546-1549 4 p.

Research output: Contribution to journalArticle

27 Scopus citations
2020

Bidirectional modulation of the voltage-gated sodium (Nav1.6) channel by rationally designed peptidomimetics

Dvorak, N. M., Wadsworth, P. A., Wang, P., Chen, H., Zhou, J. & Laezza, F., Aug 2020, In : Molecules. 25, 15, 3365.

Research output: Contribution to journalArticle

Open Access
2015

Targeting Krüppel-like factor 5 (KLF5) for cancer therapy

Gao, Y., Ding, Y., Chen, H., Chen, H. & Zhou, J., 2015, In : Current Topics in Medicinal Chemistry. 15, 8, p. 699-713 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M. R., Jun 1 2015, In : Journal of Surgical Research. 196, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2017

YD277 suppresses triple-negative breast cancer partially through activating the endoplasmic reticulum stress pathway

Chen, Z., Wu, Q., Ding, Y., Zhou, W., Liu, R., Chen, H., Zhou, J., Feng, J. & Chen, C., 2017, In : Theranostics. 7, 8, p. 2339-2349 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2013

Overcoming synthetic challenges of oridonin a-ring structural diversification: Regio- and stereoselective installation of azides and 1,2,3-triazoles at the c-1, c-2, or c-3 position

Ding, C., Zhang, Y., Chen, H., Wild, C., Wang, T., White, M. A., Shen, Q. & Zhou, J., Jul 19 2013, In : Organic Letters. 15, 14, p. 3718-3721 4 p.

Research output: Contribution to journalArticle

39 Scopus citations
2016

Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors

Wild, C. T., Zhu, Y., Na, Y., Mei, F., Ynalvez, M. A., Chen, H., Cheng, X. & Zhou, J., May 12 2016, In : ACS Medicinal Chemistry Letters. 7, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2019

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In : Journal of Proteomics. 205, 103415.

Research output: Contribution to journalArticle

8 Scopus citations

Dual activity of niclosamide to suppress replication of integrated HIV-1 and Mycobacterium tuberculosis (Beijing)

Fan, X. Z., Xu, J., Files, M., Cirillo, J. D., Endsley, J. J., Zhou, J. & Endsley, M. A., May 2019, In : Tuberculosis. 116, p. S28-S33

Research output: Contribution to journalArticle

3 Scopus citations
2016

Direct Activation of Bax Protein for Cancer Therapy

Liu, Z., Ding, Y., Ye, N., Wild, C., Chen, H. & Zhou, J., Mar 1 2016, In : Medicinal Research Reviews. 36, 2, p. 313-341 29 p.

Research output: Contribution to journalArticle

57 Scopus citations
2012

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP

Chen, H., Tsalkova, T., Mei, F. C., Hu, Y., Cheng, X. & Zhou, J., Jun 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 12, p. 4038-4043 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
2019

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

11 Scopus citations
2020

Epigenetic suppression of HIV in myeloid cells by the BRD4-selective small molecule modulator ZL0580

Alamer, E., Zhong, C., Liu, Z., Niu, Q., Long, F., Guo, L., Gelman, B. B., Soong, L., Zhou, J. & Hu, H., Jun 1 2020, In : Journal of virology. 94, 11, e01880-19.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Chemistry and Bioactivity of ent-Kaurene Diterpenoids

Ding, C., Ding, Y., Chen, H. & Zhou, J., 2017, Studies in Natural Products Chemistry. Elsevier B.V., Vol. 54. p. 141-197 57 p. (Studies in Natural Products Chemistry; vol. 54).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

Zhou, J., Yun, E. J., Chen, W., Ding, Y., Wu, K., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Pong, R. C., Chen, H., He, D., Zhou, J. & Hsieh, J. T., Mar 23 2017, In : Cell death & disease. 8, 3, p. e2701

Research output: Contribution to journalArticle

14 Scopus citations