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Author

  • Jia Zhou
2016

Scaffold repurposing of old drugs towards new cancer drug discovery

Chen, H., Wu, J., Gao, Y., Chen, H. & Zhou, J., Aug 1 2016, In : Current Topics in Medicinal Chemistry. 16, 19, p. 2107-2114 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

Bohanon, F. J., Wang, X., Graham, B. M., Ding, C., Ding, Y., Radhakrishnan, G., Rastellini, C., Zhou, J. & Radhakrishnan, R., Dec 1 2015, In : Journal of Surgical Research. 199, 2, p. 441-449 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2019

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

Liu, G., Yin, T., Kim, H., Ding, C., Yu, Z., Wang, H., Chen, H., Yan, R., Wold, E. A., Zou, H., Liu, X., Ding, Y., Shen, Q. & Zhou, J., Sep 15 2019, In : European journal of medicinal chemistry. 178, p. 589-605 17 p.

Research output: Contribution to journalArticle

Applications of bioorthogonal chemistry in tumor-targeted drug discovery

Liu, G., Wold, E. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 11, p. 892-897 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease

Li, Z., Sakamuru, S., Huang, R., Brecher, M., Koetzner, C. A., Zhang, J., Chen, H., Qin, C. F., Zhang, Q. Y., Zhou, J., Kramer, L. D., Xia, M. & Li, H., Feb 1 2018, In : Antiviral Research. 150, p. 217-225 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Small Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.

Sampson, C. M., Kasper, J., Felsing, D., Raval, S., Ye, N., P, W., Rytting, E., Zhou, J., Allen, J. & Hommel, J., Aug 23 2018, In : Pharmacology Research and Perspectives. 6, (5):e00425. , doi: 10.1002/prp2.425.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2013

Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist

Chen, H., Ding, C., Wild, C., Liu, H., Wang, T., White, M. A., Cheng, X. & Zhou, J., Mar 20 2013, In : Tetrahedron Letters. 54, 12, p. 1546-1549 4 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Evolutions in fragment-based drug design: The deconstruction-reconstruction approach

Chen, H., Zhou, X., Wang, A., Zheng, Y., Gao, Y. & Zhou, J., Jan 2015, In : Drug Discovery Today. 20, 1, p. 105-113 9 p.

Research output: Contribution to journalReview article

66 Scopus citations
2017

Chemistry and Bioactivity of ent-Kaurene Diterpenoids

Ding, C., Ding, Y., Chen, H. & Zhou, J., 2017, Studies in Natural Products Chemistry. Elsevier B.V., Vol. 54. p. 141-197 57 p. (Studies in Natural Products Chemistry; vol. 54).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2018

Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Xu, J., Wold, E. A., Ding, Y., Shen, Q. & Zhou, J., 2018, In : Molecules. 23, 2, 474.

Research output: Contribution to journalReview article

31 Scopus citations
2016

Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors

Wild, C. T., Zhu, Y., Na, Y., Mei, F., Ynalvez, M. A., Chen, H., Cheng, X. & Zhou, J., May 12 2016, In : ACS Medicinal Chemistry Letters. 7, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. R. & Zhou, J., May 10 2018, In : European journal of medicinal chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2019

Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions

Liu, Z., Wadsworth, P., Singh, A. K., Chen, H., Wang, P., Folorunso, O., Scaduto, P., Ali, S. R., Laezza, F. & Zhou, J., Feb 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI

Feng, J. F., Van, K. C., Gurkoff, G. G., Kopriva, C., Olszewski, R. T., Song, M., Sun, S., Xu, M., Neale, J. H., Yuen, P. W., Lowe, D. A., Zhou, J. & Lyeth, B. G., Jun 13 2011, In : Brain Research. 1395, p. 62-73 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues

Chen, W., Zhou, J., Wu, K., Huang, J., Ding, Y., Yun, E. J., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Chen, H., Lin, H., Sagalowsky, A., He, D., Zhou, J. & Hsieh, J. T., 2016, In : Oncotarget. 7, 35, p. 56842-56854 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Meet our editorial board member

Zhou, J., Sep 1 2016, In : Current Drug Discovery Technologies. 13, 3, p. 121-122 2 p.

Research output: Contribution to journalEditorial

2018

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis

Li, D., Wang, H., Ding, Y., Zhang, Z., Zheng, Z., Dong, J., Kim, H., Meng, X., Zhou, Q., Zhou, J., Fang, L. & Shen, Q., Jun 28 2018, In : Cancer Letters. 424, p. 97-108 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia

Gurkoff, G. G., Feng, J. F., Van, K. C., Izadi, A., Ghiasvand, R., Shahlaie, K., Song, M., Lowe, D. A., Zhou, J. & Lyeth, B. G., Jun 17 2013, In : Brain Research. 1515, p. 98-107 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2018

Luteolin-mediated inhibition of hepatic stellate cell activation via suppression of the STAT3 pathway

Cummins, C. B., Wang, X., Nunez Lopez, O., Graham, G., Tie, H. Y., Zhou, J. & Radhakrishnan, R. S., Jun 2018, In : International journal of molecular sciences. 19, 6, 1567.

Research output: Contribution to journalArticle

9 Scopus citations