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  • Istvan Boldogh
2016

Facilitation of allergic sensitization and allergic airway inflammation by pollen-induced innate neutrophil recruitment

Hosoki, K., Aguilera-Aguirre, L., Brasier, A. R., Kurosky, A., Boldogh, I. & Sur, S., Jan 2016, In : American journal of respiratory cell and molecular biology. 54, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In : DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2015

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Innate responses to pollen allergens

Hosoki, K., Boldogh, I. & Sur, S., Feb 13 2015, In : Current opinion in allergy and clinical immunology. 15, 1, p. 79-88 10 p.

Research output: Contribution to journalReview article

16 Scopus citations
2014

Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model

Csillag, A., Kumar, B. V., Szabó, K., Szilasi, M., Papp, Z., Szilasi, M. E., Pázmándi, K., Boldogh, I., Rajnavölgyi, É., Bácsi, A. & László, J. F., Jun 6 2014, In : Journal of the Royal Society Interface. 11, 95, 20140097.

Research output: Contribution to journalArticle

12 Scopus citations
2018

The establishment of methods for free PAR generation and PAR reader detection

Ke, Y., Wang, K., Xu, H., Wang, C., Zhang, J., Zeng, X., Wang, R., Boldogh, I. & Ba, X., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Probes.

Research output: Contribution to journalArticle

1 Scopus citations
2014

NEIL2 Protects against Oxidative DNA damage induced by sidestream smoke in human cells

Sarker, A. H., Chatterjee, A., Williams, M., Lin, S., Havel, C., Jacob, P., Boldogh, I., Hazra, T. K., Talbot, P. & Hang, B., Mar 3 2014, In : PloS one. 9, 3, e90261.

Research output: Contribution to journalArticle

20 Scopus citations

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I., Rao, K. S., Mitra, S. & Hegde, M. L., Sep 1 2014, In : Biomolecules. 4, 3, p. 678-703 26 p.

Research output: Contribution to journalReview article

21 Scopus citations
2015

BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51

Qi, W., Wang, R., Chen, H., Wang, X., Xiao, T., Boldogh, I., Ba, X., Han, L. & Zeng, X., 2015, In : Journal of Cell Science. 128, 2, p. 317-330 14 p.

Research output: Contribution to journalArticle

40 Scopus citations
2012

Hypolipidemic activity of eryngium carlinae on streptozotocin-induced diabetic rats

Noriega-Cisneros, R., Ortiz-Vila, O., Esquivel-Gutiérrez, E., Clemente-Guerrero, M., Manzo-Avalos, S., Salgado-Garciglia, R., Cortés-Rojo, C., Boldogh, I. & Saavedra-Molina, A., 2012, In : Biochemistry Research International. 603501.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes

Menon, R., Polettini, J., Syed, T. A., Saade, G. R. & Boldogh, I., Jan 1 2014, In : American Journal of Reproductive Immunology. 72, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2019

Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation

Pázmándi, K., Sütő, M., Fekete, T., Varga, A., Boldizsár, E., Boldogh, I. & Bácsi, A., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 209-220 12 p.

Research output: Contribution to journalArticle

Open Access
2013

Senescence of primary amniotic cells via oxidative DNA damage

Menon, R., Boldogh, I., Urrabaz-Garza, R., Polettini, J., Syed, T. A., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Dec 27 2013, In : PloS one. 8, 12, e83416.

Research output: Contribution to journalArticle

56 Scopus citations
2012

Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z., Bacsi, A., Sur, S., Hazra, T. K. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

Research output: Contribution to journalArticle

83 Scopus citations
2016

The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma

Belanger, K. A. K., Ameredes, B. T., Boldogh, I. & Aguilera-Aguirre, L., 2016, In : Mediators of inflammation. 2016, 3762561.

Research output: Contribution to journalReview article

4 Scopus citations
2012

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats

Marton, O., Koltai, E., Takeda, M., Koch, L. G., Britton, S. L., Davies, K. J. A., Boldogh, I. & Radak, Z., Jan 1 2015, In : Pflugers Archiv European Journal of Physiology. 467, 4, p. 779-788 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

The rate of training response to aerobic exercise affects brain function of rats

Marton, O., Koltai, E., Takeda, M., Mimura, T., Pajk, M., Abraham, D., Koch, L. G., Britton, S. L., Higuchi, M., Boldogh, I. & Radak, Z., Oct 1 2016, In : Neurochemistry International. 99, p. 16-23 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle

Radak, Z., Bori, Z., Koltai, E., Fatouros, I. G., Jamurtas, A. Z., Douroudos, I. I., Terzis, G., Nikolaidis, M. G., Chatzinikolaou, A., Sovatzidis, A., Kumagai, S., Naito, H. & Boldogh, I., Jul 15 2011, In : Free Radical Biology and Medicine. 51, 2, p. 417-423 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
2015

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection

Fang, L., Choudhary, S., Tian, B., Boldogh, I., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R. P. & Brasier, A. R., Jan 1 2015, In : Journal of virology. 89, 5, p. 2628-2642 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

ATM regulates NF-κB-dependent immediate-early genes via RelA ser 276 phosphorylation coupled to CDK9 promoter recruitment

Fang, L., Choudhary, S., Zhao, Y., Edeh, C. B., Yang, C., Boldogh, I. & Brasier, A. R., 2014, In : Nucleic acids research. 42, 13, p. 8416-8432 17 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

Novel recombinant human lactoferrin: Differential activation of oxidative stress related gene expression

Kruzel, M. L., Actor, J. K., Zimecki, M., Wise, J., Płoszaj, P., Mirza, S., Kruzel, M., Hwang, S. A., Ba, X. & Boldogh, I., Dec 1 2013, In : Journal of Biotechnology. 168, 4, p. 666-675 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro

Menon, R., Boldogh, I., Hawkins, H. K., Woodson, M., Polettini, J., Syed, T. A., Fortunato, S. J., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Jun 2014, In : American Journal of Pathology. 184, 6, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

104 Scopus citations
2019

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Brasier, A. R. & Boldogh, I., 2019, In : Drugs in Context. 8, 2019-8-3.

Research output: Contribution to journalReview article

Open Access
2015

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 20-33 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Effects of diabetes on oxidative and nitrosative stress in kidney mitochondria from aged rats

Pérez-Gallardo, R. V., Noriega-Cisneros, R., Esquivel-Gutiérrez, E., Calderón-Cortés, E., Cortés-Rojo, C., Manzo-Avalos, S., Campos-García, J., Salgado-Garciglia, R., Montoya-Pérez, R., Boldogh, I. & Saavedra-Molina, A., Dec 9 2014, In : Journal of Bioenergetics and Biomembranes. 46, 6, p. 511-518 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging

German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Apr 14 2016, (Accepted/In press) In : Mechanisms of Ageing and Development.

Research output: Contribution to journalArticle

9 Scopus citations
2019

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M. L., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2012

Alternaria-induced release of IL-18 from damaged airway epithelial cells: An NF-κB dependent mechanism of Th2 differentiation?

Murai, H., Qi, H., Choudhury, B., Wild, J., Dharajiya, N., Vaidya, S., Kalita, A., Bacsi, A., Corry, D., Kurosky, A., Brasier, A., Boldogh, I. & Sur, S., Feb 7 2012, In : PloS one. 7, 2, e30280.

Research output: Contribution to journalArticle

22 Scopus citations

Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

Hegde, M. L., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2020

The systemic role of SIRT1 in exercise mediated adaptation

Radak, Z., Suzuki, K., Posa, A., Petrovszky, Z., Koltai, E. & Boldogh, I., Aug 2020, In : Redox Biology. 35, 101467.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2018

The roles of base excision repair enzyme OGG1 in gene expression

Wang, R., Hao, W., Pan, L., Boldogh, I. & Ba, X., Oct 1 2018, In : Cellular and Molecular Life Sciences. 75, 20, p. 3741-3750 10 p.

Research output: Contribution to journalReview article

10 Scopus citations
2011

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

89 Scopus citations
2012

Human DNA glycosylase NEIL1's interactions with downstream repair proteins is critical for efficient repair of oxidized DNA base damage and enhanced cell survival

Hegde, M. L., Hegde, P. M., Arijit, D., Boldogh, I. & Mitra, S., Dec 2012, In : Biomolecules. 2, 4, p. 564-578 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4643-4653 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2015

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha

Batnasan, E., Wang, R., Wen, J., Ke, Y., Li, X., Bohio, A. A., Zeng, X., Huo, H., Han, L., Boldogh, I. & Ba, X., Jan 5 2015, In : Toxicology Letters. 232, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In : PloS one. 8, 2, e57442.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Mitochondrial dysfunctions related with oxidative stress

Saavedra-Molina, A., Boldogh, I., Manzo-Avalos, S., Cortés-Rojo, C., Aguilera-Aguirre, L., Montoya-Pérez, R. & Bacsi, A., Dec 1 2011, Mitochondria: Structure, Functions and Dysfunctions. Nova Science Publishers, Inc., p. 411-439 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Systems approaches to modeling chronic mucosal inflammation

Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., Nov 18 2013, In : BioMed Research International. 2013, 505864.

Research output: Contribution to journalArticle

27 Scopus citations
2020

Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

Hao, W., Wang, J., Zhang, Y., Wang, C., Xia, L., Zhang, W., Zafar, M., Kang, J. Y., Wang, R., Ali Bohio, A., Pan, L., Zeng, X., Wei, M., Boldogh, I. & Ba, X., Jun 1 2020, In : FASEB Journal. 34, 6, p. 7427-7441 15 p.

Research output: Contribution to journalArticle

Open Access
2012

Ragweed Subpollen Particles of Respirable Size Activate Human Dendritic Cells

Pazmandi, K., Kumar, B. V., Szabo, K., Boldogh, I., Szoor, A., Vereb, G., Veres, A., Lanyi, A., Rajnavolgyi, E. & Bacsi, A., Dec 14 2012, In : PloS one. 7, 12, e52085.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage

Koltai, E., Zhao, Z., Lacza, Z., Cselenyak, A., Vacz, G., Nyakas, C., Boldogh, I., Ichinoseki-Sekine, N. & Radak, Z., Dec 1 2011, In : Rejuvenation Research. 14, 6, p. 585-596 12 p.

Research output: Contribution to journalArticle

34 Scopus citations
2014

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

Torma, F., Bori, Z., Koltai, E., Felszeghy, K., Vacz, G., Koch, L., Britton, S., Boldogh, I. & Radak, Z., Aug 2014, In : Brain Research Bulletin. 107, p. 54-60 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes

Noriega-Cisneros, R., Cortés-Rojo, C., Manzo-Avalos, S., Clemente-Guerrero, M., Calderón-Cortés, E., Salgado-Garciglia, R., Montoya-Pérez, R., Boldogh, I. & Saavedra-Molina, A., Nov 1 2013, In : Mitochondrion. 13, 6, p. 835-840 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1

Hosoki, K., Ying, S., Corrigan, C., Qi, H., Kurosky, A., Jennings, K., Sun, Q., Boldogh, I. & Sur, S., May 2015, In : PloS one. 10, 5, e0126035.

Research output: Contribution to journalArticle

44 Scopus citations
2014

Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

Pazmandi, K., Agod, Z., Kumar, B. V., Szabo, A., Fekete, T., Sogor, V., Veres, A., Boldogh, I., Rajnavolgyi, E., Lanyi, A. & Bacsi, A., 2014, In : Free Radical Biology and Medicine. 77, p. 281-290 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015

Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Ziaaldini, M. M., Koltai, E., Csende, Z., Goto, S., Boldogh, I., Taylor, A. W. & Radak, Z., Jul 1 2015, In : Experimental Gerontology. 67, p. 9-14 6 p.

Research output: Contribution to journalArticle

41 Scopus citations
2011

Apoptosis induced by persistent single-strand breaks in mitochondrial genome: Critical role of EXOG (5′-exo/endonuclease) in their repair

Tann, A. W., Boldogh, I., Meiss, G., Qian, W., Van Houten, B., Mitra, S. & Szczesny, B., Sep 16 2011, In : Journal of Biological Chemistry. 286, 37, p. 31975-31983 9 p.

Research output: Contribution to journalArticle

101 Scopus citations
2014

The role of 8-oxoguanine DNA glycosylase-1 in inflammation

Ba, X., Aguilera-Aguirre, L., Rashid, Q. T. A. N., Bacsi, A., Radak, Z., Sur, S., Hosoki, K., Hegde, M. L. & Boldogh, I., Sep 23 2014, In : International journal of molecular sciences. 15, 9, p. 16975-16997 23 p.

Research output: Contribution to journalReview article

49 Scopus citations

8-Oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors

Ba, X., Bacsi, A., Luo, J., Aguilera-Aguirre, L., Zeng, X., Radak, Z., Brasier, A. R. & Boldogh, I., Mar 1 2014, In : Journal of Immunology. 192, 5, p. 2384-2394 11 p.

Research output: Contribution to journalArticle

50 Scopus citations