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  • Thomas Geisbert
2018

Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans

Cross, R. W., Speranza, E., Borisevich, V., Widen, S. G., Wood, T. G., Shim, R. S., Adams, R. D., Gerhardt, D. M., Bennett, R. S., Honko, A. N., Johnson, J. C., Hensley, L. E., Geisbert, T. W. & Connor, J. H., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S486-S495

Research output: Contribution to journalArticle

8 Scopus citations
2015

Vaccination with a Highly Attenuated Recombinant Vesicular Stomatitis Virus Vector Protects Against Challenge with a Lethal Dose of Ebola Virus

Matassov, D., Marzi, A., Latham, T., Xu, R., Ota-Setlik, A., Feldmann, F., Geisbert, J. B., Mire, C. E., Hamm, S., Nowak, B., Egan, M. A., Geisbert, T. W., Eldridge, J. H., Feldmann, H. & Clarke, D. K., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S443-S451

Research output: Contribution to journalArticle

31 Scopus citations

Development of Prototype Filovirus Recombinant Antigen Immunoassays

Boisen, M. L., Oottamasathien, D., Jones, A. B., Millett, M. M., Nelson, D. S., Bornholdt, Z. A., Fusco, M. L., Abelson, D. M., Oda, S. I., Hartnett, J. N., Rowland, M. M., Heinrich, M. L., Akdag, M., Goba, A., Momoh, M., Fullah, M., Baimba, F., Gbakie, M., Safa, S., Fonnie, R. & 14 others, Kanneh, L., Cross, R. W., Geisbert, J. B., Geisbert, T. W., Kulakosky, P. C., Grant, D. S., Shaffer, J. G., Schieffelin, J. S., Wilson, R. B., Saphire, E. O., Branco, L. M., Garry, R. F., Khan, S. H. & Pitts, K. R., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S359-S367

Research output: Contribution to journalArticle

12 Scopus citations
2014

Viral-vectored vaccines to control pathogenic filoviruses

Mire, C. & Geisbert, T., Jul 1 2014, Novel Technologies for Vaccine Development. Springer-Verlag Wien, Vol. 9783709118184. p. 33-60 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2018

Small animal models of filovirus disease: recent advances and future directions

Cross, R. W., Fenton, K. & Geisbert, T. W., Nov 2 2018, In : Expert Opinion on Drug Discovery. 13, 11, p. 1027-1040 14 p.

Research output: Contribution to journalReview article

4 Scopus citations
2011

Ebola haemorrhagic fever

Feldmann, H. & Geisbert, T. W., 2011, In : The Lancet. 377, 9768, p. 849-862 14 p.

Research output: Contribution to journalReview article

818 Scopus citations
2015

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

Thi, E. P., Mire, C., Lee, A. C. H., Geisbert, J. B., Zhou, J. Z., Agans, K. N., Snead, N. M., Deer, D. J., Barnard, T. R., Fenton, K. A., Maclachlan, I. & Geisbert, T., May 21 2015, In : Nature. 521, 7552, p. 362-365 4 p.

Research output: Contribution to journalArticle

157 Scopus citations
2014

Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Thi, E. P., Mire, C. E., Ursic-Bedoya, R., Geisbert, J. B., Lee, A. C. H., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., MacLachlan, I. & Geisbert, T. W., Aug 20 2014, In : Science Translational Medicine. 6, 250, 250ra116.

Research output: Contribution to journalArticle

49 Scopus citations
2016

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

Goba, A., Khan, S. H., Fonnie, M., Fullah, M., Moigboi, A., Kovoma, A., Sinnah, V., Yoko, N., Rogers, H., Safai, S., Momoh, M., Koroma, V., Kamara, F. K., Konowu, E., Yillah, M., French, I., Mustapha, I., Kanneh, F., Foday, M., McCarthy, H. & 64 others, Kallon, T., Kallon, M., Naiebu, J., Sellu, J., Jalloh, A. A., Gbakie, M., Kanneh, L., Massaly, J. L. B., Kargbo, D., Kargbo, B., Vandi, M., Gbetuwa, M., Gevao, S. M., Sandi, J. D., Jalloh, S. C., Grant, D. S., Blyden, S. O., Crozier, I., Schieffelin, J. S., McLellan, S. L., Jacob, S. T., Boisen, M. L., Hartnett, J. N., Cross, R. W., Branco, L. M., Andersen, K. G., Yozwiak, N. L., Gire, S. K., Tariyal, R., Park, D. J., Haislip, A. M., Bishop, C. M., Melnik, L. I., Gallaher, W. R., Wimley, W. C., He, J., Shaffer, J. G., Sullivan, B. M., Grillo, S., Oman, S., Garry, C. E., Edwards, D. R., McCormick, S. J., Elliott, D. H., Rouelle, J. A., Kannadka, C. B., Reyna, A. A., Bradley, B. T., Yu, H., Yenni, R. E., Hastie, K. M., Geisbert, J. B., Kulakosky, P. C., Wilson, R. B., Oldstone, M. B. A., Pitts, K. R., Henderson, L. A., Robinson, J. E., Geisbert, T. W., Saphire, E. O., Happi, C. T., Asogun, D. A., Sabeti, P. C. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S110-S121

Research output: Contribution to journalArticle

19 Scopus citations
2015

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Mire, C. E., Geisbert, J. B., Versteeg, K. M., Mamaeva, N., Agans, K. N., Geisbert, T. W. & Connor, J. H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S384-S388

Research output: Contribution to journalArticle

21 Scopus citations
2011

Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to ad5 and protect nonhuman primates against ebolavirus challenge

Geisbert, T. W., Bailey, M., Hensley, L., Asiedu, C., Geisbert, J., Stanley, D., Honko, A., Johnson, J., Mulangu, S., Pau, M. G., Custers, J., Vellinga, J., Hendriks, J., Jahrling, P., Roederer, M., Goudsmit, J., Koup, R. & Sullivan, N. J., May 2011, In : Journal of virology. 85, 9, p. 4222-4233 12 p.

Research output: Contribution to journalArticle

117 Scopus citations

Management of accidental exposure to Ebola virus in the biosafety Level 4 Laboratory, Hamburg, Germany

Günther, S., Feldmann, H., Geisbert, T. W., Hensley, L. E., Rollin, P. E., Nichol, S. T., Ströher, U., Artsob, H., Peters, C. J., Ksiazek, T. G., Becker, S., Ter Meulen, J., Ölschläger, S., Schmidt-Chanasit, J., Sudeck, H., Burchard, G. D. & Schmiedel, S., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S785-S790

Research output: Contribution to journalArticle

103 Scopus citations
2018

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

Warfield, K. L., Howell, K. A., Vu, H., Geisbert, J., Wong, G., Shulenin, S., Sproule, S., Holtsberg, F. W., Leung, D. W., Amarasinghe, G. K., Swenson, D. L., Bavari, S., Kobinger, G. P., Geisbert, T. & Aman, M. J., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S553-S564

Research output: Contribution to journalArticle

9 Scopus citations
2020

Structure and characterization of crimean-congo hemorrhagic fever virus GP38

Mishra, A. K., Moyer, C. L., Abelson, D. M., Deer, D. J., El Omari, K., Duman, R., Lobel, L., Lutwama, J. J., Dye, J. M., Wagner, A., Chandran, K., Cross, R. W., Geisbert, T. W., Zeitlin, L., Bornholdt, Z. A. & McLellan, J. S., Mar 1 2020, In : Journal of virology. 94, 8, e02005-19.

Research output: Contribution to journalArticle

Open Access
2014

Lassa Fever in Post-Conflict Sierra Leone

Shaffer, J. G., Grant, D. S., Schieffelin, J. S., Boisen, M. L., Goba, A., Hartnett, J. N., Levy, D. C., Yenni, R. E., Moses, L. M., Fullah, M., Momoh, M., Fonnie, M., Fonnie, R., Kanneh, L., Koroma, V. J., Kargbo, K., Ottomassathien, D., Muncy, I. J., Jones, A. B., Illick, M. M. & 31 others, Kulakosky, P. C., Haislip, A. M., Bishop, C. M., Elliot, D. H., Brown, B. L., Zhu, H., Hastie, K. M., Andersen, K. G., Gire, S. K., Tabrizi, S., Tariyal, R., Stremlau, M., Matschiner, A., Sampey, D. B., Spence, J. S., Cross, R. W., Geisbert, J. B., Folarin, O. A., Happi, C. T., Pitts, K. R., Geske, F. J., Geisbert, T. W., Saphire, E. O., Robinson, J. E., Wilson, R. B., Sabeti, P. C., Henderson, L. A., Khan, S. H., Bausch, D. G., Branco, L. M. & Garry, R. F., Mar 2014, In : PLoS neglected tropical diseases. 8, 3, e2748.

Research output: Contribution to journalArticle

88 Scopus citations
2016

Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

Thi, E. P., Lee, A. C. H., Geisbert, J. B., Ursic-Bedoya, R., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., Kondratowicz, A. S., MacLachlan, I., Geisbert, T. & Mire, C., Aug 22 2016, In : Nature Microbiology. 1, 16142.

Research output: Contribution to journalArticle

20 Scopus citations
2015

A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

Safronetz, D., Mire, C., Rosenke, K., Feldmann, F., Haddock, E., Geisbert, T. & Feldmann, H., Apr 17 2015, In : PLoS neglected tropical diseases. 9, 4, e0003736.

Research output: Contribution to journalArticle

50 Scopus citations

Lack of Marburg Virus Transmission from Experimentally Infected to Susceptible In-Contact Egyptian Fruit Bats

Paweska, J. T., Van Vuren, P. J., Fenton, K. A., Graves, K., Grobbelaar, A. A., Moolla, N., Leman, P., Weyer, J., Storm, N., McCulloch, S. D., Scott, T. P., Markotter, W., Odendaal, L., Clift, S. J., Geisbert, T. W., Hale, M. J. & Kemp, A., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S109-S118

Research output: Contribution to journalArticle

29 Scopus citations
2019

Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever

Rodriguez, S. E., Cross, R. W., Fenton, K. A., Bente, D. A., Mire, C. E. & Geisbert, T. W., Dec 1 2019, In : Scientific reports. 9, 1, 7755.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets

Satterfield, B. A., Cross, R. W., Fenton, K. A., Borisevich, V., Agans, K. N., Deer, D. J., Graber, J., Basler, C. F., Geisbert, T. W. & Mirea, C. E., 2016, In : Journal of virology. 90, 14, p. 6326-6343 18 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Animal models for viral hemorrhagic fevers

Warfield, K. L. & Geisbert, T., Jan 1 2012, Biodefense Research Methodology and Animal Models, Second Edition. CRC Press, p. 271-310 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Vaccines and antivirals for filoviruses

Mire, C. & Geisbert, T., Jan 1 2014, Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., p. 587-620 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Medical research: Ebola therapy protects severely ill monkeys

Geisbert, T. W., Oct 2 2014, In : Nature. 514, 7520, p. 41-43 3 p.

Research output: Contribution to journalShort survey

13 Scopus citations
2011

Progress in filovirus vaccine development: Evaluating the potential for clinical use

Falzarano, D., Geisbert, T. W. & Feldmann, H., Jan 1 2011, In : Expert review of vaccines. 10, 1, p. 63-77 15 p.

Research output: Contribution to journalReview article

77 Scopus citations
2013

Filoviridae: Marburg and ebola viruses

Feldmann, H., Sanchez, A. & Geisbert, T., May 21 2013, Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1.

Research output: Chapter in Book/Report/Conference proceedingChapter

81 Scopus citations
2011

Therapeutics of Ebola hemorrhagic fever: Whole-genome transcriptional analysis of successful disease mitigation

Yen, J. Y., Garamszegi, S., Geisbert, J. B., Rubins, K. H., Geisbert, T. W., Honko, A., Xia, Y., Connor, J. H. & Hensley, L. E., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1043-S1052

Research output: Contribution to journalArticle

30 Scopus citations

Pathogenesis of marburg hemorrhagic fever in cynomolgus macaques

Hensley, L. E., Alves, D. A., Geisbert, J. B., Fritz, E. A., Reed, C., Larsen, T. & Geisbert, T. W., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1021-S1031

Research output: Contribution to journalArticle

54 Scopus citations
2014

A recombinant Hendra Virus G glycoprotein subunit vaccine protects nonhuman primates against hendra virus challenge

Mire, C. E., Geisbert, J. B., Agans, K. N., Feng, Y. R., Fenton, K. A., Bossart, K. N., Yan, L., Chan, Y. P., Broder, C. C. & Geisbert, T. W., May 2014, In : Journal of virology. 88, 9, p. 4624-4631 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

The domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus

Cross, R., Mire, C., Borisevich, V., Geisbert, J. B., Fenton, K. A. & Geisbert, T., Aug 15 2016, In : Journal of Infectious Diseases. 214, 4, p. 565-569 5 p.

Research output: Contribution to journalArticle

40 Scopus citations
2011

Recombinant vesicular stomatitis virus-based vaccines against Ebola and marburg virus infections

Geisbert, T. W. & Feldmann, H., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1075-S1081

Research output: Contribution to journalArticle

123 Scopus citations

Pathogenesis of lassa fever in cynomolgus macaques

Hensley, L. E., Smith, M. A., Geisbert, J. B., Fritz, E. A., Daddario-Dicaprio, K. M., Larsen, T. & Geisbert, T. W., 2011, In : Virology journal. 8, 205.

Research output: Contribution to journalArticle

67 Scopus citations
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAS in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., Sep 25 2014, In : mBio. 5, 6, e02011-14.

Research output: Contribution to journalArticle

44 Scopus citations
2016

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

Edwards, M. R., Liu, G., Mire, C. E., Sureshchandra, S., Luthra, P., Yen, B., Shabman, R. S., Leung, D. W., Messaoudi, I., Geisbert, T. W., Amarasinghe, G. K. & Basler, C. F., Feb 23 2016, In : Cell Reports. 14, 7, p. 1632-1640 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2015

Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever

Hartnett, J. N., Boisen, M. L., Oottamasathien, D., Jones, A. B., Millett, M. M., Nelson, D. S., Muncy, I. J., Goba, A., Momoh, M., Fullah, M., Mire, C. E., Geisbert, J. B., Geisbert, T. W., Holton, D. L., Rouelle, J. A., Kannadka, C. B., Reyna, A. A., Moses, L. M., Khan, S. H., Gevao, S. M. & 6 others, Grant, D. S., Robinson, J. E., Happi, C., Pitts, K. R., Garry, R. F. & Branco, L. M., May 1 2015, In : Future Virology. 10, 5, p. 559-584 26 p.

Research output: Contribution to journalReview article

9 Scopus citations
2013

Animal models for highly pathogenic emerging viruses

Safronetz, D., Geisbert, T. W. & Feldmann, H., Apr 2013, In : Current Opinion in Virology. 3, 2, p. 205-209 5 p.

Research output: Contribution to journalReview article

22 Scopus citations
2016

Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates

Mire, C. E., Geisbert, J. B., Agans, K. N., Thi, E. P., Lee, A. C. H., Fenton, K. A. & Geisbert, T. W., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S367-S374

Research output: Contribution to journalArticle

28 Scopus citations
2019

The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus

Jasenosky, L. D., Cadena, C., Mire, C. E., Borisevich, V., Haridas, V., Ranjbar, S., Nambu, A., Bavari, S., Soloveva, V., Sadukhan, S., Cassell, G. H., Geisbert, T. W., Hur, S. & Goldfeld, A. E., Sep 27 2019, In : iScience. 19, p. 1279-1290 12 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2020

An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

Geisbert, J. B., Borisevich, V., Prasad, A. N., Agans, K. N., Foster, S. L., Deer, D. J., Cross, R. W., Mire, C. E., Geisbert, T. W. & Fenton, K. A., May 11 2020, In : Journal of Infectious Diseases. 221, p. S414-S418

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Post-exposure treatments for Ebola and Marburg virus infections

Cross, R. W., Mire, C. E., Feldmann, H. & Geisbert, T. W., Jun 1 2018, In : Nature Reviews Drug Discovery. 17, 6, p. 413-434 22 p.

Research output: Contribution to journalReview article

48 Scopus citations
2011

Label-free multiplexed virus detection using spectral reflectance imaging

Lopez, C. A., Daaboul, G. G., Vedula, R. S., Özkumur, E., Bergstein, D. A., Geisbert, T. W., Fawcett, H. E., Goldberg, B. B., Connor, J. H. & Ünlü, M. S., Apr 15 2011, In : Biosensors and Bioelectronics. 26, 8, p. 3432-3437 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Single immunization with a monovalent vesicular stomatitis virus-based vaccine protects nonhuman primates against heterologous challenge with bundibugyo ebolavirus

Falzarano, D., Feldmann, F., Grolla, A., Leung, A., Ebihara, H., Strong, J. E., Marzi, A., Takada, A., Jones, S., Gren, J., Geisbert, J., Jones, S. M., Geisbert, T. W. & Feldmann, H., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1082-S1089

Research output: Contribution to journalArticle

40 Scopus citations
2016

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Cross, R., Mire, C., Branco, L. M., Geisbert, J. B., Rowland, M. M., Heinrich, M. L., Goba, A., Momoh, M., Grant, D. S., Fullah, M., Khan, S. H., Robinson, J. E., Geisbert, T. & Garry, R. F., Sep 1 2016, In : Antiviral Research. 133, p. 218-222 5 p.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Protection against lethal marburg virus infection mediated by lipid encapsulated small interfering RNA

Ursic-Bedoya, R., Mire, C. E., Robbins, M., Geisbert, J. B., Judge, A., MacLachlan, I. & Geisbert, T. W., Feb 15 2014, In : Journal of Infectious Diseases. 209, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2012

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates

Mire, C. E., Miller, A. D., Carville, A., Westmoreland, S. V., Geisbert, J. B., Mansfield, K. G., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Mar 2012, In : PLoS neglected tropical diseases. 6, 3, e1567.

Research output: Contribution to journalArticle

68 Scopus citations
2015

Stat1-Deficient Mice Are Not an Appropriate Model for Efficacy Testing of Recombinant Vesicular Stomatitis Virus-Based Filovirus Vaccines

Marzi, A., Kercher, L., Marceau, J., York, A., Callsion, J., Gardner, D. J., Geisbert, T. W. & Feldmann, H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S404-S409

Research output: Contribution to journalArticle

14 Scopus citations

Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus

Mire, C. E., Matassov, D., Geisbert, J. B., Latham, T. E., Agans, K. N., Xu, R., Ota-Setlik, A., Egan, M. A., Fenton, K. A., Clarke, D. K., Eldridge, J. H. & Geisbert, T. W., Apr 30 2015, In : Nature. 520, 7549, p. 688-691 4 p.

Research output: Contribution to journalArticle

68 Scopus citations
2018

Predicting outcome and improving treatment for Lassa fever

Geisbert, T., Jan 1 2018, (Accepted/In press) In : The Lancet Infectious Diseases.

Research output: Contribution to journalArticle

5 Scopus citations
2012

A Hendra virus G glycoprotein subunit vaccine protects African green monkeys from Nipah virus challenge

Bossart, K. N., Rockx, B., Feldmann, F., Brining, D., Scott, D., LaCasse, R., Geisbert, J. B., Feng, Y. R., Chan, Y. P., Hickey, A. C., Broder, C. C., Feldmann, H. & Geisbert, T. W., Aug 8 2012, In : Science Translational Medicine. 4, 146, 146ra107.

Research output: Contribution to journalArticle

67 Scopus citations
2016

Single-vector, single-injection recombinant vesicular stomatitis virus vaccines against high-containment viruses

Whitt, M. A., Geisbert, T. W. & Mire, C. E., Apr 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1403. p. 295-311 17 p. (Methods in Molecular Biology; vol. 1403).

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Inhibition of the host antiviral response by Nipah virus: Current understanding and future perspectives

Satterfield, B. A., Geisbert, T. & Mire, C., May 1 2016, In : Future Virology. 11, 5, p. 331-344 14 p.

Research output: Contribution to journalArticle

5 Scopus citations