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  • Kathryn Cunningham
2015

Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder

Howell, L. L. & Cunningham, K. A., 2015, In : Pharmacological reviews. 67, 1, p. 176-197 22 p.

Research output: Contribution to journalReview article

107 Scopus citations
2011

5-HT2c Receptors localize to dopamine and gaba neurons in the rat mesoaccumbens pathway

Bubar, M. J., Stutz, S. J. & Cunningham, K. A., 2011, In : PloS one. 6, 6, e20508.

Research output: Contribution to journalArticle

75 Scopus citations
2013

Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 1 2013, In : Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2020

Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants

Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In : Frontiers in Psychiatry. 11, 532.

Research output: Contribution to journalArticle

Open Access
2011

Serotonin (5-hydroxytryptamine) 5-HT2A receptor: Association with inherent and cocaine-evoked behavioral disinhibition in rats

Anastasio, N. C., Stoffel, E. C., Fox, R. G., Bubar, M. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jun 2011, In : Behavioural Pharmacology. 22, 3, p. 248-261 14 p.

Research output: Contribution to journalArticle

34 Scopus citations
2018

Innovative Therapeutic Intervention for Opioid Use Disorder

Moeller, F. G. & Cunningham, K. A., Jan 1 2018, In : Neuropsychopharmacology. 43, 1, p. 220-221 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations
2012
19 Scopus citations
2014

Frontiers of biomolecular exploration in brain disorders

Nilsson, C. L. & Cunningham, K. A., Jan 2014, In : Neuropsychopharmacology. 39, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

2020

Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In : Neuropharmacology. 168, 108009.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder

Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 30 2018, In : Psychiatry Research - Neuroimaging. 271, p. 59-66 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U

Kasper, J. M., McCue, D. L., Milton, A. J., Szwed, A., Sampson, C. M., Huang, M., Carlton, S., Meltzer, H. Y., Cunningham, K. A. & Hommel, J. D., Dec 1 2016, In : Biological Psychiatry. 80, 11, p. 878-887 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls

Ma, L., Steinberg, J. L., Cunningham, K. A., Lane, S. D., Bjork, J. M., Neelakantan, H., Price, A. E., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., 2015, In : NeuroImage: Clinical. 7, p. 837-847 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Functional status of the serotonin 5-HT 2C receptor (5-HT 2C R) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence

Anastasio, N. C., Stutz, S. J., Fox, R. G., Sears, R. M., Emeson, R. B., Dileone, R. J., O'Neil, R. T., Fink, L. H., Li, D., Green, T. A., Gerard Moeller, F. & Cunningham, K. A., Jan 2014, In : Neuropsychopharmacology. 39, 2, p. 360-372 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2013

Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior

Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In : Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction

Cunningham, K. A. & Anastasio, N. C., 2014, In : Neuropharmacology. 76, PART B, p. 460-478 19 p.

Research output: Contribution to journalReview article

79 Scopus citations
2015

Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity

Anastasio, N. C., Stutz, S. J., Fink, L. H. L., Swinford-Jackson, S. E., Sears, R. M., Dileone, R. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 15 2015, In : ACS chemical neuroscience. 6, 7, p. 1248-1258 11 p.

Research output: Contribution to journalArticle

44 Scopus citations
2018

Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907

Gilbertson, S. R., Chen, Y. C., Soto, C. A., Yang, Y., Rice, K. C., Cunningham, K. A. & Anastasio, N. C., May 1 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 8, p. 1381-1385 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2012

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators

Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In : ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues

Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In : Addictive Behaviors. 37, 2, p. 193-197 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2018

Novel Bivalent 5-HT 2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo

Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C., Cunningham, K. A., Gilbertson, S. R. & Anastasio, N. C., Mar 21 2018, In : ACS chemical neuroscience. 9, 3, p. 514-521 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study

Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In : Frontiers in Psychiatry. 3, JUN, Article 60.

Research output: Contribution to journalArticle

26 Scopus citations
2020

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In : Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2011

Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Waters, A. J., Cunningham, K. A. & Moeller, F. G., Mar 2011, In : American Journal of Drug and Alcohol Abuse. 37, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2013

Synergism between a serotonin 5-HT2A receptor (5-HT 2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction

Cunningham, K. A., Anastasio, N. C., Fox, R. G., Stutz, S. J., Bubar, M. J., Swinford, S. E., Watson, C. S., Gilbertson, S. R., Rice, K. C., Rosenzweig-Lipson, S. & Moeller, F. G., Jan 16 2013, In : ACS chemical neuroscience. 4, 1, p. 110-121 12 p.

Research output: Contribution to journalArticle

63 Scopus citations
2016

Is There a causal relation between maternal acetaminophen administration and ADHD?

Saad, A., Hegde, S., Kechichian, T., Gamble, P., Rahman, M., Stutz, S. J., Anastasio, N. C., Alshehri, W., Lei, J., Mori, S., Kajs, B., Cunningham, K. A., Saade, G., Burd, I. & Costantine, M., Jun 2016, In : PloS one. 11, 6, e0157380.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Editors' Favorites of 2017

Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In : ACS Chemical Neuroscience. 9, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

1 Scopus citations
2013

Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., May 17 2013, In : Frontiers in Psychiatry. 4, FEB, Article 2.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In : ACS Chemical Neuroscience. 7, 5, p. 546-552 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity

Anastasio, N. C., Liu, S., Maili, L., Swinford, S., Lane, S. D., Fox, R. G., Hamon, S. C., Nielsen, D. A., Cunningham, K. A. & Moeller, F. G., 2014, In : Translational psychiatry. 4, e369.

Research output: Contribution to journalArticle

27 Scopus citations
2020

Serotonin neurobiology in cocaine use disorder

Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: From behavioral to cellular evidence

Martin, C. B. P., Martin, V. S., Trigo, J. M., Chevarin, C., Maldonado, R., Fink, L. H., Cunningham, K. A., Hamon, M., Lanfumey, L. & Mongeau, R., 2015, In : International Journal of Neuropsychopharmacology. 18, 3

Research output: Contribution to journalArticle

8 Scopus citations
2018

Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction

Felsing, D. E., Anastasio, N. C., Miszkiel, J. M., Gilbertson, S. R., Allen, J. A. & Cunningham, K. A., Aug 2018, In : PloS one. 13, 8, e0203137.

Research output: Contribution to journalArticle

10 Scopus citations

A protocol for measuring cue reactivity in a rat model of cocaine use disorder

Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In : Journal of Visualized Experiments. 2018, 136, e55864.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications

Hamilton, K. R., Littlefield, A. K., Anastasio, N. C., Cunningham, K. A., Fink, L. H. L., Wing, V. C., Mathias, C. W., Lane, S. D., Schütz, C. G., Swann, A. C., Lejuez, C. W., Clark, L., Moeller, F. G. & Potenza, M. N., Apr 1 2015, In : Personality Disorders: Theory, Research, and Treatment. 6, 2, p. 168-181 14 p.

Research output: Contribution to journalArticle

66 Scopus citations
2013

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1

Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In : Molecular and cellular biology. 33, 5, p. 918-926 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
2018
6 Scopus citations
2012

Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In : Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

PPARγ agonism attenuates cocaine cue reactivity

Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. A. & Dineley, K. T., Jan 2018, In : Addiction Biology. 23, 1, p. 55-68 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

De La Garza, R., Bubar, M. J., Carbone, C. L., Moeller, F. G., Newton, T. F., Anastasio, N. C., Harper, T. A., Ware, D. L., Fuller, M. A., Holstein, G. J., Jayroe, J. B., Bandak, S. I., Reiman, K. Z., Neale, A. C., Pickford, L. B. & Cunningham, K. A., Jun 3 2015, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 59, p. 40-48 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Multi-well plate immunoassays for measuring signaling protein activations/deactivations and membrane vs. intracellular receptor levels

Watson, C. S., Jeng, Y. J., Bulayeva, N. N., Finnerty, C. C., Koong, L. Y., Zivadinovic, D., Alyea, R. A., Midoro-Horiuti, T., Goldblum, R. M., Anastasio, N. C., Cunningham, K. A., Seitz, P. K. & Smith, T. D., 2014, In : Methods in Molecular Biology. 1204, p. 123-133 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2020

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In : Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journalArticle

2011

Synthesis and evaluation of dimeric derivatives of 5-HT 2A receptor (5-HT 2AR) antagonist M-100907

Shashack, M. J., Cunningham, K. A., Seitz, P. K., McGinnis, A., Smith, T. D., Watson, C. S. & Gilbertson, S. R., Nov 16 2011, In : ACS chemical neuroscience. 2, 11, p. 640-644 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system

Swinford-Jackson, S. E., Anastasio, N. C., Fox, R. G., Stutz, S. J. & Cunningham, K. A., Jun 2 2016, In : Neuroscience. 324, p. 50-61 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Serotonin2C receptors in the ventral pallidum regulate motor function in rats

Graves, S. M., Viskniskki, A. A., Cunningham, K. A. & Celeste Napier, T., Aug 7 2013, In : NeuroReport. 24, 11, p. 605-608 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

Cunningham, K. A., Fox, R. G., Anastasio, N. C., Bubar, M. J., Stutz, S. J., Moeller, F. G., Gilbertson, S. R. & Rosenzweig-Lipson, S., Sep 2011, In : Neuropharmacology. 61, 3, p. 513-523 11 p.

Research output: Contribution to journalArticle

76 Scopus citations
2015

Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity

Liu, S., Maili, L., Lane, S. D., Schmitz, J. M., Spellicy, C. J., Cunningham, K. A., Moeller, F. G. & Nielsen, D. A., Sep 7 2015, In : Psychiatric Genetics. 25, 5, p. 213-214 2 p.

Research output: Contribution to journalLetter

3 Scopus citations
2020

Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex

Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In : Neuroscience. 435, p. 161-173 13 p.

Research output: Contribution to journalArticle

2015

Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis

Ma, L., Steinberg, J. L., Cunningham, K., Lane, S. D., Kramer, L. A., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Apr 1 2015, In : Brain Connectivity. 5, 3, p. 177-186 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Individual differences in impulsive action reflect variation in the cortical serotonin 5-HT 2A receptor system

Fink, L. H., Anastasio, N. C., Fox, R. G., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 13 2015, In : Neuropsychopharmacology. 40, 8, p. 1957-1968 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2018

Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience

Nilsson, C. L. & Cunningham, K., Jan 17 2018, In : ACS Chemical Neuroscience. 9, 1, 1 p.

Research output: Contribution to journalEditorial

2 Scopus citations