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  • Jia Zhou
2014

Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis

Bohanon, F. J., Wang, X., Ding, C., Ding, Y., Radhakrishnan, G. L., Rastellini, C., Zhou, J. & Radhakrishnan, R. S., Jul 2014, In : Journal of Surgical Research. 190, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Development of a concise synthetic approach to access oroxin A

Chen, H., He, G., Li, C., Dong, L., Xie, X., Wu, J., Gao, Y. & Zhou, J., 2014, In : RSC Advances. 4, 85, p. 45151-45154 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2020

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Liu, X., Xu, J., Zhou, J. & Shen, Q., 2020, (Accepted/In press) In : Genes and Diseases.

Research output: Contribution to journalReview article

Open Access
2018

Antifibrosis effect of novel oridonin analog CYD0618 via suppression of the NF-κB pathway

Cummins, C. B., Wang, X., Xu, J., Hughes, B. D., Ding, Y., Chen, H., Zhou, J. & Radhakrishnan, R. S., Dec 2018, In : Journal of Surgical Research. 232, p. 283-292 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

P-selectin-mediated platelet adhesion promotes tumor growth

Qi, C., Wei, B., Zhou, W., Yang, Y., Li, B., Guo, S., Li, J., Ye, J., Li, J., Zhang, Q., Lan, T., He, X., Cao, L., Zhou, J., Geng, J. & Wang, L., 2015, In : Oncotarget. 6, 9, p. 6584-6596 13 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations
2013

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Chen, H., Wang, C. Z., Ding, C., Wild, C., Copits, B., Swanson, G. T., Johnson, K. M. & Zhou, J., Feb 2013, In : ChemMedChem. 8, 2, p. 226-230 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

Chen, H., Gao, Y., Wu, J., Chen, Y., Chen, B., Hu, J. & Zhou, J., Nov 1 2014, In : Cancer Letters. 354, 1, p. 5-11 7 p.

Research output: Contribution to journalShort survey

62 Scopus citations
2018

Synthesis and structure–activity relationship studies of MI-2 analogues as MALT1 inhibitors

Wu, G., Wang, H., Zhou, W., Zeng, B., Mo, W., Zhu, K., Liu, R., Zhou, J., Chen, C. & Chen, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Transcription factor STAT3 as a novel molecular target for cancer prevention

Xiong, A., Yang, Z., Shen, Y., Zhou, J. & Shen, Q., Jun 2014, In : Cancers. 6, 2, p. 926-957 32 p.

Research output: Contribution to journalReview article

158 Scopus citations
2018

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis

Li, D., Wang, H., Ding, Y., Zhang, Z., Zheng, Z., Dong, J., Kim, H., Meng, X., Zhou, Q., Zhou, J., Fang, L. & Shen, Q., Jun 28 2018, In : Cancer Letters. 424, p. 97-108 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Small-molecule Bax agonists for cancer therapy

Xin, M., Li, R., Xie, M., Park, D., Owonikoko, T. K., Sica, G. L., Corsino, P. E., Zhou, J., Ding, C., White, M. A., Magis, A. T., Ramalingam, S. S., Curran, W. J., Khuri, F. R. & Deng, X., Jan 1 2014, In : Nature communications. 5, 4935.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations
2018

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

Wang, P. & Zhou, J., Jan 1 2018, In : Current Topics in Medicinal Chemistry. 18, 16, p. 1354-1356 3 p.

Research output: Contribution to journalReview article

17 Scopus citations
2012

NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia

Feng, J. F., Gurkoff, G. G., Van, K. C., Song, M., Lowe, D. A., Zhou, J. & Lyeth, B. G., Aug 21 2012, In : Brain Research. 1469, p. 144-152 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Allosteric Modulation of G Protein-Coupled Receptors: An Emerging Approach of Drug Discovery

Wild, C., Cunningham, K. A. & Zhou, J., Feb 13 2014, In : Austin Journal of Pharmacology and Therapeutics. 2, p. 3

Research output: Contribution to journalArticle

2017

Modulation of Bax and mTOR for cancer therapeutics

Li, R., Ding, C., Zhang, J., Xie, M., Park, D., Ding, Y., Chen, G., Zhang, G., Gilbert-Ross, M., Zhou, W., Marcus, A. I., Sun, S. Y., Chen, Z. G., Sica, G. L., Ramalingam, S. S., Magis, A. T., Fu, H., Khuri, F. R., Curran, W. J., Owonikoko, T. K. & 3 others, Shin, D. M., Zhou, J. & Deng, X., Jun 1 2017, In : Cancer Research. 77, 11, p. 3001-3012 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 "Therapeutic Window"

Zhu, Y., Chen, H., Boulton, S., Mei, F., Ye, N., Melacini, G., Zhou, J. & Cheng, X., Mar 23 2015, In : Scientific reports. 5, 9344.

Research output: Contribution to journalArticle

62 Scopus citations
2020

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5159-5184 26 p.

Research output: Contribution to journalArticle

2019

HFIP-promoted Michael reactions: direct para-selective C-H activation of anilines with maleimides

Li, B., Mao, Q., Zhou, J., Liu, F. & Ye, N., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 8, p. 2242-2246 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Luteolin-mediated inhibition of hepatic stellate cell activation via suppression of the STAT3 pathway

Cummins, C. B., Wang, X., Nunez Lopez, O., Graham, G., Tie, H. Y., Zhou, J. & Radhakrishnan, R. S., Jun 2018, In : International journal of molecular sciences. 19, 6, 1567.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. R. & Zhou, J., May 10 2018, In : European journal of medicinal chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2017

Suppression of the growth and invasion of human head and neck squamous cell carcinomas via regulating STAT3 signaling and the miR-21/β-catenin axis with HJC0152

Wang, Y., Wang, S., Wu, Y., Ren, Y., Li, Z., Yao, X., Zhang, C., Ye, N., Jing, C., Dong, J., Zhang, K., Sun, S., Zhao, M., Guo, W., Qu, X., Qiao, Y., Chen, H., Kong, L., Jin, R., Wang, X. & 4 others, Zhang, L., Zhou, J., Shen, Q. & Zhou, X., Apr 2017, In : Molecular Cancer Therapeutics. 16, 4, p. 578-590 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Oridonin ring A-based diverse constructions of enone functionality: Identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis

Ding, C., Zhang, Y., Chen, H., Yang, Z., Wild, C., Ye, N., Ester, C. D., Xiong, A., White, M. A., Shen, Q. & Zhou, J., Nov 14 2013, In : Journal of medicinal chemistry. 56, 21, p. 8814-8825 12 p.

Research output: Contribution to journalArticle

51 Scopus citations
2014

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

Chen, H., Yang, Z., Ding, C., Xiong, A., Wild, C., Wang, L., Ye, N., Cai, G., Flores, R. M., Ding, Y., Shen, Q. & Zhou, J., Jul 23 2014, In : European journal of medicinal chemistry. 82, p. 195-203 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2020

A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

Zhou, Z., Li, X., Liu, Z., Huang, L., Yao, Y., Li, L., Chen, J., Zhang, R., Zhou, J., Wang, L. & Zhang, Q. Q., Jul 10 2020, In : Frontiers in Pharmacology. 11, 1043.

Research output: Contribution to journalArticle

Open Access
2014

KRAS – An Evolving Cancer Target

Ye, N. & Zhou, J., Jan 12 2014, In : Austin Journal of Cancer and Clinical Research. 1, p. 3

Research output: Contribution to journalArticle

2017

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of medicinal chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

92 Scopus citations
2019

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S. J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In : Life Sciences. 221, p. 1-12 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

Almahariq, M., Tsalkova, T., Mei, F. C., Chen, H., Zhou, J., Sastry, S. K., Schwede, F. & Cheng, X., Jan 2013, In : Molecular pharmacology. 83, 1, p. 122-128 7 p.

Research output: Contribution to journalArticle

132 Scopus citations
2015

Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells

Bohanon, F. J., Wang, X., Graham, B. M., Prasai, A., Vasudevan, S. J., Ding, C., Ding, Y., Radhakrishnan, G. L., Rastellini, C., Zhou, J. & Radhakrishnan, R. S., Sep 7 2015, In : Molecular and Cellular Biochemistry. 410, 1-2, p. 293-300 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2018

GPCR allosteric modulators: Mechanistic advantages and therapeutic applications

Wold, E. A. & Zhou, J., 2018, In : Current topics in medicinal chemistry. 18, 23, p. 2002-2006 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2015

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M. R., Jun 1 2015, In : Journal of Surgical Research. 196, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Evolutions in fragment-based drug design: The deconstruction-reconstruction approach

Chen, H., Zhou, X., Wang, A., Zheng, Y., Gao, Y. & Zhou, J., Jan 2015, In : Drug Discovery Today. 20, 1, p. 105-113 9 p.

Research output: Contribution to journalReview article

66 Scopus citations
2013

Overcoming synthetic challenges of oridonin a-ring structural diversification: Regio- and stereoselective installation of azides and 1,2,3-triazoles at the c-1, c-2, or c-3 position

Ding, C., Zhang, Y., Chen, H., Wild, C., Wang, T., White, M. A., Shen, Q. & Zhou, J., Jul 19 2013, In : Organic Letters. 15, 14, p. 3718-3721 4 p.

Research output: Contribution to journalArticle

39 Scopus citations
2020

Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist

Shao, H., Mohamed, H., Boulton, S., Huang, J., Wang, P., Chen, H., Zhou, J., Luchowska-Stańska, U., Jentsch, N. G., Armstrong, A. L., Magolan, J., Yarwood, S. & Melacini, G., May 14 2020, In : Journal of medicinal chemistry. 63, 9, p. 4762-4775 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Fragment-based drug design: Strategic advances and lessons learned

Chen, H., Zhou, X., Gao, Y., Chen, H. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 212-232 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2020

Epigenetic suppression of HIV in myeloid cells by the BRD4-selective small molecule modulator ZL0580

Alamer, E., Zhong, C., Liu, Z., Niu, Q., Long, F., Guo, L., Gelman, B. B., Soong, L., Zhou, J. & Hu, H., Jun 1 2020, In : Journal of virology. 94, 11, e01880-19.

Research output: Contribution to journalArticle

1 Scopus citations

HJC0152 suppresses human non–small-cell lung cancer by inhibiting STAT3 and modulating metabolism

Lu, L., Li, H., Wu, X., Rao, J., Zhou, J., Fan, S. & Shen, Q., Mar 1 2020, In : Cell Proliferation. 53, 3, e12777.

Research output: Contribution to journalArticle

Open Access
2015

Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

Bohanon, F. J., Wang, X., Graham, B. M., Ding, C., Ding, Y., Radhakrishnan, G. L., Rastellini, C., Zhou, J. & Radhakrishnan, R. S., Dec 1 2015, In : Journal of Surgical Research. 199, 2, p. 441-449 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Discovery of O-alkylamino-tethered niclosamide derivatives as potent and orally bioavailable anticancer agents

Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q. & Zhou, J., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 180-185 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
2018

Exchange proteins directly activated by cAMP and their roles in respiratory syncytial virus infection

Choi, E. J., Ren, Y., Chen, Y., Liu, S., Wu, W., Ren, J., Wang, P., Garofalo, R. P., Zhou, J. & Bao, X., Nov 1 2018, In : Journal of virology. 92, 22, e01200-18.

Research output: Contribution to journalArticle

2 Scopus citations
2019

An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain

Fu, W., Nelson, T. S., Santos, D. F., Doolen, S., Gutierrez, J. J. P., Ye, N., Zhou, J. & Taylor, B. K., Aug 1 2019, In : Pain. 160, 8, p. 1754-1765 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Identification and characterization of small molecules as potent and specific EPAC2 antagonists

Chen, H., Tsalkova, T., Chepurny, O. G., Mei, F. C., Holz, G. G., Cheng, X. & Zhou, J., Feb 14 2013, In : Journal of medicinal chemistry. 56, 3, p. 952-962 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia

Gurkoff, G. G., Feng, J. F., Van, K. C., Izadi, A., Ghiasvand, R., Shahlaie, K., Song, M., Lowe, D. A., Zhou, J. & Lyeth, B. G., Jun 17 2013, In : Brain Research. 1515, p. 98-107 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2017

Small-molecule inhibitors of protein-protein interactions

Liu, Z., Chen, H., Wold, E. A. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 329-353 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2014

STAT3 modulation to enhance motor neuron differentiation in human neural stem cells

Natarajan, R., Singal, V., Benes, R., Gao, J., Chan, H., Chen, H., Yu, Y., Zhou, J. & Wu, P., Jun 19 2014, In : PloS one. 9, 6, e100405.

Research output: Contribution to journalArticle

11 Scopus citations
2018

Exchange protein directly activated by cAMP modulates ebola virus uptake into vascular endothelial cells

Drelich, A., Judy, B., He, X., Chang, Q., Yu, S., Li, X., Lu, F., Wakamiya, M., Popov, V., Zhou, J., Ksiazek, T. & Gong, B., Oct 16 2018, In : Viruses. 10, 10, 563.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In : Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

Research output: Contribution to journalArticle

13 Scopus citations
2015

Medicinal chemistry in oncology: New approaches and future trends

Zhou, J., 2015, In : Current topics in medicinal chemistry. 15, 8, 1 p.

Research output: Contribution to journalEditorial