Find Research Outputs

Search in all content

Filters for Publications

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Michael Sheetz
2016

High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography

Hu, J., Gondarenko, A. A., Dang, A. P., Bashour, K. T., O'Connor, R. S., Lee, S., Liapis, A., Ghassemi, S., Milone, M. C., Sheetz, M. P., Dustin, M. L., Kam, L. C. & Hone, J. C., Apr 13 2016, In : Nano Letters. 16, 4, p. 2198-2204 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Mechanical feedback between membrane tension and dynamics

Gauthier, N. C., Masters, T. A. & Sheetz, M., Oct 1 2012, In : Trends in Cell Biology. 22, 10, p. 527-535 9 p.

Research output: Contribution to journalReview article

216 Scopus citations

Second-generation covalent TMP-tag for live cell imaging

Chen, Z., Jing, C., Gallagher, S. S., Sheetz, M. & Cornish, V. W., Aug 22 2012, In : Journal of the American Chemical Society. 134, 33, p. 13692-13699 8 p.

Research output: Contribution to journalArticle

82 Scopus citations
2019

Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions

Changede, R., Cai, H., Wind, S. J. & Sheetz, M. P., Dec 1 2019, In : Nature Materials. 18, 12, p. 1366-1375 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

Santos, L. C., Blair, D. A., Kumari, S., Cammer, M., Iskratsch, T., Herbin, O., Alexandropoulos, K., Dustin, M. L. & Sheetz, M. P., Nov 1 2016, In : Immunology and Cell Biology. 94, 10, p. 981-993 13 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2014

Appreciating force and shape-the rise of mechanotransduction in cell biology

Iskratsch, T., Wolfenson, H. & Sheetz, M., Dec 11 2014, In : Nature Reviews Molecular Cell Biology. 15, 12, p. 825-833 9 p.

Research output: Contribution to journalReview article

295 Scopus citations
2011

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading

Gauthier, N. C., Fardin, M. A., Roca-Cusachs, P. & Sheetz, M. P., Aug 30 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14467-14472 6 p.

Research output: Contribution to journalArticle

Open Access
179 Scopus citations

Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading

Rangamani, P., Fardin, M. A., Xiong, Y., Lipshtat, A., Rossier, O., Sheetz, M. P. & Iyengar, R., Feb 16 2011, In : Biophysical journal. 100, 4, p. 845-857 13 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2016

Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate

Sonam, S., Sathe, S. R., Yim, E. K. F., Sheetz, M. & Lim, C. T., Feb 16 2016, In : Scientific reports. 6, 20415.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations
2017

Molecular stretching modulates mechanosensing pathways

Hu, X., Margadant, F. M., Yao, M. & Sheetz, M. P., Jul 1 2017, In : Protein Science. 26, 7, p. 1337-1351 15 p.

Research output: Contribution to journalReview article

23 Scopus citations
2012

Finding the weakest link-exploring integrin-mediated mechanical molecular pathways

Roca-Cusachs, P., Iskratsch, T. & Sheetz, M. P., Jul 1 2012, In : Journal of Cell Science. 125, 13, p. 3025-3038 14 p.

Research output: Contribution to journalComment/debate

Open Access
152 Scopus citations
2014

Can small institutes address some problems facing biomedical researchers?

Sheetz, M., Nov 1 2014, In : Molecular Biology of the Cell. 25, 21, p. 3267-3269 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations
2017

MDia1 senses both force and torque during F-actin filament polymerization

Yu, M., Yuan, X., Lu, C., Le, S., Kawamura, R., Efremov, A. K., Zhao, Z., Kozlov, M. M., Sheetz, M., Bershadsky, A. & Yan, J., Dec 1 2017, In : Nature communications. 8, 1, 1650.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations
2011

Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization.

Palma, M., Abramson, J. J., Gorodetsky, A. A., Nuckolls, C., Sheetz, M. P., Wind, S. J. & Hone, J., 2011, In : Methods in molecular biology (Clifton, N.J.). 749, p. 169-185 17 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Cooperative vinculin binding to talin mapped by time-resolved super resolution microscopy

Hu, X., Jing, C., Xu, X., Nakazawa, N., Cornish, V. W., Margadant, F. M. & Sheetz, M. P., Jul 13 2016, In : Nano Letters. 16, 7, p. 4062-4068 7 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2011

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

Lynch, C. D., Gauthier, N. C., Biais, N., Lazar, A. M., Roca-Cusachs, P., Yu, C. H. & Sheetz, M., Apr 15 2011, In : Molecular Biology of the Cell. 22, 8, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2016

F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback

Masters, T. A., Sheetz, M. & Gauthier, N. C., Apr 1 2016, In : Cytoskeleton. 73, 4, p. 180-196 17 p.

Research output: Contribution to journalArticle

10 Scopus citations
2019

A tale of two states: Normal and transformed, with and without rigidity sensing

Sheetz, M., Jan 1 2019, In : Annual Review of Cell and Developmental Biology. 35, p. 169-190 22 p.

Research output: Contribution to journalReview article

1 Scopus citations
2012

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M. P., Trepat, X. & Ladoux, B., Jul 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations
2018

EGFR family and Src family kinase interactions: mechanics matters?

Chen, Z., Oh, D., Dubey, A. K., Yao, M., Yang, B., Groves, J. T. & Sheetz, M., Apr 1 2018, In : Current Opinion in Cell Biology. 51, p. 97-102 6 p.

Research output: Contribution to journalReview article

16 Scopus citations
2011

Selective biomolecular nanoarrays for parallel single-molecule investigations

Palma, M., Abramson, J. J., Gorodetsky, A. A., Penzo, E., Gonzalez, R. L., Sheetz, M. P., Nuckolls, C., Hone, J. & Wind, S. J., May 25 2011, In : Journal of the American Chemical Society. 133, 20, p. 7656-7659 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cellular mechanotransduction: Filamin A strains to regulate motility

Lynch, C. D. & Sheetz, M., Nov 22 2011, In : Current Biology. 21, 22

Research output: Contribution to journalShort survey

Open Access
6 Scopus citations
2019

Large and reversible myosin-dependent forces in rigidity sensing

Lohner, J., Rupprecht, J. F., Hu, J., Mandriota, N., Saxena, M., de Araujo, D. P., Hone, J., Sahin, O., Prost, J. & Sheetz, M., Jul 1 2019, In : Nature Physics. 15, 7, p. 689-695 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

The role of feature curvature in contact guidance

Mathur, A., Moore, S. W., Sheetz, M. & Hone, J., Jul 1 2012, In : Acta Biomaterialia. 8, 7, p. 2595-2601 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Bifunctional nanoarrays for probing the immune response at the single-molecule level

Cai, H., Depoil, D., Palma, M., Sheetz, M., Dustin, M. L. & Wind, S. J., Nov 1 2013, In : Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures. 31, 6, 6F902.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair

Moore, S. W. & Sheetz, M. P., Nov 2011, In : Developmental Neurobiology. 71, 11, p. 1090-1101 12 p.

Research output: Contribution to journalArticle

51 Scopus citations
2016

The mechanical response of talin

Yao, M., Goult, B. T., Klapholz, B., Hu, X., Toseland, C. P., Guo, Y., Cong, P., Sheetz, M. P. & Yan, J., Jul 7 2016, In : Nature communications. 7, 11966.

Research output: Contribution to journalArticle

Open Access
106 Scopus citations
2018

Erratum: Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions (Developmental cell (2018) 44 3 (326-336.e3) PII: S1534-5807(18)30409-X)

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Jun 4 2018, In : Developmental cell. 45, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Cai, H., Muller, J., Depoil, D., Mayya, V., Sheetz, M. P., Dustin, M. L. & Wind, S. J., Jul 1 2018, In : Nature Nanotechnology. 13, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Differential mechanical stability of filamin A rod segments

Chen, H., Zhu, X., Cong, P., Sheetz, M. P., Nakamura, F. & Yan, J., Sep 7 2011, In : Biophysical journal. 101, 5, p. 1231-1237 7 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
2012

Cells test substrate rigidity by local contractions on submicrometer pillars

Ghassemi, S., Meacci, G., Liu, S., Gondarenko, A. A., Mathur, A., Roca-Cusachs, P., Sheetz, M. P. & Hone, J., Apr 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5328-5333 6 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations
2011

New approach for measuring protrusive forces in cells

Mathur, A., Roca-Cusachs, P., Rossier, O. M., Wind, S. J., Sheetz, M. & Hone, J., Jan 1 2011, In : Journal of Vacuum Science and Technology B:Nanotechnology and Microelectronics. 29, 6, 06FA02.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Higuchi, S., Lin, Q., Wang, J., Lim, T. K., Joshi, S. B., Anand, G. S., Chung, M. C. M., Sheetz, M. P. & Fujita, H., Mar 2013, In : Journal of Bioscience and Bioengineering. 115, 3, p. 320-325 6 p.

Research output: Contribution to journalArticle

33 Scopus citations
2012

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

Pan, C. Q., Sudol, M., Sheetz, M. & Low, B. C., Nov 1 2012, In : Cellular Signalling. 24, 11, p. 2143-2165 23 p.

Research output: Contribution to journalReview article

Open Access
47 Scopus citations
2011

Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin

Margadant, F., Chew, L. L., Hu, X., Yu, H., Bate, N., Zhang, X. & Sheetz, M., Dec 2011, In : PLoS Biology. 9, 12, e1001223.

Research output: Contribution to journalArticle

Open Access
129 Scopus citations
2019

Stopping transformed cancer cell growth by rigidity sensing

Yang, B., Wolfenson, H., Chung, V. Y., Nakazawa, N., Liu, S., Hu, J., Huang, R. Y. J. & Sheetz, M. P., Jan 1 2019, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

5 Scopus citations
2014

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M. & Sheetz, M., Aug 19 2014, In : FEBS Letters. 588, 16, p. 2663-2670 8 p.

Research output: Contribution to journalReview article

Open Access
202 Scopus citations
2017

Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

Saxena, M., Changede, R., Hone, J., Wolfenson, H. & Sheetz, M., Dec 13 2017, In : Nano Letters. 17, 12, p. 7242-7251 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2019

Steps in Mechanotransduction Pathways that Control Cell Morphology

Wolfenson, H., Yang, B. & Sheetz, M. P., Feb 10 2019, In : Annual review of physiology. 81, p. 585-605 21 p.

Research output: Contribution to journalReview article

26 Scopus citations
2017

Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics

Changede, R. & Sheetz, M., Jan 1 2017, In : BioEssays. 39, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations
2012

Force-dependent cell signaling in stem cell differentiation

Yim, E. K. F. & Sheetz, M., Nov 6 2012, In : Stem Cell Research and Therapy. 3, 5, 41.

Research output: Contribution to journalReview article

Open Access
87 Scopus citations
2013

Analysis of the local organization and dynamics of cellular actin networks

Luo, W., Yu, C. H., Lieu, Z. Z., Allard, J., Mogilner, A., Sheetz, M. P. & Bershadsky, A. D., 2013, In : Journal of Cell Biology. 202, 7, p. 1057-1073 17 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
2016

Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains

Sathe, A. R., Shivashankar, G. V. & Sheetz, M., May 15 2016, In : Journal of Cell Science. 129, 10, p. 1981-1988 8 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2012

The lasker awards: Motors take centre stage

Sheetz, M., Spudich, J. & Vale, R., Nov 1 2012, In : Nature Cell Biology. 14, 11, 1 p.

Research output: Contribution to journalEditorial

Open Access
2016

α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M. R., Iskratsch, T., Mathur, A., Ghassemi, S., Gauthier, N., Tabdanov, E., Lohner, J., Gondarenko, A., Chander, A. C., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M. P., Nov 7 2016, In : Molecular Biology of the Cell. 27, 22, p. 3471-3479 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
2017

EGFR and HER2 activate rigidity sensing only on rigid matrices

Saxena, M., Liu, S., Yang, B., Hajal, C., Changede, R., Hu, J., Wolfenson, H., Hone, J. & Sheetz, M. P., Jul 1 2017, In : Nature Materials. 16, 7, p. 775-781 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Mechanical confinement triggers glioma linear migration dependent on formin FHOD3

Monzo, P., Chong, Y. K., Guetta-Terrier, C., Krishnasamy, A., Sathe, S. R., Yim, E. K. F., Ng, W. H., Ang, B. T., Tang, C., Ladoux, B., Gauthier, N. C. & Sheetz, M., Apr 15 2016, In : Molecular Biology of the Cell. 27, 8, p. 1246-1261 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Formin DAAM1 organizes actin filaments in the cytoplasmic nodal actin network

Luo, W., Lieu, Z. Z., Manser, E., Bershadsky, A. D. & Sheetz, M. P., Oct 2016, In : PloS one. 11, 10, e0163915.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2014

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P. & Yan, J., Apr 9 2014, In : Scientific reports. 4, 4610.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations
2017

Spatial control of biological ligands on surfaces applied to T cell activation

Cai, H., Depoil, D., Muller, J., Sheetz, M. P., Dustin, M. L. & Wind, S. J., 2017, Methods in Molecular Biology. Humana Press Inc., p. 307-331 25 p. (Methods in Molecular Biology; vol. 1584).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations