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  • Kathryn Cunningham
2019

Targeting the 5-ht2c receptor in biological context and the current state of 5-ht2c receptor ligand development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

8 Scopus citations
2017

Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption

McGrath, E. L., Gao, J., Kuo, Y. F., Dunn, T. J., Ray, M. J., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Dec 12 2017, In : Stem Cell Reports. 9, 6, p. 1916-1930 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine

Simmler, L. D., Anacker, A. M. J., Levin, M. H., Vaswani, N. M., Gresch, P. J., Nackenoff, A. G., Anastasio, N. C., Stutz, S. J., Cunningham, K. A., Wang, J., Zhang, B., Henry, L. K., Stewart, A., Veenstra-VanderWeele, J. & Blakely, R. D., Jan 1 2017, In : British Journal of Pharmacology. 174, 16, p. 2716-2738 23 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

5-HT2c Receptors localize to dopamine and gaba neurons in the rat mesoaccumbens pathway

Bubar, M. J., Stutz, S. J. & Cunningham, K. A., 2011, In : PloS one. 6, 6, e20508.

Research output: Contribution to journalArticle

75 Scopus citations
2013

Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 1 2013, In : Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2020

Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants

Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In : Frontiers in Psychiatry. 11, 532.

Research output: Contribution to journalArticle

Open Access
2011

Serotonin (5-hydroxytryptamine) 5-HT2A receptor: Association with inherent and cocaine-evoked behavioral disinhibition in rats

Anastasio, N. C., Stoffel, E. C., Fox, R. G., Bubar, M. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jun 2011, In : Behavioural Pharmacology. 22, 3, p. 248-261 14 p.

Research output: Contribution to journalArticle

34 Scopus citations
2012
19 Scopus citations
2019

Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges

Sholler, D. J. & Cunningham, K. A., Jul 17 2019, In : ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.

Research output: Contribution to journalEditorial

2014

Frontiers of biomolecular exploration in brain disorders

Nilsson, C. L. & Cunningham, K. A., Jan 2014, In : Neuropsychopharmacology. 39, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

2019

In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)

Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., 2019, In : Frontiers in Pharmacology. 10, JULY, 907.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2020

Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In : Neuropharmacology. 168, 108009.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning

Cortez, I. D., Bulavin, D. V., Wu, P., McGrath, E. L., Cunningham, K. A., Wakamiya, M., Papaconstantinou, J. & Dineley, K. T., Mar 30 2017, In : Behavioural Brain Research. 322, p. 212-222 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2019

Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex

Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. C. & Cunningham, K. A., Jul 17 2019, In : ACS chemical neuroscience. 10, 7, p. 3241-3248 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U

Kasper, J. M., McCue, D. L., Milton, A. J., Szwed, A., Sampson, C. M., Huang, M., Carlton, S., Meltzer, H. Y., Cunningham, K. A. & Hommel, J. D., Dec 1 2016, In : Biological Psychiatry. 80, 11, p. 878-887 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Functional status of the serotonin 5-HT 2C receptor (5-HT 2C R) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence

Anastasio, N. C., Stutz, S. J., Fox, R. G., Sears, R. M., Emeson, R. B., Dileone, R. J., O'Neil, R. T., Fink, L. H., Li, D., Green, T. A., Gerard Moeller, F. & Cunningham, K. A., Jan 2014, In : Neuropsychopharmacology. 39, 2, p. 360-372 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2013

Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior

Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In : Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction

Cunningham, K. A. & Anastasio, N. C., 2014, In : Neuropharmacology. 76, PART B, p. 460-478 19 p.

Research output: Contribution to journalReview article

79 Scopus citations
2012

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators

Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In : ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues

Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In : Addictive Behaviors. 37, 2, p. 193-197 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2019

Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats

Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In : Appetite. 133, p. 231-239 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study

Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In : Frontiers in Psychiatry. 3, JUN, Article 60.

Research output: Contribution to journalArticle

26 Scopus citations
2020

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In : Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats

Anastasio, N. C., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. D. & Cunningham, K. A., Sep 1 2019, In : Neuropsychopharmacology. 44, 10, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Waters, A. J., Cunningham, K. A. & Moeller, F. G., Mar 2011, In : American Journal of Drug and Alcohol Abuse. 37, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2013

Synergism between a serotonin 5-HT2A receptor (5-HT 2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction

Cunningham, K. A., Anastasio, N. C., Fox, R. G., Stutz, S. J., Bubar, M. J., Swinford, S. E., Watson, C. S., Gilbertson, S. R., Rice, K. C., Rosenzweig-Lipson, S. & Moeller, F. G., Jan 16 2013, In : ACS chemical neuroscience. 4, 1, p. 110-121 12 p.

Research output: Contribution to journalArticle

63 Scopus citations
2016

Is There a causal relation between maternal acetaminophen administration and ADHD?

Saad, A., Hegde, S., Kechichian, T., Gamble, P., Rahman, M., Stutz, S. J., Anastasio, N. C., Alshehri, W., Lei, J., Mori, S., Kajs, B., Cunningham, K. A., Saade, G., Burd, I. & Costantine, M., Jun 2016, In : PloS one. 11, 6, e0157380.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., May 17 2013, In : Frontiers in Psychiatry. 4, FEB, Article 2.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In : ACS Chemical Neuroscience. 7, 5, p. 546-552 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity

Anastasio, N. C., Liu, S., Maili, L., Swinford, S., Lane, S. D., Fox, R. G., Hamon, S. C., Nielsen, D. A., Cunningham, K. A. & Moeller, F. G., 2014, In : Translational psychiatry. 4, e369.

Research output: Contribution to journalArticle

27 Scopus citations
2020

Serotonin neurobiology in cocaine use disorder

Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

Research output: Chapter in Book/Report/Conference proceedingChapter

2019

Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro

Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In : Scientific reports. 9, 1, 16737.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder

Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In : Psychiatry Research - Neuroimaging. 294, 110977.

Research output: Contribution to journalArticle

2 Scopus citations
2017

PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial

Schmitz, J. M., Green, C. E., Hasan, K. M., Vincent, J., Suchting, R., Weaver, M. F., Moeller, F. G., Narayana, P. A., Cunningham, K. A., Dineley, K. T. & Lane, S. D., Oct 2017, In : Addiction. 112, 10, p. 1861-1868 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1

Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In : Molecular and cellular biology. 33, 5, p. 918-926 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
2019

The 5-HT2A receptor (5-HT2AR) regulates impulsive action and cocaine cue reactivity in Male Sprague-Dawley rats

Sholler, D. J., Stutz, S. J., Fox, R. G., Boone, E. L., Wang, Q., Rice, K. C., Gerard Moeller, F., Anastasio, N. C. & Cunningham, K. A., Jan 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Lorcaserin Suppresses Oxycodone Self-Administration and Relapse Vulnerability in Rats

Neelakantan, H., Holliday, E. D., Fox, R. G., Stutz, S. J., Comer, S. D., Haney, M., Anastasio, N. C., Moeller, F. G. & Cunningham, K. A., May 17 2017, In : ACS chemical neuroscience. 8, 5, p. 1065-1073 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2012

Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In : Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

Gao, Y., Yao, T., Deng, Z., Sohn, J. W., Sun, J., Huang, Y., Kong, X., Yu, K. J., Wang, R. T., Chen, H., Guo, H., Yan, J., Cunningham, K. A., Chang, Y., Liu, T. & Williams, K. W., Jan 17 2017, In : Cell Reports. 18, 3, p. 583-592 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Editors’ Favorites of 2016

Lindsley, C. W., Hooker, J. M., Cunningham, K. A. & Andrews, A. M., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations
2019
1 Scopus citations

Chronic poly-drug administration damages adult mouse brain neural stem cells

McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J., Dineley, K., Cunningham, K., Kaphalia, B. & Wu, P., Nov 15 2019, In : Brain Research. 1723, 146425.

Research output: Contribution to journalArticle

2014

Multi-well plate immunoassays for measuring signaling protein activations/deactivations and membrane vs. intracellular receptor levels

Watson, C. S., Jeng, Y. J., Bulayeva, N. N., Finnerty, C. C., Koong, L. Y., Zivadinovic, D., Alyea, R. A., Midoro-Horiuti, T., Goldblum, R. M., Anastasio, N. C., Cunningham, K. A., Seitz, P. K. & Smith, T. D., 2014, In : Methods in Molecular Biology. 1204, p. 123-133 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2020

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In : Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journalArticle

2019

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Synthesis and evaluation of dimeric derivatives of 5-HT 2A receptor (5-HT 2AR) antagonist M-100907

Shashack, M. J., Cunningham, K. A., Seitz, P. K., McGinnis, A., Smith, T. D., Watson, C. S. & Gilbertson, S. R., Nov 16 2011, In : ACS chemical neuroscience. 2, 11, p. 640-644 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system

Swinford-Jackson, S. E., Anastasio, N. C., Fox, R. G., Stutz, S. J. & Cunningham, K. A., Jun 2 2016, In : Neuroscience. 324, p. 50-61 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Serotonin2C receptors in the ventral pallidum regulate motor function in rats

Graves, S. M., Viskniskki, A. A., Cunningham, K. A. & Celeste Napier, T., Aug 7 2013, In : NeuroReport. 24, 11, p. 605-608 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

Translating pharmacology into therapeutics to fight the opioid crisis

Marek, G. J., Cunningham, K. A. & Rasmussen, K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 394-395 2 p.

Research output: Contribution to journalEditorial

Open Access
2017

Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist

Chen, Y. C., Hartley, R. M., Anastasio, N. C., Cunningham, K. A. & Gilbertson, S. R., May 17 2017, In : ACS chemical neuroscience. 8, 5, p. 1004-1010 7 p.

Research output: Contribution to journalArticle

6 Scopus citations